| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Zhang, Jialin Chen, Jiadong Tao, Changchang Hu, Longkun Chen, Hongshi Zhao, Guowei Xu, Boon C Heng, Hong Wei Ouyan. The promotion of osteochondral repair by combined intra-articular injection of parathyroid hormone-related protein and implantation of a bi-layer collagen-silk scaffold. Biomaterials. vol 34. issue 25. 2013-12-31. PMID:23702148. |
defects treated with pthrp at the 4-6 weeks time window exhibited better regeneration (reconstitution of cartilage and subchondral bone) with minimal terminal differentiation (hypertrophy, ossification and matrix degradation), as well as enhanced chondrogenesis (cell shape, col2 and gag accumulation) compared with treatment at other time windows. |
2013-12-31 |
2023-08-12 |
rabbit |
| Zhonglin Chai, Aozhi Dai, Yugang Tu, Jiaze Li, Tieqiao Wu, Yu Wang, Lorna J Hale, Frank Koentgen, Merlin C Thomas, Mark E Coope. Genetic deletion of cell division autoantigen 1 retards diabetes-associated renal injury. Journal of the American Society of Nephrology : JASN. vol 24. issue 11. 2013-12-23. PMID:23929772. |
notably, cda1 deletion significantly reduced diabetes-associated renal matrix accumulation and immunohistochemical staining for collagens iii and iv and attenuated glomerular and tubulointerstitial injury indices, despite the presence of persistent hyperglycemia, polyuria, renal hypertrophy, and hyperfiltration. |
2013-12-23 |
2023-08-12 |
mouse |
| Vivek Gupta, Nilesh Gupta, Imam H Shaik, Reza Mehvar, Eva Nozik-Grayck, Ivan F McMurtry, Masahiko Oka, Masanobu Komatsu, Fakhrul Ahsa. Inhaled PLGA particles of prostaglandin E₁ ameliorate symptoms and progression of pulmonary hypertension at a reduced dosing frequency. Molecular pharmaceutics. vol 10. issue 5. 2013-12-16. PMID:23485062. |
the influence of formulations on disease progression was studied by measuring the mean pulmonary arterial pressure (mpap), evaluating right ventricular hypertrophy and assessing various molecular and cellular makers including the degree of muscularization, platelet aggregation, matrix metalloproteinase-2 (mmp-2), and proliferating cell nuclear antigen (pcna). |
2013-12-16 |
2023-08-12 |
rat |
| Zhensen Zhu, Jie Ding, Heather A Shankowsky, Edward E Tredge. The molecular mechanism of hypertrophic scar. Journal of cell communication and signaling. vol 7. issue 4. 2013-12-16. PMID:23504443. |
hypertrophic scar (hts) is a dermal form of fibroproliferative disorder which often develops after thermal or traumatic injury to the deep regions of the skin and is characterized by excessive deposition and alterations in morphology of collagen and other extracellular matrix (ecm) proteins. |
2013-12-16 |
2023-08-12 |
Not clear |
| Tatiana Tsoutsman, Xiaoyu Wang, Kendra Garchow, Bruce Riser, Stephen Twigg, Christopher Semsaria. CCN2 plays a key role in extracellular matrix gene expression in severe hypertrophic cardiomyopathy and heart failure. Journal of molecular and cellular cardiology. vol 62. 2013-12-11. PMID:23756156. |
ccn2 plays a key role in extracellular matrix gene expression in severe hypertrophic cardiomyopathy and heart failure. |
2013-12-11 |
2023-08-12 |
mouse |
| S Eid, W Abou-Kheir, R Sabra, G Daoud, A Jaffa, F N Ziyadeh, L Roman, A A Ei. Involvement of renal cytochromes P450 and arachidonic acid metabolites in diabetic nephropathy. Journal of biological regulators and homeostatic agents. vol 27. issue 3. 2013-11-27. PMID:24152838. |
dn is characterized by hyperfiltration, hypertrophy, extracellular matrix accumulation, and proteinuria. |
2013-11-27 |
2023-08-12 |
rat |
| Hyo-Bum Kwa. Aging, exercise, and extracellular matrix in the heart. Journal of exercise rehabilitation. vol 9. issue 3. 2013-11-26. PMID:24278882. |
