| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chang Liu, Shanshan Guan, Jingwen E, Zhijie Yang, Xinyue Zhang, Jianan Ju, Song Wang, Hao Zhan. Insight into the Inhibitory Mechanism of Aryl Formyl Piperidine Derivatives on Monoacylglycerol Lipase through Molecular Dynamics Simulations. Molecules (Basel, Switzerland). vol 27. issue 21. 2022-11-11. PMID:36364337. |
monoacylglycerol lipase (magl) can regulate the endocannabinoid system and thus becomes a target of antidepressant drugs. |
2022-11-11 |
2023-08-14 |
Not clear |
| Jing Xu, Guanghui Zheng, Juntao Hu, Weiwei Ge, Jennifer L Bradley, Joseph P Ornato, Wanchun Tan. The monoacylglycerol lipase inhibitor, JZL184, has comparable effects to therapeutic hypothermia, attenuating global cerebral injury in a rat model of cardiac arrest. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 156. 2022-10-17. PMID:36252353. |
monoacylglycerol lipase (magl) is an enzyme that is predominantly responsible for the metabolism of endocannabinoid 2-arachidonoylglycerol (2-ag) to arachidonic acid (aa) metabolites, which are associated with inflammation. |
2022-10-17 |
2023-08-14 |
rat |
| Yingfang He, Uwe Grether, Marco F Taddio, Carla Meier, Claudia Keller, Martin R Edelmann, Michael Honer, Sylwia Huber, Matthias B Wittwer, Dominik Heer, Hans Richter, Ludovic Collin, Melanie N Hug, Manuel Hilbert, Annemarieke G J Postmus, Anna Floor Stevens, Mario van der Stelt, Stefanie D Krämer, Roger Schibli, Linjing Mu, Luca C Gobb. Multi-parameter optimization: Development of a morpholin-3-one derivative with an improved kinetic profile for imaging monoacylglycerol lipase in the brain. European journal of medicinal chemistry. vol 243. 2022-09-22. PMID:36137365. |
monoacylglycerol lipase (magl) is a gatekeeper in regulating endocannabinoid signaling and has gained substantial attention as a therapeutic target for neurological disorders. |
2022-09-22 |
2023-08-14 |
Not clear |
| Hui Deng, Qianwen Zhang, Qian Lei, Na Yang, Kai Yang, Jianbing Jiang, Zhiyi Y. Discovering monoacylglycerol lipase inhibitors by a combination of fluorogenic substrate assay and activity-based protein profiling. Frontiers in pharmacology. vol 13. 2022-09-15. PMID:36105202. |
the endocannabinoid 2-arachidonoylglycerol (2-ag) is predominantly metabolized by monoacylglycerol lipase (magl) in the brain. |
2022-09-15 |
2023-08-14 |
Not clear |
| Yuta Kudo, Keiichi Konoki, Mari Yotsu-Yamashit. Mass spectrometry-guided discovery of new analogues of bicyclic phosphotriester salinipostin and evaluation of their monoacylglycerol lipase inhibitory activity. Bioscience, biotechnology, and biochemistry. 2022-08-02. PMID:35918181. |
previously known and herein-identified spt analogues inhibited the activity of human monoacylglycerol lipase (magl), a key serine hydrolase in the endocannabinoid system, in the nanomolar range. |
2022-08-02 |
2023-08-14 |
human |
| Alexius Lampkin, Vaishali Baksh. Effects of Increasing Endocannabinoid 2-AG Tone on Sensorimotor Gating and Anxiety-like behavior. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556730. |
we were particularly interested in pursuing an understudied approach, augmentation of endogenous endocannabinoid 'tone' via inhibition of monoacylglycerol lipase (magl), the breakdown enzyme for the endocannabinoid 2-ag. |
2022-05-13 |
2023-08-13 |
rat |
| Ran Cheng, Masayuki Fujinaga, Jing Yang, Jian Rong, Ahmed Haider, Daisuke Ogasawara, Richard S Van, Tuo Shao, Zhen Chen, Xiaofei Zhang, Erick R Calderon Leon, Yiding Zhang, Wakana Mori, Katsushi Kumata, Tomoteru Yamasaki, Lin Xie, Shaofa Sun, Lu Wang, Chongzhao Ran, Yihan Shao, Benjamin Cravatt, Lee Josephson, Ming-Rong Zhang, Steven H Lian. A novel monoacylglycerol lipase-targeted Acta pharmacologica Sinica. 2022-05-05. PMID:35513432. |
a novel monoacylglycerol lipase-targeted monoacylglycerol lipase (magl) constitutes a serine hydrolase that orchestrates endocannabinoid homeostasis and exerts its function by catalyzing the degradation of 2-arachidonoylglycerol (2-ag) to arachidonic acid (aa). |
