| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marta Fernández-Nogales, José J Luca. Altered Levels and Isoforms of Tau and Nuclear Membrane Invaginations in Huntington's Disease. Frontiers in cellular neuroscience. vol 13. 2020-09-28. PMID:32009905. |
after their discovery in hd brains, tnis have also been reported in hippocampal neurons of early braak stage ad cases and in frontal and temporal cortical neurons of ftd-mapt cases due to the intronic ivs10+16 mutation in the tau gene (mapt) which results in an increased 4r-/3r-tau ratio similar to that observed in hd. |
2020-09-28 |
2023-08-13 |
mouse |
| Nobuko Hongo, Yusaku Takamura, Hiroshi Nishimaru, Jumpei Matsumoto, Kazuyuki Tobe, Takashi Saito, Takaomi C Saido, Hisao Nishij. Astaxanthin Ameliorated Parvalbumin-Positive Neuron Deficits and Alzheimer's Disease-Related Pathological Progression in the Hippocampus of Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32218736. |
astaxanthin ameliorated parvalbumin-positive neuron deficits and alzheimer's disease-related pathological progression in the hippocampus of growing evidence suggests that oxidative stress due to amyloid β (aβ) accumulation is involved in alzheimer's disease (ad) through the formation of amyloid plaque, which leads to hyperphosphorylation of tau, microglial activation, and cognitive deficits. |
2020-09-28 |
2023-08-13 |
mouse |
| Mercedes A Hernández-Sapiéns, Edwin E Reza-Zaldívar, Ricardo R Cevallos, Ana L Márquez-Aguirre, Karlen Gazarian, Alejandro A Canales-Aguirr. A Three-Dimensional Alzheimer's Disease Cell Culture Model Using iPSC-Derived Neurons Carrying A246E Mutation in PSEN1. Frontiers in cellular neuroscience. vol 14. 2020-09-28. PMID:32655369. |
alzheimer's disease (ad) is a chronic brain disorder characterized by progressive intellectual decline and memory and neuronal loss, caused mainly by extracellular deposition of amyloid-β (aβ) and intracellular accumulation of hyperphosphorylated tau protein, primarily in areas implicated in memory and learning as prefrontal cortex and hippocampus. |
2020-09-28 |
2023-08-13 |
Not clear |
| Isidro Ferrer, Pol Andrés-Benito, Julia Sala-Jarque, Vanessa Gil, José Antonio Del Ri. Capacity for Seeding and Spreading of Argyrophilic Grain Disease in a Wild-Type Murine Model; Comparisons With Primary Age-Related Tauopathy. Frontiers in molecular neuroscience. vol 13. 2020-09-28. PMID:32670019. |
agd has a characteristic pattern progressively involving the entorhinal cortex, amygdala, hippocampus, dentate gyrus, presubiculum, subiculum, hypothalamic nuclei, temporal cortex, and neocortex and brainstem, thus suggesting that argyrophilic grain pathology is a natural model of tau propagation. |
2020-09-28 |
2023-08-13 |
mouse |
| Isidro Ferrer, Pol Andrés-Benito, Julia Sala-Jarque, Vanessa Gil, José Antonio Del Ri. Capacity for Seeding and Spreading of Argyrophilic Grain Disease in a Wild-Type Murine Model; Comparisons With Primary Age-Related Tauopathy. Frontiers in molecular neuroscience. vol 13. 2020-09-28. PMID:32670019. |
abnormal hyper-phosphorylated tau deposits were found in ipsilateral hippocampal neurons, grains (dots) in the hippocampus, and threads, dots and coiled bodies in the fimbria, as well as the ipsilateral and contralateral corpus callosum. |
2020-09-28 |
2023-08-13 |
mouse |
| Isidro Ferrer, Pol Andrés-Benito, Julia Sala-Jarque, Vanessa Gil, José Antonio Del Ri. Capacity for Seeding and Spreading of Argyrophilic Grain Disease in a Wild-Type Murine Model; Comparisons With Primary Age-Related Tauopathy. Frontiers in molecular neuroscience. vol 13. 2020-09-28. PMID:32670019. |
abnormal hyper-phosphorylated tau deposits were found in neurons in the ipsilateral hippocampus, coiled bodies and threads in the fimbria, and the ipsilateral and contralateral corpus callosum, which extended with time along the anterior-posterior axis and distant regions such as hypothalamic nuclei and nuclei of the septum when comparing mice surviving 7 months with mice surviving 3 months. |
