| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiang-Zhen Yuan, Sen Sun, Chen-Chen Tan, Jin-Tai Yu, Lan Ta. The Role of ADAM10 in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 58. issue 2. 2018-03-16. PMID:28409746. |
increasing evidence indicates that adam10 not only reduces the generation of aβ but may also affect the pathology of ad through potential mechanisms including reducing tau pathology, maintaining normal synaptic functions, and promoting hippocampal neurogenesis and the homeostasis of neuronal networks. |
2018-03-16 |
2023-08-13 |
Not clear |
| Anna E Blanken, Sona Hurtz, Chris Zarow, Kristina Biado, Hedieh Honarpisheh, Johanne Somme, Jenny Brook, Spencer Tung, Emily Kraft, Darrick Lo, Denise W Ng, Harry V Vinters, Liana G Apostolov. Associations between hippocampal morphometry and neuropathologic markers of Alzheimer's disease using 7 T MRI. NeuroImage. Clinical. vol 15. 2018-03-02. PMID:28491492. |
hippocampal slices were stained for amyloid beta (aβ), tau, and cresyl violet to evaluate neuronal counts. |
2018-03-02 |
2023-08-13 |
human |
| Anna E Blanken, Sona Hurtz, Chris Zarow, Kristina Biado, Hedieh Honarpisheh, Johanne Somme, Jenny Brook, Spencer Tung, Emily Kraft, Darrick Lo, Denise W Ng, Harry V Vinters, Liana G Apostolov. Associations between hippocampal morphometry and neuropathologic markers of Alzheimer's disease using 7 T MRI. NeuroImage. Clinical. vol 15. 2018-03-02. PMID:28491492. |
the hippocampal subfields, ca1, ca2, ca3, ca4, and subiculum were manually traced so that the neuronal counts, aβ, and tau burden could be obtained for each region. |
2018-03-02 |
2023-08-13 |
human |
| Anna E Blanken, Sona Hurtz, Chris Zarow, Kristina Biado, Hedieh Honarpisheh, Johanne Somme, Jenny Brook, Spencer Tung, Emily Kraft, Darrick Lo, Denise W Ng, Harry V Vinters, Liana G Apostolov. Associations between hippocampal morphometry and neuropathologic markers of Alzheimer's disease using 7 T MRI. NeuroImage. Clinical. vol 15. 2018-03-02. PMID:28491492. |
there were subfield specific associations between hippocampal radial distance and tau in ca2, and cresyl violet neuronal counts in ca1 and subiculum. |
2018-03-02 |
2023-08-13 |
human |
| Benjamin Combs, Chelsey Hamel, Nicholas M Kanaa. Pathological conformations involving the amino terminus of tau occur early in Alzheimer's disease and are differentially detected by monoclonal antibodies. Neurobiology of disease. vol 94. 2018-02-27. PMID:27260838. |
we then determined the pattern of tau pathology labeled by each antibody in human hippocampal sections at various disease stages in order to characterize pad exposure in the context of disease progression. |
2018-02-27 |
2023-08-13 |
human |
| Yin Li, Ze-Xu Li, Tan Jin, Zhan-You Wang, Pu Zha. Tau Pathology Promotes the Reorganization of the Extracellular Matrix and Inhibits the Formation of Perineuronal Nets by Regulating the Expression and the Distribution of Hyaluronic Acid Synthases. Journal of Alzheimer's disease : JAD. vol 57. issue 2. 2018-02-26. PMID:28234253. |
these findings suggest that by abolishing the axonal-localization of has1 and promoting the expression of has3 and the synthesis of shorter-chain ha, the tau pathology breaks the balance of ecm components, promotes the reorganization of the ecm, and inhibits the formation of pnns in the hippocampus, and then regulates neuronal plasticity during the progression of ad. |
2018-02-26 |
2023-08-13 |
mouse |
| Xiaoxu Sun, Shanshan Li, Lixing Xu, Hao Wang, Zhanqiang Ma, Qiang Fu, Rong Qu, Shiping M. Paeoniflorin ameliorates cognitive dysfunction via regulating SOCS2/IRS-1 pathway in diabetic rats. Physiology & behavior. vol 174. 2018-02-26. PMID:28322909. |
