| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michelle R Dickerson, Susan F Murphy, Michael J Urban, Zakar White, Pamela J VandeVor. Chronic Anxiety- and Depression-Like Behaviors Are Associated With Glial-Driven Pathology Following Repeated Blast Induced Neurotrauma. Frontiers in behavioral neuroscience. vol 15. 2021-12-27. PMID:34955781. |
these behaviors were also correlated with astrocyte pathology (glial-fibrillary acid protein, gfap) and dendritic alterations (microtubule-associated proteins, map2) within the hippocampus and mc regions at 52 weeks. |
2021-12-27 |
2023-08-13 |
rat |
| Yin Yuxiong, Xiang Xujin, Tang Yi, Chen Ya, Li Yujuan, Hu Shanshan, Wang Huiwe. Brain-specific TRAF7 deletion ameliorates traumatic brain injury by suppressing MEKK3-regulated glial inflammation and neuronal death. International immunopharmacology. vol 103. 2021-12-25. PMID:34953447. |
moreover, the aberrant activation of astrocyte and microglia in cortex and hippocampus of tbi mice was significantly restrained by traf7 conditional knockout in brain, as indicated by the increased expression of gfap and iba1. |
2021-12-25 |
2023-08-13 |
mouse |
| b' Marija Juri\\xc4\\x87, Marta Balog, Vedrana Ivi\\xc4\\x87, Benjamin Benzon, Anita Racetin, Ivana Bo\\xc4\\x8dina, Nives Kevi\\xc4\\x87, Suzana Konjevoda, K\\xc3\\xa1lm\\xc3\\xa1n F Sz\\xc5\\xb1cs, R\\xc3\\xb3bert G\\xc3\\xa1sp\\xc3\\xa1r, Marija Heffer, Katarina Vukojevi\\xc4\\x87, Sandor G Vari, Natalija Filipovi\\xc4\\x8. Chronic Stress and Gonadectomy Affect the Expression of Cx37, Cx40 and Cx43 in the Spinal Cord. Life (Basel, Switzerland). vol 11. issue 12. 2021-12-24. PMID:34947861.' |
we did not find any effect of chronic stress and castration, alone or together, on cx43 expression in the dh, but the percentage of cx43 overlapping the astrocyte marker glial fibrillary acidic protein (gfap) increased in the male stressed group after the castration. |
2021-12-24 |
2023-08-13 |
rat |
| Yu Zhou, Wei-Jiang Zhao, Wei Quan, Chen-Meng Qiao, Chun Cui, Hui Hong, Yun Shi, Gu-Yu Niu, Li-Ping Zhao, Yan-Qin She. Dynamic changes of activated AHR in microglia and astrocytes in the substantia nigra-striatum system in an MPTP-induced Parkinson's disease mouse model. Brain research bulletin. vol 176. 2021-12-10. PMID:34478811. |
to determine exactly the ahr activation in relation to changes of glial cell reactivity, double if labeling was performed for either iba1 (microglia marker) and p-ahr, or gfap (astrocyte marker) and p-ahr. |
2021-12-10 |
2023-08-13 |
mouse |
| Lei Wu, Shuang Li, Chao Li, Bin He, Linyi Lv, Jia Wang, Jierui Wang, Weixuan Wang, Yanshu Zhan. The role of regulatory T cells on the activation of astrocytes in the brain of high-fat diet mice following lead exposure. Chemico-biological interactions. vol 351. 2021-12-10. PMID:34742682. |
tgf-β and il-10 secreted by treg cells and the intracellular transcription factor foxp3 were evaluated as a measure of treg cell function; astrocyte activation was assessed by evaluating glial fibrillary acidic protein (gfap) expression. |
2021-12-10 |
2023-08-13 |
mouse |
| Yoshiki Takai, Tatsuro Misu, Hiroyoshi Suzuki, Toshiyuki Takahashi, Hiromi Okada, Shinya Tanaka, Kenji Okita, Shunichi Sasou, Mika Watanabe, Chihiro Namatame, Yuki Matsumoto, Hirohiko Ono, Kimihiko Kaneko, Shuhei Nishiyama, Hiroshi Kuroda, Ichiro Nakashima, Hans Lassmann, Kazuo Fujihara, Yasuto Itoyama, Masashi Aok. Staging of astrocytopathy and complement activation in neuromyelitis optica spectrum disorders. Brain : a journal of neurology. vol 144. issue 8. 2021-12-08. PMID:33711152. |
astrocytopathy in aqp4-igg+nmosd was classified into the following four stages defined by the astrocyte morphology and immunoreactivity for gfap: (i) astrocyte lysis: extensive loss of astrocytes with fragmented and/or dust-like particles; (ii) progenitor recruitment: loss of astrocytes except small nucleated cells with gfap-positive fibre-forming foot processes; (iii) protoplasmic gliosis: presence of star-shaped astrocytes with abundant gfap-reactive cytoplasm; and (iv) fibrous gliosis: lesions composed of densely packed mature astrocytes. |
