| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kuntaek Lim, Su Yeon Kim, Byoungsub Lee, Christiane Segarra, Sungmin Kang, Youngran Ju, Mary Jo Schmerr, Joliette Coste, Sang Yun Kim, Takashi Yokoyama, Seong Soo A A. Magnetic microparticle-based multimer detection system for the detection of prion oligomers in sheep. International journal of nanomedicine. vol 10. issue Spec Iss. 2016-11-07. PMID:26425091. |
the putative transmissible agents are infectious prion proteins (prp(sc)), which are formed by the conversion of the normal prion protein on the glycoprotein cell surface in the presence of other prp(sc). |
2016-11-07 |
2023-08-13 |
mouse |
| Kuntaek Lim, Su Yeon Kim, Byoungsub Lee, Christiane Segarra, Sungmin Kang, Youngran Ju, Mary Jo Schmerr, Joliette Coste, Sang Yun Kim, Takashi Yokoyama, Seong Soo A A. Magnetic microparticle-based multimer detection system for the detection of prion oligomers in sheep. International journal of nanomedicine. vol 10. issue Spec Iss. 2016-11-07. PMID:26425091. |
to address this issue, many laboratories attempted to develop a sensitive and accurate blood diagnostic test to detect prp(sc). |
2016-11-07 |
2023-08-13 |
mouse |
| Kuntaek Lim, Su Yeon Kim, Byoungsub Lee, Christiane Segarra, Sungmin Kang, Youngran Ju, Mary Jo Schmerr, Joliette Coste, Sang Yun Kim, Takashi Yokoyama, Seong Soo A A. Magnetic microparticle-based multimer detection system for the detection of prion oligomers in sheep. International journal of nanomedicine. vol 10. issue Spec Iss. 2016-11-07. PMID:26425091. |
previously, we reported that, compared to normal controls, the multimer detection system (mds) was more efficient in detecting prp(sc) in infected hamster brain homogenate, mouse plasma spiked with purified prp(sc) from scrapie mouse brain, and scrapie-infected hamster plasmas. |
2016-11-07 |
2023-08-13 |
mouse |
| Kuntaek Lim, Su Yeon Kim, Byoungsub Lee, Christiane Segarra, Sungmin Kang, Youngran Ju, Mary Jo Schmerr, Joliette Coste, Sang Yun Kim, Takashi Yokoyama, Seong Soo A A. Magnetic microparticle-based multimer detection system for the detection of prion oligomers in sheep. International journal of nanomedicine. vol 10. issue Spec Iss. 2016-11-07. PMID:26425091. |
in this study, mds detected prp(sc) in plasma samples from scrapie-infected sheep expressing clinical symptoms, demonstrating 100% sensitivity and specificity in these samples. |
2016-11-07 |
2023-08-13 |
mouse |
| Valentina Villa, Stefano Thellung, Alessandro Corsaro, Federica Novelli, Bruno Tasso, Luca Colucci-D'Amato, Elena Gatta, Michele Tonelli, Tullio Flori. Celecoxib Inhibits Prion Protein 90-231-Mediated Pro-inflammatory Responses in Microglial Cells. Molecular neurobiology. vol 53. issue 1. 2016-11-02. PMID:25404089. |
we report that the prion protein fragment encompassing amino acids 90-231 (prp90-231), a model of the neurotoxic activity of the pathogenic prion protein (prp(sc)), causes activation of both primary microglia cultures and n9 microglial cells in vitro. |
2016-11-02 |
2023-08-13 |
Not clear |
| Takeshi Fuchigami, Yuki Yamashita, Masao Kawasaki, Ayaka Ogawa, Mamoru Haratake, Ryuichiro Atarashi, Kazunori Sano, Takehiro Nakagaki, Kaori Ubagai, Masahiro Ono, Sakura Yoshida, Noriyuki Nishida, Morio Nakayam. Characterisation of radioiodinated flavonoid derivatives for SPECT imaging of cerebral prion deposits. Scientific reports. vol 5. 2016-10-28. PMID:26669576. |
prion diseases are fatal neurodegenerative diseases characterised by deposition of amyloid plaques containing abnormal prion protein aggregates (prp(sc)). |
2016-10-28 |
2023-08-13 |
mouse |
