| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Parul Gupta, Shubhangini Tiwari, Abhishek Singh, Amit Pal, Amit Mishra, Sarika Sing. Rivastigmine attenuates the Alzheimer's disease related protein degradation and apoptotic neuronal death signalling. The Biochemical journal. vol 478. issue 7. 2021-09-13. PMID:33660768. |
the known inhibitory effect of rivastigmine on cognition and acetylcholinesterase activity was observed in both cortex and hippocampus and further its effect on tau level, amyloid aggregation, biochemical alterations, endoplasmic reticulum (er) stress, calcium homeostasis, proteasome activity and apoptosis was estimated. |
2021-09-13 |
2023-08-13 |
rat |
| Lauren E McCollum, Sandhitsu R Das, Long Xie, Robin de Flores, Jieqiong Wang, Sharon X Xie, Laura E M Wisse, Paul A Yushkevich, David A Wol. Oh brother, where art tau? Amyloid, neurodegeneration, and cognitive decline without elevated tau. NeuroImage. Clinical. vol 31. 2021-09-13. PMID:34119903. |
β-amyloid and tau status were determined by csf assays, while neurodegeneration status was based on hippocampal volume on mri. |
2021-09-13 |
2023-08-13 |
human |
| David S Priemer, Rebecca D Folkert. Dementia in the Forensic Setting: Diagnoses Obtained Using a Condensed Protocol at the Office of Chief Medical Examiner, New York City. Journal of neuropathology and experimental neurology. vol 80. issue 8. 2021-09-13. PMID:34388235. |
others included age-related tau astrogliopathy, hippocampal sclerosis of aging, progressive supranuclear palsy, multiple system atrophy, amyotrophic lateral sclerosis, argyrophilic grain disease, and creutzfeldt-jakob disease. |
2021-09-13 |
2023-08-13 |
Not clear |
| Jamie M Walker, Yelena Fudym, Kurt Farrell, Megan A Iida, Kevin F Bieniek, Sudha Seshadri, Charles L White, John F Crary, Timothy E Richardso. Asymmetry of Hippocampal Tau Pathology in Primary Age-Related Tauopathy and Alzheimer Disease. Journal of neuropathology and experimental neurology. vol 80. issue 5. 2021-09-09. PMID:33860327. |
asymmetry of hippocampal tau pathology in primary age-related tauopathy and alzheimer disease. |
2021-09-09 |
2023-08-13 |
Not clear |
| Xin Wang, En-Jie Liu, Qian Liu, Shi-Hong Li, Ting Li, Qiu-Zhi Zhou, Yan-Chao Liu, Huaqiu Zhang, Jian-Zhi Wan. Tau Acetylation in Entorhinal Cortex Induces its Chronic Hippocampal Propagation and Cognitive Deficits in Mice. Journal of Alzheimer's disease : JAD. vol 77. issue 1. 2021-09-08. PMID:32804150. |
tau acetylation in entorhinal cortex induces its chronic hippocampal propagation and cognitive deficits in mice. |
2021-09-08 |
2023-08-13 |
mouse |
| Israa M Abd El-Fatah, Heba M A Abdelrazek, Sherehan M Ibrahim, Dalaal M Abdallah, Hanan S El-Abha. Dimethyl fumarate abridged tauo-/amyloidopathy in a D-Galactose/ovariectomy-induced Alzheimer's-like disease: Modulation of AMPK/SIRT-1, AKT/CREB/BDNF, AKT/GSK-3β, adiponectin/Adipo1R, and NF-κB/IL-1β/ROS trajectories. Neurochemistry international. vol 148. 2021-09-08. PMID:34052296. |
mechanistically, dmf suppressed the hippocampal contents of ad-surrogate markers; viz., apolipoprotein (apo)-e1, bace1, aβ42, and hyperphosphorylated tau. |
2021-09-08 |
2023-08-13 |
rat |
| Yuhan Ma, Jing Wang, Dihui Xu, Yabing Chen, Xiaodong Ha. Chronic MC-LR exposure promoted Aβ and p-tau accumulation via regulating Akt/GSK-3β signal pathway. The Science of the total environment. vol 794. 2021-09-06. PMID:34323745. |
in this study, we observed β-amyloid (aβ) accumulation and tau hyperphosphorylation (p-tau) at sites of ser396 and thr205 in mouse hippocampus and cortex, alzheimer's disease (ad) like changes, after chronic exposure to mc-lr at different concentrations (1, 7.5, 15 and 30 μg/l) for 180 days. |
2021-09-06 |
2023-08-13 |
