| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qian Huang, Aihua Ye, Pin Li, Junjie Bao, Robert E Garfield, Huishu Li. Nicotine ameliorates inflammatory mediators in RU486 induced preterm labor model through activating cholinergic anti-inflammatory pathway. Cytokine. vol 160. 2022-10-03. PMID:36191359. |
the role of nicotine, an anti-inflammatory agent that is mediated by cholinergic anti-inflammatory pathways (cap), remains unclear in the pathogenesis. |
2022-10-03 |
2023-08-14 |
Not clear |
| Amany E El-Naggar, Mai M Helmy, Sahar M El-Gowilly, Mahmoud M El-Ma. Central Adenosine A1 Receptors Arbitrate the Nicotine Counteraction of Cardiovascular and Autonomic Dysfunctions in Septic Rats. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35560918. |
given the interplay between cholinergic and adenosinergic neuronal circuits in the central nervous system, we tested the hypothesis that central adenosine a1 receptors (a1rs) modulate the offsetting action of nicotine on cardiovascular and inflammatory insults induced by sepsis. |
2022-05-13 |
2023-08-13 |
rat |
| Hong-Wei Wang, Xian-Hua Jin, Ying-Han Xu, Chun-Ping Chu, Fu-Yang Pei, Xiao-Ping Song, De-Lai Qi. Nicotine depresses facial stimulation-evoked molecular layer interneuron-Purkinje cell synaptic transmission via α7 nicotinic acetylcholine receptors in mouse cerebellar cortex. European journal of pharmacology. 2022-03-01. PMID:35231469. |
these results indicate that micro-application of nicotine to the cerebellar molecular layer depresses facial stimulation-induced mli-pc synaptic transmission by activating α7 nachrs, suggesting that cholinergic inputs modulate mli-pc synapses to process sensory information in the cerebellar cortex of mice in vivo. |
2022-03-01 |
2023-08-13 |
mouse |
| Priscilla Giner, Liliana Maynez-Anchondo, Anna E Liley, Kevin P Uribe, Gabriel A Frietze, Nicholas W Simon, Ian A Mende. Increased Risky Choice and Reduced International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163155. |
the study also aims to investigate possible long-term effects of nicotine vapor exposure on the expression of genes coding for cholinergic and dopaminergic receptors in brain. |
2022-02-15 |
2023-08-13 |
rat |
| Yuichiro Nakata, Kento Miura, Norimasa Yamasaki, Sawako Ogata, Shuka Miura, Naohisa Hosomi, Osamu Kaminum. Expression and Function of Nicotinic Acetylcholine Receptors in Induced Regulatory T Cells. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163704. |
a contribution of the cholinergic system to immune cell function has been suggested, though the role of nicotine and its receptors in t cells, especially regulatory t (treg) cells, is unclear. |
2022-02-15 |
2023-08-13 |
Not clear |
| Lilian Custodio, Samantha Malone, Michael T Bardo, Jill R Turne. Nicotine and Opioid Co-Dependence: Findings from Bench Research to Clinical Trials. Neuroscience and biobehavioral reviews. 2021-12-30. PMID:34968525. |
this review explores the contribution of genetics and neural mechanisms influencing nicotine and opioid reward, respiration, and antinociception, emphasizing the interaction of cholinergic and opioid receptor systems. |
2021-12-30 |
2023-08-13 |
Not clear |
| Kartheek Gavini, Euitaek Yang, Kodeeswaran Parameshwara. Developmental nicotine exposure impairs memory and reduces acetylcholine levels in the hippocampus of mice. Brain research bulletin. vol 176. 2021-12-10. PMID:34358612. |
these results suggest that developmental nicotine exposure impairs hippocampus dependent memory forms and this effect is likely mediated by altered cholinergic function. |
2021-12-10 |
2023-08-13 |
mouse |
| Elizabeth A Souter, Yen-Chu Chen, Vivien Zell, Valeria Lallai, Thomas Steinkellner, William S Conrad, William Wisden, Kenneth D Harris, Christie D Fowler, Thomas S Hnask. Disruption of VGLUT1 in cholinergic medial habenula projections increases nicotine self-administration. eNeuro. 2021-12-08. PMID:34876472. |
disruption of vglut1 in cholinergic medial habenula projections increases nicotine self-administration. |
2021-12-08 |
2023-08-13 |
Not clear |
| Elizabeth A Souter, Yen-Chu Chen, Vivien Zell, Valeria Lallai, Thomas Steinkellner, William S Conrad, William Wisden, Kenneth D Harris, Christie D Fowler, Thomas S Hnask. Disruption of VGLUT1 in cholinergic medial habenula projections increases nicotine self-administration. eNeuro. 2021-12-08. PMID:34876472. |
cholinergic projections from the medial habenula (mhb) to the interpeduncular nucleus (ipn) have been studied for their complex contributions to nicotine addiction and have been implicated in nicotine reinforcement, aversion, and withdrawal. |
2021-12-08 |
2023-08-13 |
Not clear |
| Elizabeth A Souter, Yen-Chu Chen, Vivien Zell, Valeria Lallai, Thomas Steinkellner, William S Conrad, William Wisden, Kenneth D Harris, Christie D Fowler, Thomas S Hnask. Disruption of VGLUT1 in cholinergic medial habenula projections increases nicotine self-administration. eNeuro. 2021-12-08. PMID:34876472. |
