| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Borges-Alvarez, F Benavente, M Márquez, J Barbosa, V Sanz-Nebo. Evaluation of non-immunoaffinity methods for isolation of cellular prion protein from bovine brain. Analytical biochemistry. vol 451. 2014-11-12. PMID:24463017. |
research suggests that tses are caused by conversion of the cellular prion protein (prp(c)), which is encoded in many tissues, especially brain, to the pathological form (prp(sc)). |
2014-11-12 |
2023-08-12 |
cattle |
| M Borges-Alvarez, F Benavente, M Márquez, J Barbosa, V Sanz-Nebo. Evaluation of non-immunoaffinity methods for isolation of cellular prion protein from bovine brain. Analytical biochemistry. vol 451. 2014-11-12. PMID:24463017. |
this conversion affects prp(sc) structure, conferring different biochemical properties, such as the increased resistance to proteinase k, that have been widely used for its purification. |
2014-11-12 |
2023-08-12 |
cattle |
| D Simon, M E Herva, M J Benitez, J J Garrido, A I Rojo, A Cuadrado, J M Torres, F Wandosel. Dysfunction of the PI3K-Akt-GSK-3 pathway is a common feature in cell culture and in vivo models of prion disease. Neuropathology and applied neurobiology. vol 40. issue 3. 2014-11-05. PMID:23741998. |
transmissible spongiform encephalopathies, also called prion diseases, are characterized by the cerebral accumulation of misfolded prion protein (prp(sc) ) and subsequent neurodegeneration. |
2014-11-05 |
2023-08-12 |
Not clear |
| Wei Chen, Marc W van der Kamp, Valerie Dagget. Structural and dynamic properties of the human prion protein. Biophysical journal. vol 106. issue 5. 2014-11-04. PMID:24606939. |
prion diseases involve the conformational conversion of the cellular prion protein (prp(c)) to its misfolded pathogenic form (prp(sc)). |
2014-11-04 |
2023-08-12 |
human |
| Wei Chen, Marc W van der Kamp, Valerie Dagget. Structural and dynamic properties of the human prion protein. Biophysical journal. vol 106. issue 5. 2014-11-04. PMID:24606939. |
this study reveals detailed structural and dynamic properties of huprp, providing insight into the mechanism of the conversion of prp(c) to prp(sc). |
2014-11-04 |
2023-08-12 |
human |
| René C L Olsthoor. G-quadruplexes within prion mRNA: the missing link in prion disease? Nucleic acids research. vol 42. issue 14. 2014-11-04. PMID:25030900. |
cellular ribonucleic acid (rna) plays a crucial role in the initial conversion of cellular prion protein prp(c) to infectious prp(sc) or scrapie. |
2014-11-04 |
2023-08-13 |
Not clear |
| René C L Olsthoor. G-quadruplexes within prion mRNA: the missing link in prion disease? Nucleic acids research. vol 42. issue 14. 2014-11-04. PMID:25030900. |
prp(c) binding to g4 rnas destabilizes its structure and is thought to trigger its conversion to prp(sc). |
2014-11-04 |
2023-08-13 |
Not clear |
| Yuko Ushiki-Kaku, Yoshihisa Shimizu, Naoko Tabeta, Yoshifumi Iwamaru, Kiyoko Ogawa-Goto, Shunji Hattori, Takashi Yokoyam. Heterogeneity of abnormal prion protein (PrP(Sc)) in murine scrapie prions determined by PrP(Sc)-specific monoclonal antibodies. The Journal of veterinary medical science. vol 76. issue 2. 2014-11-03. PMID:24132297. |
heterogeneity of abnormal prion protein (prp(sc)) in murine scrapie prions determined by prp(sc)-specific monoclonal antibodies. |
2014-11-03 |
2023-08-12 |
Not clear |
| Yuko Ushiki-Kaku, Yoshihisa Shimizu, Naoko Tabeta, Yoshifumi Iwamaru, Kiyoko Ogawa-Goto, Shunji Hattori, Takashi Yokoyam. Heterogeneity of abnormal prion protein (PrP(Sc)) in murine scrapie prions determined by PrP(Sc)-specific monoclonal antibodies. The Journal of veterinary medical science. vol 76. issue 2. 2014-11-03. PMID:24132297. |
in prion diseases, abnormal prion protein (prp(sc)) is considered as the main component of the infectious agent. |
2014-11-03 |
2023-08-12 |
Not clear |
| Yuko Ushiki-Kaku, Yoshihisa Shimizu, Naoko Tabeta, Yoshifumi Iwamaru, Kiyoko Ogawa-Goto, Shunji Hattori, Takashi Yokoyam. Heterogeneity of abnormal prion protein (PrP(Sc)) in murine scrapie prions determined by PrP(Sc)-specific monoclonal antibodies. The Journal of veterinary medical science. vol 76. issue 2. 2014-11-03. PMID:24132297. |
delineation of prp(sc) conformation is expected to be a critical factor in understanding properties of prions. |
2014-11-03 |
2023-08-12 |
Not clear |