the cardiac remodeling involves loss of cardiac myocytes, reactive hypertrophy of the remaining cells, and increased extracellular matrix (ecm) and fibrosis in the aging heart, especially left ventricles. |
2013-11-26 |
2023-08-12 |
Not clear |
| Yi Lin, Makoto Kuro-o, Zhongjie Su. Genetic deficiency of anti-aging gene klotho exacerbates early nephropathy in STZ-induced diabetes in male mice. Endocrinology. vol 154. issue 10. 2013-11-25. PMID:23928372. |
klotho deficiency in kl(+/-) mutant mice exacerbated stz-induced increases in urine albumin, blood urea nitrogen, expansion of mesangial matrix in renal glomeruli, and kidney hypertrophy, suggesting a protective role of klotho in kidney function and structure. |
2013-11-25 |
2023-08-12 |
mouse |
| E Kupidlowska, K Dobrzynska, E Parys, A M Zobe. Effect of coumarin and xanthotoxin on mitochondrial structure, oxygen uptake, and succinate dehydrogenase activity in onion root cells. Journal of chemical ecology. vol 20. issue 10. 2013-11-19. PMID:24241824. |
they caused changes in the structure of the mitochondrial matrix to become dense, and protrusions of mitochondrial membranes were visible parallelling their hypertrophy, indicating alteration in the structure and physiology of these organelles. |
2013-11-19 |
2023-08-12 |
Not clear |
| Takaaki Koga, Takahiro Niikura, Sang Yang Lee, Yoshihiro Dogaki, Etsuko Okumachi, Kotaro Nishida, Ryosuke Kuroda, Masahiro Kurosak. In vitro hypertrophy and calcification of human fracture haematoma-derived cells in chondrogenic differentiation. International orthopaedics. vol 37. issue 5. 2013-11-14. PMID:23446329. |
in this study, we investigated whether haematoma-derived cells (hcs) could differentiate into hypertrophic chondrocytes and finally induce calcification of the extracellular matrix in vitro. |
2013-11-14 |
2023-08-12 |
human |
| Yusuke Kaida, Kei Fukami, Takanori Matsui, Yuichiro Higashimoto, Yuri Nishino, Nana Obara, Yosuke Nakayama, Ryotaro Ando, Maki Toyonaga, Seiji Ueda, Masayoshi Takeuchi, Hiroyoshi Inoue, Seiya Okuda, Sho-ichi Yamagish. DNA aptamer raised against AGEs blocks the progression of experimental diabetic nephropathy. Diabetes. vol 62. issue 9. 2013-11-12. PMID:23630304. |
urinary albumin and 8-hydroxy-2'-deoxy-guanosine levels were increased, and glomerular hypertrophy and enhanced extracellular matrix accumulation were observed in kkay/ta mice, all of which were prevented by ages-aptamer. |
2013-11-12 |
2023-08-12 |
mouse |
| William T Gerthoffer, Dedmer Schaafsma, Pawan Sharma, Saeid Ghavami, Andrew J Halayk. Motility, survival, and proliferation. Comprehensive Physiology. vol 2. issue 1. 2013-11-04. PMID:23728975. |
however, terminally differentiated smooth muscle cells are phenotypically plastic and have multifunctional capacity for proliferation, cellular hypertrophy, migration, and the synthesis of extracellular matrix and inflammatory mediators. |
2013-11-04 |
2023-08-12 |
Not clear |
| Xiao Hu, Huo Ran, Wang Dechang, Wang Yibing, Feng Yongqiang, Li Qian. Absence of the adenosine A(2A) receptor attenuates hypertrophic scarring in mice. Journal of burn care & research : official publication of the American Burn Association. vol 34. issue 3. 2013-10-31. PMID:23412328. |
hypertrophic scar following cutaneous wounding is the result of the body overproducing collagen, and it has been shown that the activation of the adenosine a(2a) receptor promotes tissue repair, wound healing, and extracellular matrix production. |
2013-10-31 |
2023-08-12 |
mouse |
