| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaofeng Cui, Akihiko Hasegawa, Martin Lotz, Darryl D'Lim. Structured three-dimensional co-culture of mesenchymal stem cells with meniscus cells promotes meniscal phenotype without hypertrophy. Biotechnology and bioengineering. vol 109. issue 9. 2013-01-28. PMID:22422555. |
the meniscal and hypertrophic gene expression, gross appearance and structure of the pellets, meniscus extracellular matrix (ecm), histology and immunohistochemistry of proteoglycan and collagen were evaluated. |
2013-01-28 |
2023-08-12 |
Not clear |
| Ratnadeep Basu, Jiwon Lee, Zuocheng Wang, Vaibhav B Patel, Dong Fan, Subhash K Das, George C Liu, Rohan John, James W Scholey, Gavin Y Oudit, Zamaneh Kassir. Loss of TIMP3 selectively exacerbates diabetic nephropathy. American journal of physiology. Renal physiology. vol 303. issue 9. 2013-01-24. PMID:22896043. |
however, timp3 levels increased in akita kidneys and deletion of timp3 exacerbated the diabetic renal injury in the akita mouse, characterized by increased albuminuria, mesangial matrix expansion, and kidney hypertrophy. |
2013-01-24 |
2023-08-12 |
mouse |
| Pietro Francia, Arianna Uccellini, Alessandra Frattari, Anna Modestino, Agnese Ricotta, Cristina Balla, Ludovica Scialla, Massimo Volp. Extracellular matrix remodelling in myocardial hypertrophy and failure : focus on osteopontin. High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension. vol 16. issue 4. 2013-01-23. PMID:23334911. |
extracellular matrix remodelling in myocardial hypertrophy and failure : focus on osteopontin. |
2013-01-23 |
2023-08-12 |
rat |
| Pietro Francia, Arianna Uccellini, Alessandra Frattari, Anna Modestino, Agnese Ricotta, Cristina Balla, Ludovica Scialla, Massimo Volp. Extracellular matrix remodelling in myocardial hypertrophy and failure : focus on osteopontin. High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension. vol 16. issue 4. 2013-01-23. PMID:23334911. |
in general, evidence supports the concept that osteopontin plays a crucial role in extracellular matrix remodelling following myocardial adaptation to hypertrophic, inflammatory and neurohormonal stimuli in the overloaded heart. |
2013-01-23 |
2023-08-12 |
rat |
| Hong Zhang, Yan Zhang, Yi-Ping Jiang, Lan-Ke Zhang, Cheng Peng, Kun He, Khalid Rahman, Lu-Ping Qi. Curative effects of oleanolic Acid on formed hypertrophic scars in the rabbit ear model. Evidence-based complementary and alternative medicine : eCAM. vol 2012. 2013-01-18. PMID:23326292. |
hypertrophic scarring is a common proliferative disorder of dermal fibroblasts characterized by collagen overproduction and excessive deposition of extracellular matrix (ecm). |
2013-01-18 |
2023-08-12 |
rabbit |
| Kelei Chen, Thomas Kok Hiong Teh, Sujata Ravi, Siew Lok Toh, James Cho Hong Go. Osteochondral interface generation by rabbit bone marrow stromal cells and osteoblasts coculture. Tissue engineering. Part A. vol 18. issue 17-18. 2013-01-16. PMID:22721548. |
more importantly, chondrogenic rbmscs in the coculture system were shown to form the osteochondral interface layer by expressing calcified cartilage zone specific extracellular matrix marker collagen x and the hypertrophic chondrocyte marker mmp-13, which were not observed in the control group. |
2013-01-16 |
2023-08-12 |
rabbit |
| Nirmalya Dey, Nandini Ghosh-Choudhury, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. TGFβ-stimulated microRNA-21 utilizes PTEN to orchestrate AKT/mTORC1 signaling for mesangial cell hypertrophy and matrix expansion. PloS one. vol 7. issue 8. 2013-01-10. PMID:22879939. |
