| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yeong-Gon Choi, Hae-Young Shin, Jae-Il Kim, Eun-Kyoung Choi, Richard I Carp, Yong-Sun Ki. N(ε)-Carboxymethyl Modification of Lysine Residues in Pathogenic Prion Isoforms. Molecular neurobiology. vol 53. issue 5. 2017-12-25. PMID:25983034. |
the current study investigated whether n(ε)-(carboxymethyl)lysine (cml), a major age form specific to lys residues produced by nonenzymatic glycation, is an age adduct of the n-terminus of prp(sc). |
2017-12-25 |
2023-08-13 |
Not clear |
| Yeong-Gon Choi, Hae-Young Shin, Jae-Il Kim, Eun-Kyoung Choi, Richard I Carp, Yong-Sun Ki. N(ε)-Carboxymethyl Modification of Lysine Residues in Pathogenic Prion Isoforms. Molecular neurobiology. vol 53. issue 5. 2017-12-25. PMID:25983034. |
we show that cml is linked to at least one lys residue at the n-terminus of prp(sc) in 263k prion-infected hamster brains and at least one of the eight lys residues (positions 101, 104, 106, 110, 185, 194, 204, and 220) in the proteinase k (pk)-resistant core region of prp(sc). |
2017-12-25 |
2023-08-13 |
Not clear |
| Yeong-Gon Choi, Hae-Young Shin, Jae-Il Kim, Eun-Kyoung Choi, Richard I Carp, Yong-Sun Ki. N(ε)-Carboxymethyl Modification of Lysine Residues in Pathogenic Prion Isoforms. Molecular neurobiology. vol 53. issue 5. 2017-12-25. PMID:25983034. |
the nonenzymatic glycation of the lys residue(s) of prp(sc) with cml likely occurs in the widespread prion-deposit areas within infected brains, particularly in some of the numerous tyrosine hydroxylase-positive thalamic and hypothalamic nuclei. |
2017-12-25 |
2023-08-13 |
Not clear |
| Yeong-Gon Choi, Hae-Young Shin, Jae-Il Kim, Eun-Kyoung Choi, Richard I Carp, Yong-Sun Ki. N(ε)-Carboxymethyl Modification of Lysine Residues in Pathogenic Prion Isoforms. Molecular neurobiology. vol 53. issue 5. 2017-12-25. PMID:25983034. |
cml glycation does not occur in prp(c) but is seen in the pathologic prp(sc) isoform. |
2017-12-25 |
2023-08-13 |
Not clear |
| Yeong-Gon Choi, Hae-Young Shin, Jae-Il Kim, Eun-Kyoung Choi, Richard I Carp, Yong-Sun Ki. N(ε)-Carboxymethyl Modification of Lysine Residues in Pathogenic Prion Isoforms. Molecular neurobiology. vol 53. issue 5. 2017-12-25. PMID:25983034. |
furthermore, the modification of prp(sc) with cml may be closely involved in prion propagation and deposition in pathological brain areas. |
2017-12-25 |
2023-08-13 |
Not clear |
| Soochan Kim, Sinsuk Han, Hyung Soo Lee, Yong-Sun Kim, Eun-Kyoung Choi, Mi-Yeon Ki. Impaired spleen structure and chemokine expression in ME7 scrapie-infected mice. Immunobiology. vol 221. issue 8. 2017-11-29. PMID:27021907. |
in addition, the networks of follicular dendritic cells, which are known to express high levels of the cellular prion protein (prp(c)) and to accumulate prp(sc) following scrapie infection, were larger in me7-infected spleens. |
2017-11-29 |
2023-08-13 |
mouse |
| Soochan Kim, Sinsuk Han, Hyung Soo Lee, Yong-Sun Kim, Eun-Kyoung Choi, Mi-Yeon Ki. Impaired spleen structure and chemokine expression in ME7 scrapie-infected mice. Immunobiology. vol 221. issue 8. 2017-11-29. PMID:27021907. |
these data indicate that me7-infected spleens display phenotype characteristics different from those reported for prnp(0/0) spleens mainly due to the gain of prp(sc) function and suggest that the prp(c) is required, not only to form the splenic white pulp structure, but also to maintain the intact t zone structure. |
2017-11-29 |
2023-08-13 |
mouse |
| Canbin Zheng, Qingtang Zhu, Xiaolin Liu, Xijun Huang, Caifeng He, Li Jiang, Daping Quan, Xiang Zhou, Zhaowei Zh. Effect of platelet-rich plasma (PRP) concentration on proliferation, neurotrophic function and migration of Schwann cells in vitro. Journal of tissue engineering and regenerative medicine. vol 10. issue 5. 2017-11-20. PMID:23723151. |
cell culture experiments showed that 2.5-20% prp significantly stimulated sc proliferation and migration compared to untreated controls in a dose-dependent manner. |
2017-11-20 |
2023-08-12 |
rat |
| Clive Bate, William Nolan, Alun William. Does the tail wag the dog? How the structure of a glycosylphosphatidylinositol anchor affects prion formation. Prion. vol 10. issue 2. 2017-11-07. PMID:26901126. |
prp(c) containing a gpi anchor from which the sialic acid had been removed (desialylated prp(c)) was not converted to prp(sc) in prion-infected neuronal cell lines and in scrapie-infected primary cortical neurons. |
2017-11-07 |
2023-08-13 |
dog |
| Clive Bate, William Nolan, Alun William. Does the tail wag the dog? How the structure of a glycosylphosphatidylinositol anchor affects prion formation. Prion. vol 10. issue 2. 2017-11-07. PMID:26901126. |
the presence of desialylated prp(c) caused the dissociation of cytoplasmic phospholipase a2 (cpla2) from prp-containing lipid rafts, reduced the activation of cpla2 and inhibited prp(sc) production. |
