| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kentaro Masujin, Yuko Kaku-Ushiki, Ritsuko Miwa, Hiroyuki Okada, Yoshihisa Shimizu, Kazuo Kasai, Yuichi Matsuura, Takashi Yokoyam. The N-terminal sequence of prion protein consists an epitope specific to the abnormal isoform of prion protein (PrP(Sc)). PloS one. vol 8. issue 2. 2013-08-29. PMID:23469131. |
the n-terminal sequence of prion protein consists an epitope specific to the abnormal isoform of prion protein (prp(sc)). |
2013-08-29 |
2023-08-12 |
mouse |
| Kentaro Masujin, Yuko Kaku-Ushiki, Ritsuko Miwa, Hiroyuki Okada, Yoshihisa Shimizu, Kazuo Kasai, Yuichi Matsuura, Takashi Yokoyam. The N-terminal sequence of prion protein consists an epitope specific to the abnormal isoform of prion protein (PrP(Sc)). PloS one. vol 8. issue 2. 2013-08-29. PMID:23469131. |
the conformation of abnormal prion protein (prp(sc)) differs from that of cellular prion protein (prp(c)), but the precise characteristics of prp(sc) remain to be elucidated. |
2013-08-29 |
2023-08-12 |
mouse |
| Kentaro Masujin, Yuko Kaku-Ushiki, Ritsuko Miwa, Hiroyuki Okada, Yoshihisa Shimizu, Kazuo Kasai, Yuichi Matsuura, Takashi Yokoyam. The N-terminal sequence of prion protein consists an epitope specific to the abnormal isoform of prion protein (PrP(Sc)). PloS one. vol 8. issue 2. 2013-08-29. PMID:23469131. |
to clarify the properties of native prp(sc), we attempted to generate novel prp(sc)-specific monoclonal antibodies (mabs) by immunizing prp-deficient mice with intact prp(sc) purified from bovine spongiform encephalopathy (bse)-affected mice. |
2013-08-29 |
2023-08-12 |
mouse |
| Kentaro Masujin, Yuko Kaku-Ushiki, Ritsuko Miwa, Hiroyuki Okada, Yoshihisa Shimizu, Kazuo Kasai, Yuichi Matsuura, Takashi Yokoyam. The N-terminal sequence of prion protein consists an epitope specific to the abnormal isoform of prion protein (PrP(Sc)). PloS one. vol 8. issue 2. 2013-08-29. PMID:23469131. |
the generated mabs 6a12 and 8d5 selectivity precipitated prp(sc) from the brains of prion-affected mice, sheep, and cattle, but did not precipitate prp(c) from the brains of healthy animals. |
2013-08-29 |
2023-08-12 |
mouse |
| Kentaro Masujin, Yuko Kaku-Ushiki, Ritsuko Miwa, Hiroyuki Okada, Yoshihisa Shimizu, Kazuo Kasai, Yuichi Matsuura, Takashi Yokoyam. The N-terminal sequence of prion protein consists an epitope specific to the abnormal isoform of prion protein (PrP(Sc)). PloS one. vol 8. issue 2. 2013-08-29. PMID:23469131. |
this indicates that a prp(sc)-specific epitope exists in the n-terminal region of prp(sc), and mabs 6a12 and 8d5 are powerful tools with which to detect native and intact prp(sc). |
2013-08-29 |
2023-08-12 |
mouse |
| Kentaro Masujin, Yuko Kaku-Ushiki, Ritsuko Miwa, Hiroyuki Okada, Yoshihisa Shimizu, Kazuo Kasai, Yuichi Matsuura, Takashi Yokoyam. The N-terminal sequence of prion protein consists an epitope specific to the abnormal isoform of prion protein (PrP(Sc)). PloS one. vol 8. issue 2. 2013-08-29. PMID:23469131. |
we found that the ratio of proteinase k (pk)-sensitive prp(sc) to pk-resistant prp(sc) was constant throughout the disease time course. |
2013-08-29 |
2023-08-12 |
mouse |
