| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jenna Crowell, Andrew Hughson, Byron Caughey, Richard A Besse. Host Determinants of Prion Strain Diversity Independent of Prion Protein Genotype. Journal of virology. vol 89. issue 20. 2015-12-15. PMID:26246570. |
phenotypic diversity in prion diseases can be specified by prion strains in which biological traits are propagated through an epigenetic mechanism mediated by distinct prp(sc) conformations. |
2015-12-15 |
2023-08-13 |
mouse |
| Jenna Crowell, Andrew Hughson, Byron Caughey, Richard A Besse. Host Determinants of Prion Strain Diversity Independent of Prion Protein Genotype. Journal of virology. vol 89. issue 20. 2015-12-15. PMID:26246570. |
limited proteinase k digestion revealed strain-specific prp(sc) polypeptide patterns that were maintained in both hosts, but the solubility and conformational stability of prp(sc) differed for the cwd strains in a host-dependent manner. |
2015-12-15 |
2023-08-13 |
mouse |
| Jenna Crowell, Andrew Hughson, Byron Caughey, Richard A Besse. Host Determinants of Prion Strain Diversity Independent of Prion Protein Genotype. Journal of virology. vol 89. issue 20. 2015-12-15. PMID:26246570. |
wst cwd produced prp(sc) amyloid plaques in the brain of the sgh that were partially insoluble and stable at a high concentration of protein denaturant. |
2015-12-15 |
2023-08-13 |
mouse |
| Jenna Crowell, Andrew Hughson, Byron Caughey, Richard A Besse. Host Determinants of Prion Strain Diversity Independent of Prion Protein Genotype. Journal of virology. vol 89. issue 20. 2015-12-15. PMID:26246570. |
however, in transgenic mice, prp(sc) from wst cwd did not assemble into plaques, was highly soluble, and had low conformational stability. |
2015-12-15 |
2023-08-13 |
mouse |
| Jenna Crowell, Andrew Hughson, Byron Caughey, Richard A Besse. Host Determinants of Prion Strain Diversity Independent of Prion Protein Genotype. Journal of virology. vol 89. issue 20. 2015-12-15. PMID:26246570. |
similar studies using the hy and dy strains of transmissible mink encephalopathy resulted in minor differences in prion biological and prp(sc) properties between transgenic mice and sgh. |
2015-12-15 |
2023-08-13 |
mouse |
| Jenna Crowell, Andrew Hughson, Byron Caughey, Richard A Besse. Host Determinants of Prion Strain Diversity Independent of Prion Protein Genotype. Journal of virology. vol 89. issue 20. 2015-12-15. PMID:26246570. |
these findings indicate that host-specific pathways that are independent of prnp can alter the prp(sc) conformation of certain prion strains, leading to changes in the biophysical properties of prp(sc), neuropathology, and clinical prion disease. |
2015-12-15 |
2023-08-13 |
mouse |
| Elizaveta Katorcha, Natallia Makarava, Regina Savtchenko, Alessandra D'Azzo, Ilia V Baskako. Sialylation of prion protein controls the rate of prion amplification, the cross-species barrier, the ratio of PrPSc glycoform and prion infectivity. PLoS pathogens. vol 10. issue 9. 2015-12-08. PMID:25211026. |
the central event underlying prion diseases involves conformational change of the cellular form of the prion protein (prp(c)) into the disease-associated, transmissible form (prp(sc)). |
2015-12-08 |
2023-08-13 |
Not clear |
| Elizaveta Katorcha, Natallia Makarava, Regina Savtchenko, Alessandra D'Azzo, Ilia V Baskako. Sialylation of prion protein controls the rate of prion amplification, the cross-species barrier, the ratio of PrPSc glycoform and prion infectivity. PLoS pathogens. vol 10. issue 9. 2015-12-08. PMID:25211026. |
the current work highlights the previously unappreciated role of sialylation of prp(c) glycans in prion pathogenesis, including its role in controlling prion replication rate, infectivity, cross-species barrier and prp(sc) glycoform ratio. |
2015-12-08 |
2023-08-13 |
Not clear |
| Elizaveta Katorcha, Natallia Makarava, Regina Savtchenko, Alessandra D'Azzo, Ilia V Baskako. Sialylation of prion protein controls the rate of prion amplification, the cross-species barrier, the ratio of PrPSc glycoform and prion infectivity. PLoS pathogens. vol 10. issue 9. 2015-12-08. PMID:25211026. |
as a result, pmcab-derived prp(sc) was less sialylated than brain-derived prp(sc). |
2015-12-08 |
2023-08-13 |
Not clear |
| Elizaveta Katorcha, Natallia Makarava, Regina Savtchenko, Alessandra D'Azzo, Ilia V Baskako. Sialylation of prion protein controls the rate of prion amplification, the cross-species barrier, the ratio of PrPSc glycoform and prion infectivity. PLoS pathogens. vol 10. issue 9. 2015-12-08. PMID:25211026. |
nevertheless, enzymatic de-sialylation of prp(c) using sialidase was found to increase the rate of prp(sc) amplification in pmcab from 10- to 10,000-fold in a strain-dependent manner. |
2015-12-08 |
2023-08-13 |
Not clear |
| Elizaveta Katorcha, Natallia Makarava, Regina Savtchenko, Alessandra D'Azzo, Ilia V Baskako. Sialylation of prion protein controls the rate of prion amplification, the cross-species barrier, the ratio of PrPSc glycoform and prion infectivity. PLoS pathogens. vol 10. issue 9. 2015-12-08. PMID:25211026. |
