| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mathéa Pietri, Caroline Dakowski, Samia Hannaoui, Aurélie Alleaume-Butaux, Julia Hernandez-Rapp, Audrey Ragagnin, Sophie Mouillet-Richard, Stéphane Haik, Yannick Bailly, Jean-Michel Peyrin, Jean-Marie Launay, Odile Kellermann, Benoit Schneide. PDK1 decreases TACE-mediated α-secretase activity and promotes disease progression in prion and Alzheimer's diseases. Nature medicine. vol 19. issue 9. 2013-11-25. PMID:23955714. |
inhibition of pdk1 promotes localization of tace to the plasma membrane, restores tace-dependent α-secretase activity and cleavage of app, prp(c) and tnfr1, and attenuates prp(sc)- and aβ-induced neurotoxicity. |
2013-11-25 |
2023-08-12 |
mouse |
| Mathéa Pietri, Caroline Dakowski, Samia Hannaoui, Aurélie Alleaume-Butaux, Julia Hernandez-Rapp, Audrey Ragagnin, Sophie Mouillet-Richard, Stéphane Haik, Yannick Bailly, Jean-Michel Peyrin, Jean-Marie Launay, Odile Kellermann, Benoit Schneide. PDK1 decreases TACE-mediated α-secretase activity and promotes disease progression in prion and Alzheimer's diseases. Nature medicine. vol 19. issue 9. 2013-11-25. PMID:23955714. |
in mice, inhibition or sirna-mediated silencing of pdk1 extends survival and reduces motor impairment following prp(sc) infection and in app-transgenic mice reduces alzheimer's disease-like pathology and memory impairment. |
2013-11-25 |
2023-08-12 |
mouse |
| Caterina Maestrale, Giovanni Di Guardo, Maria Giovanna Cancedda, Giuseppe Marruchella, Mariangela Masia, Stefania Sechi, Simonetta Macciocu, Cinzia Santucciu, Mara Petruzzi, Ciriaco Ligio. A lympho-follicular microenvironment is required for pathological prion protein deposition in chronically inflamed tissues from scrapie-affected sheep. PloS one. vol 8. issue 5. 2013-11-22. PMID:23658779. |
in sheep scrapie, pathological prion protein (prp(sc)) deposition occurs in the lymphoreticular and central nervous systems. |
2013-11-22 |
2023-08-12 |
Not clear |
| Caterina Maestrale, Giovanni Di Guardo, Maria Giovanna Cancedda, Giuseppe Marruchella, Mariangela Masia, Stefania Sechi, Simonetta Macciocu, Cinzia Santucciu, Mara Petruzzi, Ciriaco Ligio. A lympho-follicular microenvironment is required for pathological prion protein deposition in chronically inflamed tissues from scrapie-affected sheep. PloS one. vol 8. issue 5. 2013-11-22. PMID:23658779. |
we investigated prp(sc) distribution in scrapie-affected sheep showing simultaneous evidence of chronic lymphofollicular, lymphoproliferative/non-lymphofollicular, and/or granulomatous inflammations in their mammary gland, lung, and ileum. |
2013-11-22 |
2023-08-12 |
Not clear |
| Caterina Maestrale, Giovanni Di Guardo, Maria Giovanna Cancedda, Giuseppe Marruchella, Mariangela Masia, Stefania Sechi, Simonetta Macciocu, Cinzia Santucciu, Mara Petruzzi, Ciriaco Ligio. A lympho-follicular microenvironment is required for pathological prion protein deposition in chronically inflamed tissues from scrapie-affected sheep. PloS one. vol 8. issue 5. 2013-11-22. PMID:23658779. |
to do this, prp(sc) detection was carried out via immunohistochemistry and western blotting techniques, as well as through inflammatory cell immunophenotyping. |
2013-11-22 |
2023-08-12 |
Not clear |
| Caterina Maestrale, Giovanni Di Guardo, Maria Giovanna Cancedda, Giuseppe Marruchella, Mariangela Masia, Stefania Sechi, Simonetta Macciocu, Cinzia Santucciu, Mara Petruzzi, Ciriaco Ligio. A lympho-follicular microenvironment is required for pathological prion protein deposition in chronically inflamed tissues from scrapie-affected sheep. PloS one. vol 8. issue 5. 2013-11-22. PMID:23658779. |
