| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maya Molinari, Ori J Lieberman, David Sulzer, Emanuela Santini, Anders Borgkvis. 5-HT1B receptors mediate dopaminergic inhibition of vesicular fusion and GABA release from striatonigral synapses. bioRxiv : the preprint server for biology. 2024-04-01. PMID:38559006. |
these d1rs are primarily located on the terminals of striatonigral medium spiny neurons, suggesting their involvement in the regulation of neurotransmitter release from the direct pathway in response to somatodendritic dopamine release. |
2024-04-01 |
2024-04-04 |
Not clear |
| Andrew D Chapp, Chinonso A Nwakama, Pramit P Jagtap, Chau-Mi H Phan, Mark J Thomas, Paul G Mermelstei. Fundamental Sex Differences in Cocaine-Induced Plasticity of Dopamine D1 Receptor- and D2 Receptor-Expressing Medium Spiny Neurons in the Mouse Nucleus Accumbens Shell. Biological psychiatry global open science. vol 4. issue 3. 2024-03-27. PMID:38533248. |
fundamental sex differences in cocaine-induced plasticity of dopamine d1 receptor- and d2 receptor-expressing medium spiny neurons in the mouse nucleus accumbens shell. |
2024-03-27 |
2024-03-29 |
mouse |
| Vladimir Babenko, Olga Redina, Dmitry Smagin, Irina Kovalenko, Anna Galyamina, Natalia Kudryavtsev. Brain-Region-Specific Genes Form the Major Pathways Featuring Their Basic Functional Role: Their Implication in Animal Chronic Stress Model. International journal of molecular sciences. vol 25. issue 5. 2024-03-13. PMID:38474132. |
the most connected pathways, along with the highest brsg number, were observed in the striatum, referred to as medium spiny neurons (msns), which make up 95% of neurons and exhibit synchronous firing upon dopamine influx. |
2024-03-13 |
2024-03-15 |
mouse |
| Kangsheng Zhu, Siruan Chen, Xia Qin, Wanjun Bai, Jie Hao, Xiaolei Xu, Han Guo, Hui Bai, Zuxiao Yang, Sheng Wang, Zongmao Zhao, Tengfei Ji, Dezhi Kong, Wei Zhan. Exploring the therapeutic potential of cannabidiol for sleep deprivation-induced hyperalgesia. Neuropharmacology. 2024-03-01. PMID:38428482. |
the nucleus accumbens (nac) plays a crucial role in the modulation of pain and sleep, with its activity regulated by two distinct types of medium spiny neurons (msns) expressing dopamine 1 or dopamine 2 (d1-or d2) receptors (referred to as d1-msns and d2-msns, respectively). |
2024-03-01 |
2024-03-04 |
mouse |
| Yu-Ting Huang, Ya-Wen Chen, Tze-Yen Lin, Jin-Chung Che. Suppression of presynaptic corticostriatal glutamate activity attenuates L-dopa-induced dyskinesia in 6-OHDA-lesioned Parkinson's disease mice. Neurobiology of disease. 2024-02-24. PMID:38401650. |
this condition results from both dopamine (da)-dependent and da-independent mechanisms, as glutamate inputs from corticostriatal projection neurons impact da-responsive medium spiny neurons in the striatum to cause the dyskinetic behaviors. |
2024-02-24 |
2024-02-27 |
mouse |
| Dillon S McDevitt, Quinn W Wade, Greer E McKendrick, Jacob Nelsen, Mariya Starostina, Nam Tran, Julie A Blendy, Nicholas M Grazian. The paraventricular thalamic nucleus and its projections in regulating reward and context associations. eNeuro. 2024-02-13. PMID:38351131. |
lastly, using brain slice electrophysiology, we found that bath perfused morphine (10 μm) significantly reduced pvt excitatory synaptic transmission on both dopamine d1-receptor and d2-receptor expressing medium spiny neurons in the nacsh, but that inhibiting pvt afferents in the nacsh was not sufficient to evoke cpp. |
2024-02-13 |
2024-02-16 |
mouse |
| Yue Zhang, Jingwen Gao, Na Li, Peng Xu, Shimeng Qu, Jinqian Cheng, Mingrui Wang, Xueru Li, Yaheng Song, Fan Xiao, Xinyu Yang, Jihong Liu, Hao Hong, Ronghao Mu, Xiaotian Li, Youmei Wang, Hui Xu, Yuan Xie, Tianming Gao, Guangji Wang, Jiye A. Targeting cAMP in D1-MSNs in the nucleus accumbens, a new rapid antidepressant strategy. Acta pharmaceutica Sinica. B. vol 14. issue 2. 2024-02-07. PMID:38322327. |