while it has been established that mhb cholinergic projections co-release glutamate, no direct evidence has demonstrated a role for this glutamate projection in nicotine consumption. |
2021-12-08 |
2023-08-13 |
Not clear |
| S R Hauser, Z A Rodd, G A Deehan, T Liang, Shafiqur Rahman, Richard L Bel. Effects of adolescent substance use disorders on central cholinergic function. International review of neurobiology. vol 160. 2021-11-11. PMID:34696873. |
this review will focus on the effects of peri-adolescent nicotine and/or alcohol use, or exposure, on the cholinergic system during adulthood from preclinical and clinical studies. |
2021-11-11 |
2023-08-13 |
Not clear |
| S R Hauser, Z A Rodd, G A Deehan, T Liang, Shafiqur Rahman, Richard L Bel. Effects of adolescent substance use disorders on central cholinergic function. International review of neurobiology. vol 160. 2021-11-11. PMID:34696873. |
this review further explores potential cholinergic agents and pharmacological manipulations to counteract peri-adolescent nicotine and/or alcohol abuse. |
2021-11-11 |
2023-08-13 |
Not clear |
| Julie M Miw. Lynx1 prototoxins: critical accessory proteins of neuronal nicotinic acetylcholine receptors. Current opinion in pharmacology. vol 56. 2021-10-25. PMID:33254061. |
nicotinic receptors of the cholinergic system are ligand-gated ion channels, responding to the excitatory neurotransmitter, acetylcholine, and the addictive component of tobacco, nicotine. |
2021-10-25 |
2023-08-13 |
Not clear |
| Angel Carvajal-Oliveros, Carmen Domínguez-Baleón, Rafaella V Zárate, Jorge M Campusano, Verónica Narváez-Padilla, Enrique Reynau. Nicotine suppresses Parkinson's disease like phenotypes induced by Synphilin-1 overexpression in Drosophila melanogaster by increasing tyrosine hydroxylase and dopamine levels. Scientific reports. vol 11. issue 1. 2021-10-22. PMID:33953275. |
nicotine is a cholinergic agonist and is the principal psychoactive compound in tobacco linked to cigarette addiction. |
2021-10-22 |
2023-08-13 |
drosophila_melanogaster |
| Angel Carvajal-Oliveros, Carmen Domínguez-Baleón, Rafaella V Zárate, Jorge M Campusano, Verónica Narváez-Padilla, Enrique Reynau. Nicotine suppresses Parkinson's disease like phenotypes induced by Synphilin-1 overexpression in Drosophila melanogaster by increasing tyrosine hydroxylase and dopamine levels. Scientific reports. vol 11. issue 1. 2021-10-22. PMID:33953275. |
nicotine is beneficial on fly survival and motility increasing tyrosine hydroxylase and dopamine levels, suggesting that cholinergic agonists may promote survival and metabolic function of the dopaminergic neurons that express sph-1. |
2021-10-22 |
2023-08-13 |
drosophila_melanogaster |
| Andrew M Smith, Linda P Dwoskin, James R Paul. Early exposure to nicotine during critical periods of brain development: Mechanisms and consequences. Journal of pediatric biochemistry. vol 1. issue 2. 2021-10-21. PMID:24904708. |
nicotine activates, and subsequently desensitizes, neuronal nicotinic acetylcholine receptor subtypes (achrs), which are expressed in the developing central nervous system (cns) prior to the in-growth of cholinergic neurons. |
2021-10-21 |
2023-08-13 |
Not clear |
| Yann S Mineur, Marina R Picciott. Biological basis for the co-morbidity between smoking and mood disorders. Journal of dual diagnosis. vol 5. issue 2. 2021-10-20. PMID:20046987. |
results from clinical and pre-clinical studies have seemed somewhat paradoxical because heightened cholinergic activity can induce depression while both nicotine and nicotinic antagonists can be antidepressant-like. |
2021-10-20 |
2023-08-12 |
human |
| Yann S Mineur, Marina R Picciott. Biological basis for the co-morbidity between smoking and mood disorders. Journal of dual diagnosis. vol 5. issue 2. 2021-10-20. PMID:20046987. |
these observations can be reconciled by considering that high affinity nicotinic receptors in the brain can be desensitized by chronic nicotine use, leading to blunted cholinergic activity. |
2021-10-20 |
2023-08-12 |
human |
| Alfonso Claros-Guzmán, Martín G Rodríguez, Birmania Heredia-Rivera, Rodolfo González-Segovi. Three-dimensional analysis of the heart function and effect cholinergic agonists in the cockroach Gromphadorhina portentosa. Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology. vol 206. issue 6. 2021-10-19. PMID:32955634. |
we used this methodology for assessing the physiological responses of the cockroach heart upon the application of different cholinergic neurotransmitters (acetylcholine, nicotine and muscarine). |
2021-10-19 |
2023-08-13 |
drosophila_melanogaster |
| Miranda L Fisher, James R Pauly, Brett Froeliger, Jill R Turne. Translational Research in Nicotine Addiction. Cold Spring Harbor perspectives in medicine. vol 11. issue 6. 2021-09-29. PMID:32513669. |
likewise, translational studies investigating single-nucleotide polymorphisms (snps) within the cholinergic, dopaminergic, and opioid systems have found high levels of involvement of these neurotransmitter systems in regulating the reinforcing aspects of nicotine in both humans and mouse models. |
2021-09-29 |
2023-08-13 |
mouse |