| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anca Zanfirescu, Anca Ungurianu, Dragos Paul Mihai, Denise Radulescu, George Mihai Nitulesc. Targeting Monoacylglycerol Lipase in Pursuit of Therapies for Neurological and Neurodegenerative Diseases. Molecules (Basel, Switzerland). vol 26. issue 18. 2021-11-11. PMID:34577139. |
monoacylglycerol lipase (magl) is a key enzyme involved in the metabolism of 2-ag (2-arachidonoylglycerol), a neuroprotective endocannabinoid intimately linked to the generation of pro- and anti-inflammatory molecules. |
2021-11-11 |
2023-08-13 |
Not clear |
| Jing Liu, Kirstin Hester, Carey Pop. Dose- and time-related effects of acute diisopropylfluorophosphate intoxication on forced swim behavior and sucrose preference in rats. Neurotoxicology. vol 82. 2021-10-29. PMID:33232745. |
adult male rats were treated with vehicle (peanut oil, 1 ml/kg, sc) or dfp (2.0, 2.25 or 2.5 mg/kg) followed by sacrifice 4 h later for measurement of op-sensitive serine hydrolases (cholinesterase [che], fatty acid amide hydrolase [faah], and monoacylglycerol lipase [magl]) in hippocampus. |
2021-10-29 |
2023-08-13 |
rat |
| Alex J Berry, Olga Zubko, Suzanne J Reeves, Robert J Howar. Endocannabinoid system alterations in Alzheimer's disease: A systematic review of human studies. Brain research. vol 1749. 2021-10-27. PMID:32980333. |
we attempted to identify reported changes in the expression and activity of: cannabinoid receptors 1 and 2; anandamide (aea); 2-arachidonoylglycerol (2-ag); monoacylglycerol lipase (magl); fatty acid amide hydrolase (faah); and transient receptor potential cation channel v1 (trpv1). |
2021-10-27 |
2023-08-13 |
human |
| Despina Kokona, Dimitris Spyridakos, Manolis Tzatzarakis, Sofia Papadogkonaki, Eirini Filidou, Konstantinos I Arvanitidis, George Kolios, Manjunath Lamani, Alexandros Makriyannis, Michael S Malamas, Kyriaki Thermo. The endocannabinoid 2-arachidonoylglycerol and dual ABHD6/MAGL enzyme inhibitors display neuroprotective and anti-inflammatory actions in the in vivo retinal model of AMPA excitotoxicity. Neuropharmacology. vol 185. 2021-10-21. PMID:33450278. |
here, we aimed to investigate the ability of the endocannabinoid 2-arachidonoylglycerol (2-ag) and novel inhibitors of its metabolic enzymes, α/β-hydrolase domain-containing 6 (abhd6) and monoacylglycerol lipase (magl), a) to protect the retina against excitotoxicity and b) the mechanisms involved in the neuroprotection. |
2021-10-21 |
2023-08-13 |
rat |
| Casey R Vickstrom, Xiaojie Liu, Shuai Liu, Meng-Ming Hu, Lianwei Mu, Ying Hu, Hao Yu, Santidra L Love, Cecilia J Hillard, Qing-Song Li. Role of endocannabinoid signaling in a septohabenular pathway in the regulation of anxiety- and depressive-like behavior. Molecular psychiatry. vol 26. issue 7. 2021-10-15. PMID:33093652. |
this endocannabinoid-mediated depolarization-induced suppression of inhibition (dsi) was limited by monoacylglycerol lipase (magl) but not by fatty acid amide hydrolase. |
2021-10-15 |
2023-08-13 |
Not clear |
| Tomoteru Yamasaki, Akiko Hatori, Yiding Zhang, Wakana Mori, Yusuke Kurihara, Masanao Ogawa, Hidekatsu Wakizaka, Jian Rong, Lu Wang, Steven Liang, Ming-Rong Zhan. Neuroprotective effects of minocycline and KML29, a potent inhibitor of monoacylglycerol lipase, in an experimental stroke model: a small-animal positron emission tomography study. Theranostics. vol 11. issue 19. 2021-10-15. PMID:34646382. |
monoacylglycerol lipase (magl) is a modulator of 2-arachidonoylglycerol (2-ag), which is involved in retrograde inhibition of glutamate release in the endocannabinoid system. |
2021-10-15 |
2023-08-13 |
rat |
| Giulia Bononi, Giacomo Tonarini, Giulio Poli, Ivana Barravecchia, Isabella Caligiuri, Marco Macchia, Flavio Rizzolio, Gian Carlo Demontis, Filippo Minutolo, Carlotta Granchi, Tiziano Tuccinard. Monoacylglycerol lipase (MAGL) inhibitors based on a diphenylsulfide-benzoylpiperidine scaffold. European journal of medicinal chemistry. vol 223. 2021-10-12. PMID:34218085. |
