| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Xu, Guanghui Zheng, Juntao Hu, Weiwei Ge, Jennifer L Bradley, Joseph P Ornato, Wanchun Tan. The monoacylglycerol lipase inhibitor, JZL184, has comparable effects to therapeutic hypothermia, attenuating global cerebral injury in a rat model of cardiac arrest. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 156. 2022-10-17. PMID:36252353. |
monoacylglycerol lipase (magl) is an enzyme that is predominantly responsible for the metabolism of endocannabinoid 2-arachidonoylglycerol (2-ag) to arachidonic acid (aa) metabolites, which are associated with inflammation. |
2022-10-17 |
2023-08-14 |
rat |
| Laura López-Gómez, Agata Szymaszkiewicz, Marta Zielińska, Raquel Abal. The Enteric Glia and Its Modulation by the Endocannabinoid System, a New Target for Cannabinoid-Based Nutraceuticals? Molecules (Basel, Switzerland). vol 27. issue 19. 2022-10-14. PMID:36235308. |
the endogenous cannabinoid system (ecs) includes endogenous classical cannabinoids (anandamide, 2-arachidonoylglycerol), cannabinoid-like ligands (oleoylethanolamide (oea) and palmitoylethanolamide (pea)), enzymes involved in their metabolism (faah, magl, cox-2) and classical (cb1 and cb2) and non-classical (trpv1, gpr55, ppar) receptors. |
2022-10-14 |
2023-08-14 |
Not clear |
| Yingfang He, Uwe Grether, Marco F Taddio, Carla Meier, Claudia Keller, Martin R Edelmann, Michael Honer, Sylwia Huber, Matthias B Wittwer, Dominik Heer, Hans Richter, Ludovic Collin, Melanie N Hug, Manuel Hilbert, Annemarieke G J Postmus, Anna Floor Stevens, Mario van der Stelt, Stefanie D Krämer, Roger Schibli, Linjing Mu, Luca C Gobb. Multi-parameter optimization: Development of a morpholin-3-one derivative with an improved kinetic profile for imaging monoacylglycerol lipase in the brain. European journal of medicinal chemistry. vol 243. 2022-09-22. PMID:36137365. |
monoacylglycerol lipase (magl) is a gatekeeper in regulating endocannabinoid signaling and has gained substantial attention as a therapeutic target for neurological disorders. |
2022-09-22 |
2023-08-14 |
Not clear |
| Hui Deng, Qianwen Zhang, Qian Lei, Na Yang, Kai Yang, Jianbing Jiang, Zhiyi Y. Discovering monoacylglycerol lipase inhibitors by a combination of fluorogenic substrate assay and activity-based protein profiling. Frontiers in pharmacology. vol 13. 2022-09-15. PMID:36105202. |
the endocannabinoid 2-arachidonoylglycerol (2-ag) is predominantly metabolized by monoacylglycerol lipase (magl) in the brain. |
2022-09-15 |
2023-08-14 |
Not clear |
| Yuta Kudo, Keiichi Konoki, Mari Yotsu-Yamashit. Mass spectrometry-guided discovery of new analogues of bicyclic phosphotriester salinipostin and evaluation of their monoacylglycerol lipase inhibitory activity. Bioscience, biotechnology, and biochemistry. 2022-08-02. PMID:35918181. |
previously known and herein-identified spt analogues inhibited the activity of human monoacylglycerol lipase (magl), a key serine hydrolase in the endocannabinoid system, in the nanomolar range. |
2022-08-02 |
2023-08-14 |
human |
| Alexius Lampkin, Vaishali Baksh. Effects of Increasing Endocannabinoid 2-AG Tone on Sensorimotor Gating and Anxiety-like behavior. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556730. |
we were particularly interested in pursuing an understudied approach, augmentation of endogenous endocannabinoid 'tone' via inhibition of monoacylglycerol lipase (magl), the breakdown enzyme for the endocannabinoid 2-ag. |
2022-05-13 |
2023-08-13 |
rat |
| Ran Cheng, Masayuki Fujinaga, Jing Yang, Jian Rong, Ahmed Haider, Daisuke Ogasawara, Richard S Van, Tuo Shao, Zhen Chen, Xiaofei Zhang, Erick R Calderon Leon, Yiding Zhang, Wakana Mori, Katsushi Kumata, Tomoteru Yamasaki, Lin Xie, Shaofa Sun, Lu Wang, Chongzhao Ran, Yihan Shao, Benjamin Cravatt, Lee Josephson, Ming-Rong Zhang, Steven H Lian. A novel monoacylglycerol lipase-targeted Acta pharmacologica Sinica. 2022-05-05. PMID:35513432. |
