| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Natasha M Puri, Giovanna R Romano, Ting-Yu Lin, Quynh N Mai, Roshanak Iranneja. The organic cation Transporter 2 regulates dopamine D1 receptor signaling at the Golgi apparatus. eLife. vol 11. 2022-04-25. PMID:35467530. |
we further demonstrate that dopamine activates golgi-d1dr in murine striatal medium spiny neurons (msn) and this activity depends on oct2 function. |
2022-04-25 |
2023-08-13 |
Not clear |
| Margaux Teil, Sandra Dovero, Mathieu Bourdenx, Marie-Laure Arotcarena, Sandrine Camus, Gregory Porras, Marie-Laure Thiolat, Ines Trigo-Damas, Celine Perier, Cristina Estrada, Nuria Garcia-Carrillo, Michele Morari, Wassilios G Meissner, María Trinidad Herrero, Miquel Vila, Jose A Obeso, Erwan Bezard, Benjamin Deha. Brain injections of glial cytoplasmic inclusions induce a multiple system atrophy-like pathology. Brain : a journal of neurology. 2022-03-14. PMID:35285474. |
we found loss of both nigral dopamine neurons and striatal medium spiny neurons, as well as loss of oligodendrocytes in the same regions, which are characteristics of multiple system atrophy. |
2022-03-14 |
2023-08-13 |
Not clear |
| Marlene Cervantes, Robert G Lewis, Maria Agnese Della-Fazia, Emiliana Borrelli, Paolo Sassone-Cors. Dopamine D2 receptor signaling in the brain modulates circadian liver metabolomic profiles. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 11. 2022-03-10. PMID:35271395. |
significancewe analyzed the liver metabolome of mice deficient in the expression of the dopamine d2 receptor (d2r) in striatal medium spiny neurons (imsn-d2rko) and found profound changes in the liver circadian metabolome compared to control mice. |
2022-03-10 |
2023-08-13 |
mouse |
| Tengfei Ma, Zhenbo Huang, Xueyi Xie, Yifeng Cheng, Xiaowen Zhuang, Matthew J Childs, Himanshu Gangal, Xuehua Wang, Laura N Smith, Rachel J Smith, Yubin Zhou, Jun Wan. Chronic alcohol drinking persistently suppresses thalamostriatal excitation of cholinergic neurons to impair cognitive flexibility. The Journal of clinical investigation. 2021-12-23. PMID:34941575. |
cins are known to inhibit glutamatergic transmission in dopamine d1 receptor-expressing medium spiny neurons (d1-msns) but facilitate this transmission in d2-msns, which may contribute to flexible behavior. |
2021-12-23 |
2023-08-13 |
Not clear |
| Przemysław Cieśla. Glutamate receptors in the dopamine system – function and role in reinforcement learning Postepy biochemii. vol 67. issue 3. 2021-12-11. PMID:34894387. |
the article describes the functional role of n-methyl-d-aspartate (nmda) receptors in driving the phasic activity in dopamine neurons, and a role of nmda and metabotropic glutamate 5 (mglur5) receptors in induction of plasticity in dopaminoceptive striatal medium spiny neurons. |
2021-12-11 |
2023-08-13 |
mouse |
| Aaron J Barbour, Sara R Nass, Yun K Hahn, Kurt F Hauser, Pamela E Knap. Restoration of KCC2 Membrane Localization in Striatal Dopamine D2 Receptor-Expressing Medium Spiny Neurons Rescues Locomotor Deficits in HIV Tat-Transgenic Mice. ASN neuro. vol 13. 2021-12-08. PMID:34445881. |
restoration of kcc2 membrane localization in striatal dopamine d2 receptor-expressing medium spiny neurons rescues locomotor deficits in hiv tat-transgenic mice. |
2021-12-08 |
2023-08-13 |
mouse |
| Jing He, Michael Kleyman, Jianjiao Chen, Aydin Alikaya, Kathryn M Rothenhoefer, Bilge Esin Ozturk, Morgan Wirthlin, Andreea C Bostan, Kenneth Fish, Leah C Byrne, Andreas R Pfenning, William R Stauffe. Transcriptional and anatomical diversity of medium spiny neurons in the primate striatum. Current biology : CB. 2021-11-19. PMID:34727523. |