2022-05-05 |
2023-08-13 |
Not clear |
| Min-Che Tung, Kit-Man Fung, Hsin-Mie Hsu, Tien-Sheng Tsen. Discovery of 8-prenylnaringenin from hop ( RSC advances. vol 11. issue 49. 2022-05-02. PMID:35498911. |
discovery of 8-prenylnaringenin from hop ( monoacylglycerol lipase (magl), a serine hydrolase, converts endocannabinoid 2-arachidonoylglycerol (2-ag) to arachidonic acid (aa) and glycerol in the brain and plays a bidirectional role in controlling nueroinflammation. |
2022-05-02 |
2023-08-13 |
human |
| Shivanshu Bajaj, Saima Zameer, Shreshta Jain, Vaishali Yadav, Divya Vohor. Effect of the MAGL/FAAH Dual Inhibitor JZL-195 on Streptozotocin-Induced Alzheimer's Disease-like Sporadic Dementia in Mice with an Emphasis on Aβ, HSP-70, Neuroinflammation, and Oxidative Stress. ACS chemical neuroscience. 2022-03-22. PMID:35316021. |
recently, pharmacological inhibition of endocannabinoid (ecb)-degrading enzymes, fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), is being investigated to modulate the pathology of alzheimer's disease. |
2022-03-22 |
2023-08-13 |
mouse |
| Yingfang He, Luca C Gobbi, Adrienne Müller Herde, Didier Rombach, Martin Ritter, Bernd Kuhn, Matthias B Wittwer, Dominik Heer, Benoit Hornsperger, Charles Bell, Fionn O'Hara, Jörg Benz, Michael Honer, Claudia Keller, Ludovic Collin, Hans Richter, Roger Schibli, Uwe Grether, Linjing M. Discovery, synthesis and evaluation of novel reversible monoacylglycerol lipase radioligands bearing a morpholine-3-one scaffold. Nuclear medicine and biology. vol 108-109. 2022-03-06. PMID:35248850. |
monoacylglycerol lipase (magl) is a serine hydrolase that plays an important role in the endocannabinoid degradation in the brain. |
2022-03-06 |
2023-08-13 |
Not clear |
| Ryosuke Arakawa, Akihiro Takano, Sangram Nag, Zhisheng Jia, Nahid Amini, Kevin P Maresca, Lei Zhang, Edmund J Keliher, Christopher R Butler, Justin R Piro, Tarek A Samad, Deborah Smith, Deane Nason, Steve O'Neil, Patrick Trapa, Kari R Fonseca, John Litchfield, Timothy McCarthy, Richard E Carson, Christer Halldi. Target occupancy study and whole-body dosimetry with a MAGL PET ligand [ EJNMMI research. vol 12. issue 1. 2022-03-04. PMID:35244788. |
target occupancy study and whole-body dosimetry with a magl pet ligand [ monoacylglycerol lipase (magl) is a key serine hydrolase which terminates endocannabinoid signaling and regulates arachidonic acid driven inflammatory responses within the central nervous system. |
2022-03-04 |
2023-08-13 |
Not clear |
| Ikumi Mizuno, Shingo Matsuda, Suguru Tohyama, Akihiro Mizutan. The role of the cannabinoid system in fear memory and extinction in male and female mice. Psychoneuroendocrinology. vol 138. 2022-02-17. PMID:35176534. |
an enhancement of 2-arachidonylglycerol (2-ag, one of the two major endocannabinoids) via jzl184 (an inhibitor of the 2-ag hydrolase monoacylglycerol lipase [magl]), augmented the retrieval of fear memory through the activation of cb1r but not cb2r in female mice. |
2022-02-17 |
2023-08-13 |
mouse |
| Tuo Shao, Zhen Chen, Jian Rong, Vasily Belov, Jiahui Chen, Andre Jeyarajan, Xiaoyun Deng, Hualong Fu, Qingzhen Yu, Steve H Rwema, Wenyu Lin, Mikhail Papisov, Lee Josephson, Raymond T Chung, Steven H Lian. [ Acta pharmaceutica Sinica. B. vol 12. issue 1. 2022-02-07. PMID:35127387. |
[ monoacylglycerol lipase (magl) is a pivotal enzyme in the endocannabinoid system, which metabolizes 2-arachidonoylglycerol (2-ag) into the proinflammatory eicosanoid precursor arachidonic acid (aa). |
2022-02-07 |
2023-08-13 |
Not clear |
| Yingfang He, Matthias Schild, Uwe Grether, Jörg Benz, Lea Leibrock, Dominik Heer, Andreas Topp, Ludovic Collin, Bernd Kuhn, Matthias Wittwer, Claudia Keller, Luca C Gobbi, Roger Schibli, Linjing M. Development of High Brain-Penetrant and Reversible Monoacylglycerol Lipase PET Tracers for Neuroimaging. Journal of medicinal chemistry. 2022-01-28. PMID:35089028. |
monoacylglycerol lipase (magl) is one of the key enzymes in the endocannabinoid system. |
2022-01-28 |
2023-08-13 |
