| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Si-Yu Ren, Zhen-Zhen Wang, Yi Zhang, Nai-Hong Che. Potential application of endocannabinoid system agents in neuropsychiatric and neurodegenerative diseases-focusing on FAAH/MAGL inhibitors. Acta pharmacologica Sinica. vol 41. issue 10. 2021-06-28. PMID:32203086. |
the inhibitors of two endocannabinoid hydrolases, i.e., fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), have the capacity to increase the level of endocannabinoids indirectly, causing fewer side effects than those associated with direct supplementation of cannabinoids. |
2021-06-28 |
2023-08-13 |
Not clear |
| Ziad Omra. New Disulfiram Derivatives as MAGL-Selective Inhibitors. Molecules (Basel, Switzerland). vol 26. issue 11. 2021-06-22. PMID:34070869. |
monoacylglycerol lipase (magl) is a key enzyme in the human endocannabinoid system. |
2021-06-22 |
2023-08-13 |
human |
| Estefania Rojo-Bustamante, Ignacio Íñigo-Marco, Miguel Angel Abellanas, Rodrigo Vinueza-Gavilanes, Ana Baltanás, Esther Luquin, Montserrat Arrasate, Maria S Aymeric. CB2 Receptors and Neuron-Glia Interactions Modulate Neurotoxicity Generated by MAGL Inhibition. Biomolecules. vol 10. issue 8. 2021-06-14. PMID:32824740. |
monoacylglycerol lipase inhibition (magl) has emerged as an interesting therapeutic target for neurodegenerative disease treatment due to its ability to modulate the endocannabinoid system and to prevent the production of proinflammatory mediators. |
2021-06-14 |
2023-08-13 |
rat |
| Jan Lukas Prüser, Robert Ramer, Felix Wittig, Igor Ivanov, Jutta Merkord, Burkhard Hin. The Monoacylglycerol Lipase Inhibitor JZL184 Inhibits Lung Cancer Cell Invasion and Metastasis via the CB Molecular cancer therapeutics. vol 20. issue 5. 2021-06-11. PMID:33632876. |
an important enzyme for the endocannabinoid metabolism is the monoacylglycerol lipase (magl), which catalyzes the degradation of 2-arachidonoylglycerol (2-ag) to glycerol and free fatty acids. |
2021-06-11 |
2023-08-13 |
mouse |
| Bin Zhu, Peter J Connolly, Yue-Mei Zhang, Mark E McDonnell, Haiyan Bian, Shu-Chen Lin, Li Liu, Sui-Po Zhang, Kristen M Chevalier, Michael R Brandt, Cynthia M Milligan, Christopher M Flores, Mark J Maciela. The discovery of azetidine-piperazine di-amides as potent, selective and reversible monoacylglycerol lipase (MAGL) inhibitors. Bioorganic & medicinal chemistry letters. vol 30. issue 14. 2021-06-01. PMID:32527545. |
monoacylglycerol lipase (magl) is the enzyme that is primarily responsible for hydrolyzing the endocannabinoid 2-arachidononylglycerol (2-ag) to arachidonic acid (aa). |
2021-06-01 |
2023-08-13 |
rat |
| Peter Manza, Kai Yuan, Ehsan Shokri-Kojori, Dardo Tomasi, Nora D Volko. Brain structural changes in cannabis dependence: association with MAGL. Molecular psychiatry. vol 25. issue 12. 2021-05-14. PMID:31695165. |
regions with high magl expression, and therefore with potentially physiologically restricted endogenous cannabinoid signaling, may be more vulnerable to the effects of chronic cannabis use on cortical thickness. |
2021-05-14 |
2023-08-13 |
human |
| C M Diester, A H Lichtman, S S Negu. Behavioral Battery for Testing Candidate Analgesics in Mice. II. Effects of Endocannabinoid Catabolic Enzyme Inhibitors and ∆9-Tetrahydrocannabinol. The Journal of pharmacology and experimental therapeutics. vol 377. issue 2. 2021-05-13. PMID:33622769. |
enhanced signaling of the endocannabinoid (ecb) system through inhibition of the catabolic enzymes monoacylglycerol lipase (magl) and fatty acid amide hydrolase (faah) has received increasing interest for development of candidate analgesics. |
2021-05-13 |
2023-08-13 |
mouse |