here, we identified a specific reduction of cyclic adenosine monophosphate (camp) in the subset of dopamine d1 receptor medium spiny neurons (d1-msns) in the nac that promoted stress susceptibility, while the stimulation of camp production in nac d1-msns efficiently rescued depression-like behaviors. |
2024-02-07 |
2024-02-09 |
mouse |
| Yue Zhang, Jingwen Gao, Na Li, Peng Xu, Shimeng Qu, Jinqian Cheng, Mingrui Wang, Xueru Li, Yaheng Song, Fan Xiao, Xinyu Yang, Jihong Liu, Hao Hong, Ronghao Mu, Xiaotian Li, Youmei Wang, Hui Xu, Yuan Xie, Tianming Gao, Guangji Wang, Jiye A. Targeting cAMP in D1-MSNs in the nucleus accumbens, a new rapid antidepressant strategy. Acta pharmaceutica Sinica. B. vol 14. issue 2. 2024-02-07. PMID:38322327. |
ketamine treatment enhanced camp both in d1-msns and dopamine d2 receptor medium spiny neurons (d2-msns) of depressed mice, however, the rapid antidepressant effect of ketamine solely depended on elevating camp in nac d1-msns. |
2024-02-07 |
2024-02-09 |
mouse |
| Sydney P Weiner, Carolina Vasquez, Soomin Song, Kaiyang Zhao, Omar Ali, Danielle Rosenkilde, Robert C Froemke, Kenneth D Car. Sex difference in the effect of environmental enrichment on food restriction-induced persistence of cocaine conditioned place preference and mechanistic underpinnings. Addiction neuroscience. vol 10. 2024-02-07. PMID:38323217. |
mechanistic studies provided evidence of decreased basal dopamine (da) transmission, adaptive upregulation of signaling downstream of d1 da receptor stimulation, synaptic upscaling and incorporation of calcium-permeable ampa receptors (cp-ampars) in medium spiny neurons (msns) of nucleus accumbens (nac). |
2024-02-07 |
2024-02-09 |
rat |
| Sarah E Swinford-Jackson, Matthew T Rich, Phillip J Huffman, Melissa C Knouse, Arthur S Thomas, Sharvari Mankame, Samantha J Worobey, R Christopher Pierc. Low frequency deep brain stimulation of nucleus accumbens shell neuronal subpopulations attenuates cocaine seeking selectively in male rats. Addiction neuroscience. vol 9. 2024-02-05. PMID:38312329. |
nucleus accumbens medium spiny neurons (msns) can be differentiated by expression of dopamine d1 receptors (d1drs) or d2drs. |
2024-02-05 |
2024-02-07 |
rat |
| Xiaohui Bai, Kun Zhang, Chaopeng Ou, Yanyu Mu, Dongmei Chi, Jianxing Zhang, Jingxiu Huang, Xile Li, Yingjun Zhang, Wan Huang, Handong Ouyan. AKAP150 from nucleus accumbens dopamine D1 and D2 receptor-expressing medium spiny neurons regulates morphine withdrawal. iScience. vol 26. issue 11. 2023-11-13. PMID:37953959. |
akap150 from nucleus accumbens dopamine d1 and d2 receptor-expressing medium spiny neurons regulates morphine withdrawal. |
2023-11-13 |
2023-11-20 |
Not clear |
| Xiaohui Bai, Kun Zhang, Chaopeng Ou, Yanyu Mu, Dongmei Chi, Jianxing Zhang, Jingxiu Huang, Xile Li, Yingjun Zhang, Wan Huang, Handong Ouyan. AKAP150 from nucleus accumbens dopamine D1 and D2 receptor-expressing medium spiny neurons regulates morphine withdrawal. iScience. vol 26. issue 11. 2023-11-13. PMID:37953959. |
dopamine d1 receptor-expressing medium spiny neurons (d1r-msns) and dopamine d2 receptor-expressing msns (d2r-msns) in nucleus accumbens (nac) have been demonstrated to show different effects on reward and memory of abstinence. |
2023-11-13 |
2023-11-20 |
Not clear |
| Cátia Santa, Diana Rodrigues, Joana F Coelho, Sandra I Anjo, Vera M Mendes, Diogo Bessa-Neto, Michael J Dunn, David Cotter, Graça Baltazar, Patrícia Monteiro, Bruno Manada. Chronic treatment with D2-antagonist haloperidol leads to inhibitory/excitatory imbalance in striatal D1-neurons. Translational psychiatry. vol 13. issue 1. 2023-10-06. PMID:37803004. |
cell-type specific electrophysiological recordings further revealed that haloperidol not only reduces the excitability of striatal medium spiny neurons expressing dopamine d2 receptors (d2-msns) but also affects d1-msns by increasing the ratio of inhibitory/excitatory synaptic transmission (i/e ratio) specifically onto d1-msns but not d2-msns. |
2023-10-06 |
2023-10-15 |
mouse |
