| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Janine Spieker, Johannes L Frieß, Laura Sperling, Gopenath Thangaraj, Astrid Vogel-Höpker, Paul G Laye. Cholinergic control of bone development and beyond. International immunopharmacology. vol 83. 2021-02-19. PMID:32208165. |
nicotine smoking, but also exposure to pesticides or medical drugs point to the significance of cholinergic effects on bone status, as reviewed here in introduction. |
2021-02-19 |
2023-08-13 |
mouse |
| Rekha C Balachandran, Katherine M Hatcher, Megan L Sieg, Emma K Sullivan, Leonardo M Molina, Megan M Mahoney, Paul A Eubi. Pharmacological challenges examining the underlying mechanism of altered response inhibition and attention due to circadian disruption in adult Long-Evans rats. Pharmacology, biochemistry, and behavior. vol 193. 2021-01-21. PMID:32224058. |
we administered the cholinergic agonist nicotine and either the dopamine-1 receptor (dr1) antagonist sch23390 or the dr2 antagonist eticlopride under the 3 circadian conditions to identify differential drug responses between treatment groups. |
2021-01-21 |
2023-08-13 |
rat |
| Anjum Parkar, Donald C Fedrigon, Farah Alam, Giancarlo Vanini, George A Mashour, Dinesh Pa. Carbachol and Nicotine in Prefrontal Cortex Have Differential Effects on Sleep-Wake States. Frontiers in neuroscience. vol 14. 2021-01-14. PMID:33328847. |
therefore, in this study, we tested the hypothesis that delivery of cholinergic agonists - carbachol or nicotine - into prefrontal cortex of rat during slow wave sleep (sws) would produce behavioral arousal and increase the time spent in wake state. |
2021-01-14 |
2023-08-13 |
rat |
| Konstantinos Farsalinos, Raymond Niaura, Jacques Le Houezec, Anastasia Barbouni, Aristidis Tsatsakis, Dimitrios Kouretas, Apostolos Vantarakis, Konstantinos Poula. Editorial: Nicotine and SARS-CoV-2: COVID-19 may be a disease of the nicotinic cholinergic system. Toxicology reports. vol 7. 2020-12-24. PMID:32355638. |
editorial: nicotine and sars-cov-2: covid-19 may be a disease of the nicotinic cholinergic system. |
2020-12-24 |
2023-08-13 |
Not clear |
| Yousef Tizabi, Bruk Getachew, Robert L Copeland, Michael Aschne. Nicotine and the nicotinic cholinergic system in COVID-19. The FEBS journal. vol 287. issue 17. 2020-12-24. PMID:32790936. |
nicotine and the nicotinic cholinergic system in covid-19. |
2020-12-24 |
2023-08-13 |
Not clear |
| Yousef Tizabi, Bruk Getachew, Robert L Copeland, Michael Aschne. Nicotine and the nicotinic cholinergic system in COVID-19. The FEBS journal. vol 287. issue 17. 2020-12-24. PMID:32790936. |
although conflicting hypotheses on the potential role of nicotine in covid-19 pathology have recently been offered, we believe that nicotine itself, through its interaction with the nicotinic cholinergic system, as well as ace2, may not only be of use in a variety of neuropsychiatric and neurodegenerative diseases, but may also be of potential use in covid-19. |
2020-12-24 |
2023-08-13 |
Not clear |
| Yousef Tizabi, Bruk Getachew, Robert L Copeland, Michael Aschne. Nicotine and the nicotinic cholinergic system in COVID-19. The FEBS journal. vol 287. issue 17. 2020-12-24. PMID:32790936. |
thus, on one hand, while we strongly support smoking cessation as a means of harm reduction associated with covid-19, on the other hand, we support a potential therapeutic role for nicotine, nicotinic agonists, or positive allosteric modulators of nicotinic cholinergic receptors in covid-19, owing to their varied effects including mood regulation, anti-inflammatory, and purported interference with sars-cov-2 entry and/or replication. |