a novel monoacylglycerol lipase-targeted monoacylglycerol lipase (magl) constitutes a serine hydrolase that orchestrates endocannabinoid homeostasis and exerts its function by catalyzing the degradation of 2-arachidonoylglycerol (2-ag) to arachidonic acid (aa). |
2022-05-05 |
2023-08-13 |
Not clear |
| Min-Che Tung, Kit-Man Fung, Hsin-Mie Hsu, Tien-Sheng Tsen. Discovery of 8-prenylnaringenin from hop ( RSC advances. vol 11. issue 49. 2022-05-02. PMID:35498911. |
discovery of 8-prenylnaringenin from hop ( monoacylglycerol lipase (magl), a serine hydrolase, converts endocannabinoid 2-arachidonoylglycerol (2-ag) to arachidonic acid (aa) and glycerol in the brain and plays a bidirectional role in controlling nueroinflammation. |
2022-05-02 |
2023-08-13 |
human |
| Adriana Della Pietra, Juha Savinainen, Rashid Giniatulli. Inhibiting Endocannabinoid Hydrolysis as Emerging Analgesic Strategy Targeting a Spectrum of Ion Channels Implicated in Migraine Pain. International journal of molecular sciences. vol 23. issue 8. 2022-04-23. PMID:35457225. |
we describe here: (i) migraine pain signaling pathways, which could serve as specific targets for antinociception; (ii) a divergent distribution of magl and faah activities in the key regions of the pns and cns implicated in migraine pain signaling; (iii) a complexity of anti-nociceptive effects of endocbs mediated by cannabinoid receptors and through a direct modulation of ion channels in nociceptive neurons; and (iv) the spectrum of emerging potent magl and faah inhibitors which efficiently increase endocbs levels. |
2022-04-23 |
2023-08-13 |
Not clear |
| Lakhan S Khara, Md Ruhul Amin, Declan W Al. Inhibiting the endocannabinoid degrading enzymes FAAH and MAGL during zebrafish embryogenesis alters sensorimotor function. The Journal of experimental biology. 2022-04-19. PMID:35438163. |
inhibiting the endocannabinoid degrading enzymes faah and magl during zebrafish embryogenesis alters sensorimotor function. |
2022-04-19 |
2023-08-13 |
zebrafish |
| Shivanshu Bajaj, Saima Zameer, Shreshta Jain, Vaishali Yadav, Divya Vohor. Effect of the MAGL/FAAH Dual Inhibitor JZL-195 on Streptozotocin-Induced Alzheimer's Disease-like Sporadic Dementia in Mice with an Emphasis on Aβ, HSP-70, Neuroinflammation, and Oxidative Stress. ACS chemical neuroscience. 2022-03-22. PMID:35316021. |
recently, pharmacological inhibition of endocannabinoid (ecb)-degrading enzymes, fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), is being investigated to modulate the pathology of alzheimer's disease. |
2022-03-22 |
2023-08-13 |
mouse |
| Yingfang He, Luca C Gobbi, Adrienne Müller Herde, Didier Rombach, Martin Ritter, Bernd Kuhn, Matthias B Wittwer, Dominik Heer, Benoit Hornsperger, Charles Bell, Fionn O'Hara, Jörg Benz, Michael Honer, Claudia Keller, Ludovic Collin, Hans Richter, Roger Schibli, Uwe Grether, Linjing M. Discovery, synthesis and evaluation of novel reversible monoacylglycerol lipase radioligands bearing a morpholine-3-one scaffold. Nuclear medicine and biology. vol 108-109. 2022-03-06. PMID:35248850. |
monoacylglycerol lipase (magl) is a serine hydrolase that plays an important role in the endocannabinoid degradation in the brain. |
2022-03-06 |
2023-08-13 |
Not clear |
| Ryosuke Arakawa, Akihiro Takano, Sangram Nag, Zhisheng Jia, Nahid Amini, Kevin P Maresca, Lei Zhang, Edmund J Keliher, Christopher R Butler, Justin R Piro, Tarek A Samad, Deborah Smith, Deane Nason, Steve O'Neil, Patrick Trapa, Kari R Fonseca, John Litchfield, Timothy McCarthy, Richard E Carson, Christer Halldi. Target occupancy study and whole-body dosimetry with a MAGL PET ligand [ EJNMMI research. vol 12. issue 1. 2022-03-04. PMID:35244788. |
target occupancy study and whole-body dosimetry with a magl pet ligand [ monoacylglycerol lipase (magl) is a key serine hydrolase which terminates endocannabinoid signaling and regulates arachidonic acid driven inflammatory responses within the central nervous system. |
2022-03-04 |
2023-08-13 |
Not clear |
| Tuo Shao, Zhen Chen, Jian Rong, Vasily Belov, Jiahui Chen, Andre Jeyarajan, Xiaoyun Deng, Hualong Fu, Qingzhen Yu, Steve H Rwema, Wenyu Lin, Mikhail Papisov, Lee Josephson, Raymond T Chung, Steven H Lian. [ Acta pharmaceutica Sinica. B. vol 12. issue 1. 2022-02-07. PMID:35127387. |
