| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiayi Lu, Yifeng Cheng, Xueyi Xie, Kayla Woodson, Jordan Bonifacio, Emily Disney, Britton Barbee, Xuehua Wang, Mariam Zaidi, Jun Wan. Whole-Brain Mapping of Direct Inputs to Dopamine D1 and D2 Receptor-Expressing Medium Spiny Neurons in the Posterior Dorsomedial Striatum. eNeuro. vol 8. issue 1. 2021-06-18. PMID:33380525. |
whole-brain mapping of direct inputs to dopamine d1 and d2 receptor-expressing medium spiny neurons in the posterior dorsomedial striatum. |
2021-06-18 |
2023-08-13 |
mouse |
| Jiayi Lu, Yifeng Cheng, Xueyi Xie, Kayla Woodson, Jordan Bonifacio, Emily Disney, Britton Barbee, Xuehua Wang, Mariam Zaidi, Jun Wan. Whole-Brain Mapping of Direct Inputs to Dopamine D1 and D2 Receptor-Expressing Medium Spiny Neurons in the Posterior Dorsomedial Striatum. eNeuro. vol 8. issue 1. 2021-06-18. PMID:33380525. |
the posterior dorsomedial striatum (pdms) is mainly composed of medium spiny neurons (msns) expressing either dopamine d1 receptors (d1rs) or d2rs. |
2021-06-18 |
2023-08-13 |
mouse |
| Chiara Melis, Genevieve Beauvais, Brian S Muntean, Maria-Daniela Cirnaru, Garrett Otrimski, Jordi Creus-Muncunill, Kirill A Martemyanov, Pedro Gonzalez-Alegre, Michelle E Ehrlic. Striatal Dopamine Induced ERK Phosphorylation Is Altered in Mouse Models of Monogenic Dystonia. Movement disorders : official journal of the Movement Disorder Society. vol 36. issue 5. 2021-05-19. PMID:33458877. |
molecularly, it is characterized by hyper-induction of phosphorylation of extracellular signal-related kinase in response to dopamine in medium spiny neurons of the direct pathway. |
2021-05-19 |
2023-08-13 |
mouse |
| Guihua Xiao, Yilin Song, Yu Zhang, Yu Xing, Shengwei Xu, Mixia Wang, Junbo Wang, Deyong Chen, Jian Chen, Xinxia Ca. Dopamine and Striatal Neuron Firing Respond to Frequency-Dependent DBS Detected by Microelectrode Arrays in the Rat Model of Parkinson's Disease. Biosensors. vol 10. issue 10. 2021-04-16. PMID:32998190. |
(2) methods: in this work, nanocomposites-modified implantable microelectrode arrays (meas) were fabricated to synchronously record changes of dopamine (da) concentration and striatal neuron firing in the striatum during subthalamic nucleus dbs, and different responses of medium spiny projecting neurons (msns) and fast spiking interneurons (fsis) to dbs were analyzed. |
2021-04-16 |
2023-08-13 |
rat |
| Jean-Pierre Roussarie, Patricia Rodriguez-Rodrigue. Deciphering cell-type specific signal transduction in the brain: Challenges and promises. Advances in pharmacology (San Diego, Calif.). vol 90. 2021-04-07. PMID:33706931. |
decades after the discovery that dopamine triggers opposing signaling pathways in d1- and d2-expressing medium spiny neurons, it is now clear that there are as many different flavors of signaling pathways in the brain as there are neuron types. |
2021-04-07 |
2023-08-13 |
Not clear |
| Frank S Menniti, Thomas A Chappie, Christopher J Schmid. PDE10A Inhibitors-Clinical Failure or Window Into Antipsychotic Drug Action? Frontiers in neuroscience. vol 14. 2021-02-10. PMID:33551724. |
selective activation of indirect pathway medium spiny neurons by dopamine d2 receptor antagonists is putatively a key element in the mechanism of their antipsychotic efficacy. |
2021-02-10 |
2023-08-13 |
Not clear |
| Frank S Menniti, Thomas A Chappie, Christopher J Schmid. PDE10A Inhibitors-Clinical Failure or Window Into Antipsychotic Drug Action? Frontiers in neuroscience. vol 14. 2021-02-10. PMID:33551724. |
while pde10a is expressed in all medium spiny neurons, studies in rodents indicated that pde10a inhibition has behavioral effects in several key assays that phenocopy dopamine d2 receptor inhibition. |
