| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Omid A Zobeiri, Kathleen E Culle. Distinct representations of body and head motion are dynamically encoded by Purkinje cell populations in the macaque cerebellum. eLife. vol 11. 2022-04-25. PMID:35467528. |
distinct representations of body and head motion are dynamically encoded by purkinje cell populations in the macaque cerebellum. |
2022-04-25 |
2023-08-13 |
monkey |
| Michael A Gaffield, Britton A Sauerbrei, Jason M Christi. Cerebellum encodes and influences the initiation, performance, and termination of discontinuous movements in mice. eLife. vol 11. 2022-04-22. PMID:35451957. |
to provide functional evidence validating this idea, we measured and manipulated purkinje cell (pc) activity in the lateral cerebellum of mice trained to volitionally perform periodic bouts of licking for regularly allocated water rewards. |
2022-04-22 |
2023-08-13 |
mouse |
| Marion Coolen, Nami Altin, Karthyayani Rajamani, Eva Pereira, Karine Siquier-Pernet, Emilia Puig Lombardi, Nadjeda Moreno, Giulia Barcia, Marianne Yvert, Annie Laquerrière, Aurore Pouliet, Patrick Nitschké, Nathalie Boddaert, Antonio Rausell, Féréchté Razavi, Alexandra Afenjar, Thierry Billette de Villemeur, Almundher Al-Maawali, Khalid Al-Thihli, Julia Baptista, Ana Beleza-Meireles, Catherine Garel, Marine Legendre, Antoinette Gelot, Lydie Burglen, Sébastien Moutton, Vincent Cantagre. Recessive PRDM13 mutations cause fatal perinatal brainstem dysfunction with cerebellar hypoplasia and disrupt Purkinje cells differentiation. American journal of human genetics. 2022-04-07. PMID:35390279. |
notably, histopathological examinations highlighted a sparse and disorganized purkinje cell layer in the cerebellum. |
2022-04-07 |
2023-08-13 |
mouse |
| Ehsan Sedaghat-Nejad, Jay S Pi, Paul Hage, Mohammad Amin Fakharian, Reza Shadmeh. Synchronous spiking of cerebellar Purkinje cells during control of movements. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 14. 2022-03-29. PMID:35349338. |
here we report that, in the cerebellum, purkinje cell populations that share a preference for error convey, to the nucleus, when to decelerate the movement, by reducing their firing rates and temporally synchronizing the remaining spikes. |
2022-03-29 |
2023-08-13 |
Not clear |
| Tuancheng Feng, Lin Luan, Isabel Iscol Katz, Mohammed Ullah, Vivianna M Van Deerlin, John Q Trojanowski, Edward B Lee, Fenghua H. TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss. Acta neuropathologica communications. vol 10. issue 1. 2022-03-15. PMID:35287730. |
tmem106b deficiency impairs cerebellar myelination and synaptic integrity with purkinje cell loss. |
2022-03-15 |
2023-08-13 |
mouse |
| Yasmin Fidler, Jose Rosa Gome. Effects of a Single Dose of X-Ray Irradiation on MMP-9 Expression and Morphology of the Cerebellum Cortex of Adult Rats. Cerebellum (London, England). 2022-03-09. PMID:35262839. |
we conclude that the effects of a single dose of 15-gy x-ray irradiation in the cerebellum were an increase in mmp-9 expression in the first 2 weeks after irradiation, especially surrounding the purkinje cells and in the molecular layers, with morphological changes in the purkinje cell and granular cell layers, suggesting a continuous cell loss throughout the days evaluated after irradiation. |
2022-03-09 |
2023-08-13 |
rat |
| Xiang Chen, Tong Chen, Chen Dong, Huiyao Chen, Xinran Dong, Lin Yang, Liyuan Hu, Huijun Wang, Bingbing Wu, Ye Yao, Yu Xiong, Man Xiong, Yifeng Lin, Wenhao Zho. Deletion of CHD8 in cerebellar granule neuron progenitors leads to severe cerebellar hypoplasia, ataxia and psychiatric behavior in mice. Journal of genetics and genomics = Yi chuan xue bao. 2022-03-01. PMID:35231638. |
