| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sarah Gourmaud, Haochang Shou, David J Irwin, Kimberly Sansalone, Leah M Jacobs, Timothy H Lucas, Eric D Marsh, Kathryn A Davis, Frances E Jensen, Delia M Talo. Alzheimer-like amyloid and tau alterations associated with cognitive deficit in temporal lobe epilepsy. Brain : a journal of neurology. vol 143. issue 1. 2020-08-18. PMID:31834353. |
in temporal lobe epilepsy cases, hippocampal levels of phosphorylated amyloid precursor protein, its pro-amyloidogenic processing enzyme beta-site amyloid precursor protein cleaving enzyme 1, and both total and hyperphosphorylated tau expression, correlated with impaired preoperative executive function. |
2020-08-18 |
2023-08-13 |
Not clear |
| Lexiang Yu, Yao Chen, Yong Xu, Tao He, Yan Wei, Rongqiao H. D-ribose is elevated in T1DM patients and can be involved in the onset of encephalopathy. Aging. vol 11. issue 14. 2020-08-06. PMID:31307014. |
furthermore, advanced glycation end products (age), tau hyperphosphorylation and neuronal death in the hippocampal ca4/dg region were detected in t1dm rats. |
2020-08-06 |
2023-08-13 |
rat |
| Jessica Z K Caldwell, Jeffrey L Cummings, Sarah J Banks, Sebastian Palmqvist, Oskar Hansso. Cognitively normal women with Alzheimer's disease proteinopathy show relative preservation of memory but not of hippocampal volume. Alzheimer's research & therapy. vol 11. issue 1. 2020-08-06. PMID:31878968. |
we examined interactive effects of sex, diagnosis, and cerebrospinal fluid (csf) amyloid beta/phosphorylated tau ratio (aβ/p-tau) on verbal memory and hippocampal volumes. |
2020-08-06 |
2023-08-13 |
Not clear |
| Maud Gratuze, Nicolas Josset, Franck R Petry, Mathieu Pflieger, Laura Eyoum Jong, Geoffrey Truchetti, Isabelle Poitras, Jacinthe Julien, François Bezeau, Françoise Morin, Pershia Samadi, Francesca Cicchetti, Frédéric Bretzner, Emmanuel Plane. The toxin MPTP generates similar cognitive and locomotor deficits in hTau and tau knock-out mice. Brain research. vol 1711. 2020-08-04. PMID:30641037. |
mptp also induced a slight but significant increase in tau phosphorylation (thr205) in the hippocampus of htau mice, as well as a significant decrease in the soluble and insoluble tau fractions that correlated with the loss of dopaminergic neurons in the brainstem. |
2020-08-04 |
2023-08-13 |
mouse |
| Maxime Sartori, Tiago Mendes, Shruti Desai, Alessia Lasorsa, Adrien Herledan, Nicolas Malmanche, Petra Mäkinen, Mikael Marttinen, Idir Malki, Julien Chapuis, Amandine Flaig, Anaïs-Camille Vreulx, Marion Ciancia, Philippe Amouyel, Florence Leroux, Benoit Déprez, François-Xavier Cantrelle, Damien Maréchal, Laurent Pradier, Mikko Hiltunen, Isabelle Landrieu, Devrim Kilinc, Yann Herault, Jocelyn Laporte, Jean-Charles Lamber. BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr Acta neuropathologica. vol 138. issue 4. 2020-08-04. PMID:31065832. |
after killing the cohort at 18 months, immunohistochemistry revealed that bin1 overexpression prevents both tau mislocalization and somatic inclusion in the hippocampus, where an increase in bin1-tau interaction was also observed. |
2020-08-04 |
2023-08-13 |
mouse |
| David Berron, Danielle van Westen, Rik Ossenkoppele, Olof Strandberg, Oskar Hansso. Medial temporal lobe connectivity and its associations with cognition in early Alzheimer's disease. Brain : a journal of neurology. vol 143. issue 4. 2020-07-31. PMID:32252068. |
furthermore, correlation analysis in this group revealed decreasing functional connectivity between bilateral perirhinal/entorhinal cortices, anterior hippocampus and posterior-medial regions with increasing levels of phosphorylated tau. |
2020-07-31 |
2023-08-13 |
human |
| Atsuko Kubo, Hiroaki Misonou, Makoto Matsuyama, Akane Nomori, Satoko Wada-Kakuda, Akihiko Takashima, Mitsuhiro Kawata, Shigeo Murayama, Yasuo Ihara, Tomohiro Miyasak. Distribution of endogenous normal tau in the mouse brain. The Journal of comparative neurology. vol 527. issue 5. 2020-07-28. PMID:30408165. |