monoacylglycerol lipase (magl) is an enzyme belonging to the endocannabinoid system that mainly metabolizes the endocannabinoid 2-arachidonoylglycerol (2-ag). |
2021-10-12 |
2023-08-13 |
Not clear |
| Swarup Mitra, Pedro H Gobira, Craig T Werner, Jennifer A Martin, Madoka Iida, Shruthi A Thomas, Kyra Erias, Sophia Miracle, Charles Lafargue, Chunna An, David M Diet. A role for the endocannabinoid enzymes monoacylglycerol and diacylglycerol lipases in cue-induced cocaine craving following prolonged abstinence. Addiction biology. vol 26. issue 5. 2021-10-06. PMID:33496035. |
at prolonged abstinence (30 days) from cocaine self-administration, there is an increase in the nac levels of diacylglycerol lipase (dagl), the enzyme responsible for the synthesis of the endocannabinoid 2-ag, along with decreased levels of monoacylglycerol lipase (magl), which hydrolyzes 2-ag. |
2021-10-06 |
2023-08-13 |
Not clear |
| Juan Carlos Ledesma, Marta Rodríguez-Arias, Ana L Gavito, Ana M Sánchez-Pérez, José Viña, Dina Medina Vera, Fernando Rodríguez de Fonseca, José Miñarr. Adolescent binge-ethanol accelerates cognitive impairment and β-amyloid production and dysregulates endocannabinoid signaling in the hippocampus of APP/PSE mice. Addiction biology. vol 26. issue 1. 2021-10-05. PMID:32043730. |
at 6 and 12 months of age, we evaluated hippocampal-dependent learning and memory: β-amyloid concentrations and rna and protein levels of cannabinoid type-2 receptors (cb2), diacylglycerol lipase-α (daglα), and monoacylglycerol lipase (magl) in the hippocampus. |
2021-10-05 |
2023-08-13 |
mouse |
| Reshed Abohalaka, Turgut Emrah Bozkurt, Tuba Reçber, Sevgen Celik Onder, Emirhan Nemutlu, Sedef Kır, Inci Sahin-Erdeml. The effects of systemic and local fatty acid amide hydrolase and monoacylglycerol lipase inhibitor treatments on the metabolomic profile of lungs. Biomedical chromatography : BMC. 2021-09-17. PMID:34449902. |
previously, we have shown that increasing the tissue endocannabinoid levels by fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl) inhibitors can prevent airway inflammation and hyperreactivity. |
2021-09-17 |
2023-08-13 |
mouse |
| Vibhu Jha, Marzia Biagi, Valeria Spinelli, Miriana Di Stefano, Marco Macchia, Filippo Minutolo, Carlotta Granchi, Giulio Poli, Tiziano Tuccinard. Discovery of Monoacylglycerol Lipase (MAGL) Inhibitors Based on a Pharmacophore-Guided Virtual Screening Study. Molecules (Basel, Switzerland). vol 26. issue 1. 2021-09-10. PMID:33375358. |
monoacylglycerol lipase (magl) is an important enzyme of the endocannabinoid system that catalyzes the degradation of the major endocannabinoid 2-arachidonoylglycerol (2-ag). |
2021-09-10 |
2023-08-13 |
Not clear |
| Alexis F League, Benjamin L Gorman, Douglas J Hermes, Clare T Johnson, Ian R Jacobs, Barkha J Yadav-Samudrala, Justin L Poklis, Micah J Niphakis, Benjamin F Cravatt, Aron H Lichtman, Bogna M Ignatowska-Jankowska, Sylvia Fittin. Monoacylglycerol Lipase Inhibitor MJN110 Reduces Neuronal Hyperexcitability, Restores Dendritic Arborization Complexity, and Regulates Reward-Related Behavior in Presence of HIV-1 Tat. Frontiers in neurology. vol 12. 2021-09-07. PMID:34484091. |
as demand grows for supplemental strategies to combat virus-associated pathology presenting frequently as hiv-associated neurocognitive disorders (hand), the present study aimed to characterize the potential utility of inhibiting monoacylglycerol lipase (magl) activity to increase inhibitory activity at cannabinoid receptor-type 1 receptors through upregulation of 2-arachidonoylglycerol (2-ag) and downregulation of its degradation into proinflammatory metabolite arachidonic acid (aa). |
2021-09-07 |
2023-08-13 |
human |
| Ning Yang, Houyi Sun, Yi Xue, Weicheng Zhang, Hongzhi Wang, Huaqiang Tao, Xiaolong Liang, Meng Li, Yaozeng Xu, Liang Chen, Liang Zhang, Lixin Huang, Dechun Gen. Inhibition of MAGL activates the Keap1/Nrf2 pathway to attenuate glucocorticoid-induced osteonecrosis of the femoral head. Clinical and translational medicine. vol 11. issue 6. 2021-09-02. PMID:34185425. |