current evidences support that inflammatory reaction, oxidative stress, as well as abnormal insulin signaling in the hippocampus are potential causes of tau hyperphosphorylation and finally induce cognitive dysfunction. |
2018-02-26 |
2023-08-13 |
rat |
| Xiaoxu Sun, Shanshan Li, Lixing Xu, Hao Wang, Zhanqiang Ma, Qiang Fu, Rong Qu, Shiping M. Paeoniflorin ameliorates cognitive dysfunction via regulating SOCS2/IRS-1 pathway in diabetic rats. Physiology & behavior. vol 174. 2018-02-26. PMID:28322909. |
immunohistochemistry staining also had shown that tau hyperphosphorylation in the hippocampus was prevented after paeoniflorin administration. |
2018-02-26 |
2023-08-13 |
rat |
| Lucia Buccarello, Giuliano Grignaschi, Anna Maria Castaldo, Alessia Di Giancamillo, Cinzia Domeneghini, Roberto Cosimo Melcangi, Tiziana Borsell. Sex Impact on Tau-Aggregation and Postsynaptic Protein Levels in the P301L Mouse Model of Tauopathy. Journal of Alzheimer's disease : JAD. vol 56. issue 4. 2018-02-23. PMID:28157099. |
when compared to control mice (ctr), p301l transgenic mice (tg) presented a lower body weight, reduced survival rate, hyperphosphorylated tau, spine injury, and neuronal loss in both cerebral cortex and hippocampus at 15 months of age. |
2018-02-23 |
2023-08-13 |
mouse |
| Hideomi Hamasaki, Hiroyuki Honda, Tsuyoshi Okamoto, Sachiko Koyama, Satoshi O Suzuki, Tomoyuki Ohara, Toshiharu Ninomiya, Yutaka Kiyohara, Toru Iwak. Recent Increases in Hippocampal Tau Pathology in the Aging Japanese Population: The Hisayama Study. Journal of Alzheimer's disease : JAD. vol 55. issue 2. 2018-02-22. PMID:27716666. |
recent increases in hippocampal tau pathology in the aging japanese population: the hisayama study. |
2018-02-22 |
2023-08-13 |
Not clear |
| Marion T Turnbull, Elizabeth J Coulso. Cholinergic Basal Forebrain Lesion Decreases Neurotrophin Signaling without Affecting Tau Hyperphosphorylation in Genetically Susceptible Mice. Journal of Alzheimer's disease : JAD. vol 55. issue 3. 2018-02-20. PMID:27767994. |
our results reveal that the loss of bfcns in pre-symptomatic pr5 (p301l) tau transgenic mice results in a decrease in hippocampal brain-derived neurotrophic factor levels and reduced trkb receptor activation. |
2018-02-20 |
2023-08-13 |
mouse |
| Marion T Turnbull, Elizabeth J Coulso. Cholinergic Basal Forebrain Lesion Decreases Neurotrophin Signaling without Affecting Tau Hyperphosphorylation in Genetically Susceptible Mice. Journal of Alzheimer's disease : JAD. vol 55. issue 3. 2018-02-20. PMID:27767994. |
however, there was no exacerbation of the levels of phosphorylated tau or its aggregation in the hippocampus of susceptible mice. |
2018-02-20 |
2023-08-13 |
mouse |
| Marion T Turnbull, Elizabeth J Coulso. Cholinergic Basal Forebrain Lesion Decreases Neurotrophin Signaling without Affecting Tau Hyperphosphorylation in Genetically Susceptible Mice. Journal of Alzheimer's disease : JAD. vol 55. issue 3. 2018-02-20. PMID:27767994. |
this suggests that tau pathology is likely to be regulated independently of bfcn degeneration and the corresponding decrease in hippocampal neurotrophin levels, although these features may still contribute to disease etiology. |
2018-02-20 |
2023-08-13 |
mouse |
| Jesus Mendiola-Precoma, Karla Padilla, Alfredo Rodríguez-Cruz, Laura C Berumen, Ricardo Miledi, Guadalupe García-Alcoce. Theobromine-Induced Changes in A1 Purinergic Receptor Gene Expression and Distribution in a Rat Brain Alzheimer's Disease Model. Journal of Alzheimer's disease : JAD. vol 55. issue 3. 2018-02-20. PMID:27792010. |