| B Michael Silber, Satish Rao, Kimberly L Fife, Alejandra Gallardo-Godoy, Adam R Renslo, Deepak K Dalvie, Kurt Giles, Yevgeniy Freyman, Manuel Elepano, Joel R Gever, Zhe Li, Matthew P Jacobson, Yong Huang, Leslie Z Benet, Stanley B Prusine. Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice. Pharmaceutical research. vol 30. issue 4. 2013-08-27. PMID:23417511. |
to discover drugs lowering prp(sc) in prion-infected cultured neuronal cells that achieve high concentrations in brain to test in mouse models of prion disease and then treat people with these fatal diseases. |
2013-08-27 |
2023-08-12 |
mouse |
| Nahid N Jetha, Valentyna Semenchenko, David S Wishart, Neil R Cashman, Andre Marzial. Nanopore analysis of wild-type and mutant prion protein (PrP(C)): single molecule discrimination and PrP(C) kinetics. PloS one. vol 8. issue 2. 2013-08-26. PMID:23393562. |
prion diseases are fatal neurodegenerative diseases associated with the conversion of cellular prion protein (prp(c)) in the central nervous system into the infectious isoform (prp(sc)). |
2013-08-26 |
2023-08-12 |
Not clear |
| Nahid N Jetha, Valentyna Semenchenko, David S Wishart, Neil R Cashman, Andre Marzial. Nanopore analysis of wild-type and mutant prion protein (PrP(C)): single molecule discrimination and PrP(C) kinetics. PloS one. vol 8. issue 2. 2013-08-26. PMID:23393562. |
the mechanics of conversion are almost entirely unknown, with understanding stymied by the lack of an atomic-level structure for prp(sc). |
2013-08-26 |
2023-08-12 |
Not clear |
| Nahid N Jetha, Valentyna Semenchenko, David S Wishart, Neil R Cashman, Andre Marzial. Nanopore analysis of wild-type and mutant prion protein (PrP(C)): single molecule discrimination and PrP(C) kinetics. PloS one. vol 8. issue 2. 2013-08-26. PMID:23393562. |
a number of pathogenic prp(c) mutants exist that are characterized by an increased propensity for conversion into prp(sc) and that differ from wild-type by only a single amino-acid point mutation in their primary structure. |
2013-08-26 |
2023-08-12 |
Not clear |
| Kenji Sakai, Tsuyoshi Hamaguchi, Moeko Noguchi-Shinohara, Ichiro Nozaki, Ichiro Takumi, Nobuo Sanjo, Yosikazu Nakamura, Tetsuyuki Kitamoto, Nobuhito Saito, Hidehiro Mizusawa, Masahito Yamad. Graft-related disease progression in dura mater graft-associated Creutzfeldt-Jakob disease: a cross-sectional study. BMJ open. vol 3. issue 8. 2013-08-26. PMID:23975105. |
details of abnormal prion protein (prp(sc)) propagation in the human central nervous system (cns) are unclear. |
2013-08-26 |
2023-08-12 |
human |
| Kenji Sakai, Tsuyoshi Hamaguchi, Moeko Noguchi-Shinohara, Ichiro Nozaki, Ichiro Takumi, Nobuo Sanjo, Yosikazu Nakamura, Tetsuyuki Kitamoto, Nobuhito Saito, Hidehiro Mizusawa, Masahito Yamad. Graft-related disease progression in dura mater graft-associated Creutzfeldt-Jakob disease: a cross-sectional study. BMJ open. vol 3. issue 8. 2013-08-26. PMID:23975105. |
to assess the spread of prp(sc) through the human cns, we evaluated dura mater graft-associated creutzfeldt-jakob disease (dcjd) cases focusing on sites of grafting and dcjd pathological subtypes. |
2013-08-26 |
2023-08-12 |
human |
| Caroline P de Andrade, Laura L de Almeida, Luiza A de Castro, David Driemeier, Sérgio C da Silv. Development of a real-time polymerase chain reaction assay for single nucleotide polymorphism genotyping codons 136, 154, and 171 of the prnp gene and application to Brazilian sheep herds. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. vol 25. issue 1. 2013-08-22. PMID:23345274. |
