| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aditi Dey, Shuai Hao, Marlena Wosiski-Kuhn, Alexis M Stranaha. Glucocorticoid-mediated activation of GSK3β promotes tau phosphorylation and impairs memory in type 2 diabetes. Neurobiology of aging. vol 57. 2018-01-03. PMID:28609678. |
in this report, we investigated endocrine mechanisms for hippocampal tau phosphorylation in db/db and wild-type mice. |
2018-01-03 |
2023-08-13 |
mouse |
| Aditi Dey, Shuai Hao, Marlena Wosiski-Kuhn, Alexis M Stranaha. Glucocorticoid-mediated activation of GSK3β promotes tau phosphorylation and impairs memory in type 2 diabetes. Neurobiology of aging. vol 57. 2018-01-03. PMID:28609678. |
by separately manipulating peripheral and intrahippocampal corticosterone levels, we determined that hippocampal corticosteroid exposure promotes tau phosphorylation and activates glycogen synthase kinase 3β (gsk3β). |
2018-01-03 |
2023-08-13 |
mouse |
| Francesco Tamagnini, Darren A Walsh, Jon T Brown, Marie K Bondulich, Diane P Hanger, Andrew D Randal. Hippocampal neurophysiology is modified by a disease-associated C-terminal fragment of tau protein. Neurobiology of aging. vol 60. 2018-01-03. PMID:28917666. |
hippocampal neurophysiology is modified by a disease-associated c-terminal fragment of tau protein. |
2018-01-03 |
2023-08-13 |
mouse |
| Kyoung A Jhang, Jin-Sun Park, Hee-Sun Kim, Young Hae Chon. Resveratrol Ameliorates Tau Hyperphosphorylation at Ser396 Site and Oxidative Damage in Rat Hippocampal Slices Exposed to Vanadate: Implication of ERK1/2 and GSK-3β Signaling Cascades. Journal of agricultural and food chemistry. vol 65. issue 44. 2018-01-03. PMID:29022339. |
resveratrol ameliorates tau hyperphosphorylation at ser396 site and oxidative damage in rat hippocampal slices exposed to vanadate: implication of erk1/2 and gsk-3β signaling cascades. |
2018-01-03 |
2023-08-13 |
rat |
| Vega García-Escudero, Ricardo Gargini, Patricia Martín-Maestro, Esther García, Ramón García-Escudero, Jesús Avil. Tau mRNA 3'UTR-to-CDS ratio is increased in Alzheimer disease. Neuroscience letters. vol 655. 2018-01-01. PMID:28689927. |
to explain this apparently contradictory result, we studied mapt mrna stoichiometry in coding and non-coding regions, and found that the 3'utr-to-cds ratio was higher in the hippocampus of alzheimer disease patients, with higher tau protein but lower total mrna levels. |
2018-01-01 |
2023-08-13 |
mouse |
| Junjun Sun, Hong Zhou, Feng Bai, Qingguo Ren, Zhijun Zhan. Myelin injury induces axonal transport impairment but not AD-like pathology in the hippocampus of cuprizone-fed mice. Oncotarget. vol 7. issue 21. 2017-12-29. PMID:27129150. |
however, we did not observe the increased expression of beta amyloid, hyperphosphorylation of tau and loss of neurons in demyelinated hippocampus. |
2017-12-29 |
2023-08-13 |
mouse |
| Diana Miszczuk, Konrad J Dębski, Heikki Tanila, Katarzyna Lukasiuk, Asla Pitkäne. Traumatic Brain Injury Increases the Expression of Nos1, Aβ Clearance, and Epileptogenesis in APP/PS1 Mouse Model of Alzheimer's Disease. Molecular neurobiology. vol 53. issue 10. 2017-12-22. PMID:26671618. |
to elaborate the mechanisms of worsening outcomes, we studied changes in the expression of genes involved in app processing and tau pathways in the perilesional cortex, ipsilateral thalamus, and ipsilateral hippocampus 16 weeks post-tbi. |
2017-12-22 |
2023-08-13 |
mouse |
| Denglei Ma, Yanqiu Zhu, Yanzheng Li, Cuicui Yang, Li Zhang, Yali Li, Lin Li, Lan Zhan. Beneficial effects of cornel iridoid glycoside on behavioral impairment and senescence status in SAMP8 mice at different ages. Behavioural brain research. vol 312. 2017-12-19. PMID:27283974. |
