| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ben C Maddison, John Spiropoulos, Christopher M Vickery, Richard Lockey, Jonathan P Owen, Keith Bishop, Claire A Baker, Kevin C Goug. Incubation of ovine scrapie with environmental matrix results in biological and biochemical changes of PrP(Sc) over time. Veterinary research. vol 46. 2016-02-04. PMID:25928902. |
after one-day incubation on soil, two prp(sc) phenotypes were present: g338 or apl338ii. |
2016-02-04 |
2023-08-13 |
mouse |
| Ben C Maddison, John Spiropoulos, Christopher M Vickery, Richard Lockey, Jonathan P Owen, Keith Bishop, Claire A Baker, Kevin C Goug. Incubation of ovine scrapie with environmental matrix results in biological and biochemical changes of PrP(Sc) over time. Veterinary research. vol 46. 2016-02-04. PMID:25928902. |
thirteen months later some divergent prp(sc) phenotypes were seen: a mixture of apl338ii with either g338 or p338, and a completely novel prp(sc) deposition, designated cag338. |
2016-02-04 |
2023-08-13 |
mouse |
| Ben C Maddison, John Spiropoulos, Christopher M Vickery, Richard Lockey, Jonathan P Owen, Keith Bishop, Claire A Baker, Kevin C Goug. Incubation of ovine scrapie with environmental matrix results in biological and biochemical changes of PrP(Sc) over time. Veterinary research. vol 46. 2016-02-04. PMID:25928902. |
the data show that prolonged ageing of scrapie prions within an environmental matrix may result in changes in the dominant prp(sc) biological/biochemical properties. |
2016-02-04 |
2023-08-13 |
mouse |
| Nelda A Rivera, Jan Novakofski, Hsin-Yi Weng, Amy Kelly, Damian Satterthwaite-Phillips, Marilyn O Ruiz, Nohra Mateus-Pinill. Metals in obex and retropharyngeal lymph nodes of Illinois white-tailed deer and their variations associated with CWD status. Prion. vol 9. issue 1. 2016-02-01. PMID:25695915. |
on the other hand prp(sc), the misfolded isoform of prp(c) and the pathogenic agent in transmissible spongiform encephalopathies (tse), has been associated with brain metal dyshomeostasis in prion diseases. |
2016-02-01 |
2023-08-13 |
human |
| Sally A Madsen-Bouterse, David A Schneider, Rohana P Dassanayake, Thomas C Truscott, Dongyue Zhuang, Nancy Kumpula-McWhirter, Katherine I O'Rourk. PRNP variants in goats reduce sensitivity of detection of PrP(Sc) by immunoassay. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. vol 27. issue 3. 2016-01-25. PMID:26038481. |
prnp variants in goats reduce sensitivity of detection of prp(sc) by immunoassay. |
2016-01-25 |
2023-08-13 |
Not clear |
| Sally A Madsen-Bouterse, David A Schneider, Rohana P Dassanayake, Thomas C Truscott, Dongyue Zhuang, Nancy Kumpula-McWhirter, Katherine I O'Rourk. PRNP variants in goats reduce sensitivity of detection of PrP(Sc) by immunoassay. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. vol 27. issue 3. 2016-01-25. PMID:26038481. |
united states regulatory testing for scrapie primarily uses antibody f99/97.6.1 for immunohistochemistry (ihc) of the prion protein associated with scrapie (prp(sc)). |
2016-01-25 |
2023-08-13 |
Not clear |
| Sally A Madsen-Bouterse, David A Schneider, Rohana P Dassanayake, Thomas C Truscott, Dongyue Zhuang, Nancy Kumpula-McWhirter, Katherine I O'Rourk. PRNP variants in goats reduce sensitivity of detection of PrP(Sc) by immunoassay. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. vol 27. issue 3. 2016-01-25. PMID:26038481. |
decreasing f89/160.1.5 titers were used to demonstrate the impact of prp(sc) immunolabeling in preclinical goats and as a surrogate for f99/97.6.1 detection in 222 variants. |
2016-01-25 |
2023-08-13 |
Not clear |