2020-09-28 |
2023-08-13 |
mouse |
| Rodrigo A Quintanilla, Carola Tapia-Monsalves, Erick H Vergara, María José Pérez, Alejandra Arangui. Truncated Tau Induces Mitochondrial Transport Failure Through the Impairment of TRAK2 Protein and Bioenergetics Decline in Neuronal Cells. Frontiers in cellular neuroscience. vol 14. 2020-09-28. PMID:32848607. |
we expressed green fluorescent protein (gfp), gfp-full-length, and gpf-caspase-3-cleaved tau proteins in rat hippocampal neurons and immortalized cortical neurons (cn 1.4) and analyzed the expression and localization of these proteins involved in mitochondrial transport regulation. |
2020-09-28 |
2023-08-13 |
rat |
| Rodrigo A Quintanilla, Carola Tapia-Monsalves, Erick H Vergara, María José Pérez, Alejandra Arangui. Truncated Tau Induces Mitochondrial Transport Failure Through the Impairment of TRAK2 Protein and Bioenergetics Decline in Neuronal Cells. Frontiers in cellular neuroscience. vol 14. 2020-09-28. PMID:32848607. |
we observed that hippocampal neurons expressing caspase-cleaved tau showed a significant accumulation of a mitochondrial population in the soma. |
2020-09-28 |
2023-08-13 |
rat |
| Rodrigo A Quintanilla, Carola Tapia-Monsalves, Erick H Vergara, María José Pérez, Alejandra Arangui. Truncated Tau Induces Mitochondrial Transport Failure Through the Impairment of TRAK2 Protein and Bioenergetics Decline in Neuronal Cells. Frontiers in cellular neuroscience. vol 14. 2020-09-28. PMID:32848607. |
more critically, caspase-cleaved tau significantly decreased the expression of trak2 in immortalized and primary hippocampal neurons without affecting rhot1/t2 and syntaphilin levels. |
2020-09-28 |
2023-08-13 |
rat |
| Yu-Wei Zhang, Xiao-Qian Li, Wen-Fei Tan, Bo Fang, Hong M. Postoperative 24-h Acute Sleep Deprivation Improves Learning and Memory Through Inhibition of Tau Phosphorylation in the Hippocampal Neurons of Splenectomized Rats. Nature and science of sleep. vol 12. 2020-09-28. PMID:32904483. |
postoperative 24-h acute sleep deprivation improves learning and memory through inhibition of tau phosphorylation in the hippocampal neurons of splenectomized rats. |
2020-09-28 |
2023-08-13 |
rat |
| Kerstin Schlegel, Khader Awwad, Roland G Heym, David Holzinger, Annika Doell, Stefan Barghorn, Thomas R Jahn, Corinna Klein, Yulia Mordashova, Michael Schulz, Laura Gasparin. N368-Tau fragments generated by legumain are detected only in trace amount in the insoluble Tau aggregates isolated from AD brain. Acta neuropathologica communications. vol 7. issue 1. 2020-09-25. PMID:31722749. |
in brain soluble extracts, despite reduced uncleaved tau in ad, levels of n368-cleaved tau are comparable in ad and control hippocampus, suggesting that lgmn-mediated cleavage of tau is not altered in ad. |
2020-09-25 |
2023-08-13 |
mouse |
| Kerstin Schlegel, Khader Awwad, Roland G Heym, David Holzinger, Annika Doell, Stefan Barghorn, Thomas R Jahn, Corinna Klein, Yulia Mordashova, Michael Schulz, Laura Gasparin. N368-Tau fragments generated by legumain are detected only in trace amount in the insoluble Tau aggregates isolated from AD brain. Acta neuropathologica communications. vol 7. issue 1. 2020-09-25. PMID:31722749. |
to assess the potential accumulation of n368-cleaved tau in insoluble tau aggregates, we analyzed sarkosyl-insoluble extracts from ad and control hippocampus. |
2020-09-25 |
2023-08-13 |
mouse |
| Christy M Kelley, Sylvia E Perez, Elliott J Mufso. Tau pathology in the medial temporal lobe of athletes with chronic traumatic encephalopathy: a chronic effects of neurotrauma consortium study. Acta neuropathologica communications. vol 7. issue 1. 2020-09-25. PMID:31831066. |
the medial temporal lobe (mtl; i.e., hippocampus, subiculum, and entorhinal and perirhinal cortices) memory circuit displays tau lesions during the pathological progression of cte. |
2020-09-25 |
2023-08-13 |
Not clear |