we demonstrated that ectopic prp(sc) deposition occurs exclusively in the context of lymphofollicular inflammatory sites, inside newly formed and well-organized lymphoid follicles harboring follicular dendritic cells. |
2013-11-22 |
2023-08-12 |
Not clear |
| Caterina Maestrale, Giovanni Di Guardo, Maria Giovanna Cancedda, Giuseppe Marruchella, Mariangela Masia, Stefania Sechi, Simonetta Macciocu, Cinzia Santucciu, Mara Petruzzi, Ciriaco Ligio. A lympho-follicular microenvironment is required for pathological prion protein deposition in chronically inflamed tissues from scrapie-affected sheep. PloS one. vol 8. issue 5. 2013-11-22. PMID:23658779. |
on the contrary, no prp(sc) deposition was detected in granulomas, even when they were closely located to newly formed lymphoid follicles. |
2013-11-22 |
2023-08-12 |
Not clear |
| Caterina Maestrale, Giovanni Di Guardo, Maria Giovanna Cancedda, Giuseppe Marruchella, Mariangela Masia, Stefania Sechi, Simonetta Macciocu, Cinzia Santucciu, Mara Petruzzi, Ciriaco Ligio. A lympho-follicular microenvironment is required for pathological prion protein deposition in chronically inflamed tissues from scrapie-affected sheep. PloS one. vol 8. issue 5. 2013-11-22. PMID:23658779. |
a significantly more consistent expression of lymphotoxin α and β mrna was detected in lymphofollicular inflammation compared to the other two types, with lymphotoxin α and β signaling new lymphoid follicles' formation and, likely, the occurrence of ectopic prp(sc) deposition inside them. |
2013-11-22 |
2023-08-12 |
Not clear |
| Franc Llorens, Patricia Carulla, Ana Villa, Juan M Torres, Puri Fortes, Isidre Ferrer, José A del Rí. PrP(C) regulates epidermal growth factor receptor function and cell shape dynamics in Neuro2a cells. Journal of neurochemistry. vol 127. issue 1. 2013-11-19. PMID:23638794. |
although the misfolded and pathologic variant of this protein (prp(sc)) has been studied in depth, the physiological role of prp(c) remains elusive and controversial. |
2013-11-19 |
2023-08-12 |
Not clear |
| Abdelazim Elsayed Elhelaly, Yasuo Inoshima, Naotaka Ishigur. Characterization of early transient accumulation of PrP(Sc) in immune cells. Biochemical and biophysical research communications. vol 439. issue 3. 2013-11-18. PMID:24012669. |
characterization of early transient accumulation of prp(sc) in immune cells. |
2013-11-18 |
2023-08-12 |
Not clear |
| Abdelazim Elsayed Elhelaly, Yasuo Inoshima, Naotaka Ishigur. Characterization of early transient accumulation of PrP(Sc) in immune cells. Biochemical and biophysical research communications. vol 439. issue 3. 2013-11-18. PMID:24012669. |
prp(sc) is known to elicit no specific immune response and the immune cells are suspected to support its accumulation. |
2013-11-18 |
2023-08-12 |
Not clear |
| Abdelazim Elsayed Elhelaly, Yasuo Inoshima, Naotaka Ishigur. Characterization of early transient accumulation of PrP(Sc) in immune cells. Biochemical and biophysical research communications. vol 439. issue 3. 2013-11-18. PMID:24012669. |
in the present study, we investigated the response of some immune cell types to prp(sc) to characterize an observed early transient accumulation of prp(sc). |
2013-11-18 |
2023-08-12 |
Not clear |
| Abdelazim Elsayed Elhelaly, Yasuo Inoshima, Naotaka Ishigur. Characterization of early transient accumulation of PrP(Sc) in immune cells. Biochemical and biophysical research communications. vol 439. issue 3. 2013-11-18. PMID:24012669. |