interestingly, tau antibodies strongly labeled nonmyelinated axons such as hippocampal mossy fibers, while white matters generally exhibited low levels of immunoreactivity. |
2020-07-28 |
2023-08-13 |
mouse |
| A Ahnaou, C Walsh, N V Manyakov, S A Youssef, W H Drinkenbur. Early Electrophysiological Disintegration of Hippocampal Neural Networks in a Novel Locus Coeruleus Tau-Seeding Mouse Model of Alzheimer's Disease. Neural plasticity. vol 2019. 2020-07-27. PMID:31285742. |
here, a tau-seeding model in which preformed synthetic tau fibrils (k18) were unilaterally injected into the lc of p301l mice, equipped with multichannel electrodes for recording eeg in frontal cortical and ca1-ca3 hippocampal areas, was used to longitudinally quantify over 20 weeks of functional network dynamics in (1) power spectra; (2) fc using intra- and intersite phase-amplitude theta-gamma coupling (pac); (3) coherence, partial coherence, and global coherent network efficiency (eglob) estimates; and (4) the directionality of functional connectivity using extended partial direct coherence (pdc). |
2020-07-27 |
2023-08-13 |
mouse |
| A Ahnaou, C Walsh, N V Manyakov, S A Youssef, W H Drinkenbur. Early Electrophysiological Disintegration of Hippocampal Neural Networks in a Novel Locus Coeruleus Tau-Seeding Mouse Model of Alzheimer's Disease. Neural plasticity. vol 2019. 2020-07-27. PMID:31285742. |
the present results demonstrate early dysfunctional hippocampal networks, despite no spreading tau pathology to the hippocampus and frontal cortex. |
2020-07-27 |
2023-08-13 |
mouse |
| A Ahnaou, C Walsh, N V Manyakov, S A Youssef, W H Drinkenbur. Early Electrophysiological Disintegration of Hippocampal Neural Networks in a Novel Locus Coeruleus Tau-Seeding Mouse Model of Alzheimer's Disease. Neural plasticity. vol 2019. 2020-07-27. PMID:31285742. |
the ability of the k18 seed in the brainstem lc to elicit such robust functional alterations in distant hippocampal structures in the absence of pathology challenges the classic view that tau pathology spread to an area is necessary to elicit functional impairments in that area. |
2020-07-27 |
2023-08-13 |
mouse |
| Benoit Mouzon, Corbin Bachmeier, Joseph Ojo, Christopher Acker, Scott Ferguson, Gogce Crynen, Peter Davies, Michael Mullan, William Stewart, Fiona Crawfor. Chronic White Matter Degeneration, but No Tau Pathology at One-Year Post-Repetitive Mild Traumatic Brain Injury in a Tau Transgenic Model. Journal of neurotrauma. vol 36. issue 4. 2020-07-21. PMID:29993324. |
tau immunohistochemistry and enzyme-linked immunosorbent assay data suggest, however, only transient, injury-dependent increases in phosphorylated tau in the cerebral cortex beneath the impact site and in the ca1/ca3 subregion of the hippocampus after single or r-mtbi. |
2020-07-21 |
2023-08-13 |
mouse |
| Ramsey Najm, Antara Rao, Yadong Huan. Too Much Tau in Interneurons Impairs Adult Hippocampal Neurogenesis in Alzheimer's Disease. Cell stem cell. vol 26. issue 3. 2020-07-15. PMID:32142656. |
too much tau in interneurons impairs adult hippocampal neurogenesis in alzheimer's disease. |
2020-07-15 |
2023-08-13 |
mouse |
| René Andrade Machado, Vanesa Benjumea-Cuartas, José Fernando Zapata Berruecos, Piedad Matilde Agudelo-Flóres, Lina María Salazar-Peláe. Reelin, tau phosphorylation and psychiatric complications in patients with hippocampal sclerosis and structural abnormalities in temporal lobe epilepsy. Epilepsy & behavior : E&B. vol 96. 2020-07-07. PMID:31150999. |
reelin, tau phosphorylation and psychiatric complications in patients with hippocampal sclerosis and structural abnormalities in temporal lobe epilepsy. |
2020-07-07 |
2023-08-13 |
Not clear |
| Stavros Skouras, Jordi Torner, Patrik Andersson, Yury Koush, Carles Falcon, Carolina Minguillon, Karine Fauria, Francesc Alpiste, Kaj Blenow, Henrik Zetterberg, Juan D Gispert, José L Molinuev. Earliest amyloid and tau deposition modulate the influence of limbic networks during closed-loop hippocampal downregulation. Brain : a journal of neurology. vol 143. issue 3. 2020-07-06. PMID:32091109. |