2021-02-10 |
2023-08-13 |
Not clear |
| Ainhoa Bilbao, Daniela Neuhofer, Marja Sepers, Shou-Peng Wei, Manuela Eisenhardt, Sarah Hertle, Olivier Lassalle, Almudena Ramos-Uriarte, Nagore Puente, Raissa Lerner, Aurore Thomazeau, Pedro Grandes, Beat Lutz, Olivier J Manzoni, Rainer Spanage. Endocannabinoid LTD in Accumbal D1 Neurons Mediates Reward-Seeking Behavior. iScience. vol 23. issue 3. 2021-01-10. PMID:32179475. |
synaptic plasticity in dopamine d1 and d2 receptor medium spiny neurons (msns) of the nac and the endogenous cannabinoid (ecb) system have been implicated in reward seeking. |
2021-01-10 |
2023-08-13 |
Not clear |
| Ludovica Maddalena Rossi, Ingrid Reverte, Davide Ragozzino, Aldo Badiani, Marco Venniro, Daniele Capriol. Role of nucleus accumbens core but not shell in incubation of methamphetamine craving after voluntary abstinence. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 2. 2020-12-28. PMID:31422417. |
we used rnascope in-situ hybridization to quantify the colabeling of the neuronal activity marker fos, and dopamine drd1- and drd2-expressing medium spiny neurons (msns) in nac core and shell during the incubation tests. |
2020-12-28 |
2023-08-13 |
human |
| Yafang Zhang, Michelle W Kahng, Jaclynn A Elkind, Vanessa R Weir, Nicole S Hernandez, Lauren M Stein, Heath D Schmid. Activation of GLP-1 receptors attenuates oxycodone taking and seeking without compromising the antinociceptive effects of oxycodone in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 3. 2020-12-28. PMID:31581176. |
to identify a central site of action, we showed that systemic exendin-4 penetrated the brain and bound putative glp-1 receptors on dopamine d1 receptor- and dopamine d2 receptor-expressing medium spiny neurons in the nucleus accumbens shell. |
2020-12-28 |
2023-08-13 |
rat |
| Cheryl Brandenburg, Jean-Jacques Soghomonian, Kunzhong Zhang, Ina Sulkaj, Brianna Randolph, Marissa Kachadoorian, Gene J Blat. Increased Dopamine Type 2 Gene Expression in the Dorsal Striatum in Individuals With Autism Spectrum Disorder Suggests Alterations in Indirect Pathway Signaling and Circuitry. Frontiers in cellular neuroscience. vol 14. 2020-11-27. PMID:33240045. |
excitatory dopamine (da) type 1 receptors are predominantly expressed on gabaergic medium spiny neurons (msns) in the dorsal striatum as part of the "direct pathway" to gpi and snpr whereas inhibitory da type 2 receptors are predominantly expressed on msns that primarily project to gpe. |
2020-11-27 |
2023-08-13 |
Not clear |
| Akina Harada, Nidhi Kaushal, Kazunori Suzuki, Atsushi Nakatani, Konstantin Bobkov, John A Vekich, Joseph P Doyle, Haruhide Kimur. Balanced Activation of Striatal Output Pathways by Faster Off-Rate PDE10A Inhibitors Elicits Not Only Antipsychotic-Like Effects But Also Procognitive Effects in Rodents. The international journal of neuropsychopharmacology. vol 23. issue 2. 2020-11-25. PMID:31689714. |
we previously reported that the cyclic adenosine monophosphate concentration in dopamine d1 receptor-expressing medium spiny neurons (d1-msns) may be higher than that in d2-msns. |
2020-11-25 |
2023-08-13 |
Not clear |
| Sarah Zych, Christopher P For. Opioid-Induced Adaptations of cAMP Dynamics in the Nucleus Accumbens. Trends in pharmacological sciences. vol 41. issue 4. 2020-11-05. PMID:31964511. |
to investigate how opioid exposure alters dopamine (da) responses in medium spiny neurons (msns), muntean et al. |
2020-11-05 |
2023-08-13 |
Not clear |
| Renato Socodat. Dopamine D1 receptor signaling and endocannabinoid cooperate to fuel striatal plasticity: An Editorial Highlight for "Cyclic AMP-dependent protein kinase and D1 dopamine receptors regulate diacylglycerol lipase-α and synaptic 2-arachidonoyl glycerol signaling" on page 334. Journal of neurochemistry. vol 153. issue 3. 2020-11-04. PMID:32091130. |
