| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christopher J Silva, Ester Vázquez-Fernández, Bruce Onisko, Jesús R Requen. Proteinase K and the structure of PrPSc: The good, the bad and the ugly. Virus research. vol 207. 2016-05-02. PMID:25816779. |
pk has also been used as a tool to probe the structure of prp(sc). |
2016-05-02 |
2023-08-13 |
Not clear |
| Christopher J Silva, Ester Vázquez-Fernández, Bruce Onisko, Jesús R Requen. Proteinase K and the structure of PrPSc: The good, the bad and the ugly. Virus research. vol 207. 2016-05-02. PMID:25816779. |
mass spectrometry and antibodies have been used to identify pk cleavage sites in prp(sc). |
2016-05-02 |
2023-08-13 |
Not clear |
| Christopher J Silva, Ester Vázquez-Fernández, Bruce Onisko, Jesús R Requen. Proteinase K and the structure of PrPSc: The good, the bad and the ugly. Virus research. vol 207. 2016-05-02. PMID:25816779. |
these results have been used to identify the more accessible, flexible stretches connecting the β-strand components in prp(sc). |
2016-05-02 |
2023-08-13 |
Not clear |
| Christopher J Silva, Ester Vázquez-Fernández, Bruce Onisko, Jesús R Requen. Proteinase K and the structure of PrPSc: The good, the bad and the ugly. Virus research. vol 207. 2016-05-02. PMID:25816779. |
these data, combined with physical constraints imposed by spectroscopic results, were used to propose a qualitative model for the structure of prp(sc). |
2016-05-02 |
2023-08-13 |
Not clear |
| Christopher J Silva, Ester Vázquez-Fernández, Bruce Onisko, Jesús R Requen. Proteinase K and the structure of PrPSc: The good, the bad and the ugly. Virus research. vol 207. 2016-05-02. PMID:25816779. |
assuming that prp(sc) is a four rung β-solenoid, we have threaded the prp sequence to satisfy the pk proteolysis data and other experimental constraints. |
2016-05-02 |
2023-08-13 |
Not clear |
| Natalia Fernández-Borges, Hasier Eraña, Vanesa Venegas, Saioa R Elezgarai, Chafik Harrathi, Joaquín Castill. Animal models for prion-like diseases. Virus research. vol 207. 2016-05-02. PMID:25907990. |
as stated by the "protein-only hypothesis", the causal agent of tses is a self-propagating aberrant form of the prion protein (prp) that through a misfolding event acquires a β-sheet rich conformation known as prp(sc) (from scrapie). |
2016-05-02 |
2023-08-13 |
human |
| Vijit Dalal, Shruti Arya, Mily Bhattacharya, Samrat Mukhopadhya. Conformational Switching and Nanoscale Assembly of Human Prion Protein into Polymorphic Amyloids via Structurally Labile Oligomers. Biochemistry. vol 54. issue 51. 2016-04-22. PMID:26645611. |
conformational switching of the prion protein (prp) from an α-helical normal cellular form (prp(c)) to an aggregation-prone and self-propagating β-rich scrapie form (prp(sc)) underlies the molecular basis of pathogenesis in prion diseases. |
2016-04-22 |
2023-08-13 |
human |
| Ignazio Cali, Cathleen J Miller, Joseph E Parisi, Michael D Geschwind, Pierluigi Gambetti, Lawrence B Schonberge. Distinct pathological phenotypes of Creutzfeldt-Jakob disease in recipients of prion-contaminated growth hormone. Acta neuropathologica communications. vol 3. 2016-04-21. PMID:26108478. |
all iatrogenic cjd (icjd) subjects were methionine (m) homozygous at codon 129 (129mm) of the prion protein (prp) gene and had scrapie prion protein (prp(sc)) type 1 (icjdmm1). |
2016-04-21 |
2023-08-13 |
human |