surprisingly, the sialylation status of prp(c) was also found to control prp(sc) glycoform ratio. |
2015-12-08 |
2023-08-13 |
Not clear |
| Elizaveta Katorcha, Natallia Makarava, Regina Savtchenko, Alessandra D'Azzo, Ilia V Baskako. Sialylation of prion protein controls the rate of prion amplification, the cross-species barrier, the ratio of PrPSc glycoform and prion infectivity. PLoS pathogens. vol 10. issue 9. 2015-12-08. PMID:25211026. |
a decrease in pr(pc) sialylation levels resulted in a higher percentage of the diglycosylated glycoform in prp(sc). |
2015-12-08 |
2023-08-13 |
Not clear |
| Hanna Wolf, Andrea Graßmann, Romina Bester, André Hossinger, Christoph Möhl, Lydia Paulsen, Martin H Groschup, Hermann Schätzl, Ina Vorber. Modulation of Glycosaminoglycans Affects PrPSc Metabolism but Does Not Block PrPSc Uptake. Journal of virology. vol 89. issue 19. 2015-12-07. PMID:26202247. |
mammalian prions are unconventional infectious agents composed primarily of the misfolded aggregated host prion protein prp, termed prp(sc). |
2015-12-07 |
2023-08-13 |
Not clear |
| Hanna Wolf, Andrea Graßmann, Romina Bester, André Hossinger, Christoph Möhl, Lydia Paulsen, Martin H Groschup, Hermann Schätzl, Ina Vorber. Modulation of Glycosaminoglycans Affects PrPSc Metabolism but Does Not Block PrPSc Uptake. Journal of virology. vol 89. issue 19. 2015-12-07. PMID:26202247. |
chemical or genetic manipulation of glycosaminoglycans did not prevent prp(sc) uptake, arguing against their roles as essential prion attachment sites. |
2015-12-07 |
2023-08-13 |
Not clear |
| Hanna Wolf, Andrea Graßmann, Romina Bester, André Hossinger, Christoph Möhl, Lydia Paulsen, Martin H Groschup, Hermann Schätzl, Ina Vorber. Modulation of Glycosaminoglycans Affects PrPSc Metabolism but Does Not Block PrPSc Uptake. Journal of virology. vol 89. issue 19. 2015-12-07. PMID:26202247. |
however, both treatments effectively antagonized de novo prion infection independently of the prion strain and reduced prp(sc) formation in chronically infected cells. |
2015-12-07 |
2023-08-13 |
Not clear |
| Hanna Wolf, Andrea Graßmann, Romina Bester, André Hossinger, Christoph Möhl, Lydia Paulsen, Martin H Groschup, Hermann Schätzl, Ina Vorber. Modulation of Glycosaminoglycans Affects PrPSc Metabolism but Does Not Block PrPSc Uptake. Journal of virology. vol 89. issue 19. 2015-12-07. PMID:26202247. |
our results demonstrate that sulfated glycosaminoglycans are dispensable for prion internalization but play a pivotal role in persistently maintained prp(sc) formation independent of the prion strain. |
2015-12-07 |
2023-08-13 |
Not clear |
| Hermann C Altmeppen, Johannes Prox, Susanne Krasemann, Berta Puig, Katharina Kruszewski, Frank Dohler, Christian Bernreuther, Ana Hoxha, Luise Linsenmeier, Beata Sikorska, Pawel P Liberski, Udo Bartsch, Paul Saftig, Markus Glatze. The sheddase ADAM10 is a potent modulator of prion disease. eLife. vol 4. 2015-12-03. PMID:25654651. |
the prion protein (prp(c)) is highly expressed in the nervous system and critically involved in prion diseases where it misfolds into pathogenic prp(sc). |
2015-12-03 |
2023-08-13 |
mouse |
| Hermann C Altmeppen, Johannes Prox, Susanne Krasemann, Berta Puig, Katharina Kruszewski, Frank Dohler, Christian Bernreuther, Ana Hoxha, Luise Linsenmeier, Beata Sikorska, Pawel P Liberski, Udo Bartsch, Paul Saftig, Markus Glatze. The sheddase ADAM10 is a potent modulator of prion disease. eLife. vol 4. 2015-12-03. PMID:25654651. |
upon prion infection of these mice, clinical, biochemical, and morphological data reveal that lack of adam10 significantly reduces incubation times and increases prp(sc) formation. |
2015-12-03 |
2023-08-13 |
mouse |
| Qi Shi, Kang Xiao, Bao-Yun Zhang, Xiao-Mei Zhang, Li-Na Chen, Cao Chen, Chen Gao, Xiao-Ping Don. Successive passaging of the scrapie strains, ME7-ha and 139A-ha, generated by the interspecies transmission of mouse-adapted strains into hamsters markedly shortens the incubation times, but maintains their molecular and pathological properties. International journal of molecular medicine. vol 35. issue 4. 2015-12-01. PMID:25683243. |
the glycosylation patterns of brain prp(sc) in the animals infected with the 2nd passage of those 2 strains maintained similar features as those in the animals infected with the 1st passage of those strains, with predominantly diglycosylated prp(sc). |
2015-12-01 |
2023-08-13 |
mouse |
| Qi Shi, Kang Xiao, Bao-Yun Zhang, Xiao-Mei Zhang, Li-Na Chen, Cao Chen, Chen Gao, Xiao-Ping Don. Successive passaging of the scrapie strains, ME7-ha and 139A-ha, generated by the interspecies transmission of mouse-adapted strains into hamsters markedly shortens the incubation times, but maintains their molecular and pathological properties. International journal of molecular medicine. vol 35. issue 4. 2015-12-01. PMID:25683243. |
neuropathological assays revealed comparable spongiform degeneration and microglia proliferation in the brain tissues from the infected mice and hamsters, but markedly more plaque-like deposits of prp(sc) and more severe astrogliosis in the brains of the hamster. |
2015-12-01 |
2023-08-13 |
mouse |