in addition, cig treatment inhibited tau hyperphosphorylation in the hippocampus and striatum of samp8 mice at different ages. |
2017-12-19 |
2023-08-13 |
mouse |
| Lijuan Shi, Zhihua Zhang, Lin Li, Christian Hölsche. A novel dual GLP-1/GIP receptor agonist alleviates cognitive decline by re-sensitizing insulin signaling in the Alzheimer icv. STZ rat model. Behavioural brain research. vol 327. 2017-12-19. PMID:28342971. |
once-daily for 14days after stz intracerebroventricular (icv) administration significantly prevented spatial learning deficits in a y- maze test and morris water maze tests, and decreased phosphorylated tau levels in the rat cerebral cortex and hippocampus. |
2017-12-19 |
2023-08-13 |
rat |
| Yan-Juan Wang, Qing-Guo Ren, Wei-Gang Gong, Di Wu, Xiang Tang, Xiao-Li Li, Fang-Fang Wu, Feng Bai, Lin Xu, Zhi-Jun Zhan. Escitalopram attenuates β-amyloid-induced tau hyperphosphorylation in primary hippocampal neurons through the 5-HT1A receptor mediated Akt/GSK-3β pathway. Oncotarget. vol 7. issue 12. 2017-12-15. PMID:26950279. |
escitalopram attenuates β-amyloid-induced tau hyperphosphorylation in primary hippocampal neurons through the 5-ht1a receptor mediated akt/gsk-3β pathway. |
2017-12-15 |
2023-08-13 |
rat |
| Yan-Juan Wang, Qing-Guo Ren, Wei-Gang Gong, Di Wu, Xiang Tang, Xiao-Li Li, Fang-Fang Wu, Feng Bai, Lin Xu, Zhi-Jun Zhan. Escitalopram attenuates β-amyloid-induced tau hyperphosphorylation in primary hippocampal neurons through the 5-HT1A receptor mediated Akt/GSK-3β pathway. Oncotarget. vol 7. issue 12. 2017-12-15. PMID:26950279. |
to investigate whether escitalopram could inhibit amyloid-β (aβ)-induced tau hyperphosphorylation and the underlying mechanisms, we treated the rat primary hippocampal neurons with aβ1-42 and examined the effect of escitalopram on tau hyperphosphorylation. |
2017-12-15 |
2023-08-13 |
rat |
| Yan-Juan Wang, Qing-Guo Ren, Wei-Gang Gong, Di Wu, Xiang Tang, Xiao-Li Li, Fang-Fang Wu, Feng Bai, Lin Xu, Zhi-Jun Zhan. Escitalopram attenuates β-amyloid-induced tau hyperphosphorylation in primary hippocampal neurons through the 5-HT1A receptor mediated Akt/GSK-3β pathway. Oncotarget. vol 7. issue 12. 2017-12-15. PMID:26950279. |
our results demonstrated that escitalopram attenuated aβ1-42-induced tau hyperphosphorylation in primary hippocampal neurons through the 5-ht1a receptor mediated akt/gsk-3β pathway. |
2017-12-15 |
2023-08-13 |
rat |
| Aurélie Ledreux, Xiuzhe Wang, Marianne Schultzberg, Ann-Charlotte Granholm, Linnea R Freema. Detrimental effects of a high fat/high cholesterol diet on memory and hippocampal markers in aged rats. Behavioural brain research. vol 312. 2017-12-13. PMID:27343935. |
we investigated the effects of a high fat/high cholesterol (hfhc) diet on cognitive performance, neuroinflammation markers, and phosphorylated tau (p-tau) pathological markers in the hippocampus of young (4-month old) versus aged (14-month old) male rats. |
2017-12-13 |
2023-08-13 |
rat |
| Aurélie Ledreux, Xiuzhe Wang, Marianne Schultzberg, Ann-Charlotte Granholm, Linnea R Freema. Detrimental effects of a high fat/high cholesterol diet on memory and hippocampal markers in aged rats. Behavioural brain research. vol 312. 2017-12-13. PMID:27343935. |
western blot analysis of the hippocampus showed higher levels of p-tau s202/t205 and t231 in aged hfhc rats, suggesting abnormal phosphorylation of tau protein following the hfhc diet exposure. |
2017-12-13 |
2023-08-13 |
rat |