| Hui Wang, Chan Tian, Xue-Yu Fan, Li-Na Chen, Yan Lv, Jing Sun, Yang-Jing Zhao, Lu-bin Zhang, Jing Wang, Qi Shi, Chen Gao, Cao Chen, Qi-Xiang Shao, Xiao-Ping Don. Polo-like kinase 3 (PLK3) mediates the clearance of the accumulated PrP mutants transiently expressed in cultured cells and pathogenic PrP(Sc) in prion infected cell line via protein interaction. The international journal of biochemistry & cell biology. vol 62. 2016-04-19. PMID:25724737. |
polo-like kinase 3 (plk3) mediates the clearance of the accumulated prp mutants transiently expressed in cultured cells and pathogenic prp(sc) in prion infected cell line via protein interaction. |
2016-04-19 |
2023-08-13 |
Not clear |
| Hui Wang, Chan Tian, Xue-Yu Fan, Li-Na Chen, Yan Lv, Jing Sun, Yang-Jing Zhao, Lu-bin Zhang, Jing Wang, Qi Shi, Chen Gao, Cao Chen, Qi-Xiang Shao, Xiao-Ping Don. Polo-like kinase 3 (PLK3) mediates the clearance of the accumulated PrP mutants transiently expressed in cultured cells and pathogenic PrP(Sc) in prion infected cell line via protein interaction. The international journal of biochemistry & cell biology. vol 62. 2016-04-19. PMID:25724737. |
moreover, plk3 overexpression in a scrapie infected cell line caused notable reduce of prp(sc) level in a dose-dependent manner, but had minimal effect on the expression of prp(c) in its normal partner cell line. |
2016-04-19 |
2023-08-13 |
Not clear |
| Hui Wang, Chan Tian, Xue-Yu Fan, Li-Na Chen, Yan Lv, Jing Sun, Yang-Jing Zhao, Lu-bin Zhang, Jing Wang, Qi Shi, Chen Gao, Cao Chen, Qi-Xiang Shao, Xiao-Ping Don. Polo-like kinase 3 (PLK3) mediates the clearance of the accumulated PrP mutants transiently expressed in cultured cells and pathogenic PrP(Sc) in prion infected cell line via protein interaction. The international journal of biochemistry & cell biology. vol 62. 2016-04-19. PMID:25724737. |
our findings here confirmed the molecular interaction between plk3 and prp and outlined the regulatory activity of plk3 on the degradation of abnormal prps, even its pathogenic isoform prp(sc). |
2016-04-19 |
2023-08-13 |
Not clear |
| Hui Wang, Chan Tian, Xue-Yu Fan, Li-Na Chen, Yan Lv, Jing Sun, Yang-Jing Zhao, Lu-bin Zhang, Jing Wang, Qi Shi, Chen Gao, Cao Chen, Qi-Xiang Shao, Xiao-Ping Don. Polo-like kinase 3 (PLK3) mediates the clearance of the accumulated PrP mutants transiently expressed in cultured cells and pathogenic PrP(Sc) in prion infected cell line via protein interaction. The international journal of biochemistry & cell biology. vol 62. 2016-04-19. PMID:25724737. |
we, therefore, assume that the recovery of plk3 in the early stage of prion infection may be helpful to prevent the toxic accumulation of prp(sc) in the brain tissues. |
2016-04-19 |
2023-08-13 |
Not clear |
| Hiroyuki Okada, Kentaro Masujin, Kohtaro Miyazawa, Takashi Yokoyam. Acquired transmissibility of sheep-passaged L-type bovine spongiform encephalopathy prion to wild-type mice. Veterinary research. vol 46. 2016-04-13. PMID:26169916. |
disease-associated prion protein (prp(sc)) was detected in the brain and/or lymphoid tissues during the lifespan of mice that were asymptomatic subclinical carriers, indicating that wild-type mice were susceptible to sheep-passaged l-bse. |
2016-04-13 |
2023-08-13 |
mouse |
| Hiroyuki Okada, Kentaro Masujin, Kohtaro Miyazawa, Takashi Yokoyam. Acquired transmissibility of sheep-passaged L-type bovine spongiform encephalopathy prion to wild-type mice. Veterinary research. vol 46. 2016-04-13. PMID:26169916. |
the morphological characteristics of the prp(sc) of sheep-passaged l-bse included florid plaques that were distributed mainly in the cerebral cortex and hippocampus of subsequent passaged mice. |