| Keiichi Kadoyama, Kenji Matsuura, Masaoki Takano, Koji Maekura, Yukari Inoue, Shogo Matsuyam. Changes in the expression of prefoldin subunit 5 depending on synaptic plasticity in the mouse hippocampus. Neuroscience letters. vol 712. 2020-09-23. PMID:31505240. |
in transgenic mice overexpressing human tau with n279 k mutation as a model of alzheimer's disease that showed impaired synaptic plasticity, the levels of pfdn5 mrna and protein in the hippocampus were significantly decreased in an age-dependent manner as compared with age-matched control. |
2020-09-23 |
2023-08-13 |
mouse |
| M A Berezutsky, N A Durnova, T A Andronova, O V Sinichkin. [Alzheimer's disease: experimental and clinical researches of Chinese herbal medicine neurobiological effects (a review).] Advances in gerontology = Uspekhi gerontologii. vol 33. issue 2. 2020-09-22. PMID:32593241. |
various neurobiological effects of various herbal decoctions in the cells of hippocampus were demonstrated - the inhibition of amyloid β peptides aggregation, increasing of neurons quantity with normal morphology and decreasing of apoptotic cells, decreasing of inducible nitric oxide synthase (inos) production, decreasing of reactive expression level of rage and increasing reactive expression level of lrp-1, decreasing of tau protein phosphorylation at thr231 and ser422, inhibition of expression of gsk-3β and cdk-5, decreasing of activation and inflammation of microglia, production of 15 types of n-glycans in the cerebral cortex layers, which are absent in experimental animals. |
2020-09-22 |
2023-08-13 |
mouse |
| Guo-Quan Wang, Peng Zhou, Dao-Jun Xie, Shu Ye, Hua-Wu Gao, Yan Wang, Zheng-Qing Fang, Biao Ca. [Effects of Huangpu Tongqiao Capsules on EGFR-PLCγ signal pathway of hippocampus in rats with Alzheimer's disease]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 9. 2020-09-17. PMID:32495567. |
rt-pcr results showed that the mrna levels of egfr, plcγ, ip3 r and tau in hippocampus of ad rats were significantly increased(p<0.01), and hptqc could reduce the mrna levels of egfr, plcγ, ip3 r and tau in ad rats(p<0.05). |
2020-09-17 |
2023-08-13 |
rat |
| Gustavo A Rodriguez, Geoffrey M Barrett, Karen E Duff, S Abid Hussain. Chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces Aβ and tau pathology in the hippocampus. PLoS biology. vol 18. issue 8. 2020-09-17. PMID:32822389. |
chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces aβ and tau pathology in the hippocampus. |
2020-09-17 |
2023-08-13 |
mouse |
| Gustavo A Rodriguez, Geoffrey M Barrett, Karen E Duff, S Abid Hussain. Chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces Aβ and tau pathology in the hippocampus. PLoS biology. vol 18. issue 8. 2020-09-17. PMID:32822389. |
using a novel transgenic mouse line to model the impact of human app (happ)/aβ accumulation on tauopathy in the entorhinal cortex-hippocampal (ec-hipp) network, we demonstrate that happ overexpression aggravates ec-tau aggregation and accelerates pathological tau spread into the hippocampus. |
2020-09-17 |
2023-08-13 |
mouse |
| Gustavo A Rodriguez, Geoffrey M Barrett, Karen E Duff, S Abid Hussain. Chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces Aβ and tau pathology in the hippocampus. PLoS biology. vol 18. issue 8. 2020-09-17. PMID:32822389. |
chronic chemogenetic attenuation of ec neuronal hyperactivity led to reduced happ/aβ accumulation and reduced pathological tau spread into downstream hippocampus. |
2020-09-17 |
2023-08-13 |
mouse |
| Emily L Munger, Melissa K Edler, William D Hopkins, John J Ely, Joseph M Erwin, Daniel P Perl, Elliott J Mufson, Patrick R Hof, Chet C Sherwood, Mary Ann Raghant. Astrocytic changes with aging and Alzheimer's disease-type pathology in chimpanzees. The Journal of comparative neurology. vol 527. issue 7. 2020-09-16. PMID:30578640. |
both prefrontal cortex layer i and hippocampal astrocytes exhibit a high degree of astrogliosis that is positively correlated with accumulation of amyloid beta and tau proteins. |
2020-09-16 |
2023-08-13 |
chimpanzee |