| Lining Yin, Fang Han, Ying Yu, Qingyun Wan. A computational network dynamical modeling for abnormal oscillation and deep brain stimulation control of obsessive-compulsive disorder. Cognitive neurodynamics. vol 17. issue 5. 2023-10-03. PMID:37786657. |
particularly, the ocd lesion process is simulated by the loss of connectivity from striatal parvalbumin interneurons (pv) to medium spiny neurons (msns), excessive activation to the hyperdirect pathway, and high dopamine concentrations. |
2023-10-03 |
2023-10-07 |
Not clear |
| Kanako Matsumura, Amélia Nicot, In Bae Choi, Meera Asokan, Nathan N Le, Luis A Natividad, Lauren K Dobb. Endogenous opioid system modulates conditioned cocaine reward in a sex-dependent manner. Addiction biology. vol 28. issue 10. 2023-09-27. PMID:37753570. |
to address this, we generated mice with a targeted deletion of enkephalin from dopamine d2-receptor expressing medium spiny neurons and tested them in a cocaine cpp paradigm. |
2023-09-27 |
2023-10-07 |
mouse |
| Nadine J Ortner, Anupam Sah, Enrica Paradiso, Josef Shin, Strahinja Stojanovic, Niklas Hammer, Maria Haritonova, Nadja T Hofer, Andrea Marcantoni, Laura Guarina, Petronel Tuluc, Tamara Theiner, Florian Pitterl, Karl Ebner, Herbert Oberacher, Emilio Carbone, Nadia Stefanova, Francesco Ferraguti, Nicolas Singewald, Jochen Roeper, Joerg Striessni. The human channel gating-modifying A749G CACNA1D (Cav1.3) variant induces a neurodevelopmental syndrome-like phenotype in mice. JCI insight. 2023-09-12. PMID:37698939. |
the a749g mutation induced aberrant excitability of dorsomedial striatum-projecting substantia nigra dopamine neurons and medium spiny neurons in the dorsal striatum. |
2023-09-12 |
2023-10-07 |
mouse |
| Timothy J Collier, Lauren Begg, Jennifer A Stancati, Natosha M Mercado, Rhyomi C Sellnow, Ivette M Sandoval, Caryl E Sortwell, Kathy Steece-Collie. Quinpirole inhibits levodopa-induced dyskinesias at structural and behavioral levels: Efficacy negated by co-administration of isradipine. Experimental neurology. 2023-08-28. PMID:37640098. |
dopamine depletion associated with parkinsonism induces plastic changes in striatal medium spiny neurons (msn) that are maladaptive and associated with the emergence of the negative side-effect of standard treatment: the abnormal involuntary movements termed levodopa-induced dyskinesia (lid). |
2023-08-28 |
2023-09-07 |
rat |
| Dengfeng Liu, Zhengyu Xie, Panyang Gu, Xiangyu Li, Yichun Zhang, Xinying Wang, Zhiheng Chen, Suixin Deng, Yousheng Shu, Jia-Da L. Cry1Δ11 mutation induces ADHD-like symptoms through hyperactive dopamine D1 receptor signaling. JCI insight. vol 8. issue 16. 2023-08-22. PMID:37606043. |
we further demonstrated that upregulated c-fos was mainly localized in dopamine d1 receptor-expressing medium spiny neurons (drd1-msns) in the nac. |
2023-08-22 |
2023-09-07 |
mouse |
| Sriparna Ghosal, Elias Gebara, Eva Ramos-Fernández, Alessandro Chioino, Jocelyn Grosse, Isabelle Guillot de Suduiraut, Olivia Zanoletti, Bernard Schneider, Antonio Zorzano, Simone Astori, Carmen Sand. Mitofusin-2 in nucleus accumbens D2-MSNs regulates social dominance and neuronal function. Cell reports. vol 42. issue 7. 2023-07-13. PMID:37440411. |
in mice, selective mfn2 downregulation in nac dopamine d2 receptor-expressing medium spiny neurons (d2-msns) induced social subordination, accompanied by decreased accumbal mitochondrial functions and decreased excitability in d2-msns. |
2023-07-13 |
2023-08-14 |
mouse |
| Suthinee Attachaipanich, Takaaki Ozawa, Tom Macpherson, Takatoshi Hikid. Dual roles for nucleus accumbens core dopamine D1-expressing neurons projecting to the substantia nigra pars reticulata in limbic and motor control in male mice. eNeuro. 2023-05-26. PMID:37236787. |
as part of this circuit, dopamine d1 receptor-expressing medium spiny neurons (d1-msns) of the nac core are known to send a major projection to the substantia nigra pars reticulata (snr). |
2023-05-26 |
2023-08-14 |
mouse |