| Yuko Ushiki-Kaku, Yoshihisa Shimizu, Naoko Tabeta, Yoshifumi Iwamaru, Kiyoko Ogawa-Goto, Shunji Hattori, Takashi Yokoyam. Heterogeneity of abnormal prion protein (PrP(Sc)) in murine scrapie prions determined by PrP(Sc)-specific monoclonal antibodies. The Journal of veterinary medical science. vol 76. issue 2. 2014-11-03. PMID:24132297. |
however, practical methods to differentiate between conformers of prp(sc) are inadequate. |
2014-11-03 |
2023-08-12 |
Not clear |
| Yuko Ushiki-Kaku, Yoshihisa Shimizu, Naoko Tabeta, Yoshifumi Iwamaru, Kiyoko Ogawa-Goto, Shunji Hattori, Takashi Yokoyam. Heterogeneity of abnormal prion protein (PrP(Sc)) in murine scrapie prions determined by PrP(Sc)-specific monoclonal antibodies. The Journal of veterinary medical science. vol 76. issue 2. 2014-11-03. PMID:24132297. |
here, we used two prp(sc)-specific monoclonal antibodies (mabs), 3b7 and 3h6, and found that mab 3h6 detected a limited portion of prp(sc) in five mice-adapted prion strains. |
2014-11-03 |
2023-08-12 |
Not clear |
| Yuko Ushiki-Kaku, Yoshihisa Shimizu, Naoko Tabeta, Yoshifumi Iwamaru, Kiyoko Ogawa-Goto, Shunji Hattori, Takashi Yokoyam. Heterogeneity of abnormal prion protein (PrP(Sc)) in murine scrapie prions determined by PrP(Sc)-specific monoclonal antibodies. The Journal of veterinary medical science. vol 76. issue 2. 2014-11-03. PMID:24132297. |
the quantity of mab 3h6-precipitated prp(sc) was significantly lesser in 22l compared to other strains. |
2014-11-03 |
2023-08-12 |
Not clear |
| Yuko Ushiki-Kaku, Yoshihisa Shimizu, Naoko Tabeta, Yoshifumi Iwamaru, Kiyoko Ogawa-Goto, Shunji Hattori, Takashi Yokoyam. Heterogeneity of abnormal prion protein (PrP(Sc)) in murine scrapie prions determined by PrP(Sc)-specific monoclonal antibodies. The Journal of veterinary medical science. vol 76. issue 2. 2014-11-03. PMID:24132297. |
this result provides a direct evidence of the conformational heterogeneity of prp(sc) within the prion strains. |
2014-11-03 |
2023-08-12 |
Not clear |
| Yuko Ushiki-Kaku, Yoshihisa Shimizu, Naoko Tabeta, Yoshifumi Iwamaru, Kiyoko Ogawa-Goto, Shunji Hattori, Takashi Yokoyam. Heterogeneity of abnormal prion protein (PrP(Sc)) in murine scrapie prions determined by PrP(Sc)-specific monoclonal antibodies. The Journal of veterinary medical science. vol 76. issue 2. 2014-11-03. PMID:24132297. |
conformation-specific probes, like these mabs, have the potential to be powerful tools for investigating conformational variations in prp(sc). |
2014-11-03 |
2023-08-12 |
Not clear |
| Lisa Gasperini, Giuseppe Legnam. Prion protein and aging. Frontiers in cell and developmental biology. vol 2. 2014-11-03. PMID:25364751. |
the cellular prion protein (prp(c)) has been widely investigated ever since its conformational isoform, the prion (or prp(sc)), was identified as the etiological agent of prion disorders. |
2014-11-03 |
2023-08-13 |
mouse |
| Lisa Gasperini, Giuseppe Legnam. Prion protein and aging. Frontiers in cell and developmental biology. vol 2. 2014-11-03. PMID:25364751. |
additionally, the aging process may alter prp(c) biochemical properties, thus influencing its propensity to convert into prp(sc). |
2014-11-03 |
2023-08-13 |
mouse |
| Lisa Gasperini, Giuseppe Legnam. Prion protein and aging. Frontiers in cell and developmental biology. vol 2. 2014-11-03. PMID:25364751. |
in aging mice, prp(c) changes in subcellular localization and post-translational modifications have been explored in an attempt to relate them to different protein roles and propensity to convert into prp(sc). |
2014-11-03 |
2023-08-13 |
mouse |
| Stefanie A G Black, Peter K Stys, Gerald W Zamponi, Shigeki Tsutsu. Cellular prion protein and NMDA receptor modulation: protecting against excitotoxicity. Frontiers in cell and developmental biology. vol 2. 2014-11-03. PMID:25364752. |
although it is well established that misfolding of the cellular prion protein (prp(c)) into the β-sheet-rich, aggregated scrapie conformation (prp(sc)) causes a variety of transmissible spongiform encephalopathies (tses), the physiological roles of prp(c) are still incompletely understood. |
2014-11-03 |
2023-08-13 |
mouse |
| Stefanie A G Black, Peter K Stys, Gerald W Zamponi, Shigeki Tsutsu. Cellular prion protein and NMDA receptor modulation: protecting against excitotoxicity. Frontiers in cell and developmental biology. vol 2. 2014-11-03. PMID:25364752. |
inhibition of nmda receptor activity protects against prp(sc)-induced neuronal death. |
2014-11-03 |
2023-08-13 |
mouse |