genetic deletion of chd8 in cerebellar granule neuron progenitors (gnps) lead to cerebellar hypoplasia, absent of proliferation layer and ectopic of purkinje neuron. |
2022-03-01 |
2023-08-13 |
mouse |
| Inwoo Hwang, Byeong-Seong Kim, Hyo Rim Ko, Seongbong Cho, Ho Yun Lee, Sung-Woo Cho, Dongryeol Ryu, Sungbo Shim, Jee-Yin Ah. Cerebellar dysfunction and schizophrenia-like behavior in Ebp1-deficient mice. Molecular psychiatry. 2022-02-15. PMID:35165395. |
cerebellar deficits with purkinje cell (pcs) loss are observed in several neurologic disorders. |
2022-02-15 |
2023-08-13 |
mouse |
| G Cheron, D Ristori, J Marquez-Ruiz, A M Cebolla, L Ri. Electrophysiological alterations of the Purkinje cells and deep cerebellar neurons in a mouse model of Alzheimer disease (Electrophysiology on cerebellum of AD mice). The European journal of neuroscience. 2022-02-10. PMID:35141975. |
despite the central position of the purkinje cell in the cerebellum, its electrophysiological behavior in mouse models of alzheimer's disease is scarce in the literature. |
2022-02-10 |
2023-08-13 |
mouse |
| Michelle Imlau, Mamoun Saeed, Jane Cryan, Seamus Hoey, Myles McKenna, Hanne Jahns, Pamela Kell. Dysplastic gangliocytoma of the cerebellum in a cat. Veterinary pathology. 2022-02-08. PMID:35130805. |
postmortem examination confirmed the mri findings, and histopathology showed numerous large dysplastic neurons populating and displacing the purkinje cell layer and extending into the molecular and granular layers of the cerebellum. |
2022-02-08 |
2023-08-13 |
cat |
| Hanako Aoki, Miwa Higashi, Michi Okita, Noboru Ando, Shigeo Murayama, Kinya Ishikawa, Takanori Yokot. Thymidine Kinase 2 and Mitochondrial Protein COX I in the Cerebellum of Patients with Spinocerebellar Ataxia Type 31 Caused by Penta-nucleotide Repeats (TTCCA) Cerebellum (London, England). 2022-01-27. PMID:35084690. |
thymidine kinase 2 and mitochondrial protein cox i in the cerebellum of patients with spinocerebellar ataxia type 31 caused by penta-nucleotide repeats (ttcca) spinocerebellar ataxia type 31 (sca31), an autosomal-dominant neurodegenerative disorder characterized by progressive cerebellar ataxia with purkinje cell degeneration, is caused by a heterozygous 2.5-3.8 kilobase penta-nucleotide repeat of (ttcca) |
2022-01-27 |
2023-08-13 |
Not clear |
| Carlos Del Pilar, Rafael Lebrón-Galán, Ester Pérez-Martín, Laura Pérez-Revuelta, Carmelo Antonio Ávila-Zarza, José Ramón Alonso, Diego Clemente, Eduardo Weruaga, David Día. The Selective Loss of Purkinje Cells Induces Specific Peripheral Immune Alterations. Frontiers in cellular neuroscience. vol 15. 2021-12-17. PMID:34916910. |
consequently, a model of human cerebellar degeneration and ataxia -the purkinje cell degeneration (pcd) mouse- has been employed, as it allows the study of different processes of selective neuronal death in the same animal, i.e., purkinje cells in the cerebellum and mitral cells in the olfactory bulb. |
2021-12-17 |
2023-08-13 |
mouse |
| Shelanah Salih, Zubair Nizamudeen, Nigel De Melo, Lisa Chakrabarti, Virginie Sottil. Sox-positive cell population in the adult cerebellum increases upon tissue degeneration. Experimental neurology. 2021-12-13. PMID:34902356. |
in a mouse model of cerebellar degeneration, progressive purkinje cell loss was linked to cerebellar cortex disorganisation and a significant increase in sox-positive cells compared to matching controls. |
2021-12-13 |
2023-08-13 |
mouse |
