| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Suthinee Attachaipanich, Takaaki Ozawa, Tom Macpherson, Takatoshi Hikid. Dual roles for nucleus accumbens core dopamine D1-expressing neurons projecting to the substantia nigra pars reticulata in limbic and motor control in male mice. eNeuro. 2023-05-26. PMID:37236787. |
as part of this circuit, dopamine d1 receptor-expressing medium spiny neurons (d1-msns) of the nac core are known to send a major projection to the substantia nigra pars reticulata (snr). |
2023-05-26 |
2023-08-14 |
mouse |
| Tadaaki Nishioka, Suthinee Attachaipanich, Kosuke Hamaguchi, Michael Lazarus, Alban de Kerchove d'Exaerde, Tom Macpherson, Takatoshi Hikid. Error-related signaling in nucleus accumbens D2 receptor-expressing neurons guides inhibition-based choice behavior in mice. Nature communications. vol 14. issue 1. 2023-04-21. PMID:37085502. |
the encoding of such cue-outcome associations, as well as the performance of cue-guided choice behavior, is thought to involve dopamine d1 and d2 receptor-expressing medium spiny neurons (d1-/d2-msns) of the nucleus accumbens (nac). |
2023-04-21 |
2023-08-14 |
mouse |
| Alexa R Zimbelman, Benjamin Wong, Conor H Murray, Marina E Wolf, Michael T Stefani. Dopamine D1 and NMDA receptor co-regulation of protein translation in cultured nucleus accumbens neurons. bioRxiv : the preprint server for biology. 2023-04-10. PMID:37034633. |
we used nucleus accumbens (nac) medium spiny neurons (msn), co-cultured with cortical neurons to restore excitatory synapses, to examine whether dopamine modulates protein translation in nac msn. |
2023-04-10 |
2023-08-14 |
Not clear |
| Manli Zhong, Yuhan Wang, Geng Lin, Francesca-Fang Liao, Fu-Ming Zho. Dopamine-independent development and maintenance of mouse striatal medium spiny neuron dendritic spines. Neurobiology of disease. 2023-03-31. PMID:37001611. |
striatal medium spiny neurons (msns) and striatal dopamine (da) innervation are profoundly important for brain function such as motor control and cognition. |
2023-03-31 |
2023-08-14 |
mouse |
| Huan Sheng, Chao Lei, Yu Yuan, Yali Fu, Dongyang Cui, Li Yang, Da Shao, Zixuan Cao, Hao Yang, Xinli Guo, Chenshan Chu, Yaxian Wen, Zhangyin Cai, Ming Chen, Bin Lai, Ping Zhen. Nucleus accumbens circuit disinhibits lateral hypothalamus glutamatergic neurons contributing to morphine withdrawal memory in male mice. Nature communications. vol 14. issue 1. 2023-01-05. PMID:36604429. |
in the present study,our results showed that in male mice, during context-induced expression of morphine withdrawal memory, lh glutamatergic neurons played an important role; dopamine d1 receptor-expressing medium spiny neurons (d1-msns) projecting from the core of nucleus accumbens (nacc) to the lh were an important upstream circuit to activate lh glutamatergic neurons; d1-msns projecting from the nacc to the lh activated lh glutamatergic neurons through inhibiting lh local gamma-aminobutyric acid (gaba) neurons. |
2023-01-05 |
2023-08-14 |
mouse |
| Edwin J C G van den Oord, Lin Y Xie, Min Zhao, Karolina A Aberg, Shaunna L Clar. A single-nucleus transcriptomics study of alcohol use disorder in the nucleus accumbens. Addiction biology. vol 28. issue 1. 2022-12-28. PMID:36577731. |
we detected 26 transcriptome-wide significant differentially expressed genes (degs) that mainly involved medium spiny neurons with both d1-type and d2-type dopamine receptors, microglia (mgl) and oligodendrocytes. |
2022-12-28 |
2023-08-14 |
Not clear |
| Akiyo Natsubori, Momoka Miyazawa, Takashi Kojima, Makoto Hond. Region-specific involvement of ventral striatal dopamine D2 receptor-expressing medium spiny neurons in nociception. Neuroscience research. 2022-12-22. PMID:36549387. |