mouse |
| Yilin Shen, Haixia Hu, Cui Fan, Quan Wang, Tianyuan Zou, Bin Ye, Mingliang Xian. Sensorineural hearing loss may lead to dementia-related pathological changes in hippocampal neurons. Neurobiology of disease. vol 156. 2021-09-03. PMID:34082124. |
these results suggest that hearing loss alone causes neuronal degeneration, inhibition of neurogenesis, increased tau protein phosphorylation, and increased neuroinflammation in the hippocampus. |
2021-09-03 |
2023-08-13 |
mouse |
| Jing Yan, Ailin Luo, Rao Sun, Xiaole Tang, Yilin Zhao, Jie Zhang, Biyun Zhou, Hua Zheng, Honghui Yu, Shiyong L. Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery. Oxidative medicine and cellular longevity. vol 2020. 2021-09-02. PMID:33381265. |
resveratrol mitigates hippocampal tau acetylation and cognitive deficit by activation sirt1 in aged rats following anesthesia and surgery. |
2021-09-02 |
2023-08-13 |
rat |
| Jing Yan, Ailin Luo, Rao Sun, Xiaole Tang, Yilin Zhao, Jie Zhang, Biyun Zhou, Hua Zheng, Honghui Yu, Shiyong L. Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery. Oxidative medicine and cellular longevity. vol 2020. 2021-09-02. PMID:33381265. |
in the present study, our findings showed that tau acetylation mediated by sirt1 deficiency resulted in tau hyperphosphorylation in the hippocampus of the aged pocd model and consequently contributed to cognitive impairment. |
2021-09-02 |
2023-08-13 |
rat |
| Jing Yan, Ailin Luo, Rao Sun, Xiaole Tang, Yilin Zhao, Jie Zhang, Biyun Zhou, Hua Zheng, Honghui Yu, Shiyong L. Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery. Oxidative medicine and cellular longevity. vol 2020. 2021-09-02. PMID:33381265. |
interestingly, pretreatment with resveratrol almost restored the expression of sirt1, reduced the levels of acetylated tau and hyperphosphorylated tau in the hippocampus, and improved the cognitive performance in the behavioral tests. |
2021-09-02 |
2023-08-13 |
rat |
| Ghada A Badawi, Mustafa M Shokr, Hala F Zaki, Ahmed F Mohame. Pentoxifylline prevents epileptic seizure via modulating HMGB1/RAGE/TLR4 signalling pathway and improves memory in pentylenetetrazol kindling rats. Clinical and experimental pharmacology & physiology. vol 48. issue 8. 2021-09-02. PMID:33899956. |
furthermore, ptx reversed ptz hippocampal neuronal loss by decreasing protein expression of amyloid-β peptide (aβ), tau and β site-amyloid precursor protein cleavage enzyme 1 (bace1), associated with a marked reduction in expression of inflammatory mediators such as hmgb1, tl4, and rage proteins. |
2021-09-02 |
2023-08-13 |
rat |
| Xinyu Huang, Kangbai Huang, Zhaowei Li, Dongyan Bai, Yan Hao, Qinglong Wu, Wei Yi, Nenggui Xu, Youcan Pan, Liang Zhan. Electroacupuncture improves cognitive deficits and insulin resistance in an OLETF rat model of Al/D-gal induced aging model via the PI3K/Akt signaling pathway. Brain research. vol 1740. 2021-09-01. PMID:32304687. |
aβ and total tau in the hippocampus and cerebrospinal fluid (csf) were detected using western blotting (wb) and enzyme-linked immunosorbent assay (elisa). |
2021-09-01 |
2023-08-13 |
rat |
| Xinyu Huang, Kangbai Huang, Zhaowei Li, Dongyan Bai, Yan Hao, Qinglong Wu, Wei Yi, Nenggui Xu, Youcan Pan, Liang Zhan. Electroacupuncture improves cognitive deficits and insulin resistance in an OLETF rat model of Al/D-gal induced aging model via the PI3K/Akt signaling pathway. Brain research. vol 1740. 2021-09-01. PMID:32304687. |
after ea intervention, the hippocampal aβ and total tau protein levels, body weight, fpg, fins, and c-p were significantly decreased. |
2021-09-01 |
2023-08-13 |
rat |
