| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rodrigo Morales, Ping Ping Hu, Claudia Duran-Aniotz, Fabio Moda, Rodrigo Diaz-Espinoza, Baian Chen, Javiera Bravo-Alegria, Natallia Makarava, Ilia V Baskakov, Claudio Sot. Strain-dependent profile of misfolded prion protein aggregates. Scientific reports. vol 6. 2016-12-19. PMID:26877167. |
our findings may contribute to understand the mechanisms of strain variation and the role of prp(sc) aggregates in prion-induced neurodegeneration. |
2016-12-19 |
2023-08-13 |
Not clear |
| Su Yeon Shim, Srinivasarao Karri, Sampson Law, Hermann M Schatzl, Sabine Gilc. Prion infection impairs lysosomal degradation capacity by interfering with rab7 membrane attachment in neuronal cells. Scientific reports. vol 6. 2016-12-16. PMID:26865414. |
they consist of a mostly β-sheeted aggregated isoform (prp(sc)) of the cellular prion protein (prp(c)). |
2016-12-16 |
2023-08-13 |
Not clear |
| Su Yeon Shim, Srinivasarao Karri, Sampson Law, Hermann M Schatzl, Sabine Gilc. Prion infection impairs lysosomal degradation capacity by interfering with rab7 membrane attachment in neuronal cells. Scientific reports. vol 6. 2016-12-16. PMID:26865414. |
prions replicate autocatalytically in neurons and other cell types by inducing conformational conversion of prp(c) into prp(sc). |
2016-12-16 |
2023-08-13 |
Not clear |
| Su Yeon Shim, Srinivasarao Karri, Sampson Law, Hermann M Schatzl, Sabine Gilc. Prion infection impairs lysosomal degradation capacity by interfering with rab7 membrane attachment in neuronal cells. Scientific reports. vol 6. 2016-12-16. PMID:26865414. |
within neurons, prp(sc) accumulates at the plasma membrane and in vesicles of the endocytic pathway. |
2016-12-16 |
2023-08-13 |
Not clear |
| Su Yeon Shim, Srinivasarao Karri, Sampson Law, Hermann M Schatzl, Sabine Gilc. Prion infection impairs lysosomal degradation capacity by interfering with rab7 membrane attachment in neuronal cells. Scientific reports. vol 6. 2016-12-16. PMID:26865414. |
to better understand the mechanisms underlying neuronal dysfunction and death it is critical to know the impact of prp(sc) accumulation on cellular pathways. |
2016-12-16 |
2023-08-13 |
Not clear |
| Maria Cramm, Matthias Schmitz, André Karch, Eva Mitrova, Franziska Kuhn, Bjoern Schroeder, Alex Raeber, Daniela Varges, Yong-Sun Kim, Katsuya Satoh, Steven Collins, Inga Zer. Stability and Reproducibility Underscore Utility of RT-QuIC for Diagnosis of Creutzfeldt-Jakob Disease. Molecular neurobiology. vol 53. issue 3. 2016-12-13. PMID:25823511. |
real-time quaking-induced conversion (rt-quic) allows the amplification of miniscule amounts of scrapie prion protein (prp(sc)). |
2016-12-13 |
2023-08-13 |
human |
| Maria Cramm, Matthias Schmitz, André Karch, Eva Mitrova, Franziska Kuhn, Bjoern Schroeder, Alex Raeber, Daniela Varges, Yong-Sun Kim, Katsuya Satoh, Steven Collins, Inga Zer. Stability and Reproducibility Underscore Utility of RT-QuIC for Diagnosis of Creutzfeldt-Jakob Disease. Molecular neurobiology. vol 53. issue 3. 2016-12-13. PMID:25823511. |
our data indicated that the prp(sc) seed in csf is stable to any type of storage condition but sensitive to contaminations with blood (>1250 erythrocytes/μl), which results in a false negative rt-quic response. |
2016-12-13 |
2023-08-13 |
human |