medium spiny neurons (msns) constitute the vast majority of striatal neurons and the principal interface between dopamine reward signals and functionally diverse cortico-basal ganglia circuits. |
2021-11-19 |
2023-08-13 |
monkey |
| Qiang Shan, You Hu, Shijie Chen, Yao Tia. Nucleus accumbens dichotomically controls social dominance in male mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2021-11-09. PMID:34750567. |
a further electrophysiology investigation on the circuitry of these two subregions revealed that the postsynaptic strength of excitatory synapses onto the medium spiny neurons that express the d1 dopamine receptors in the shell is negatively correlated, and the postsynaptic strength of excitatory synapses onto the medium spiny neurons that express the d2 dopamine receptors in the core is positively correlated, with social dominance. |
2021-11-09 |
2023-08-13 |
mouse |
| Kunjumon Ittira Vadakka. Framework for internal sensation of pleasure using constraints from disparate findings in nucleus accumbens. World journal of psychiatry. vol 11. issue 10. 2021-11-05. PMID:34733636. |
by extending these findings and by using disparate third person observations in nac from several studies, present work provides a framework of a mechanism that generates internal sensation of pleasure that can provide interconnected explanations for: (1) ability to induce robust long-term depression (ltd) in nac from naïve animals; (2) impaired ability to induce ltd in "addicted" state; (3) attenuation of postsynaptic potentials by cocaine; and (4) reduced firing of medium spiny neurons in response to cocaine or dopamine. |
2021-11-05 |
2023-08-13 |
Not clear |
| You-Hsin Lin, Yukie Yamahashi, Keisuke Kuroda, Md Omar Faruk, Xinjian Zhang, Kiyofumi Yamada, Akihiro Yamanaka, Taku Nagai, Kozo Kaibuch. Accumbal D2R-medium spiny neurons regulate aversive behaviors through PKA-Rap1 pathway. Neurochemistry international. vol 143. 2021-11-04. PMID:33301817. |
we previously hypothesized that a balance between dopamine (da) and adenosine signals regulates the pka-rap1 pathway in medium spiny neurons expressing da d1 receptors (d1r-msns) or d2 receptors (d2r-msns) and demonstrated that the pka-rap1 pathway in d1r-msns is responsible for positive reinforcement. |
2021-11-04 |
2023-08-13 |
mouse |
| Barbara Ziółkowsk. The Role of Mesostriatal Dopamine System and Corticostriatal Glutamatergic Transmission in Chronic Pain. Brain sciences. vol 11. issue 10. 2021-10-26. PMID:34679376. |
thereby, dopamine inhibits striatal output via the d2 receptor-expressing medium spiny neurons (d2-msn). |
2021-10-26 |
2023-08-13 |
Not clear |
| Pedro R Olivetti, Peter D Balsam, Eleanor H Simpson, Christoph Kellendon. Emerging roles of striatal dopamine D2 receptors in motivated behaviour: Implications for psychiatric disorders. Basic & clinical pharmacology & toxicology. vol 126 Suppl 6. 2021-10-04. PMID:31188541. |
much of this function relies on striatal projection neurons, known as medium spiny neurons (msns) expressing dopamine d2 receptors (d2rs), or d2-msns. |
2021-10-04 |
2023-08-13 |
Not clear |
| Fabien Ducrocq, Roman Walle, Andrea Contini, Asma Oummadi, Baptiste Caraballo, Suzanne van der Veldt, Marie-Lou Boyer, Frank Aby, Tarson Tolentino-Cortez, Jean-Christophe Helbling, Lucy Martine, Stéphane Grégoire, Stéphanie Cabaret, Sylvie Vancassel, Sophie Layé, Jing Xuan Kang, Xavier Fioramonti, Olivier Berdeaux, Gabriel Barreda-Gómez, Elodie Masson, Guillaume Ferreira, David W L Ma, Clementine Bosch-Bouju, Véronique De Smedt-Peyrusse, Pierre Trifilief. Causal Link between n-3 Polyunsaturated Fatty Acid Deficiency and Motivation Deficits. Cell metabolism. vol 31. issue 4. 2021-09-03. PMID:32142670. |