| Md Ataur Rahman, Md Abdul Hannan, Md Jamal Uddin, Md Saidur Rahman, Md Mamunur Rashid, Bonglee Ki. Exposure to Environmental Arsenic and Emerging Risk of Alzheimer's Disease: Perspective Mechanisms, Management Strategy, and Future Directions. Toxics. vol 9. issue 8. 2021-08-31. PMID:34437506. |
alzheimer's disease (ad) is one of the most prevailing neurodegenerative diseases, characterized by memory dysfunction and the presence of hyperphosphorylated tau and amyloid β (aβ) aggregates in multiple brain regions, including the hippocampus and cortex. |
2021-08-31 |
2023-08-13 |
human |
| Zhiqun Tang, Dan Liang, Miaoying Cheng, Xinyi Su, Runhe Liu, Yiding Zhang, Hongkun W. Effects of Porphyromonas gingivalis and Its Underlying Mechanisms on Alzheimer-Like Tau Hyperphosphorylation in Sprague-Dawley Rats. Journal of molecular neuroscience : MN. vol 71. issue 1. 2021-08-27. PMID:32557144. |
the results showed that the severity of phosphorylated tau at the ad-related sites thr181 and thr231 and the number of activated astrocytes were notably greater in the hippocampus of rats with p. gingivalis injection. |
2021-08-27 |
2023-08-13 |
rat |
| L E M Wisse, S Ravikumar, R Ittyerah, S Lim, J Lane, M L Bedard, L Xie, S R Das, T Schuck, M Grossman, E B Lee, M D Tisdall, K Prabhakaran, J A Detre, G Mizsei, J Q Trojanowski, E Artacho-Pérula, M M de Iñiguez de Onzono Martin, M M Arroyo-Jiménez, M Muñoz Lopez, F J Molina Romero, M P Marcos Rabal, S Cebada Sánchez, J C Delgado González, C de la Rosa Prieto, M Córcoles Parada, D A Wolk, D J Irwin, R Insausti, P A Yushkevic. Downstream effects of polypathology on neurodegeneration of medial temporal lobe subregions. Acta neuropathologica communications. vol 9. issue 1. 2021-08-23. PMID:34289895. |
tau, tar dna-binding protein 43 (tdp-43), amyloid-β and α-synuclein pathology were rated on a scale of 0 (absent)-3 (severe) in the hippocampus and entorhinal cortex (erc) of 58 individuals with and without neurodegenerative diseases (median age 75.0 years, 60.3% male). |
2021-08-23 |
2023-08-13 |
Not clear |
| Ron Balczon, Mike T Lin, Ji Young Lee, Adeel Abbasi, Phoibe Renema, Sarah B Voth, Chun Zhou, Anna Koloteva, C Michael Francis, Neel R Sodha, Jean-Francois Pittet, Brant M Wagener, Jessica Bell, Chung-Sik Choi, Corey E Ventetuolo, Troy Steven. Pneumonia initiates a tauopathy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 9. 2021-08-23. PMID:34384141. |
cytotoxic amyloid and tau species were recovered from the blood and the hippocampus following pneumonia, and they were present in the extracorporeal membrane oxygenation oxygenators of patients with pneumonia, especially in those who died. |
2021-08-23 |
2023-08-13 |
mouse |
| Ron Balczon, Mike T Lin, Ji Young Lee, Adeel Abbasi, Phoibe Renema, Sarah B Voth, Chun Zhou, Anna Koloteva, C Michael Francis, Neel R Sodha, Jean-Francois Pittet, Brant M Wagener, Jessica Bell, Chung-Sik Choi, Corey E Ventetuolo, Troy Steven. Pneumonia initiates a tauopathy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 9. 2021-08-23. PMID:34384141. |
introduction of immunopurified blood-borne amyloid and tau into either the airways or the blood of uninfected animals acutely and chronically impaired hippocampal information processing. |
2021-08-23 |
2023-08-13 |
mouse |
| Ron Balczon, Mike T Lin, Ji Young Lee, Adeel Abbasi, Phoibe Renema, Sarah B Voth, Chun Zhou, Anna Koloteva, C Michael Francis, Neel R Sodha, Jean-Francois Pittet, Brant M Wagener, Jessica Bell, Chung-Sik Choi, Corey E Ventetuolo, Troy Steven. Pneumonia initiates a tauopathy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 9. 2021-08-23. PMID:34384141. |
in contrast, the infection did not impair long-term potentiation in tau knockout mice and the amyloid- and tau-dependent disruption in hippocampal signaling was less severe in tau knockout mice. |
2021-08-23 |
2023-08-13 |
mouse |