| Sally A Madsen-Bouterse, David A Schneider, Rohana P Dassanayake, Thomas C Truscott, Dongyue Zhuang, Nancy Kumpula-McWhirter, Katherine I O'Rourk. PRNP variants in goats reduce sensitivity of detection of PrP(Sc) by immunoassay. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. vol 27. issue 3. 2016-01-25. PMID:26038481. |
in the absence of epitope-relevant knowledge of individual goat prnp, a multi-antibody approach or an antibody that binds an invariant site may provide a more robust immunoassay of prp(sc) in classical scrapie, thus reducing the likelihood of false-negative results due to allelic variation. |
2016-01-25 |
2023-08-13 |
Not clear |
| Steve Simoneau, Achim Thomzig, Marie-Madeleine Ruchoux, Nicolas Vignier, Martin L Daus, Anna Poleggi, Pierre Lebon, Sophie Freire, Valerie Durand, Silvia Graziano, Roberta Galeno, Franco Cardone, Emmanuel Comoy, Maurizio Pocchiari, Michael Beekes, Jean-Philippe Deslys, Jean-Guy Fournie. Synthetic scrapie infectivity: interaction between recombinant PrP and scrapie brain-derived RNA. Virulence. vol 6. issue 2. 2016-01-19. PMID:25585171. |
with regards to this common mechanism, it appears difficult to explain the outstanding infectious properties attributed to prp(sc), the hallmark of another intriguing family of cerebral proteinopathies known as transmissible spongiform encephalopathies (tse) or prion diseases. |
2016-01-19 |
2023-08-13 |
human |
| Steve Simoneau, Achim Thomzig, Marie-Madeleine Ruchoux, Nicolas Vignier, Martin L Daus, Anna Poleggi, Pierre Lebon, Sophie Freire, Valerie Durand, Silvia Graziano, Roberta Galeno, Franco Cardone, Emmanuel Comoy, Maurizio Pocchiari, Michael Beekes, Jean-Philippe Deslys, Jean-Guy Fournie. Synthetic scrapie infectivity: interaction between recombinant PrP and scrapie brain-derived RNA. Virulence. vol 6. issue 2. 2016-01-19. PMID:25585171. |
the infectious prp(sc) or "prion" is thought to be composed solely of a misfolded form of the otherwise harmless cellular prion protein (prp(c)). |
2016-01-19 |
2023-08-13 |
human |
| Steve Simoneau, Achim Thomzig, Marie-Madeleine Ruchoux, Nicolas Vignier, Martin L Daus, Anna Poleggi, Pierre Lebon, Sophie Freire, Valerie Durand, Silvia Graziano, Roberta Galeno, Franco Cardone, Emmanuel Comoy, Maurizio Pocchiari, Michael Beekes, Jean-Philippe Deslys, Jean-Guy Fournie. Synthetic scrapie infectivity: interaction between recombinant PrP and scrapie brain-derived RNA. Virulence. vol 6. issue 2. 2016-01-19. PMID:25585171. |
to gain insight into this unique situation, we used the 263k scrapie hamster model to search for a putative prp(sc)-associated factor that contributes to the infectivity of prp(sc) amyloid. |
2016-01-19 |
2023-08-13 |
human |
| Qi Yuan, Thomas Eckland, Glenn Telling, Jason Bartz, Shannon Bartelt-Hun. Mitigation of prion infectivity and conversion capacity by a simulated natural process--repeated cycles of drying and wetting. PLoS pathogens. vol 11. issue 2. 2016-01-19. PMID:25665187. |
in this study, we examined the effect of repeated cycles of drying and wetting on prion fitness and determined that 10 cycles of repeated drying and wetting could reduce prp(sc) abundance, pmca amplification efficiency and extend the incubation period of disease. |
2016-01-19 |
2023-08-13 |
Not clear |
| Qi Yuan, Thomas Eckland, Glenn Telling, Jason Bartz, Shannon Bartelt-Hun. Mitigation of prion infectivity and conversion capacity by a simulated natural process--repeated cycles of drying and wetting. PLoS pathogens. vol 11. issue 2. 2016-01-19. PMID:25665187. |
importantly, prions bound to soil were more susceptible to inactivation by repeated cycles of drying and wetting compared to unbound prions, a result which may be due to conformational changes in soil-bound prp(sc) or consolidation of the bonding between prp(sc) and soil. |