scrapie is a transmissible spongiform encephalopathy of sheep and goats and is associated with the deposition of an abnormal isoform of prion protein (prp(sc)). |
2013-08-22 |
2023-08-12 |
Not clear |
| Giorgio Poli, Erica Corda, Piera Anna Martino, Paola Dall'ara, Silvio R Bareggi, Giampietro Bondiolotti, Barbara Iulini, Maria Mazza, Cristina Casalone, Sung Hee Hwang, Bruce D Hammock, Bora Inceogl. Therapeutic activity of inhibition of the soluble epoxide hydrolase in a mouse model of scrapie. Life sciences. vol 92. issue 23. 2013-08-20. PMID:23651659. |
in tses, neuronal loss and inflammation are associated with the accumulation of the misfolded isoform (prp(sc)) of the cellular prion protein (prp(c)). |
2013-08-20 |
2023-08-12 |
mouse |
| Alessandro Didonna, Lisa Vaccari, Alpan Bek, Giuseppe Legnam. Infrared microspectroscopy: a multiple-screening platform for investigating single-cell biochemical perturbations upon prion infection. ACS chemical neuroscience. vol 2. issue 3. 2013-08-16. PMID:22778865. |
the pathogenic prion (prp(sc)) possesses the capability to convert the host-encoded cellular isoform of the prion protein, prp(c), into nascent prp(sc). |
2013-08-16 |
2023-08-12 |
mouse |
| Ken'ichi Hagiwara, Hideyuki Hara, Kentaro Hanad. Species-barrier phenomenon in prion transmissibility from a viewpoint of protein science. Journal of biochemistry. vol 153. issue 2. 2013-08-08. PMID:23284000. |
their causative agents are prions, which are composed of disease-associated forms of prion protein (prp(sc)). |
2013-08-08 |
2023-08-12 |
mouse |
| Ken'ichi Hagiwara, Hideyuki Hara, Kentaro Hanad. Species-barrier phenomenon in prion transmissibility from a viewpoint of protein science. Journal of biochemistry. vol 153. issue 2. 2013-08-08. PMID:23284000. |
studies have suggested that the barrier is not only simply determined by differences in amino acid sequences of cellular prp (prp(c)) among animal species, but also by prion strains which are closely associated with conformational properties of prp(sc) aggregates. |
2013-08-08 |
2023-08-12 |
mouse |
| Ken'ichi Hagiwara, Hideyuki Hara, Kentaro Hanad. Species-barrier phenomenon in prion transmissibility from a viewpoint of protein science. Journal of biochemistry. vol 153. issue 2. 2013-08-08. PMID:23284000. |
although the conformational properties of prp(sc) remain largely unknown, recent investigation of local structures of prp(c) and, in particular, structural modelling of prp(sc) aggregates have provided molecular insight into this field. |
2013-08-08 |
2023-08-12 |
mouse |
| Rafael Grande-Aztatzi, Lina Rivillas-Acevedo, Liliana Quintanar, Alberto Vel. Structural models for Cu(II) bound to the fragment 92-96 of the human prion protein. The journal of physical chemistry. B. vol 117. issue 3. 2013-08-02. PMID:23240680. |
the isoform prp(sc), derived from the normal prp(c), is the pathogenic agent of tses. |
2013-08-02 |
2023-08-12 |
human |
| James M McCarthy, Markus Franke, Ulrike K Resenberger, Sibeal Waldron, Jeremy C Simpson, Jörg Tatzelt, Dietmar Appelhans, Mark S Roger. Anti-prion drug mPPIg5 inhibits PrP(C) conversion to PrP(Sc). PloS one. vol 8. issue 1. 2013-07-22. PMID:23383136. |
anti-prion drug mppig5 inhibits prp(c) conversion to prp(sc). |
2013-07-22 |
2023-08-12 |
cattle |