2017-11-07 |
2023-08-13 |
dog |
| Clive Bate, William Nolan, Alun William. Does the tail wag the dog? How the structure of a glycosylphosphatidylinositol anchor affects prion formation. Prion. vol 10. issue 2. 2017-11-07. PMID:26901126. |
we conclude that the sialic acid moiety of the gpi attached to prp(c) modifies local membrane microenvironments that are important in prp-mediated cell signaling and prp(sc) formation. |
2017-11-07 |
2023-08-13 |
dog |
| Bruno Macedo, Yraima Cordeiro, Salvador Ventur. Mammalian prion amyloid formation in bacteria. Prion. vol 10. issue 2. 2017-11-07. PMID:26910379. |
the misfolded form, the scrapie prp (prp(sc)), can aggregate into amyloid fibrils that progressively accumulate in the brain, evolving to a pathological phenotype. |
2017-11-07 |
2023-08-13 |
Not clear |
| Bruno Macedo, Yraima Cordeiro, Salvador Ventur. Mammalian prion amyloid formation in bacteria. Prion. vol 10. issue 2. 2017-11-07. PMID:26910379. |
a particular characteristic of prp(sc) is to be found as different strains, related to the diversity of conformational states it can adopt. |
2017-11-07 |
2023-08-13 |
Not clear |
| Rohana P Dassanayake, Dongyue Zhuang, Thomas C Truscott, Sally A Madsen-Bouterse, Katherine I O'Rourke, David A Schneide. A transfectant RK13 cell line permissive to classical caprine scrapie prion propagation. Prion. vol 10. issue 2. 2017-11-07. PMID:27216989. |
significant prp(sc) accumulation, which is indicative of scrapie prion propagation, was detected by tse elisa and immunohistochemistry in cprk13 cells inoculated with classical caprine scrapie inocula. |
2017-11-07 |
2023-08-13 |
mouse |
| Rohana P Dassanayake, Dongyue Zhuang, Thomas C Truscott, Sally A Madsen-Bouterse, Katherine I O'Rourke, David A Schneide. A transfectant RK13 cell line permissive to classical caprine scrapie prion propagation. Prion. vol 10. issue 2. 2017-11-07. PMID:27216989. |
importantly, prp(sc) accumulation was not detected in similarly inoculated pcrk13 cells, whether by tse elisa, immunohistochemistry, or western blot. |
2017-11-07 |
2023-08-13 |
mouse |
| Zhifu Shan, Takeshi Yamasaki, Akio Suzuki, Rie Hasebe, Motohiro Horiuch. Establishment of a simple cell-based ELISA for the direct detection of abnormal isoform of prion protein from prion-infected cells without cell lysis and proteinase K treatment. Prion. vol 10. issue 4. 2017-11-07. PMID:27565564. |
prion-infected cells have been used for analyzing the effect of compounds on the formation of abnormal isoform of prion protein (prp(sc)). |
2017-11-07 |
2023-08-13 |
mouse |
| Zhifu Shan, Takeshi Yamasaki, Akio Suzuki, Rie Hasebe, Motohiro Horiuch. Establishment of a simple cell-based ELISA for the direct detection of abnormal isoform of prion protein from prion-infected cells without cell lysis and proteinase K treatment. Prion. vol 10. issue 4. 2017-11-07. PMID:27565564. |
prp(sc) is usually detected using anti-prion protein (prp) antibodies after the removal of the cellular isoform of prion protein (prp(c)) by proteinase k (pk) treatment. |
2017-11-07 |
2023-08-13 |
mouse |
| Zhifu Shan, Takeshi Yamasaki, Akio Suzuki, Rie Hasebe, Motohiro Horiuch. Establishment of a simple cell-based ELISA for the direct detection of abnormal isoform of prion protein from prion-infected cells without cell lysis and proteinase K treatment. Prion. vol 10. issue 4. 2017-11-07. PMID:27565564. |
however, it is expected that the pk-sensitive prp(sc) (prp(sc)-sen), which possesses higher infectivity and conversion activity than the pk-resistant prp(sc) (prp(sc)-res), is also digested through pk treatment. |
2017-11-07 |
2023-08-13 |
mouse |
| Zhifu Shan, Takeshi Yamasaki, Akio Suzuki, Rie Hasebe, Motohiro Horiuch. Establishment of a simple cell-based ELISA for the direct detection of abnormal isoform of prion protein from prion-infected cells without cell lysis and proteinase K treatment. Prion. vol 10. issue 4. 2017-11-07. PMID:27565564. |
to overcome this problem, we established a novel cell-based elisa in which prp(sc) can be directly detected from cells persistently infected with prions using anti-prp monoclonal antibody (mab) 132 that recognizes epitope consisting of mouse prp amino acids 119-127. |
2017-11-07 |
2023-08-13 |
mouse |
| Zhifu Shan, Takeshi Yamasaki, Akio Suzuki, Rie Hasebe, Motohiro Horiuch. Establishment of a simple cell-based ELISA for the direct detection of abnormal isoform of prion protein from prion-infected cells without cell lysis and proteinase K treatment. Prion. vol 10. issue 4. 2017-11-07. PMID:27565564. |
mab 132 could detect both prp(sc)-sen and prp(sc)-res even if all prp(sc) molecules were not detected. |
2017-11-07 |
2023-08-13 |
mouse |