| Bin Zhu, Peter J Connolly, Sui-Po Zhang, Kristen M Chevalier, Cynthia M Milligan, Christopher M Flores, Mark J Maciela. The discovery of diazetidinyl diamides as potent and reversible inhibitors of monoacylglycerol lipase (MAGL). Bioorganic & medicinal chemistry letters. vol 30. issue 12. 2021-05-12. PMID:32334914. |
monoacylglycerol lipase (magl) has emerged as an attractive drug target because of its important role in regulating the endocannabinoid 2-arachidonoylglycerol (2-ag) and its hydrolysis product arachidonic acid (aa) in the brain. |
2021-05-12 |
2023-08-13 |
rat |
| Natasha L Grimsey, Juha R Savinainen, Bala Attili, Muneer Ahame. Regulating membrane lipid levels at the synapse by small-molecule inhibitors of monoacylglycerol lipase: new developments in therapeutic and PET imaging applications. Drug discovery today. vol 25. issue 2. 2021-04-30. PMID:31622747. |
monoacylglycerol lipase (magl) is a major endocannabinoid hydrolyzing enzyme and can be regulated to control endogenous lipid levels in the brain. |
2021-04-30 |
2023-08-13 |
Not clear |
| Teresa Chioccarelli, Marina Migliaccio, Antonio Suglia, Francesco Manfrevola, Veronica Porreca, Nadia Diano, Sonia Errico, Silvia Fasano, Gilda Cobelli. Characterization of Estrogenic Activity and Site-Specific Accumulation of Bisphenol-A in Epididymal Fat Pad: Interfering Effects on the Endocannabinoid System and Temporal Progression of Germ Cells. International journal of molecular sciences. vol 22. issue 5. 2021-04-22. PMID:33802611. |
the exposure to bpa affects the expression levels of some ecs components, namely type-1 (cb1) and type-2 cannabinoid (cb2) receptor and monoacylglycerol-lipase (magl). |
2021-04-22 |
2023-08-13 |
Not clear |
| Carlotta Granchi, Giulia Bononi, Rebecca Ferrisi, Eleonora Gori, Giulia Mantini, Sandra Glasmacher, Giulio Poli, Stefano Palazzolo, Isabella Caligiuri, Flavio Rizzolio, Vincenzo Canzonieri, Tiziana Perin, Jürg Gertsch, Andrea Sodi, Elisa Giovannetti, Marco Macchia, Filippo Minutolo, Tiziano Tuccinardi, Andrea Chicc. Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors. European journal of medicinal chemistry. vol 209. 2021-04-20. PMID:33045662. |
an interesting enzyme of the endocannabinoid system is monoacylglycerol lipase (magl). |
2021-04-20 |
2023-08-13 |
mouse |
| Carlotta Granchi, Giulia Bononi, Rebecca Ferrisi, Eleonora Gori, Giulia Mantini, Sandra Glasmacher, Giulio Poli, Stefano Palazzolo, Isabella Caligiuri, Flavio Rizzolio, Vincenzo Canzonieri, Tiziana Perin, Jürg Gertsch, Andrea Sodi, Elisa Giovannetti, Marco Macchia, Filippo Minutolo, Tiziano Tuccinardi, Andrea Chicc. Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors. European journal of medicinal chemistry. vol 209. 2021-04-20. PMID:33045662. |
biological evaluation, including assays in intact u937 cells and competitive activity-based protein profiling experiments in mouse brain membranes, confirmed the selectivity of the selected compounds for magl versus other components of the endocannabinoid system. |
2021-04-20 |
2023-08-13 |
mouse |
| Giulia Bononi, Giulio Poli, Flavio Rizzolio, Tiziano Tuccinardi, Marco Macchia, Filippo Minutolo, Carlotta Granch. An updated patent review of monoacylglycerol lipase (MAGL) inhibitors (2018-present). Expert opinion on therapeutic patents. vol 31. issue 2. 2021-04-06. PMID:33085920. |
monoacylglycerol lipase (magl) belongs to the endocannabinoid system and is responsible for the inactivation of endocannabinoid 2-arachidonoylglycerol. |
2021-04-06 |
2023-08-13 |
Not clear |
| Lu Hou, Jian Rong, Ahmed Haider, Daisuke Ogasawara, Cassis Varlow, Michael A Schafroth, Linjing Mu, Jiefeng Gan, Hao Xu, Christopher J Fowler, Ming-Rong Zhang, Neil Vasdev, Simon Ametamey, Benjamin F Cravatt, Lu Wang, Steven H Lian. Positron Emission Tomography Imaging of the Endocannabinoid System: Opportunities and Challenges in Radiotracer Development. Journal of medicinal chemistry. vol 64. issue 1. 2021-03-08. PMID:33379862. |