2016-01-19 |
2023-08-13 |
Not clear |
| Sneha Menon, Neelanjana Sengupt. Perturbations in inter-domain associations may trigger the onset of pathogenic transformations in PrP(C): insights from atomistic simulations. Molecular bioSystems. vol 11. issue 5. 2016-01-12. PMID:25855580. |
conversion of the predominantly α-helical cellular prion protein (prp(c)) to the misfolded β-sheet enriched scrapie form (prp(sc)) is a critical event in prion pathogenesis. |
2016-01-12 |
2023-08-13 |
Not clear |
| Sneha Menon, Neelanjana Sengupt. Perturbations in inter-domain associations may trigger the onset of pathogenic transformations in PrP(C): insights from atomistic simulations. Molecular bioSystems. vol 11. issue 5. 2016-01-12. PMID:25855580. |
however, the conformational triggers that lead to the isoform conversion (prp(c) to prp(sc)) remain obscure, and conjectures about the role of unusually hydrophilic, short helix h1 of the c-terminal globular domain in the transition are varied. |
2016-01-12 |
2023-08-13 |
Not clear |
| Jeong Ho Park, Yeong Gon Choi, Yun Jung Lee, Seok Joo Park, Hong Seok Choi, Kyung Chan Choi, Eun Kyoung Choi, Yong Sun Ki. Real-Time Quaking-Induced Conversion Analysis for the Diagnosis of Sporadic Creutzfeldt-Jakob Disease in Korea. Journal of clinical neurology (Seoul, Korea). vol 12. issue 1. 2016-01-12. PMID:26541494. |
newly developed assays including real-time quaking-induced conversion (rt-quic) have made it possible to detect the prpsc-like abnormal prion isoform with a high sensitivity in animal and human specimens that might contain a minute amount of prp(sc) due to in vitro prion replication. |
2016-01-12 |
2023-08-13 |
human |
| Yaoqian Pan, Liyong Sun, Jihong Wang, Wenzhuo Fu, Yongyao Fu, Jin Wang, Yigang Tong, Bo Pa. STI571 protects neuronal cells from neurotoxic prion protein fragment-induced apoptosis. Neuropharmacology. vol 93. 2016-01-01. PMID:25681617. |
prion diseases are neurodegenerative disorders caused by the accumulation of misfolded prion proteins [scrapie form of prp (prp(sc))]. |
2016-01-01 |
2023-08-13 |
Not clear |
| Yaoqian Pan, Liyong Sun, Jihong Wang, Wenzhuo Fu, Yongyao Fu, Jin Wang, Yigang Tong, Bo Pa. STI571 protects neuronal cells from neurotoxic prion protein fragment-induced apoptosis. Neuropharmacology. vol 93. 2016-01-01. PMID:25681617. |
prp(sc) accumulation in the brain causes neurotoxicity by inducing mitochondrial-apoptotic pathways. |
2016-01-01 |
2023-08-13 |
Not clear |
| Stanley B Prusiner, Amanda L Woerman, Daniel A Mordes, Joel C Watts, Ryan Rampersaud, David B Berry, Smita Patel, Abby Oehler, Jennifer K Lowe, Stephanie N Kravitz, Daniel H Geschwind, David V Glidden, Glenda M Halliday, Lefkos T Middleton, Steve M Gentleman, Lea T Grinberg, Kurt Gile. Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 38. 2016-01-01. PMID:26324905. |
prions are proteins that adopt alternative conformations that become self-propagating; the prp(sc) prion causes the rare human disorder creutzfeldt-jakob disease (cjd). |
2016-01-01 |
2023-08-13 |
mouse |
| Xiaojing Cong, Nicola Casiraghi, Giulia Rossetti, Sandipan Mohanty, Gabriele Giachin, Giuseppe Legname, Paolo Carlon. Role of Prion Disease-Linked Mutations in the Intrinsically Disordered N-Terminal Domain of the Prion Protein. Journal of chemical theory and computation. vol 9. issue 11. 2015-12-22. PMID:26583425. |
intriguingly and in sharp contrast to other pms clustered in the folded domain, n-terminal pms barely affect the conversion to the pathogenic (scrapie, or prp(sc)) isoform of prp(c). |
2015-12-22 |
2023-08-13 |
mouse |