electrophysiological recordings revealed increased collateral inhibition of dopamine d2 receptor-expressing medium spiny neurons (d2-msns) onto dopamine d1 receptor-expressing msns in the nucleus accumbens, a main brain region for the modulation of motivation. |
2021-09-03 |
2023-08-13 |
mouse |
| Kathryn Lanza, Ashley Centner, Michael Coyle, Isabella Del Priore, Fredric P Manfredsson, Christopher Bisho. Genetic suppression of the dopamine D3 receptor in striatal D1 cells reduces the development of L-DOPA-induced dyskinesia. Experimental neurology. vol 336. 2021-08-30. PMID:33249031. |
in lid, dopamine d3 receptors (d3r) are upregulated on d1 receptor (d1r)-bearing medium spiny neurons where the can synergistically drive downstream signaling and motor behaviors. |
2021-08-30 |
2023-08-13 |
rat |
| Anthony Ariza, Yasuhiro Funahashi, Sachi Kozawa, Md Omar Faruk, Taku Nagai, Mutsuki Amano, Kozo Kaibuch. Dynamic subcellular localization and transcription activity of the SRF cofactor MKL2 in the striatum are regulated by MAPK. Journal of neurochemistry. vol 157. issue 6. 2021-08-24. PMID:33449379. |
dopamine type 1 receptor (d1r) signaling activates protein kinase a (pka), which then activates mitogen-activated protein kinase (mapk) through rap1, in striatal medium spiny neurons (msns). |
2021-08-24 |
2023-08-13 |
mouse |
| Yuksel Caki. Computational neuronal correlation with enhanced synchronized activity in the basal ganglia and the slowing of thalamic theta and alpha rhythms in Parkinson's disease. The European journal of neuroscience. vol 54. issue 3. 2021-08-23. PMID:34192822. |
the dopamine-modulated type izikhevich neuron model is used for modeling the striatal region, consisting of fast-spiking interneurons, d1 and d2 type dopamine expressing medium spiny neurons. |
2021-08-23 |
2023-08-13 |
Not clear |
| Shannon L Cole, Ramesh Chandra, Maya Harris, Ishan Patel, Torrance Wang, Hyunjae Kim, Leah Jensen, Scott J Russo, Gustavo Turecki, Amy M Gancarz-Kausch, David M Dietz, Mary Kay Lob. Cocaine-induced neuron subtype mitochondrial dynamics through Egr3 transcriptional regulation. Molecular brain. vol 14. issue 1. 2021-08-12. PMID:34187517. |
further, mitochondria are differentially regulated by cocaine in dopamine receptor-1 containing medium spiny neurons (d1-msns) vs dopamine receptor-2 (d2)-msns. |
2021-08-12 |
2023-08-13 |
human |
| Simhadri Praveen Kumar, Phanithi Prakash Bab. Aberrant Dopamine Receptor Signaling Plays Critical Role in the Impairment of Striatal Neurons in Experimental Cerebral Malaria. Molecular neurobiology. vol 57. issue 12. 2021-07-01. PMID:32833186. |
dopamine receptors (d1 and d2) are widely expressed in striatal medium spiny neurons (msns) that regulate critical physiological functions related to behavior and cognition. |
2021-07-01 |
2023-08-13 |
Not clear |
| Yi Zhang, Huan Gui, Lang Hu, Chengxi Li, Jie Zhang, Xiaoli Lian. Dopamine D1 receptor in the NAc shell is involved in delayed emergence from isoflurane anesthesia in aged mice. Brain and behavior. vol 11. issue 1. 2021-06-30. PMID:33094567. |
the nucleus accumbens (nac) is a crucial arousal-related nucleus, in which activating medium spiny neurons (msns) expressing dopamine d1 receptor (d1r) could facilitate the arousal from natural sleep. |
2021-06-30 |
2023-08-13 |
mouse |
| Kari A Johnson, Lucas Voyvodic, Gabriel C Loewinger, Yolanda Mateo, David M Lovinge. Operant self-stimulation of thalamic terminals in the dorsomedial striatum is constrained by metabotropic glutamate receptor 2. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 9. 2021-06-23. PMID:31995814. |
dorsal striatal manipulations including stimulation of dopamine release and activation of medium spiny neurons (msns) are sufficient to drive reinforcement-based learning. |
2021-06-23 |
2023-08-13 |
mouse |