this editorial highlights the study by shonesy et al., which presents evidence that activation of dopamine d1 receptor and its classical downstream target camp-dependent protein kinase (pka) are involved in increasing the synthesis of 2-ag in striatal medium spiny neurons (msn) to drive dse in the corticostriatal circuit, as schematically outlined in figure 1. |
2020-11-04 |
2023-08-13 |
Not clear |
| Sarah Thoeni, Michaël Loureiro, Eoin C O'Connor, Christian Lüsche. Depression of Accumbal to Lateral Hypothalamic Synapses Gates Overeating. Neuron. vol 107. issue 1. 2020-10-08. PMID:32333845. |
dopamine d1 receptor-expressing medium spiny neurons (d1-msns) of the nucleus accumbens shell (nacsh) project to the lateral hypothalamus (lh) to authorize feeding when inhibited. |
2020-10-08 |
2023-08-13 |
Not clear |
| Tom Macpherson, Takatoshi Hikid. Nucleus Accumbens Dopamine D1-Receptor-Expressing Neurons Control the Acquisition of Sign-Tracking to Conditioned Cues in Mice. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:29977188. |
however, currently, the possible roles of dorsal striatal subregions, as well as of the two major striatal neuron types, dopamine d1-/d2-expressing medium spiny neurons (msns), in controlling the development of conditioned responses is still unclear and warrants further study. |
2020-10-01 |
2023-08-13 |
mouse |
| Yasumasa Ueda, Ko Yamanaka, Atsushi Noritake, Kazuki Enomoto, Naoyuki Matsumoto, Hiroshi Yamada, Kazuyuki Samejima, Hitoshi Inokawa, Yukiko Hori, Kae Nakamura, Minoru Kimur. Distinct Functions of the Primate Putamen Direct and Indirect Pathways in Adaptive Outcome-Based Action Selection. Frontiers in neuroanatomy. vol 11. 2020-09-30. PMID:28824386. |
reinforcement learning models posit that action reward value is encoded by the firing activity of striatal medium spiny neurons (msns) and updated upon changing reinforcement contingencies by dopamine (da) signaling to these neurons. |
2020-09-30 |
2023-08-13 |
monkey |
| Karen Brami-Cherrier, Robert G Lewis, Marlene Cervantes, Yu Liu, Paola Tognini, Pierre Baldi, Paolo Sassone-Corsi, Emiliana Borrell. Cocaine-mediated circadian reprogramming in the striatum through dopamine D2R and PPARγ activation. Nature communications. vol 11. issue 1. 2020-09-30. PMID:32895370. |
pparγ reprogramming is altered in mice with cell-specific ablation of the dopamine d2 receptor (d2r) in the striatal medium spiny neurons (msns) (imsn-d2rko). |
2020-09-30 |
2023-08-13 |
mouse |
| Sara Schiavi, Daniela Iezzi, Antonia Manduca, Stefano Leone, Francesca Melancia, Carmen Carbone, Michele Petrella, Guido Mannaioni, Alessio Masi, Viviana Trezz. Reward-Related Behavioral, Neurochemical and Electrophysiological Changes in a Rat Model of Autism Based on Prenatal Exposure to Valproic Acid. Frontiers in cellular neuroscience. vol 13. 2020-09-29. PMID:31708750. |
in addition, vpa-exposed rats showed altered expression of dopamine receptors together with inherent hyperexcitability of medium spiny neurons (msns) in the nucleus accumbens (nac). |
2020-09-29 |
2023-08-13 |
rat |
| Manuela Ingallinesi, Benjamin Galet, Jonathan Pegon, Nicole Faucon Biguet, Anh Do Thi, Mark J Millan, Clotilde Mannoury la Cour, Rolando Melon. Knock-Down of GPR88 in the Dorsal Striatum Alters the Response of Medium Spiny Neurons to the Loss of Dopamine Input and L-3-4-Dyhydroxyphenylalanine. Frontiers in pharmacology. vol 10. 2020-09-29. PMID:31708775. |
knock-down of gpr88 in the dorsal striatum alters the response of medium spiny neurons to the loss of dopamine input and l-3-4-dyhydroxyphenylalanine. |
2020-09-29 |
2023-08-13 |
rat |