| Otavio R Coelho-Filho, Ravi V Shah, Richard Mitchell, Tomas G Neilan, Heitor Moreno, Bridget Simonson, Raymond Kwong, Anthony Rosenzweig, Saumya Das, Michael Jerosch-Herol. Quantification of cardiomyocyte hypertrophy by cardiac magnetic resonance: implications for early cardiac remodeling. Circulation. vol 128. issue 11. 2013-10-31. PMID:23912910. |
the goal was to validate a cardiac magnetic resonance-based approach for the combined assessment of extracellular matrix expansion and cardiomyocyte hypertrophy. |
2013-10-31 |
2023-08-12 |
Not clear |
| Mathias H Konstandin, Mirko Völkers, Brett Collins, Pearl Quijada, Mercedes Quintana, Andrea De La Torre, Lucy Ormachea, Shabana Din, Natalie Gude, Haruhiro Toko, Mark A Sussma. Fibronectin contributes to pathological cardiac hypertrophy but not physiological growth. Basic research in cardiology. vol 108. issue 5. 2013-10-17. PMID:23912225. |
while substantial information has been published on the nature of the fundamental molecular signaling involved in hypertrophy, the role of extracellular matrix protein fibronectin (fn) in hypertrophic signaling is unclear. |
2013-10-17 |
2023-08-12 |
Not clear |
| Yasumoto Matsui, Atsushi Harad. [Aging of joint]. Clinical calcium. vol 23. issue 1. 2013-09-25. PMID:23268297. |
in oa cartilage, increased degradation and decreased production of major matrix components, like type ii collagen and aggrecan occur, as well as chondrocyte hypertrophy or apoptosis. |
2013-09-25 |
2023-08-12 |
Not clear |
| Biljana Skrbic, Johannes L Bjørnstad, Henriette S Marstein, Cathrine R Carlson, Ivar Sjaastad, Ståle Nygård, Sigrid Bjørnstad, Geir Christensen, Theis Tønnesse. Differential regulation of extracellular matrix constituents in myocardial remodeling with and without heart failure following pressure overload. Matrix biology : journal of the International Society for Matrix Biology. vol 32. issue 2. 2013-09-23. PMID:23220517. |
thus, we examined potential differences in the regulation of myocardial extracellular matrix (ecm) constituents in mice with hypertrophy only (abnonhf) and with hf (abhf) as response to comparable pressure overload. |
2013-09-23 |
2023-08-12 |
mouse |
| Ville V Meretoja, Rebecca L Dahlin, Sarah Wright, F Kurtis Kasper, Antonios G Miko. The effect of hypoxia on the chondrogenic differentiation of co-cultured articular chondrocytes and mesenchymal stem cells in scaffolds. Biomaterials. vol 34. issue 17. 2013-09-12. PMID:23489925. |
cells were cultured for six weeks within porous scaffolds, and their cellularity, cartilaginous matrix production (collagen ii/i expression ratio, hydroxyproline and gag content) and hypertrophy markers (collagen x expression, alp activity, calcium accumulation) were analyzed. |
2013-09-12 |
2023-08-12 |
Not clear |
| Ville V Meretoja, Rebecca L Dahlin, Sarah Wright, F Kurtis Kasper, Antonios G Miko. The effect of hypoxia on the chondrogenic differentiation of co-cultured articular chondrocytes and mesenchymal stem cells in scaffolds. Biomaterials. vol 34. issue 17. 2013-09-12. PMID:23489925. |
acs and co-cultures showed similarly high collagen ii/i expression ratio and gag rich matrix formation, whereas mscs produced the least hyaline cartilage-like matrix and obtained a hypertrophic phenotype with eventual calcification. |
2013-09-12 |
2023-08-12 |
Not clear |
| Indira Prasadam, Xinzhan Mao, Wei Shi, Ross Crawford, Yin Xia. Combination of MEK-ERK inhibitor and hyaluronic acid has a synergistic effect on anti-hypertrophic and pro-chondrogenic activities in osteoarthritis treatment. Journal of molecular medicine (Berlin, Germany). vol 91. issue 3. 2013-09-03. PMID:22965193. |
histology, immunostaining, rt-qpcr, western blotting and zymography were performed to assess the expression of cartilage matrix proteins and hypertrophic markers. |
2013-09-03 |
2023-08-12 |
human |