2021-12-08 |
2023-08-13 |
Not clear |
| Alexander Kirschner, Ana N Strat, John Yablonski, Hannah Yoo, Tyler Bagué, Haiyan Li, Jing Zhao, Kathryn E Bollinger, Samuel Herberg, Preethi S Ganapath. Mechanosensitive channel inhibition attenuates TGFβ2-induced actin cytoskeletal remodeling and reactivity in mouse optic nerve head astrocytes. Experimental eye research. vol 212. 2021-12-08. PMID:34656548. |
primary optic nerve head astrocytes were positive for the astrocyte marker gfap and negative for markers for microglia (f4/80) and oligodendrocytes (osp1). |
2021-12-08 |
2023-08-13 |
mouse |
| Petra Steinacker, Mhd Rami Al Shweiki, Patrick Oeckl, Heiko Graf, Albert C Ludolph, Carlos Schönfeldt-Lecuona, Markus Ott. Glial fibrillary acidic protein as blood biomarker for differential diagnosis and severity of major depressive disorder. Journal of psychiatric research. vol 144. 2021-12-07. PMID:34600287. |
our study aimed to determine the utility of glial fibrillary acidic protein (gfap), a marker of astrocyte activation, for the differential diagnosis and monitoring of mdd. |
2021-12-07 |
2023-08-13 |
Not clear |
| Petra Steinacker, Mhd Rami Al Shweiki, Patrick Oeckl, Heiko Graf, Albert C Ludolph, Carlos Schönfeldt-Lecuona, Markus Ott. Glial fibrillary acidic protein as blood biomarker for differential diagnosis and severity of major depressive disorder. Journal of psychiatric research. vol 144. 2021-12-07. PMID:34600287. |
neurofilament light chain serum levels were not different in the diagnostic groups and not associated with gfap levels (r = 0.0911, p = 0.576) pointing to an independence of astrocyte activation on neurodegeneration. |
2021-12-07 |
2023-08-13 |
Not clear |
| Teresa Lorenzi, Andrea Sagrati, Eva Montanari, Martina Senzacqua, Manrico Morroni, Mara Fabr. Hypoxia-induced expression of neuronal nitric oxide synthase in astrocytes of human corpus callosum. Brain structure & function. vol 226. issue 4. 2021-11-30. PMID:33709161. |
autoptic samples of cc from adult human subjects have been processed with immunohistochemistry and immunofluorescence using antibodies anti-nnos and anti-glial fibrillary acidic protein (gfap), the astrocyte marker. |
2021-11-30 |
2023-08-13 |
human |
| Tracy L Hageman. Alexander disease: models, mechanisms, and medicine. Current opinion in neurobiology. vol 72. 2021-11-30. PMID:34826654. |
alexander disease is a primary disorder of astrocytes caused by gain-of-function mutations in the gene for glial fibrillary acidic protein (gfap), which lead to protein aggregation and a reactive astrocyte response, with devastating effects on the central nervous system. |
2021-11-30 |
2023-08-13 |
Not clear |
| Tracy L Hageman. Alexander disease: models, mechanisms, and medicine. Current opinion in neurobiology. vol 72. 2021-11-30. PMID:34826654. |
despite these efforts, many aspects of alexander disease have remained enigmatic, particularly the initiating events in gfap accumulation and astrocyte pathology, the relation between astrocyte dysfunction and myelin deficits, and the variability in age of onset and disease severity. |
2021-11-30 |
2023-08-13 |
Not clear |
| Hang Yin, Hao Qin, Tiantian Wang, Qiang Zhuang, Qixia Yan. The Protective Effects of Apremilast Against Oxygen-Glucose Deprivation/Reperfusion (OGD/R)-Induced Inflammation and Apoptosis in Astroglia Mediated by CREB/BDNF. Neurotoxicity research. vol 39. issue 3. 2021-11-29. PMID:33826130. |
our findings show that treatment with apremilast could significantly reduce astrocyte apoptosis and cell death induced by ogd/r as evidenced by reduced release of glial fibrillary acidic protein (gfap) and improvement of the bax/bcl-2 ratio. |