after cells were treated with prp(sc)-brain homogenate, prp(sc) was transiently accumulated for the first 8-12h post-exposure then completely cleared by the 5th day of the experiment. |
2013-11-18 |
2023-08-12 |
Not clear |
| Abdelazim Elsayed Elhelaly, Yasuo Inoshima, Naotaka Ishigur. Characterization of early transient accumulation of PrP(Sc) in immune cells. Biochemical and biophysical research communications. vol 439. issue 3. 2013-11-18. PMID:24012669. |
the accumulated prp(sc) was not a de novo product of the cell prp(c). |
2013-11-18 |
2023-08-12 |
Not clear |
| Abdelazim Elsayed Elhelaly, Yasuo Inoshima, Naotaka Ishigur. Characterization of early transient accumulation of PrP(Sc) in immune cells. Biochemical and biophysical research communications. vol 439. issue 3. 2013-11-18. PMID:24012669. |
our in vitro results suggest that immune cells, especially macrophages are potential risk factors for the accumulation and intercellular spread of prp(sc) if the complete clearance of prp(sc) were not fulfilled. |
2013-11-18 |
2023-08-12 |
Not clear |
| Christopher M Vickery, Katy E Beck, Marion M Simmons, Stephen A C Hawkins, John Spiropoulo. Disease characteristics of bovine spongiform encephalopathy following inoculation into mice via three different routes. International journal of experimental pathology. vol 94. issue 5. 2013-11-14. PMID:24020404. |
strain characteristics were assessed according to standard methodology and prp(sc) immunohistochemistry deposition patterns. |
2013-11-14 |
2023-08-12 |
mouse |
| Christopher M Vickery, Katy E Beck, Marion M Simmons, Stephen A C Hawkins, John Spiropoulo. Disease characteristics of bovine spongiform encephalopathy following inoculation into mice via three different routes. International journal of experimental pathology. vol 94. issue 5. 2013-11-14. PMID:24020404. |
nevertheless, the same prp(sc) deposition pattern was associated with each route of administration. |
2013-11-14 |
2023-08-12 |
mouse |
| Christopher M Vickery, Katy E Beck, Marion M Simmons, Stephen A C Hawkins, John Spiropoulo. Disease characteristics of bovine spongiform encephalopathy following inoculation into mice via three different routes. International journal of experimental pathology. vol 94. issue 5. 2013-11-14. PMID:24020404. |
distal and mesenteric ln infectivity was detected as early as 35 dpi and displayed consistent lesion profiles and prp(sc) deposition patterns. |
2013-11-14 |
2023-08-12 |
mouse |
| Nuria Gonzalez-Montalban, Young Jin Lee, Natallia Makarava, Regina Savtchenko, Ilia V Baskako. Changes in prion replication environment cause prion strain mutation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 27. issue 9. 2013-11-12. PMID:23729586. |
on adaptation to an rna-depleted environment and then readaptation to an environment containing rna, strain 263k gave rise to a novel prp(sc) conformation referred to as 263k(r+), which is characterized by very low conformational stability, high sensitivity to proteolytic digestion, and a replication rate of 10(6)-fold/pmcab round, which exceeded that of 263k by almost 10(4)-fold. |
2013-11-12 |
2023-08-12 |
Not clear |
| Nuria Gonzalez-Montalban, Young Jin Lee, Natallia Makarava, Regina Savtchenko, Ilia V Baskako. Changes in prion replication environment cause prion strain mutation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 27. issue 9. 2013-11-12. PMID:23729586. |
the current work demonstrates that dramatic prp(sc) transformations can be induced by changes in the prion replication environment and without changes in prp primary structure. |
2013-11-12 |
2023-08-12 |
Not clear |