tgfβ-stimulated microrna-21 utilizes pten to orchestrate akt/mtorc1 signaling for mesangial cell hypertrophy and matrix expansion. |
2013-01-10 |
2023-08-12 |
Not clear |
| Nirmalya Dey, Nandini Ghosh-Choudhury, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. TGFβ-stimulated microRNA-21 utilizes PTEN to orchestrate AKT/mTORC1 signaling for mesangial cell hypertrophy and matrix expansion. PloS one. vol 7. issue 8. 2013-01-10. PMID:22879939. |
transforming growth factor-β (tgfβ) promotes glomerular hypertrophy and matrix expansion, leading to glomerulosclerosis. |
2013-01-10 |
2023-08-12 |
Not clear |
| Nirmalya Dey, Nandini Ghosh-Choudhury, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. TGFβ-stimulated microRNA-21 utilizes PTEN to orchestrate AKT/mTORC1 signaling for mesangial cell hypertrophy and matrix expansion. PloS one. vol 7. issue 8. 2013-01-10. PMID:22879939. |
specific mir-21 targets downstream of tgfβ receptor activation that control cell hypertrophy and matrix protein expression have not been studied. |
2013-01-10 |
2023-08-12 |
Not clear |
| Nirmalya Dey, Nandini Ghosh-Choudhury, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. TGFβ-stimulated microRNA-21 utilizes PTEN to orchestrate AKT/mTORC1 signaling for mesangial cell hypertrophy and matrix expansion. PloS one. vol 7. issue 8. 2013-01-10. PMID:22879939. |
our results uncover an essential role of tgfβ-induced expression of mir-21, which targets pten to initiate a non-canonical signaling circuit involving akt/mtorc1 axis for mesangial cell hypertrophy and matrix protein synthesis. |
2013-01-10 |
2023-08-12 |
Not clear |
| M A Anwar, J Shalhoub, C S Lim, M S Gohel, A H Davie. The effect of pressure-induced mechanical stretch on vascular wall differential gene expression. Journal of vascular research. vol 49. issue 6. 2013-01-03. PMID:22796658. |
morphological and molecular changes in blood vessels ascribed to elevated pressure consist of endothelial damage, neointima formation, activation of inflammatory cascades, hypertrophy, migration and phenotypic changes in vascular smooth muscle cells, as well as extracellular matrix imbalances. |
2013-01-03 |
2023-08-12 |
Not clear |
| Jacqueline Frida Schmitt, Kwee Hua See, See Kwee Hua, Zheng Yang, Yang Zheng, James Hoi Po Hui, James Hui Hoi Po, Eng Hin Lee, Lee Eng Hi. Sequential differentiation of mesenchymal stem cells in an agarose scaffold promotes a physis-like zonal alignment of chondrocytes. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 30. issue 11. 2012-12-17. PMID:22517299. |
the resultant samples displayed a heterogenic population of physis-like collagen type 2 positive cells including proliferating chondrocytes and mature chondrocytes showing hypertrophy, expression of early bone markers and matrix mineralization. |
2012-12-17 |
2023-08-12 |
human |
| Jacqueline Frida Schmitt, Kwee Hua See, See Kwee Hua, Zheng Yang, Yang Zheng, James Hoi Po Hui, James Hui Hoi Po, Eng Hin Lee, Lee Eng Hi. Sequential differentiation of mesenchymal stem cells in an agarose scaffold promotes a physis-like zonal alignment of chondrocytes. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 30. issue 11. 2012-12-17. PMID:22517299. |
the less mature chondrocytes were seen at the base of the construct while hypertrophic chondrocytes and matrix mineralization was observed closer to the surface of the construct. |
2012-12-17 |
2023-08-12 |
human |