2021-11-29 |
2023-08-13 |
Not clear |
| Talwinder Gill, Sarah E Watling, J Don Richardson, Tina McCluskey, Junchao Tong, Jeffrey H Meyer, Jerry Warsh, Rakesh Jetly, Michael G Hutchison, Shawn G Rhind, Sylvain Houle, Neil Vasdev, Stephen J Kish, Isabelle Boilea. Imaging of astrocytes in posttraumatic stress disorder: A PET study with the monoamine oxidase B radioligand [ European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 54. 2021-11-29. PMID:34773851. |
decreased astrocyte-related proteins (e.g., glial fibrillary acidic protein, gfap) and atrophic astrocytes in corticolimbic brain areas implicated in ptsd have been reported in experimental models suggesting that astrocyte pathology may be a feature of this disorder. |
2021-11-29 |
2023-08-13 |
Not clear |
| Liping Zhou, Panpan Yao, Lixia Jiang, Zhaoyun Wang, Xiaohe Ma, Guangxin Wen, Jintao Yang, Binjie Zhou, Qin Y. Salidroside-pretreated mesenchymal stem cells contribute to neuroprotection in cerebral ischemic injury in vitro and in vivo. Journal of molecular histology. vol 52. issue 6. 2021-11-26. PMID:34570327. |
the mature neuron marker neun and astrocyte marker gfap in the focal area were detected by immunofluorescence. |
2021-11-26 |
2023-08-13 |
rat |
| Santiago Ramirez, Abhisek Mukherjee, Sofia Sepulveda, Andrea Becerra-Calixto, Nicolas Bravo-Vasquez, Camila Gherardelli, Melissa Chavez, Claudio Sot. Modeling Traumatic Brain Injury in Human Cerebral Organoids. Cells. vol 10. issue 10. 2021-11-25. PMID:34685663. |
to adapt the cci procedure into cos, we have developed a phantom brain matrix, matching the mechanical characteristics of the brain, altogether with an empty mouse skull as a platform to allow the use of the stereotactic cci equipment on cos. after the cci procedure, cos were histologically prepared to evaluate neurons and astrocyte populations using the microtubule-associated protein 2 (map2) and the glial fibrillary acidic protein (gfap). |
2021-11-25 |
2023-08-13 |
mouse |
| Baisong Zhao, Yongying Pan, Haiping Xu, Xingrong Son. Wnt10a/β-catenin signalling is involved in kindlin-1-mediated astrocyte activation in a chronic construction injury rat model. The European journal of neuroscience. vol 54. issue 10. 2021-11-24. PMID:34618385. |
inhibiting gfap in vitro led to decreased kindlin-1 levels, prevented astrocyte activation, decreased wnt10a level and the release of inflammatory mediators (p < 0.05). |
2021-11-24 |
2023-08-13 |
rat |
| Bailey Balouch, Jessica L Funnell, Alexis M Ziemba, Devan L Puhl, Kathy Lin, Manoj K Gottipati, Ryan J Gilber. Conventional immunomarkers stain a fraction of astrocytes in vitro: A comparison of rat cortical and spinal cord astrocytes in naïve and stimulated cultures. Journal of neuroscience research. vol 99. issue 3. 2021-11-23. PMID:33295039. |
however, glast, glt-1, gs, and sox9 are also produced by microglia and oligodendrocytes and gfap, glast, glt-1, and gs production levels are affected by astrocyte phenotypic changes associated with reactive astrogliosis. |
2021-11-23 |
2023-08-13 |
rat |
| Jun Fan, Qiu-Ling Zhong, Ran Mo, Cheng-Lin Lu, Jing Ren, Jia-Wen Mo, Fang Guo, You-Lu Wen, Xiong Ca. Proteomic Profiling of Astrocytic O-GlcNAc Transferase-Related Proteins in the Medial Prefrontal Cortex. Frontiers in molecular neuroscience. vol 14. 2021-11-23. PMID:34803603. |
gfap, an astrocyte maker, was increased after ogt deletion. |
2021-11-23 |
2023-08-13 |
Not clear |
| Jun Cai, Yi Yan, Daying Zhang, Mengye Zhu, Zhijian Wang, Xuexue Zhang, Mu X. Silencing of lncRNA Gm14461 alleviates pain in trigeminal neuralgia through inhibiting astrocyte activation. IUBMB life. vol 72. issue 12. 2021-11-22. PMID:33141516. |
astrocyte activation was evaluated by glial fibrillary acidic protein (gfap) immunofluorescence and western blot analysis of gfap. |
2021-11-22 |
2023-08-13 |
mouse |