dementia caused by alzheimer's disease (ad) is mainly characterized by accumulation in the brain of extra- and intraneuronal amyloid-β (aβ) and tau proteins, respectively, which selectively affect specific regions, particularly the neocortex and the hippocampus. |
2018-02-20 |
2023-08-13 |
rat |
| Kateřina Storey, Silvie Johanidesová, Radoslav Matěj, Jiří Keller, Zdeněk Rohan, Robert Rusin. FTLD-TDP and progressive supranuclear palsy in comorbidity-a report of two cases with different clinical presentations. Neurocase. vol 23. issue 1. 2018-02-20. PMID:27915581. |
neuropathological examination revealed neuronal and glial tau pathology together with ubiquitin, and phospho-tdp-43-immunoreactivities in the hippocampus, striatum, mesencephalon, and frontal and temporal cortices. |
2018-02-20 |
2023-08-13 |
Not clear |
| Hsiang Liao, Liang-Mao Chou, Yi-Wen Chien, Chi-Hao Wu, Jung-Su Chang, Ching-I Lin, Shyh-Hsiang Li. Grape powder consumption affects the expression of neurodegeneration-related brain proteins in rats chronically fed a high-fructose-high-fat diet. The Journal of nutritional biochemistry. vol 43. 2018-02-19. PMID:28285155. |
western blotting was performed to measure the expression/phosphorylation levels of several cortical and hippocampal proteins, including amyloid precursor protein (app), tau, phosphatidylinositol-3-kinase (pi3k), extracellular signal-regulated kinase (erk), receptor for advanced glycation end products (rages), erythroid 2-related factor 2 (nrf2) and brain-derived neurotrophic factor (bdnf). |
2018-02-19 |
2023-08-13 |
rat |
| Suryanarayan Biswal, Deepti Sharma, Kushal Kumar, Tapas Chandra Nag, Kalpana Barhwal, Sunil Kumar Hota, Bhuvnesh Kuma. Global hypoxia induced impairment in learning and spatial memory is associated with precocious hippocampal aging. Neurobiology of learning and memory. vol 133. 2018-02-15. PMID:27246251. |
a single episode of chronic hypobaric hypoxia exposure also resulted in the up-regulation of pro-aging protein, s100a9 and down regulation of tau, snap25, apoe and sod2 in the hippocampus similar to that in aged rats indicating hypoxia induced accelerated aging. |
2018-02-15 |
2023-08-13 |
rat |
| Sarah L DeVos, Rebecca L Miller, Kathleen M Schoch, Brandon B Holmes, Carey S Kebodeaux, Amy J Wegener, Guo Chen, Tao Shen, Hien Tran, Brandon Nichols, Tom A Zanardi, Holly B Kordasiewicz, Eric E Swayze, C Frank Bennett, Marc I Diamond, Timothy M Mille. Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy. Science translational medicine. vol 9. issue 374. 2018-02-01. PMID:28123067. |
the resolution of tau pathology was accompanied by the prevention of hippocampal volume loss, neuronal death, and nesting deficits. |
2018-02-01 |
2023-08-13 |
mouse |
| Lixia Yu, Yuan Chen, Weiguang Wang, Zhonghai Xiao, Yan Hon. Multi-Vitamin B Supplementation Reverses Hypoxia-Induced Tau Hyperphosphorylation and Improves Memory Function in Adult Mice. Journal of Alzheimer's disease : JAD. vol 54. issue 1. 2018-01-29. PMID:27497480. |
mice in the hh group exhibited significant spatial working and passive memory impairment, increased tau phosphorylation at thr181, ser262, ser202/thr205, and ser396 in the cortex and hippocampus, and elevated hcy levels compared with controls. |
2018-01-29 |
2023-08-13 |
mouse |
| Ana Laura Calderon-Garcidueñas, Charles Duyckaert. Alzheimer disease. Handbook of clinical neurology. vol 145. 2018-01-29. PMID:28987180. |
tau pathology affects in a stereotyped order some specific nuclei of the brainstem, the entorhinal area, the hippocampus, and the neocortex - first the associative areas and secondarily the primary cortices (braak stages). |
2018-01-29 |
2023-08-13 |
Not clear |