| Jiapu Zhang, Feng Wang, Subhojyoti Chatterje. Molecular dynamics studies on the buffalo prion protein. Journal of biomolecular structure & dynamics. vol 34. issue 4. 2016-12-13. PMID:26043781. |
in molecular structures, these neurodegenerative diseases are caused by the conversion from a soluble normal cellular prion protein (prp(c)), predominantly with α-helices, into insoluble abnormally folded infectious prions (prp(sc)), rich in β-sheets. |
2016-12-13 |
2023-08-13 |
human |
| Pawel Stocki, Maxime Sawicki, Charles E Mays, Seo Jung Hong, Daniel C Chapman, David Westaway, David B William. Inhibition of the FKBP family of peptidyl prolyl isomerases induces abortive translocation and degradation of the cellular prion protein. Molecular biology of the cell. vol 27. issue 5. 2016-12-13. PMID:26764098. |
both fk506 treatment and fkbp10 depletion were effective in reducing prp(sc) propagation in cell models. |
2016-12-13 |
2023-08-13 |
mouse |
| Ajai K Tripathi, Neena Sing. Prion Protein-Hemin Interaction Upregulates Hemoglobin Synthesis: Implications for Cerebral Hemorrhage and Sporadic Creutzfeldt-Jakob Disease. Journal of Alzheimer's disease : JAD. vol 51. issue 1. 2016-12-13. PMID:26836195. |
hemin is known to induce endocytosis of prion-protein (prp(c)) from the neuronal plasma membrane, potentially limiting propagation of the disease causing prp-scrapie (prp(sc)) isoform. |
2016-12-13 |
2023-08-13 |
mouse |
| Justin J Greenlee, Jodi D Smith, Amir N Hami. Oral inoculation of neonatal Suffolk sheep with the agent of classical scrapie results in PrP(Sc) accumulation in sheep with the PRNP ARQ/ARQ but not the ARQ/ARR genotype. Research in veterinary science. vol 105. 2016-12-13. PMID:27033930. |
oral inoculation of neonatal suffolk sheep with the agent of classical scrapie results in prp(sc) accumulation in sheep with the prnp arq/arq but not the arq/arr genotype. |
2016-12-13 |
2023-08-13 |
Not clear |
| Justin J Greenlee, Jodi D Smith, Amir N Hami. Oral inoculation of neonatal Suffolk sheep with the agent of classical scrapie results in PrP(Sc) accumulation in sheep with the PRNP ARQ/ARQ but not the ARQ/ARR genotype. Research in veterinary science. vol 105. 2016-12-13. PMID:27033930. |
this study reports the failure to detect prp(sc) in nervous or lymphoid tissues of suffolk sheep of the prnp arq/arr genotype after oral inoculation with a u.s. scrapie isolate. |
2016-12-13 |
2023-08-13 |
Not clear |
| Ping Ping Hu, Rodrigo Morales, Claudia Duran-Aniotz, Ines Moreno-Gonzalez, Uffaf Khan, Claudio Sot. Role of Prion Replication in the Strain-dependent Brain Regional Distribution of Prions. The Journal of biological chemistry. vol 291. issue 24. 2016-12-13. PMID:27056328. |
in this study, isolated brain structures from animals infected with four hamster prion strains (hy, dy, 139h, and sslow) were analyzed for their content of protease-resistant prp(sc) our data show that these strains have different profiles of prp deposition along the brain. |
2016-12-13 |
2023-08-13 |
Not clear |
| Ping Ping Hu, Rodrigo Morales, Claudia Duran-Aniotz, Ines Moreno-Gonzalez, Uffaf Khan, Claudio Sot. Role of Prion Replication in the Strain-dependent Brain Regional Distribution of Prions. The Journal of biological chemistry. vol 291. issue 24. 2016-12-13. PMID:27056328. |
our results suggest that the variable regional distribution of prp(sc) in distinct strains is not determined by differences on prion formation, but on other factors or cellular pathways. |