2016-04-13 |
2023-08-13 |
mouse |
| Hiroyuki Okada, Kentaro Masujin, Kohtaro Miyazawa, Takashi Yokoyam. Acquired transmissibility of sheep-passaged L-type bovine spongiform encephalopathy prion to wild-type mice. Veterinary research. vol 46. 2016-04-13. PMID:26169916. |
the prp(sc) glycoform profiles of wild-type mice infected with sheep-passaged l-bse were similar to those of the original isolate. |
2016-04-13 |
2023-08-13 |
mouse |
| Carlos E Giraldo, María E Álvarez, Jorge U Carmon. Effects of sodium citrate and acid citrate dextrose solutions on cell counts and growth factor release from equine pure-platelet rich plasma and pure-platelet rich gel. BMC veterinary research. vol 11. 2016-04-11. PMID:25889052. |
the aims of this study were 1) to compare the effects of the anticoagulants sodium citrate (sc), acid citrate dextrose solution a (acd-a) and acd-b on platelet (plt), leukocyte (wbc) and on some parameters associated to platelet activation including mean platelet volume (mpv) and platelet distribution width (pdw) between whole blood, pure prp (p-prp) and platelet-poor plasma (ppp); 2) to compare transforming growth factor beta 1 (tgf-β(1)) and platelet-derived growth factor isoform bb (pdgf-bb) concentrations in supernatants from pure prg (p-prg), platelet-poor gel (ppg), p-prp lysate (positive control) and plasma (negative control); 3) to establish the possible correlations between all the studied cellular and molecular parameters. |
2016-04-11 |
2023-08-13 |
Not clear |
| Rohana P Dassanayake, Thomas C Truscott, Dongyue Zhuang, David A Schneider, Sally A Madsen-Bouterse, Alan J Young, James B Stanton, William C Davis, Katherine I O'Rourk. Classical natural ovine scrapie prions detected in practical volumes of blood by lamb and transgenic mouse bioassays. Journal of veterinary science. vol 16. issue 2. 2016-04-06. PMID:25549221. |
scrapie is diagnosed antemortem in sheep by detecting misfolded isoforms of prion protein (prp(sc)) in lymphoid follicles of the rectal mucosa and nictitating membranes. |
2016-04-06 |
2023-08-13 |
mouse |
| Rohana P Dassanayake, Thomas C Truscott, Dongyue Zhuang, David A Schneider, Sally A Madsen-Bouterse, Alan J Young, James B Stanton, William C Davis, Katherine I O'Rourk. Classical natural ovine scrapie prions detected in practical volumes of blood by lamb and transgenic mouse bioassays. Journal of veterinary science. vol 16. issue 2. 2016-04-06. PMID:25549221. |
assay sensitivity is limited if (a) the biopsy is collected early during disease development, (b) an insufficient number of follicles is collected, or (c) peripheral accumulation of prp(sc) is reduced or delayed. |
2016-04-06 |
2023-08-13 |
mouse |
| Sandra Pritzkow, Rodrigo Morales, Fabio Moda, Uffaf Khan, Glenn C Telling, Edward Hoover, Claudio Sot. Grass plants bind, retain, uptake, and transport infectious prions. Cell reports. vol 11. issue 8. 2016-04-05. PMID:25981035. |
here, we analyzed the binding and retention of infectious prion protein (prp(sc)) to plants. |
2016-04-05 |
2023-08-13 |
Not clear |
| Sandra Pritzkow, Rodrigo Morales, Fabio Moda, Uffaf Khan, Glenn C Telling, Edward Hoover, Claudio Sot. Grass plants bind, retain, uptake, and transport infectious prions. Cell reports. vol 11. issue 8. 2016-04-05. PMID:25981035. |
small quantities of prp(sc) contained in diluted brain homogenate or in excretory materials (urine and feces) can bind to wheat grass roots and leaves. |
2016-04-05 |
2023-08-13 |
Not clear |