| Takeshi Fuchigami, Yuki Yamashita, Masao Kawasaki, Ayaka Ogawa, Mamoru Haratake, Ryuichiro Atarashi, Kazunori Sano, Takehiro Nakagaki, Kaori Ubagai, Masahiro Ono, Sakura Yoshida, Noriyuki Nishida, Morio Nakayam. Characterisation of radioiodinated flavonoid derivatives for SPECT imaging of cerebral prion deposits. Scientific reports. vol 5. 2016-10-28. PMID:26669576. |
this study aimed to evaluate the potential of radioiodinated flavonoid derivatives for single photon emission computed tomography (spect) imaging of prp(sc). |
2016-10-28 |
2023-08-13 |
mouse |
| Takeshi Fuchigami, Yuki Yamashita, Masao Kawasaki, Ayaka Ogawa, Mamoru Haratake, Ryuichiro Atarashi, Kazunori Sano, Takehiro Nakagaki, Kaori Ubagai, Masahiro Ono, Sakura Yoshida, Noriyuki Nishida, Morio Nakayam. Characterisation of radioiodinated flavonoid derivatives for SPECT imaging of cerebral prion deposits. Scientific reports. vol 5. 2016-10-28. PMID:26669576. |
fluorescent imaging using brain sections from mouse-adapted bovine spongiform encephalopathy (mbse)-infected mice demonstrated that sc-nme2 clearly labelled prp(sc)-positive prion deposits in the mice brain. |
2016-10-28 |
2023-08-13 |
mouse |
| Takeshi Fuchigami, Yuki Yamashita, Masao Kawasaki, Ayaka Ogawa, Mamoru Haratake, Ryuichiro Atarashi, Kazunori Sano, Takehiro Nakagaki, Kaori Ubagai, Masahiro Ono, Sakura Yoshida, Noriyuki Nishida, Morio Nakayam. Characterisation of radioiodinated flavonoid derivatives for SPECT imaging of cerebral prion deposits. Scientific reports. vol 5. 2016-10-28. PMID:26669576. |
spect/computed tomography (ct) imaging and ex vivo autoradiography demonstrated that [(123)i]sc-ome showed consistent brain distribution with the presence of prp(sc) deposits in the mbse-infected mice brain. |
2016-10-28 |
2023-08-13 |
mouse |
| Jérôme Chapuis, Mohammed Moudjou, Fabienne Reine, Laetitia Herzog, Emilie Jaumain, Céline Chapuis, Isabelle Quadrio, Jacques Boulliat, Armand Perret-Liaudet, Michel Dron, Hubert Laude, Human Rezaei, Vincent Béringu. Emergence of two prion subtypes in ovine PrP transgenic mice infected with human MM2-cortical Creutzfeldt-Jakob disease prions. Acta neuropathologica communications. vol 4. 2016-10-14. PMID:26847207. |
prions are primarily formed of macromolecular assemblies of the disease-associated prion protein prp(sc), a misfolded isoform of the host-encoded prion protein prp(c). |
2016-10-14 |
2023-08-13 |
mouse |
| Jérôme Chapuis, Mohammed Moudjou, Fabienne Reine, Laetitia Herzog, Emilie Jaumain, Céline Chapuis, Isabelle Quadrio, Jacques Boulliat, Armand Perret-Liaudet, Michel Dron, Hubert Laude, Human Rezaei, Vincent Béringu. Emergence of two prion subtypes in ovine PrP transgenic mice infected with human MM2-cortical Creutzfeldt-Jakob disease prions. Acta neuropathologica communications. vol 4. 2016-10-14. PMID:26847207. |
based on both the m/v polymorphism at codon 129 of prp and the electrophoretic signature of prp(sc) in the brain, sporadic cjd is classified in different subtypes, which may encode different strains. |
2016-10-14 |
2023-08-13 |
mouse |
| Jérôme Chapuis, Mohammed Moudjou, Fabienne Reine, Laetitia Herzog, Emilie Jaumain, Céline Chapuis, Isabelle Quadrio, Jacques Boulliat, Armand Perret-Liaudet, Michel Dron, Hubert Laude, Human Rezaei, Vincent Béringu. Emergence of two prion subtypes in ovine PrP transgenic mice infected with human MM2-cortical Creutzfeldt-Jakob disease prions. Acta neuropathologica communications. vol 4. 2016-10-14. PMID:26847207. |
here, we transmitted experimentally one rare subtype of human cjd, designated cortical mm2 (129 mm with type 2 prp(sc)), to transgenic mice overexpressing either human or the vrq allele of ovine prp(c). |
2016-10-14 |
2023-08-13 |
mouse |