2016-12-13 |
2023-08-13 |
Not clear |
| Chris McKinnon, Rob Goold, Ralph Andre, Anny Devoy, Zaira Ortega, Julie Moonga, Jacqueline M Linehan, Sebastian Brandner, José J Lucas, John Collinge, Sarah J Tabriz. Prion-mediated neurodegeneration is associated with early impairment of the ubiquitin-proteasome system. Acta neuropathologica. vol 131. issue 3. 2016-11-08. PMID:26646779. |
prion diseases are a group of fatal neurodegenerative disorders characterised by the accumulation of misfolded prion protein (prp(sc)) in the brain. |
2016-11-08 |
2023-08-13 |
mouse |
| Chris McKinnon, Rob Goold, Ralph Andre, Anny Devoy, Zaira Ortega, Julie Moonga, Jacqueline M Linehan, Sebastian Brandner, José J Lucas, John Collinge, Sarah J Tabriz. Prion-mediated neurodegeneration is associated with early impairment of the ubiquitin-proteasome system. Acta neuropathologica. vol 131. issue 3. 2016-11-08. PMID:26646779. |
we show that the onset of ups dysfunction correlates closely with prp(sc) deposition, preceding earliest behavioural deficits and neuronal loss. |
2016-11-08 |
2023-08-13 |
mouse |
| Chris McKinnon, Rob Goold, Ralph Andre, Anny Devoy, Zaira Ortega, Julie Moonga, Jacqueline M Linehan, Sebastian Brandner, José J Lucas, John Collinge, Sarah J Tabriz. Prion-mediated neurodegeneration is associated with early impairment of the ubiquitin-proteasome system. Acta neuropathologica. vol 131. issue 3. 2016-11-08. PMID:26646779. |
in prion-infected cad5 cells, we demonstrate that activation of the ups by the small molecule inhibitor iu1 is sufficient to induce clearance of polyubiquitinated substrates and reduce misfolded prp(sc) load. |
2016-11-08 |
2023-08-13 |
mouse |
| Thibaut Imberdis, Adeline Ayrolles-Torro, Alysson Duarte Rodrigues, Joan Torrent, Maria Teresa Alvarez-Martinez, Gabor G Kovacs, Jean-Michel Verdier, Mike Robitzer, Véronique Perrie. A Fluorescent Oligothiophene-Bis-Triazine ligand interacts with PrP fibrils and detects SDS-resistant oligomers in human prion diseases. Molecular neurodegeneration. vol 11. 2016-11-08. PMID:26809712. |
prion diseases are characterized by the accumulation in the central nervous system of an abnormally folded isoform of the prion protein, named prp(sc). |
2016-11-08 |
2023-08-13 |
human |
| Thibaut Imberdis, Adeline Ayrolles-Torro, Alysson Duarte Rodrigues, Joan Torrent, Maria Teresa Alvarez-Martinez, Gabor G Kovacs, Jean-Michel Verdier, Mike Robitzer, Véronique Perrie. A Fluorescent Oligothiophene-Bis-Triazine ligand interacts with PrP fibrils and detects SDS-resistant oligomers in human prion diseases. Molecular neurodegeneration. vol 11. 2016-11-08. PMID:26809712. |
aggregation of prp(sc) into oligomers and fibrils is critically involved in the pathogenesis of prion diseases. |
2016-11-08 |
2023-08-13 |
human |
| Thibaut Imberdis, Adeline Ayrolles-Torro, Alysson Duarte Rodrigues, Joan Torrent, Maria Teresa Alvarez-Martinez, Gabor G Kovacs, Jean-Michel Verdier, Mike Robitzer, Véronique Perrie. A Fluorescent Oligothiophene-Bis-Triazine ligand interacts with PrP fibrils and detects SDS-resistant oligomers in human prion diseases. Molecular neurodegeneration. vol 11. 2016-11-08. PMID:26809712. |
we previously identified thienyl pyrimidine compounds that induce sds-resistant prp(sc) (rsds-prp(sc)) oligomers in prion-infected samples. |
2016-11-08 |
2023-08-13 |
human |