2020-12-24 |
2023-08-13 |
Not clear |
| Luiz Dratcu, Xavier Bolan. Does Nicotine Prevent Cytokine Storms in COVID-19? Cureus. vol 12. issue 10. 2020-12-07. PMID:33269148. |
nicotine, an α7-nach receptor agonist, may boost the cholinergic anti-inflammatory pathway and hinder the uncontrolled overproduction of pro-inflammatory cytokines triggered by the sars-cov-2 virus, which is understood to be the main pathway to poor outcomes and death in severe covid-19. |
2020-12-07 |
2023-08-13 |
Not clear |
| Jean-Noël Houchat, Alison Cartereau, Anaïs Le Mauff, Emiliane Taillebois, Steeve H Than. An Overview on the Effect of Neonicotinoid Insecticides on Mammalian Cholinergic Functions through the Activation of Neuronal Nicotinic Acetylcholine Receptors. International journal of environmental research and public health. vol 17. issue 9. 2020-10-08. PMID:32384754. |
major studies on the influence of neonicotinoid insecticides on cholinergic functions have been conducted using nicotine low-affinity homomeric α7 and high-affinity heteromeric α4β2 receptors, as they are the most abundant in the nervous system. |
2020-10-08 |
2023-08-13 |
rat |
| Hyun Woo Lee, Soo Hyun Yang, Jin Yong Kim, Hyun Ki. The Role of the Medial Habenula Cholinergic System in Addiction and Emotion-Associated Behaviors. Frontiers in psychiatry. vol 10. 2020-10-01. PMID:30873055. |
recently, however, the medial habenula cholinergic system has attracted more attention because of its potential to provide therapeutic targets for the treatment of nicotine withdrawal symptoms, drug addiction, and various mood disorders. |
2020-10-01 |
2023-08-13 |
Not clear |
| Cheng Xiao, Chun-Yi Zhou, Jin-Hong Jiang, Cui Yi. Neural circuits and nicotinic acetylcholine receptors mediate the cholinergic regulation of midbrain dopaminergic neurons and nicotine dependence. Acta pharmacologica Sinica. vol 41. issue 1. 2020-10-01. PMID:31554960. |
neural circuits and nicotinic acetylcholine receptors mediate the cholinergic regulation of midbrain dopaminergic neurons and nicotine dependence. |
2020-10-01 |
2023-08-13 |
Not clear |
| Cheng Xiao, Chun-Yi Zhou, Jin-Hong Jiang, Cui Yi. Neural circuits and nicotinic acetylcholine receptors mediate the cholinergic regulation of midbrain dopaminergic neurons and nicotine dependence. Acta pharmacologica Sinica. vol 41. issue 1. 2020-10-01. PMID:31554960. |
nicotine hijacks nicotinic acetylcholine receptors (nachrs) and interferes with physiological function of the cholinergic system. |
2020-10-01 |
2023-08-13 |
Not clear |
| Cheng Xiao, Chun-Yi Zhou, Jin-Hong Jiang, Cui Yi. Neural circuits and nicotinic acetylcholine receptors mediate the cholinergic regulation of midbrain dopaminergic neurons and nicotine dependence. Acta pharmacologica Sinica. vol 41. issue 1. 2020-10-01. PMID:31554960. |
in this review, we describe the anatomical organization of the cholinergic system and the key nachr subtypes mediating cholinergic regulation of da transmission and nicotine reward and dependence, in an effort to identify potential targets for smoking intervention. |
2020-10-01 |
2023-08-13 |
Not clear |
| Ge Li-Sha, Chen Xing-Xing, Wu Lian-Pin, Zhou De-Pu, Li Xiao-Wei, Lin Jia-Feng, Li Yue-Chu. Right Cervical Vagotomy Aggravates Viral Myocarditis in Mice Via the Cholinergic Anti-inflammatory Pathway. Frontiers in pharmacology. vol 8. 2020-09-30. PMID:28197102. |