earliest amyloid and tau deposition modulate the influence of limbic networks during closed-loop hippocampal downregulation. |
2020-07-06 |
2023-08-13 |
human |
| Stavros Skouras, Jordi Torner, Patrik Andersson, Yury Koush, Carles Falcon, Carolina Minguillon, Karine Fauria, Francesc Alpiste, Kaj Blenow, Henrik Zetterberg, Juan D Gispert, José L Molinuev. Earliest amyloid and tau deposition modulate the influence of limbic networks during closed-loop hippocampal downregulation. Brain : a journal of neurology. vol 143. issue 3. 2020-07-06. PMID:32091109. |
in this study, we aimed to identify the effects of amyloid-β peptide 42 (amyloid-β42) and phosphorylated tau on the patterns of functional connectomics involved in hippocampal downregulation. |
2020-07-06 |
2023-08-13 |
human |
| Stavros Skouras, Jordi Torner, Patrik Andersson, Yury Koush, Carles Falcon, Carolina Minguillon, Karine Fauria, Francesc Alpiste, Kaj Blenow, Henrik Zetterberg, Juan D Gispert, José L Molinuev. Earliest amyloid and tau deposition modulate the influence of limbic networks during closed-loop hippocampal downregulation. Brain : a journal of neurology. vol 143. issue 3. 2020-07-06. PMID:32091109. |
across subjects, our main findings during hippocampal downregulation were: (i) in the absence of abnormal biomarkers, age correlated with eigenvector centrality negatively in the insula and midcingulate cortex, and positively in the inferior temporal gyrus; (ii) abnormal csf amyloid-β42 (<1098) correlated negatively with eigenvector centrality in the anterior cingulate cortex and primary motor cortex; and (iii) abnormal csf phosphorylated tau levels (>19.2) correlated with eigenvector centrality positively in the ventral striatum, anterior cingulate and somatosensory cortex, and negatively in the precuneus and orbitofrontal cortex. |
2020-07-06 |
2023-08-13 |
human |
| Grace I Hallinan, Mariana Vargas-Caballero, Jonathan West, Katrin Deinhard. Tau Misfolding Efficiently Propagates between Individual Intact Hippocampal Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 48. 2020-07-02. PMID:31658988. |
tau misfolding efficiently propagates between individual intact hippocampal neurons. |
2020-07-02 |
2023-08-13 |
Not clear |
| David Berron, Arturo Cardenas-Blanco, Daniel Bittner, Coraline D Metzger, Annika Spottke, Michael T Heneka, Klaus Fliessbach, Anja Schneider, Stefan J Teipel, Michael Wagner, Oliver Speck, Frank Jessen, Emrah Düze. Higher CSF Tau Levels Are Related to Hippocampal Hyperactivity and Object Mnemonic Discrimination in Older Adults. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 44. 2020-06-29. PMID:31541019. |
higher csf tau levels are related to hippocampal hyperactivity and object mnemonic discrimination in older adults. |
2020-06-29 |
2023-08-13 |
human |
| David Berron, Arturo Cardenas-Blanco, Daniel Bittner, Coraline D Metzger, Annika Spottke, Michael T Heneka, Klaus Fliessbach, Anja Schneider, Stefan J Teipel, Michael Wagner, Oliver Speck, Frank Jessen, Emrah Düze. Higher CSF Tau Levels Are Related to Hippocampal Hyperactivity and Object Mnemonic Discrimination in Older Adults. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 44. 2020-06-29. PMID:31541019. |
importantly, csf tau levels were associated with increased fmri activity in the hippocampus, and both increased hippocampal activity as well as tau levels were associated with mnemonic discrimination of objects, but again not scenes. |
2020-06-29 |
2023-08-13 |
human |
| Elise Gondard, Maria Luisa Soto-Montenegro, Amanda Cassol, Andres M Lozano, Clement Haman. Transcranial direct current stimulation does not improve memory deficits or alter pathological hallmarks in a rodent model of Alzheimer's disease. Journal of psychiatric research. vol 114. 2020-06-25. PMID:31054455. |
in addition, ad transgenics had an increased expression of tau, phosphorylated-tau and amyloid precursor protein in the hippocampus. |
2020-06-25 |
2023-08-13 |
mouse |