Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Karah Nazor Friberg, Gene Hung, Ed Wancewicz, Kurt Giles, Chris Black, Sue Freier, Frank Bennett, Stephen J Dearmond, Yevgeniy Freyman, Pierre Lessard, Sina Ghaemmaghami, Stanley B Prusine. Intracerebral Infusion of Antisense Oligonucleotides Into Prion-infected Mice. Molecular therapy. Nucleic acids. vol 1. 2013-01-25. PMID:23344724. |
those asos were also evaluated in scrapie-infected cultured cells (scn2a) for their efficacy in diminishing the levels of the disease-causing prion protein (prp(sc)). |
2013-01-25 |
2023-08-12 |
mouse |
Jae-Suk Seo, Myung-Hee Moon, Jae-Kyo Jeong, Jae-Won Seol, You-Jin Lee, Byung-Hyun Park, Sang-Youel Par. SIRT1, a histone deacetylase, regulates prion protein-induced neuronal cell death. Neurobiology of aging. vol 33. issue 6. 2013-01-24. PMID:21074897. |
prion diseases associated with the conversion of the cellular prion protein (prp(c)) to the misfolded isoform (prp(sc)), affect the central nervous system (cns) of humans and animals. |
2013-01-24 |
2023-08-12 |
Not clear |
A M Thackray, R Lockey, K E Beck, J Spiropoulos, R Bujdos. Evidence for co-infection of ovine prion strains in classical scrapie isolates. Journal of comparative pathology. vol 147. issue 2-3. 2013-01-22. PMID:22522075. |
riii mice with short incubation times had higher levels of total and proteinase k-resistant prp(sc) compared with those riii mice with long incubation times, while mice with long incubation times had large aggregates and plaques of prp(sc). |
2013-01-22 |
2023-08-12 |
mouse |
A M Thackray, R Lockey, K E Beck, J Spiropoulos, R Bujdos. Evidence for co-infection of ovine prion strains in classical scrapie isolates. Journal of comparative pathology. vol 147. issue 2-3. 2013-01-22. PMID:22522075. |
me7 prp(sc) differed in stability compared with the 87a prion strain, while prp(sc) associated with 221c had similar stability to that of the 221c variant. |
2013-01-22 |
2023-08-12 |
mouse |
A M Thackray, R Lockey, K E Beck, J Spiropoulos, R Bujdos. Evidence for co-infection of ovine prion strains in classical scrapie isolates. Journal of comparative pathology. vol 147. issue 2-3. 2013-01-22. PMID:22522075. |
the data show that different prion strains can emerge from the same ovine scrapie isolate following serial passage in wild type mice and that the transmission properties of these strains correlate with distinct patterns of prp(sc) deposition. |
2013-01-22 |
2023-08-12 |
mouse |
Nuria Gonzalez-Montalban, Ilia V Baskako. Assessment of strain-specific PrP(Sc) elongation rates revealed a transformation of PrP(Sc) properties during protein misfolding cyclic amplification. PloS one. vol 7. issue 7. 2013-01-16. PMID:22815972. |
assessment of strain-specific prp(sc) elongation rates revealed a transformation of prp(sc) properties during protein misfolding cyclic amplification. |
2013-01-16 |
2023-08-12 |
Not clear |
Nuria Gonzalez-Montalban, Ilia V Baskako. Assessment of strain-specific PrP(Sc) elongation rates revealed a transformation of PrP(Sc) properties during protein misfolding cyclic amplification. PloS one. vol 7. issue 7. 2013-01-16. PMID:22815972. |
prion replication is believed to consist of two components, a growth or elongation of infectious isoform of the prion protein (prp(sc)) particles and their fragmentation, a process that provides new replication centers. |
2013-01-16 |
2023-08-12 |
Not clear |
Nuria Gonzalez-Montalban, Ilia V Baskako. Assessment of strain-specific PrP(Sc) elongation rates revealed a transformation of PrP(Sc) properties during protein misfolding cyclic amplification. PloS one. vol 7. issue 7. 2013-01-16. PMID:22815972. |
the current study introduced an experimental approach that employs protein misfolding cyclic amplification with beads (pmcab) and relies on a series of kinetic experiments for assessing elongation rates of prp(sc) particles. |
2013-01-16 |
2023-08-12 |
Not clear |
Nuria Gonzalez-Montalban, Ilia V Baskako. Assessment of strain-specific PrP(Sc) elongation rates revealed a transformation of PrP(Sc) properties during protein misfolding cyclic amplification. PloS one. vol 7. issue 7. 2013-01-16. PMID:22815972. |
the elongation rate of brain-derived prp(sc) was found to be strain-specific. |
2013-01-16 |
2023-08-12 |
Not clear |
Nuria Gonzalez-Montalban, Ilia V Baskako. Assessment of strain-specific PrP(Sc) elongation rates revealed a transformation of PrP(Sc) properties during protein misfolding cyclic amplification. PloS one. vol 7. issue 7. 2013-01-16. PMID:22815972. |
in parallel to an increase in elongation rates, the percentages of diglycosylated prp glycoforms increased in pmcab-derived prp(sc) comparing to those of brain-derived prp(sc). |
2013-01-16 |
2023-08-12 |
Not clear |