we found that right cervical vagotomy inhibited the cholinergic anti-inflammatory pathway, aggravated myocardial lesions, up-regulated the expression of tnf-α, il-1β, and il-6, and worsened the impaired left ventricular function in murine viral myocarditis, and these changes were reversed by co-treatment with nicotine by activating the cholinergic anti-inflammatory pathway. |
2020-09-30 |
2023-08-13 |
mouse |
| Ge Li-Sha, Chen Xing-Xing, Wu Lian-Pin, Zhou De-Pu, Li Xiao-Wei, Lin Jia-Feng, Li Yue-Chu. Right Cervical Vagotomy Aggravates Viral Myocarditis in Mice Via the Cholinergic Anti-inflammatory Pathway. Frontiers in pharmacology. vol 8. 2020-09-30. PMID:28197102. |
these results indicate that vagal nerve plays an important role in mediating the anti-inflammatory effect in viral myocarditis, and that cholinergic stimulation with nicotine also plays its peripheral anti-inflammatory role relying on α7nachr, without requirement for the integrity of vagal nerve in the model. |
2020-09-30 |
2023-08-13 |
mouse |
| Mohammed Z Ariffin, Chian-Ming Low, Sanjay Khann. Medial Septum Modulates Cellular Response Induced in Hippocampus on Microinjection of Cholinergic Agonists into Hypothalamic Lateral Supramammillary Nucleus. Frontiers in neuroanatomy. vol 11. 2020-09-30. PMID:28966579. |
microinjection of the broad-spectrum cholinergic agonist, carbachol, or the cholinergic-nicotinic receptor agonist, nicotine, into the lsum and the msum in urethane anesthetized rat evoked a similar pattern of hippocampal theta rhythm. |
2020-09-30 |
2023-08-13 |
rat |
| Anna Maria Lavezz. Toxic Effect of Cigarette Smoke on Brainstem Nicotinic Receptor Expression: Primary Cause of Sudden Unexplained Perinatal Death. Toxics. vol 6. issue 4. 2020-09-29. PMID:30340403. |
among the neurotoxicants contained in tobacco smoke, if absorbed during pregnancy, nicotine significantly affects α7-nicotinic acetylcholine receptors, which play essential roles in the development of the brainstem regions receiving cholinergic projections in perinatal life. |
2020-09-29 |
2023-08-13 |
Not clear |
| Raj Kumar Tiwari, Vikas Sharma, Ravindra Kumar Pandey, Shiv Shankar Shukl. Nicotine Addiction: Neurobiology and Mechanism. Journal of pharmacopuncture. vol 23. issue 1. 2020-09-28. PMID:32322429. |
neurological systems such as gabaergic, serotonergic, noradrenergic, and brain stem cholinergic may also be involved to mediate the actions of nicotine. |
2020-09-28 |
2023-08-13 |
Not clear |
| Junjie Bao, Yong Zou, Yuanyuan Liu, Li Yuan, Robert E Garfield, Huishu Li. Nicotine protects fetus against LPS-induced fetal growth restriction through ameliorating placental inflammation and vascular development in late pregnancy in rats. Bioscience reports. vol 39. issue 7. 2020-09-11. PMID:31209145. |
our previous work has shown that nicotine suppressed lipopolysaccharide (lps)-induced placental inflammation by inhibiting cytokine release as well as infiltration of leukocytes into the placenta through the cholinergic anti-inflammatory pathway. |
2020-09-11 |
2023-08-13 |
rat |
| Junjie Bao, Yong Zou, Yuanyuan Liu, Li Yuan, Robert E Garfield, Huishu Li. Nicotine protects fetus against LPS-induced fetal growth restriction through ameliorating placental inflammation and vascular development in late pregnancy in rats. Bioscience reports. vol 39. issue 7. 2020-09-11. PMID:31209145. |
these data demonstrated that activation of the cholinergic anti-inflammatory pathway by nicotine protected fetus against lps-induced fgr through ameliorating placental inflammation and vascular development in late pregnancy in rats. |
2020-09-11 |
2023-08-13 |
rat |