[ monoacylglycerol lipase (magl) is a pivotal enzyme in the endocannabinoid system, which metabolizes 2-arachidonoylglycerol (2-ag) into the proinflammatory eicosanoid precursor arachidonic acid (aa). |
2022-02-07 |
2023-08-13 |
Not clear |
| Tuo Shao, Zhen Chen, Jian Rong, Vasily Belov, Jiahui Chen, Andre Jeyarajan, Xiaoyun Deng, Hualong Fu, Qingzhen Yu, Steve H Rwema, Wenyu Lin, Mikhail Papisov, Lee Josephson, Raymond T Chung, Steven H Lian. [ Acta pharmaceutica Sinica. B. vol 12. issue 1. 2022-02-07. PMID:35127387. |
magl and other endogenous cannabinoid (ec) degrading enzymes are involved in the fibrogenic signaling pathways that induce hepatic stellate cell (hsc) activation and ecm accumulation during chronic liver disease. |
2022-02-07 |
2023-08-13 |
Not clear |
| Yingfang He, Matthias Schild, Uwe Grether, Jörg Benz, Lea Leibrock, Dominik Heer, Andreas Topp, Ludovic Collin, Bernd Kuhn, Matthias Wittwer, Claudia Keller, Luca C Gobbi, Roger Schibli, Linjing M. Development of High Brain-Penetrant and Reversible Monoacylglycerol Lipase PET Tracers for Neuroimaging. Journal of medicinal chemistry. 2022-01-28. PMID:35089028. |
monoacylglycerol lipase (magl) is one of the key enzymes in the endocannabinoid system. |
2022-01-28 |
2023-08-13 |
Not clear |
| Maximilian Barth, Stefan Rudolph, Jan Kampschulze, Imke Meyer Zu Vilsendorf, Walburga Hanekamp, Dennis Mulac, Klaus Langer, Matthias Leh. Hexafluoroisopropyl carbamates as selective MAGL and dual MAGL/FAAH inhibitors: biochemical and physicochemical properties. ChemMedChem. 2022-01-24. PMID:35072346. |
a series of hexafluoroisopropyl carbamates with indolyl-alkyl- and azaindolylalkyl-substituents at the carbamate nitrogen was synthesized and evaluated for inhibition of the endocannabinoid degrading enzymes fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl). |
2022-01-24 |
2023-08-13 |
Not clear |
| Keisuke Takahata, Chie Seki, Yasuyuki Kimura, Manabu Kubota, Masanori Ichise, Yasunori Sano, Yasuharu Yamamoto, Kenji Tagai, Hitoshi Shimada, Soichiro Kitamura, Kiwamu Matsuoka, Hironobu Endo, Hitoshi Shinotoh, Kazunori Kawamura, Ming-Rong Zhang, Yuhei Takado, Makoto Higuch. First-in-human in vivo undefined imaging and quantification of monoacylglycerol lipase in the brain: a PET study with European journal of nuclear medicine and molecular imaging. 2022-01-13. PMID:35022846. |
first-in-human in vivo undefined imaging and quantification of monoacylglycerol lipase in the brain: a pet study with monoacylglycerol lipase (magl) regulates cannabinoid neurotransmission and the pro-inflammatory arachidonic acid pathway by degrading endocannabinoids. |
2022-01-13 |
2023-08-13 |
human |
| Shivanshu Bajaj, Shreshta Jain, Preeti Vyas, Sandhya Bawa, Divya Vohor. The role of endocannabinoid pathway in the neuropathology of Alzheimer's disease: Can the inhibitors of MAGL and FAAH prove to be potential therapeutic targets against the cognitive impairment associated with Alzheimer's disease? Brain research bulletin. vol 174. 2021-12-10. PMID:34217798. |
the role of endocannabinoid pathway in the neuropathology of alzheimer's disease: can the inhibitors of magl and faah prove to be potential therapeutic targets against the cognitive impairment associated with alzheimer's disease? |
2021-12-10 |
2023-08-13 |
Not clear |
| Shivanshu Bajaj, Shreshta Jain, Preeti Vyas, Sandhya Bawa, Divya Vohor. The role of endocannabinoid pathway in the neuropathology of Alzheimer's disease: Can the inhibitors of MAGL and FAAH prove to be potential therapeutic targets against the cognitive impairment associated with Alzheimer's disease? Brain research bulletin. vol 174. 2021-12-10. PMID:34217798. |
in order to modulate endocannabinoid system, number of agents have been reported amongst which are inhibitors of the monoacylglycerol (magl) and fatty acid amide hydrolase (faah), the enzymes that hydrolyses 2-ag and aea respectively. |
2021-12-10 |
2023-08-13 |
Not clear |