region-specific involvement of ventral striatal dopamine d2 receptor-expressing medium spiny neurons in nociception. |
2022-12-22 |
2023-08-14 |
Not clear |
| Youngcho Kim, Dennis Jung, Mayu Oya, Morgan Kennedy, Tomas Lence, Stephanie L Alberico, Nandakumar S Narayana. Phase-adaptive brain stimulation of striatal D1 medium spiny neurons in dopamine-depleted mice. Scientific reports. vol 12. issue 1. 2022-12-16. PMID:36526822. |
we focused on striatal medium spiny neurons expressing d1-type dopamine receptors because these neurons can facilitate movement. |
2022-12-16 |
2023-08-14 |
mouse |
| Sarah E Swinford-Jackson, Phillip J Huffman, Melissa C Knouse, Arthur S Thomas, Matthew T Rich, Sharvari Mankame, Samantha J Worobey, Mateo Sarmiento, Ayanna Coleman, R Christopher Pierc. High frequency DBS-like optogenetic stimulation of nucleus accumbens dopamine D2 receptor-containing neurons attenuates cocaine reinstatement in male rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022-11-29. PMID:36446928. |
medium spiny neurons in the nucleus accumbens are differentiated by expression of dopamine d1 receptors (d1drs) or d2drs, activation of which promotes or inhibits cocaine-related behaviors, respectively. |
2022-11-29 |
2023-08-14 |
rat |
| Zicong Shang, Lin Yang, Ziwu Wang, Yu Tian, Yanjing Gao, Zihao Su, Rongliang Guo, Weiwei Li, Guoping Liu, Xiaosu Li, Zhengang Yang, Zhenmeiyu Li, Zhuangzhi Zhan. The transcription factor Frontiers in cell and developmental biology. vol 10. 2022-09-09. PMID:36081908. |
the transcription factor the striatum is primarily composed of two types of medium spiny neurons (msns) expressing either d1- or d2-type dopamine receptors. |
2022-09-09 |
2023-08-14 |
Not clear |
| Mathieu Di Miceli, Asma Derf, Benjamin Gronie. Consequences of Acute or Chronic Methylphenidate Exposure Using Ex Vivo Neurochemistry and In Vivo Electrophysiology in the Prefrontal Cortex and Striatum of Rats. International journal of molecular sciences. vol 23. issue 15. 2022-08-12. PMID:35955717. |
furthermore, chronic mph treatment resulted in decreased efficiency of extracellular dopamine to modulate nmda-induced firing activities of medium spiny neurons in the striatum, together with lower mph-induced (100 µm) dopamine outflow, suggesting desensitization to both dopamine and mph in striatal regions. |
2022-08-12 |
2023-08-14 |
rat |
| Dandan Qian, Wei Li, Jinwen Xue, Yi Wu, Ziling Wang, Tao Shi, Songting Li, Jingxuan Yang, Shi Qiu, Shaoli Wang, Yousheng Shu, Liang Chen, Qiao Wang, Ti-Fei Yuan, Douglas Zhou, Wei L. A striatal SOM-driven ChAT-iMSN loop generates beta oscillations and produces motor deficits. Cell reports. vol 40. issue 3. 2022-07-20. PMID:35858550. |
the amplified beta power originates from a striatal loop driven by somatostatin-expressing (som) interneurons and constituted by choline acetyltransferase (chat)-expressing interneurons and dopamine d2 receptor (d2r)-expressing medium spiny neurons (imsns). |
2022-07-20 |
2023-08-14 |
Not clear |
| Tom Macpherson, Ji Yoon Kim, Takatoshi Hikid. Nucleus Accumbens Core Dopamine D2 Receptor-Expressing Neurons Control Reversal Learning but Not Set-Shifting in Behavioral Flexibility in Male Mice. Frontiers in neuroscience. vol 16. 2022-07-15. PMID:35837123. |
here we investigated the contribution of the two major nac neuronal populations, medium spiny neurons expressing either dopamine d1 or d2 receptors (d1-/d2-msns), in guiding reversal learning and set-shifting in an attentional set-shifting task (asst). |
2022-07-15 |
2023-08-14 |
mouse |