Nuria Gonzalez-Montalban, Ilia V Baskako. Assessment of strain-specific PrP(Sc) elongation rates revealed a transformation of PrP(Sc) properties during protein misfolding cyclic amplification. PloS one. vol 7. issue 7. 2013-01-16. PMID:22815972. |
these results suggest that pmcab selects the same molecular features regardless of strain initial characteristics and that convergent evolution of prp(sc) properties occurred during in vitro amplification. |
2013-01-16 |
2023-08-12 |
Not clear |
Catherine E Vrentas, Justin J Greenlee, Trudy L Tatum, Eric M Nicholso. Relationships between PrPSc stability and incubation time for United States scrapie isolates in a natural host system. PloS one. vol 7. issue 8. 2013-01-16. PMID:22916207. |
transmissible spongiform encephalopathies (tses), including scrapie in sheep (ovis aries), are fatal neurodegenerative diseases caused by the misfolding of the cellular prion protein (prp(c)) into a â-rich conformer (prp(sc)) that accumulates into higher-order structures in the brain and other tissues. |
2013-01-16 |
2023-08-12 |
mouse |
Catherine E Vrentas, Justin J Greenlee, Trudy L Tatum, Eric M Nicholso. Relationships between PrPSc stability and incubation time for United States scrapie isolates in a natural host system. PloS one. vol 7. issue 8. 2013-01-16. PMID:22916207. |
distinct strains of tses exist, characterized by different pathologic profiles upon passage into rodents and representing distinct conformations of prp(sc). |
2013-01-16 |
2023-08-12 |
mouse |
Catherine E Vrentas, Justin J Greenlee, Trudy L Tatum, Eric M Nicholso. Relationships between PrPSc stability and incubation time for United States scrapie isolates in a natural host system. PloS one. vol 7. issue 8. 2013-01-16. PMID:22916207. |
one biochemical method of distinguishing strains is the stability of prp(sc) as determined by unfolding in guanidine hydrochloride (gdnhcl), which is tightly and positively correlated with the incubation time of disease upon passage into mice. |
2013-01-16 |
2023-08-12 |
mouse |
Oscar A Peralta, William R Huckle, Willard H Eyeston. Developmental expression of the cellular prion protein (PrP(C) ) in bovine embryos. Molecular reproduction and development. vol 79. issue 7. 2013-01-15. PMID:22674901. |
the mammalian cellular prion protein (prp(c) ) is a highly conserved glycoprotein that may undergo conversion into a conformationally altered isoform (scrapie prion protein or prp(sc) ), widely believed to be the pathogenic agent of transmissible spongiform encephalopathies (tses). |
2013-01-15 |
2023-08-12 |
cattle |
Oscar A Peralta, William R Huckle, Willard H Eyeston. Developmental expression of the cellular prion protein (PrP(C) ) in bovine embryos. Molecular reproduction and development. vol 79. issue 7. 2013-01-15. PMID:22674901. |
although much is known about prp(sc) conversion and its role in tses, the normal function of prp(c) has not been elucidated. |
2013-01-15 |
2023-08-12 |
cattle |
John G Gray, Sandor Dudas, Catherine Graham, Stefanie Czu. Performance analysis of rapid diagnostic tests on atypical bovine spongiform encephalopathy. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. vol 24. issue 5. 2013-01-14. PMID:22855378. |
though these tests are validated to detect c-type bse disease-associated prion (prp(sc)), test-specific properties may influence their ability to detect h- and/or l-type bse prp(sc), where both are atypical from c-type prp(sc). |
2013-01-14 |
2023-08-12 |
cattle |
John G Gray, Sandor Dudas, Catherine Graham, Stefanie Czu. Performance analysis of rapid diagnostic tests on atypical bovine spongiform encephalopathy. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. vol 24. issue 5. 2013-01-14. PMID:22855378. |
molecular characterization shows atypical bse prp(sc) to have a different sensitivity to proteinase activity and different affinities for certain prion-specific antibodies. |
2013-01-14 |
2023-08-12 |
cattle |
John G Gray, Sandor Dudas, Catherine Graham, Stefanie Czu. Performance analysis of rapid diagnostic tests on atypical bovine spongiform encephalopathy. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. vol 24. issue 5. 2013-01-14. PMID:22855378. |
it is important to understand how atypical bse prp(sc) may affect the performance of rapid-tests, which are typically dependent on the use of specific proteases and antibodies. |
2013-01-14 |
2023-08-12 |
cattle |
John G Gray, Sandor Dudas, Catherine Graham, Stefanie Czu. Performance analysis of rapid diagnostic tests on atypical bovine spongiform encephalopathy. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. vol 24. issue 5. 2013-01-14. PMID:22855378. |
the current study used experimentally generated c-, h-, and l-type bse prp(sc) to evaluate 3 tests used in various national bse surveillance programs: an immunochromatographic assay, a standard sandwich enzyme-linked immunosorbent assay (stndelisa), and a prp(sc)-conformation-specific elisa (confelisa). |
2013-01-14 |
2023-08-12 |
cattle |