| Xu Zhang, Roeland Hancock, Sabato Santaniell. Transcranial direct current stimulation of cerebellum alters spiking precision in cerebellar cortex: A modeling study of cellular responses. PLoS computational biology. vol 17. issue 12. 2021-12-09. PMID:34882680. |
we then pair the ef with multicompartment models of the purkinje cell (pc), deep cerebellar neuron (dcn), and granule cell (grc) and quantify the acute response of these neurons under various orientations, physiological conditions, and sequences of presynaptic stimuli. |
2021-12-09 |
2023-08-13 |
Not clear |
| Chunlian Song, Xin Huang, Yunmei Gao, Xue Zhang, Yulei Wang, Yajing Zhang, Tao Lv, Zhihui Zhang, Yalun Zhang, Qiong Pan, Yue Shu, Xianghua Sh. Histopathology of brain functional areas in pigs infected by porcine pseudorabies virus. Research in veterinary science. vol 141. 2021-12-08. PMID:34763257. |
immunohistochemistry showed that the virus was mainly localized in neurons, microglia, nerve fibers, cerebellar granular layer, and purkinje cell layer. |
2021-12-08 |
2023-08-13 |
Not clear |
| Shu Ho, Rebecca Lajaunie, Marion Lerat, Mickaël Le, Valérie Crépel, Karine Loulier, Jean Livet, Jean-Pierre Kessler, Païkan Marcagg. A stable proportion of Purkinje cell inputs from parallel fibers are silent during cerebellar maturation. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 45. 2021-12-07. PMID:34740966. |
a stable proportion of purkinje cell inputs from parallel fibers are silent during cerebellar maturation. |
2021-12-07 |
2023-08-13 |
mouse |
| Ester Pérez-Martín, Rodrigo Muñoz-Castañeda, Marie-Jo Moutin, Carmelo A Ávila-Zarza, José M Muñoz-Castañeda, Carlos Del Pilar, José R Alonso, Annie Andrieux, David Díaz, Eduardo Weruag. Oleoylethanolamide Delays the Dysfunction and Death of Purkinje Cells and Ameliorates Behavioral Defects in a Mouse Model of Cerebellar Neurodegeneration. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 18. issue 3. 2021-12-04. PMID:33829414. |
in this study, we evaluated the effects of oea on the disruption of both cerebellar structure and physiology and on the behavior of purkinje cell degeneration (pcd) mutant mice. |
2021-12-04 |
2023-08-13 |
mouse |
| François G C Blot, Wilhelmina H J J Krijnen, Sandra Den Hoedt, Catarina Osório, Joshua J White, Monique T Mulder, Martijn Schonewill. Sphingolipid metabolism governs Purkinje cell patterned degeneration in Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 36. 2021-12-02. PMID:34479994. |
sphingolipid metabolism governs purkinje cell patterned degeneration in patterned degeneration of purkinje cells (pcs) can be observed in a wide range of neuropathologies, but mechanisms behind nonrandom cerebellar neurodegeneration remain unclear. |
2021-12-02 |
2023-08-13 |
Not clear |
| Sinem Balta Beylergil, Palak Gupta, Aasef G Shaik. Does Inferior-Olive Hypersynchrony Affect Vestibular Heading Perception? Cerebellum (London, England). vol 20. issue 5. 2021-11-30. PMID:31939030. |
deficiency in cerebellar function due to purkinje cell loss results in inaccurate multisensory integration and impaired heading perception. |
2021-11-30 |
2023-08-13 |
Not clear |
| Rin Khang, Areum Jo, Hojin Kang, Hanna Kim, Eunsang Kwag, Ji-Yeong Lee, Okjae Koo, Jinsu Park, Hark Kyun Kim, Dong-Gyu Jo, Inwoo Hwang, Jee-Yin Ahn, Yunjong Lee, Jeong-Yun Choi, Yun-Song Lee, Joo-Ho Shi. Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation. Scientific reports. vol 11. issue 1. 2021-11-27. PMID:34815492. |
we confirmed the reduction of zfp212 and pld3 in the cb of an alcohol-induced cerebellar degeneration mouse model, suggesting that the znf212-pld3 relationship is important for purkinje cell survival. |
2021-11-27 |
2023-08-13 |
mouse |