| Carlos Hedman, Rosa Bolea, Belén Marín, Fabien Cobrière, Hicham Filali, Francisco Vazquez, José Luis Pitarch, Antonia Vargas, Cristina Acín, Bernardino Moreno, Martí Pumarola, Olivier Andreoletti, Juan José Badiol. Transmission of sheep-bovine spongiform encephalopathy to pigs. Veterinary research. vol 47. 2016-10-11. PMID:26742788. |
intracellular and neuropil-associated pathological prion protein (prp(sc)) deposition was consistently observed in different brain sections and corroborated by western blot. |
2016-10-11 |
2023-08-13 |
mouse |
| Carlos Hedman, Rosa Bolea, Belén Marín, Fabien Cobrière, Hicham Filali, Francisco Vazquez, José Luis Pitarch, Antonia Vargas, Cristina Acín, Bernardino Moreno, Martí Pumarola, Olivier Andreoletti, Juan José Badiol. Transmission of sheep-bovine spongiform encephalopathy to pigs. Veterinary research. vol 47. 2016-10-11. PMID:26742788. |
prp(sc) was detected by immunohistochemistry and enzyme immunoassay in the following tissues in at least one animal: lymphoid tissues, peripheral nerves, gastrointestinal tract, skeletal muscle, adrenal gland and pancreas. |
2016-10-11 |
2023-08-13 |
mouse |
| Carlos Hedman, Rosa Bolea, Belén Marín, Fabien Cobrière, Hicham Filali, Francisco Vazquez, José Luis Pitarch, Antonia Vargas, Cristina Acín, Bernardino Moreno, Martí Pumarola, Olivier Andreoletti, Juan José Badiol. Transmission of sheep-bovine spongiform encephalopathy to pigs. Veterinary research. vol 47. 2016-10-11. PMID:26742788. |
prp(sc) deposition was revealed by immunohistochemistry alone in the retina, optic nerve and kidney. |
2016-10-11 |
2023-08-13 |
mouse |
| Carlos Hedman, Rosa Bolea, Belén Marín, Fabien Cobrière, Hicham Filali, Francisco Vazquez, José Luis Pitarch, Antonia Vargas, Cristina Acín, Bernardino Moreno, Martí Pumarola, Olivier Andreoletti, Juan José Badiol. Transmission of sheep-bovine spongiform encephalopathy to pigs. Veterinary research. vol 47. 2016-10-11. PMID:26742788. |
these results demonstrate the efficient transmission of sh-bse in pigs and show for the first time that in this species propagation of bovine prp(sc) in a wide range of peripheral tissues is possible. |
2016-10-11 |
2023-08-13 |
mouse |
| Yin Xu, Chan Tian, Jing Sun, Jin Zhang, Ke Ren, Xue-Yu Fan, Ke Wang, Hui Wang, Yu-E Yan, Cao Chen, Qi Shi, Xiao-Ping Don. FBXW7-Induced MTOR Degradation Forces Autophagy to Counteract Persistent Prion Infection. Molecular neurobiology. vol 53. issue 1. 2016-10-07. PMID:25579381. |
knockdown of atg5 and the presence of three autophagic inhibitors resulted in a significant increase of prp(sc). |
2016-10-07 |
2023-08-13 |
human |
| Yin Xu, Chan Tian, Jing Sun, Jin Zhang, Ke Ren, Xue-Yu Fan, Ke Wang, Hui Wang, Yu-E Yan, Cao Chen, Qi Shi, Xiao-Ping Don. FBXW7-Induced MTOR Degradation Forces Autophagy to Counteract Persistent Prion Infection. Molecular neurobiology. vol 53. issue 1. 2016-10-07. PMID:25579381. |
the mammalian target of rapamycin (mtor) levels in smb-s15 cells were also markedly decreased, in direct relation to prp(sc) accumulation. |
2016-10-07 |
2023-08-13 |
human |
| Yin Xu, Chan Tian, Jing Sun, Jin Zhang, Ke Ren, Xue-Yu Fan, Ke Wang, Hui Wang, Yu-E Yan, Cao Chen, Qi Shi, Xiao-Ping Don. FBXW7-Induced MTOR Degradation Forces Autophagy to Counteract Persistent Prion Infection. Molecular neurobiology. vol 53. issue 1. 2016-10-07. PMID:25579381. |
knockdown of fbxw7 in smb-s15 cells remarkably inhibited autophagic flux and increased prp(sc) accumulation. |
2016-10-07 |
2023-08-13 |
human |
| Yin Xu, Chan Tian, Jing Sun, Jin Zhang, Ke Ren, Xue-Yu Fan, Ke Wang, Hui Wang, Yu-E Yan, Cao Chen, Qi Shi, Xiao-Ping Don. FBXW7-Induced MTOR Degradation Forces Autophagy to Counteract Persistent Prion Infection. Molecular neurobiology. vol 53. issue 1. 2016-10-07. PMID:25579381. |
autophagy may serve as innate immunity to degrade prp(sc) and maintain prion homeostasis. |
2016-10-07 |
2023-08-13 |
human |