here, we found that monoacylglycerol lipase (magl), a key molecule in the endocannabinoid system, was significantly upregulated during gc treatment in osteoblasts both in vitro and in vivo. |
2021-09-02 |
2023-08-13 |
Not clear |
| Pretal P Muldoon, Lois S Akinola, Joel E Schlosburg, Aron H Lichtman, Laura J Sim-Selley, Anu Mahadevan, Benjamin F Cravatt, M Imad Dama. Inhibition of monoacylglycerol lipase reduces nicotine reward in the conditioned place preference test in male mice. Neuropharmacology. vol 176. 2021-08-13. PMID:32479813. |
contrary to our hypothesis, we found that inhibition of monoacylglycerol lipase (magl), the primary catabolic enzyme of 2-ag, attenuates nicotine conditioned place preference (cpp) in mice, through a non-cb1 receptor-mediated mechanism. |
2021-08-13 |
2023-08-13 |
mouse |
| Jack Hashem, Mei Hu, Jian Zhang, Fei Gao, Chu Che. Inhibition of 2-Arachidonoylglycerol Metabolism Alleviates Neuropathology and Improves Cognitive Function in a Tau Mouse Model of Alzheimer's Disease. Molecular neurobiology. vol 58. issue 8. 2021-07-17. PMID:33939165. |
it has been proposed that monoacylglycerol lipase (magl), the key enzyme degrading the endocannabinoid 2-arachidonoylglycerol (2-ag) in the brain, is a therapeutic target for ad based on the studies using the app transgenic models of ad. |
2021-07-17 |
2023-08-13 |
mouse |
| Silvia Marino, Giovana Carrasco, Boya Li, Karan M Shah, Darren L Lath, Antonia Sophocleous, Michelle A Lawson, Aymen I Idri. JZL184, A Monoacylglycerol Lipase Inhibitor, Induces Bone Loss in a Multiple Myeloma Model of Immunocompetent Mice. Calcified tissue international. vol 107. issue 1. 2021-07-14. PMID:32285169. |
pharmacological manipulation of monoacylglycerol lipase (magl), an enzyme responsible for the degradation of the endocannabinoid 2-arachidonoyl glycerol (2-ag), reduced skeletal tumour burden and osteolysis associated with osteosarcoma and advanced breast and prostate cancers. |
2021-07-14 |
2023-08-13 |
mouse |
| Si-Yu Ren, Zhen-Zhen Wang, Yi Zhang, Nai-Hong Che. Potential application of endocannabinoid system agents in neuropsychiatric and neurodegenerative diseases-focusing on FAAH/MAGL inhibitors. Acta pharmacologica Sinica. vol 41. issue 10. 2021-06-28. PMID:32203086. |
the inhibitors of two endocannabinoid hydrolases, i.e., fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), have the capacity to increase the level of endocannabinoids indirectly, causing fewer side effects than those associated with direct supplementation of cannabinoids. |
2021-06-28 |
2023-08-13 |
Not clear |
| Ziad Omra. New Disulfiram Derivatives as MAGL-Selective Inhibitors. Molecules (Basel, Switzerland). vol 26. issue 11. 2021-06-22. PMID:34070869. |
monoacylglycerol lipase (magl) is a key enzyme in the human endocannabinoid system. |
2021-06-22 |
2023-08-13 |
human |
| Estefania Rojo-Bustamante, Ignacio Íñigo-Marco, Miguel Angel Abellanas, Rodrigo Vinueza-Gavilanes, Ana Baltanás, Esther Luquin, Montserrat Arrasate, Maria S Aymeric. CB2 Receptors and Neuron-Glia Interactions Modulate Neurotoxicity Generated by MAGL Inhibition. Biomolecules. vol 10. issue 8. 2021-06-14. PMID:32824740. |
monoacylglycerol lipase inhibition (magl) has emerged as an interesting therapeutic target for neurodegenerative disease treatment due to its ability to modulate the endocannabinoid system and to prevent the production of proinflammatory mediators. |
2021-06-14 |
2023-08-13 |
rat |
| Jan Lukas Prüser, Robert Ramer, Felix Wittig, Igor Ivanov, Jutta Merkord, Burkhard Hin. The Monoacylglycerol Lipase Inhibitor JZL184 Inhibits Lung Cancer Cell Invasion and Metastasis via the CB Molecular cancer therapeutics. vol 20. issue 5. 2021-06-11. PMID:33632876. |
an important enzyme for the endocannabinoid metabolism is the monoacylglycerol lipase (magl), which catalyzes the degradation of 2-arachidonoylglycerol (2-ag) to glycerol and free fatty acids. |
2021-06-11 |
2023-08-13 |
mouse |