| Samy L Habib, Mukesh Yadav, Shaza Tizani, Basant Bhandari, Anthony J Valent. Tuberin inhibits production of the matrix protein fibronectin in diabetes. Journal of the American Society of Nephrology : JASN. vol 23. issue 10. 2012-12-13. PMID:22904348. |
taken together, these data suggest that tuberin plays a central role in the development of renal hypertrophy and in modulating the production of the matrix protein fibronectin in diabetes. |
2012-12-13 |
2023-08-12 |
rat |
| Alsayed Ahmed Alnahal, Usama Ahmed Khalil, Magada Alsayed Diab, Ali Fahmy Zanat. Expression of angiotensin-converting enzyme mRNA gene in the kidneys of patients with glomerulonephrites. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia. vol 23. issue 5. 2012-12-04. PMID:22982912. |
in conclusion, a higher level of ace mrna gene expression in patients suffering from gn may suggest a role of the ras in the process of gn, perhaps contributing to glomerular hypertrophy and matrix overproduction. |
2012-12-04 |
2023-08-12 |
human |
| Patrick Lacolley, Véronique Regnault, Antonino Nicoletti, Zhenlin Li, Jean-Baptiste Miche. The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles. Cardiovascular research. vol 95. issue 2. 2012-11-23. PMID:22467316. |
vsmcs of conduit arteries respond to hypertension-induced increases in wall stress by an increase in cell protein synthesis (hypertrophy) and extracellular matrix secretion. |
2012-11-23 |
2023-08-12 |
human |
| Debbie Y Dao, Jennifer H Jonason, Yongchun Zhang, Wei Hsu, Di Chen, Matthew J Hilton, Regis J O'Keef. Cartilage-specific β-catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 27. issue 8. 2012-11-23. PMID:22508079. |
second, cartilage-specific β-catenin facilitates primary and secondary ossification center formation via the induction of chondrocyte hypertrophy, possibly through enhanced matrix metalloproteinase (mmp) expression at sites of cartilage degradation, and potentially by enhancing indian hedgehog (ihh) signaling activity to recruit vascular tissues. |
2012-11-23 |
2023-08-12 |
mouse |
| Yuan Zhang, Amanda J Edgley, Alison J Cox, Andrew K Powell, Bing Wang, Andrew R Kompa, David I Stapleton, Steven C Zammit, Spencer J Williams, Henry Krum, Richard E Gilbert, Darren J Kell. FT011, a new anti-fibrotic drug, attenuates fibrosis and chronic heart failure in experimental diabetic cardiomyopathy. European journal of heart failure. vol 14. issue 5. 2012-11-19. PMID:22417655. |
cardiac remodelling in diabetes includes pathological accumulation of extracellular matrix and myocyte hypertrophy that contribute to heart dysfunction. |
2012-11-19 |
2023-08-12 |
rat |
| Zhou-Yan Bian, Xiang Wei, Shan Deng, Qi-Zhu Tang, Jinghua Feng, Yan Zhang, Chen Liu, Ding-Sheng Jiang, Ling Yan, Lian-Feng Zhang, Manyin Chen, John Fassett, Yingjie Chen, You-Wen He, Qinglin Yang, Peter P Liu, Hongliang L. Disruption of mindin exacerbates cardiac hypertrophy and fibrosis. Journal of molecular medicine (Berlin, Germany). vol 90. issue 8. 2012-11-16. PMID:22367478. |
cardiac hypertrophy is a response of the myocardium to increased workload and is characterised by an increase of myocardial mass and an accumulation of extracellular matrix (ecm). |
2012-11-16 |
2023-08-12 |
mouse |
| Gunnar Wagner, Michael Max Sachs. Congenital malalignment of the big toe nail. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG. vol 10. issue 5. 2012-11-13. PMID:22117849. |
this longitudinal axis shift is due to a deviation of the nail matrix, possibly caused by increased traction of the hypertrophic extensor tendon of the hallux. |
2012-11-13 |
2023-08-12 |
Not clear |