| Gwenaëlle Laverne, Jonathan Pesce, Ana Reynders, Etienne Combrisson, Eduardo Gascon, Christophe Melon, Lydia Kerkerian-Le Goff, Nicolas Maurice, Corinne Beurrie. Cholinergic interneuron inhibition potentiates corticostriatal transmission in direct medium spiny neurons and rescues motor learning in parkinsonism. Cell reports. vol 40. issue 1. 2022-07-06. PMID:35793632. |
here, we examine the impact of cin firing inhibition on glutamatergic transmission between the cortex and the medium spiny neurons expressing dopamine d1 receptor (d1 msns). |
2022-07-06 |
2023-08-14 |
mouse |
| Favio A Krapacher, Diana Fernández-Suárez, Annika Andersson, Alvaro Carrier-Ruiz, Carlos F Ibáñe. Convergent dopamine and ALK4 signaling to PCBP1 controls FosB alternative splicing and cocaine behavioral sensitization. The EMBO journal. 2022-06-22. PMID:35730718. |
here, we report that dopamine d1 receptor signaling synergizes with the activin/alk4/smad3 pathway to potentiate the generation of Δfosb mrna in medium spiny neurons (msns) of the nucleus accumbens (nac) via activation of the rna-binding protein pcbp1, a regulator of mrna splicing. |
2022-06-22 |
2023-08-14 |
mouse |
| Ryota Imai, Keita Mizuno, Yuji Omiya, Kazushige Mizoguchi, Yuko Maejima, Kenju Shimomur. The effects of ninjin'yoeito on the electrophysiological properties of dopamine neurons in the ventral tegmental area/substantia nigra pars compacta and medium spiny neurons in the nucleus accumbens. Aging. vol 14. issue undefined. 2022-06-06. PMID:35660668. |
the effects of ninjin'yoeito on the electrophysiological properties of dopamine neurons in the ventral tegmental area/substantia nigra pars compacta and medium spiny neurons in the nucleus accumbens. |
2022-06-06 |
2023-08-14 |
mouse |
| Niamh Moriarty, Jessica A Kauhausen, Chiara Pavan, Cameron Pj Hunt, Isabelle R de Luzy, Vanessa Penna, Charlotte M Ermine, Lachlan H Thompson, Clare L Paris. Understanding the influence of target acquisition on survival, integration and phenotypic maturation of dopamine neurons within stem cell-derived neural grafts in a Parkinson's disease model. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-05-24. PMID:35610045. |
vm progenitors were grafted into female mice with 6ohda-lesions of host midbrain dopamine neurons, with some animals also receiving intrastriatal quinolinic acid injections to ablate medium spiny neurons (msn) - the a9 neuron primary target. |
2022-05-24 |
2023-08-13 |
mouse |
| Sarah M Zych, Christopher P For. Divergent properties and independent regulation of striatal dopamine and GABA co-transmission. Cell reports. vol 39. issue 7. 2022-05-18. PMID:35584679. |
both dopamine and gaba are loaded into snc synaptic vesicles by the vesicular monoamine transporter 2 (vmat2), and co-release of gaba provides strong inhibition to the striatum by directly inhibiting striatal medium spiny projection neurons (msns) through activation of gaba |
2022-05-18 |
2023-08-13 |
Not clear |
| Ryan W Tam, Albert J Keun. Human Pluripotent Stem Cell-Derived Medium Spiny Neuron-like Cells Exhibit Gene Desensitization. Cells. vol 11. issue 9. 2022-05-14. PMID:35563715. |
here through transcriptomic analysis, we map the dynamic responses of human stem cell-derived medium spiny neuron-like cells (hmsn-like cells) to dopamine. |
2022-05-14 |
2023-08-13 |
human |
| Dennis A Burke, Veronica A Alvare. Serotonin receptors contribute to dopamine depression of lateral inhibition in the nucleus accumbens. Cell reports. vol 39. issue 6. 2022-05-11. PMID:35545050. |
here, we dissect out the direct actions of dopamine on lateral inhibition between medium spiny neurons (msns) in mouse brain slices and find that they are pathway specific. |
2022-05-11 |
2023-08-13 |
mouse |