| Zi-Ai Zhao, Ya-Lei Ning, Ping Li, Nan Yang, Yan Peng, Ren-Ping Xiong, Yan Zhao, Dong Liu, Xu-Jia Zeng, Jiang-Fan Chen, Yuan-Guo Zho. Widespread hyperphosphorylated tau in the working memory circuit early after cortical impact injury of brain (Original study). Behavioural brain research. vol 323. 2017-12-13. PMID:28163095. |
given that tau hyperphosphorylation is an important cause of cognitive impairment in patients of alzheimer's disease, our present study detected the presence of hyperphosphorylated tau (p-tau), mainly at ser404, in multiple brain regions, including the ipsilateral parietal cortex, contralateral hippocampus and prefrontal cortex, immediately after the injury in a mouse tbi model; these changes lasted for at least 4w. |
2017-12-13 |
2023-08-13 |
mouse |
| Kayla Raider, Delin Ma, Janna L Harris, Isabella Fuentes, Robert S Rogers, Joshua L Wheatley, Paige C Geiger, Hung-Wen Yeh, In-Young Choi, William M Brooks, John A Stanfor. A high fat diet alters metabolic and bioenergetic function in the brain: A magnetic resonance spectroscopy study. Neurochemistry international. vol 97. 2017-12-12. PMID:27125544. |
hippocampal pampk levels correlated significantly with tcr, aspartate (asp), phosphoethanolamine (pe), and taurine (tau), indicating beneficial effects of ampk activation on brain metabolic and energetic function, membrane turnover, and edema. |
2017-12-12 |
2023-08-13 |
rat |
| Sofia Lopes, João Vaz-Silva, Vitor Pinto, Christina Dalla, Nikolaos Kokras, Benedikt Bedenk, Natalie Mack, Michael Czisch, Osborne F X Almeida, Nuno Sousa, Ioannis Sotiropoulo. Tau protein is essential for stress-induced brain pathology. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 26. 2017-12-12. PMID:27274066. |
here, we demonstrate that stress-driven hippocampal deficits in wild-type mice are accompanied by synaptic missorting of tau and enhanced fyn/glun2b-driven synaptic signaling. |
2017-12-12 |
2023-08-13 |
mouse |
| Sofia Lopes, João Vaz-Silva, Vitor Pinto, Christina Dalla, Nikolaos Kokras, Benedikt Bedenk, Natalie Mack, Michael Czisch, Osborne F X Almeida, Nuno Sousa, Ioannis Sotiropoulo. Tau protein is essential for stress-induced brain pathology. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 26. 2017-12-12. PMID:27274066. |
in contrast, mice lacking tau [tau knockout (tau-ko) mice] do not exhibit stress-induced pathological behaviors and atrophy of hippocampal dendrites or deficits of hippocampal connectivity. |
2017-12-12 |
2023-08-13 |
mouse |
| Elliott J Mufson, Milos D Ikonomovic, Scott E Counts, Sylvia E Perez, Michael Malek-Ahmadi, Stephen W Scheff, Stephen D Ginsber. Molecular and cellular pathophysiology of preclinical Alzheimer's disease. Behavioural brain research. vol 311. 2017-12-05. PMID:27185734. |
in this review, we illustrate relevant clinical pathological research in preclinical ad and throughout the progression of dementia in several areas including aβ and tau pathobiology, single population expression profiling of vulnerable hippocampal and basal forebrain neurons, neuroplasticity, neuroimaging, cerebrospinal fluid (csf) biomarker studies and their correlation with antemortem cognitive endpoints. |
2017-12-05 |
2023-08-13 |
Not clear |
| Hyeongki Kim, Kyu-Sun Lee, Ae-Kyeong Kim, Miri Choi, Kwangman Choi, Mingu Kang, Seung-Wook Chi, Min-Sung Lee, Jeong-Soo Lee, So-Young Lee, Woo-Joo Song, Kweon Yu, Sungchan Ch. A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition. Disease models & mechanisms. vol 9. issue 8. 2017-12-04. PMID:27483355. |
moreover, oral administration of cx-4945 acutely suppressed tau hyperphosphorylation in the hippocampus of dyrk1a-overexpressing mice. |
2017-12-04 |
2023-08-13 |
mouse |