Not clear |
| Maximilian Barth, Stefan Rudolph, Jan Kampschulze, Imke Meyer Zu Vilsendorf, Walburga Hanekamp, Dennis Mulac, Klaus Langer, Matthias Leh. Hexafluoroisopropyl carbamates as selective MAGL and dual MAGL/FAAH inhibitors: biochemical and physicochemical properties. ChemMedChem. 2022-01-24. PMID:35072346. |
a series of hexafluoroisopropyl carbamates with indolyl-alkyl- and azaindolylalkyl-substituents at the carbamate nitrogen was synthesized and evaluated for inhibition of the endocannabinoid degrading enzymes fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl). |
2022-01-24 |
2023-08-13 |
Not clear |
| Keisuke Takahata, Chie Seki, Yasuyuki Kimura, Manabu Kubota, Masanori Ichise, Yasunori Sano, Yasuharu Yamamoto, Kenji Tagai, Hitoshi Shimada, Soichiro Kitamura, Kiwamu Matsuoka, Hironobu Endo, Hitoshi Shinotoh, Kazunori Kawamura, Ming-Rong Zhang, Yuhei Takado, Makoto Higuch. First-in-human in vivo undefined imaging and quantification of monoacylglycerol lipase in the brain: a PET study with European journal of nuclear medicine and molecular imaging. 2022-01-13. PMID:35022846. |
first-in-human in vivo undefined imaging and quantification of monoacylglycerol lipase in the brain: a pet study with monoacylglycerol lipase (magl) regulates cannabinoid neurotransmission and the pro-inflammatory arachidonic acid pathway by degrading endocannabinoids. |
2022-01-13 |
2023-08-13 |
human |
| Justin Matheson, Xin Ming Matthew Zhou, Zoe Bourgault, Bernard Le Fol. Potential of Fatty Acid Amide Hydrolase (FAAH), Monoacylglycerol Lipase (MAGL), and Diacylglycerol Lipase (DAGL) Enzymes as Targets for Obesity Treatment: A Narrative Review. Pharmaceuticals (Basel, Switzerland). vol 14. issue 12. 2021-12-28. PMID:34959715. |
potential of fatty acid amide hydrolase (faah), monoacylglycerol lipase (magl), and diacylglycerol lipase (dagl) enzymes as targets for obesity treatment: a narrative review. |
2021-12-28 |
2023-08-13 |
human |
| Jenny L Wilkerson, Joshua A Bilbrey, Jasmine S Felix, Alexandros Makriyannis, Lance R McMaho. Untapped endocannabinoid pharmacological targets: Pipe dream or pipeline? Pharmacology, biochemistry, and behavior. vol 206. 2021-11-24. PMID:33932409. |
the endocannabinoid system comprises both cannabinoid receptors, their endogenous ligands including 2-arachidonoylglycerol (2-ag), n-arachidonylethanolamine (anandamide, aea), and enzymes that regulate the synthesis and degradation of endogenous ligands which include diacylglycerol lipase alpha (dagl-α), diacylglycerol lipase beta (dagl-β), fatty acid amide hydrolase (faah), monoacylglycerol lipase (magl), α/β hydrolase domain 6 (abhd6). |
2021-11-24 |
2023-08-13 |
Not clear |
| Dan P Covey, Edith Hernandez, Miguel Á Luján, Joseph F Chee. Chronic Augmentation of Endocannabinoid Levels Persistently Increases Dopaminergic Encoding of Reward Cost and Motivation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 32. 2021-11-22. PMID:34230105. |
because endocannabinoid (ecb) signaling facilitates goal seeking and nac da release, we further investigated whether repeated augmentation of the ecb 2-arachidonoylglycerol with a low dose of a monoacylglycerol lipase (magl) inhibitor facilitates motivation and da signaling without the development of tolerance. |
2021-11-22 |
2023-08-13 |
mouse |
| Yasushi Hattori, Chie Seki, Jun Maeda, Yuji Nagai, Kazunobu Aoyama, Ming-Rong Zhang, Takafumi Minamimoto, Tatsuki Koike, Makoto Higuch. Quantification of monoacylglycerol lipase and its occupancy by an exogenous ligand in rhesus monkey brains using [ Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2021-11-13. PMID:34727758. |
quantification of monoacylglycerol lipase and its occupancy by an exogenous ligand in rhesus monkey brains using [ monoacylglycerol lipase (magl) is a cytosolic serine hydrolase that cleaves monoacylglycerols into fatty acids and is a potential target for the novel treatment of cns disorders related to the endocannabinoid system and neuroinflammation. |
2021-11-13 |
2023-08-13 |
monkey |