herein, we summarized the recent development of pet tracers for imaging cannabinoid receptors 1 (cb1r) and 2 (cb2r) as well as the key enzymes monoacylglycerol lipase (magl) and fatty acid amide hydrolase (faah), particularly focusing on pet neuroimaging applications. |
2021-03-08 |
2023-08-13 |
human |
| Gaurav Bedse, Mathew N Hill, Sachin Pate. 2-Arachidonoylglycerol Modulation of Anxiety and Stress Adaptation: From Grass Roots to Novel Therapeutics. Biological psychiatry. vol 88. issue 7. 2021-03-03. PMID:32197779. |
although initial preclinical and clinical development efforts focused on pharmacological inhibition of fatty acid amide hydrolase to elevate levels of the endocannabinoid anandamide, more recent efforts have focused on inhibition of monoacylglycerol lipase (magl) to enhance signaling of the most abundant and efficacious endocannabinoid ligand, 2-arachidonoylglycerol (2-ag). |
2021-03-03 |
2023-08-13 |
Not clear |
| Amal Thomas, Bright N Okine, David P Finn, Willias Masoch. Peripheral deficiency and antiallodynic effects of 2-arachidonoyl glycerol in a mouse model of paclitaxel-induced neuropathic pain. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 129. 2021-03-01. PMID:32603895. |
we also evaluated the peripheral antiallodynic activity of the endocannabinoid 2-arachidonoyl glycerol (2-ag) and an inhibitor of monoacylglycerol lipase (magl), an enzyme responsible for 2-ag hydrolysis. |
2021-03-01 |
2023-08-13 |
mouse |
| Sally Miller, Laura Daily, Vijai Dharla, Juerg Gertsch, Michael S Malamas, Iwao Ojima, Martin Kaczocha, Daisuke Ogasawara, Alex Straike. Endocannabinoid metabolism and transport as targets to regulate intraocular pressure. Experimental eye research. vol 201. 2021-03-01. PMID:32979397. |
inhibition of magl activity raises levels of the endocannabinoid 2-arachidonoyl glycerol and substantially lowers iop. |
2021-03-01 |
2023-08-13 |
Not clear |
| Alessandra Longaretti, Chiara Forastieri, Marina Gabaglio, Tiziana Rubino, Elena Battaglioli, Francesco Ruscon. Termination of acute stress response by the endocannabinoid system is regulated through lysine-specific demethylase 1-mediated transcriptional repression of 2-AG hydrolases ABHD6 and MAGL. Journal of neurochemistry. vol 155. issue 1. 2021-02-10. PMID:32141088. |
termination of acute stress response by the endocannabinoid system is regulated through lysine-specific demethylase 1-mediated transcriptional repression of 2-ag hydrolases abhd6 and magl. |
2021-02-10 |
2023-08-13 |
mouse |
| Malte Feja, Martin P K Leigh, Ajay N Baindur, Justin J McGraw, Ken T Wakabayashi, Benjamin F Cravatt, Caroline E Bas. The novel MAGL inhibitor MJN110 enhances responding to reward-predictive incentive cues by activation of CB1 receptors. Neuropharmacology. vol 162. 2021-01-06. PMID:31628934. |
conversely, enhancing endocannabinoid signaling, particularly 2-arachidonyl glycerol (2-ag), by inhibition of monoacyl glycerol lipase (magl), may facilitate some aspects of reward seeking. |
2021-01-06 |
2023-08-13 |
rat |
| Jing Wang, Xiaohua Zhang, Chongmei Yang, Shulei Zha. Effect of monoacylglycerol lipase inhibition on intestinal permeability in chronic stress model. Biochemical and biophysical research communications. vol 525. issue 4. 2020-12-28. PMID:32173532. |
the endocannabinoid 2-arachidonoylglycerol (2-ag) is an anti-nociceptive lipid, which is inactivated through cellular uptake and subsequent catabolism by monoacylglycerol lipase (magl). |
2020-12-28 |
2023-08-13 |
rat |