| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| MaKenna Y Cealie, James C Douglas, Linh H D Le, Erik D Vonkaenel, Matthew N McCall, Paul D Drew, Ania K Majewsk. Developmental ethanol exposure has minimal impact on cerebellar microglial dynamics, morphology, and interactions with Purkinje cells during adolescence. Frontiers in neuroscience. vol 17. 2023-05-23. PMID:37214408. |
to better understand these mechanisms, we examined the cerebellum on a cellular level by studying microglia, the principal immune cells of the central nervous system, and purkinje cells, the sole output of the cerebellum. |
2023-05-23 |
2023-08-14 |
Not clear |
| Naserddine Hamadi, Sumaya Beegam, Nur Elena Zaaba, Ozaz Elzaki, Mariam Abdulla Altamimi, Abderrahim Nemma. Neuroinflammation, Oxidative Stress, Apoptosis, Microgliosis and Astrogliosis in the Cerebellum of Mice Chronically Exposed to Waterpipe Smoke. Biomedicines. vol 11. issue 4. 2023-05-16. PMID:37189722. |
immunofluorescence analysis of the cerebellum showed that wps exposure significantly augmented the number of ionized calcium-binding adaptor molecule 1 and glial fibrillary acidic protein-positive microglia and astroglia, respectively. |
2023-05-16 |
2023-08-14 |
mouse |
| Devlina Ghosh, Gajendra Singh, Prabhaker Mishra, Aditi Singh, Alok Kumar, Neeraj Sinh. Alteration in mitochondrial dynamics promotes the proinflammatory response of microglia and is involved in cerebellar dysfunction of young and aged mice following LPS exposure. Neuroscience letters. 2023-04-28. PMID:37116576. |
alteration in mitochondrial dynamics promotes the proinflammatory response of microglia and is involved in cerebellar dysfunction of young and aged mice following lps exposure. |
2023-04-28 |
2023-08-14 |
mouse |
| Devlina Ghosh, Gajendra Singh, Prabhaker Mishra, Aditi Singh, Alok Kumar, Neeraj Sinh. Alteration in mitochondrial dynamics promotes the proinflammatory response of microglia and is involved in cerebellar dysfunction of young and aged mice following LPS exposure. Neuroscience letters. 2023-04-28. PMID:37116576. |
following lps stimulation, we observed microglia activation and subsequent elevation in proinflammatory cytokines (m1; tnf-α, ifn-γ) with nlrp3 activationand a concomitant reduction in the expression of anti-inflammatory markers (m2; ym1, tgf-β1) in the cerebellar tissue of aged mice compared with the young lps and aged controls. |
2023-04-28 |
2023-08-14 |
mouse |
| Shu-Tao Xie, Wen-Chu Fan, Xian-Sen Zhao, Xiao-Yang Ma, Ze-Lin Li, Yan-Ran Zhao, Fa Yang, Ying Shi, Hui Rong, Zhi-San Cui, Jun-Yi Chen, Hong-Zhao Li, Chao Yan, Qipeng Zhang, Jian-Jun Wang, Xiao-Yang Zhang, Xiao-Ping Gu, Zheng-Liang Ma, Jing-Ning Zh. Proinflammatory activation of microglia in the cerebellum hyperexcites Purkinje cells to trigger ataxia. Pharmacological research. 2023-04-17. PMID:37068531. |
proinflammatory activation of microglia in the cerebellum hyperexcites purkinje cells to trigger ataxia. |
2023-04-17 |
2023-08-14 |
mouse |
| Shu-Tao Xie, Wen-Chu Fan, Xian-Sen Zhao, Xiao-Yang Ma, Ze-Lin Li, Yan-Ran Zhao, Fa Yang, Ying Shi, Hui Rong, Zhi-San Cui, Jun-Yi Chen, Hong-Zhao Li, Chao Yan, Qipeng Zhang, Jian-Jun Wang, Xiao-Yang Zhang, Xiao-Ping Gu, Zheng-Liang Ma, Jing-Ning Zh. Proinflammatory activation of microglia in the cerebellum hyperexcites Purkinje cells to trigger ataxia. Pharmacological research. 2023-04-17. PMID:37068531. |
here, by employing chemogenetic approaches to manipulate cerebellar microglia selectively and directly, we found that specific chemogenetic activation of microglia in the cerebellar vermis directly leads to ataxia symptoms in wild-type mice and aggravated ataxic motor deficits in 3-acetylpyridine (3-ap) mice, a classic mouse model of cerebellar ataxia. |
2023-04-17 |
2023-08-14 |
mouse |
| Shu-Tao Xie, Wen-Chu Fan, Xian-Sen Zhao, Xiao-Yang Ma, Ze-Lin Li, Yan-Ran Zhao, Fa Yang, Ying Shi, Hui Rong, Zhi-San Cui, Jun-Yi Chen, Hong-Zhao Li, Chao Yan, Qipeng Zhang, Jian-Jun Wang, Xiao-Yang Zhang, Xiao-Ping Gu, Zheng-Liang Ma, Jing-Ning Zh. Proinflammatory activation of microglia in the cerebellum hyperexcites Purkinje cells to trigger ataxia. Pharmacological research. 2023-04-17. PMID:37068531. |
our findings thus reveal a causal relationship between proinflammatory activation of cerebellar microglia and ataxic motor symptoms, which may offer novel evidence for therapeutic intervention for cerebellar ataxias by targeting microglia and microglia-derived inflammatory mediators. |
2023-04-17 |
2023-08-14 |
mouse |
| Maxine D Rouvroye, Hetty J Bontkes, John G J M Bol, Birgit Lissenberg-Witte, Valerie Byrnes, Fadel Bennani, Ekaterina S Jordanova, Micha M M Wilhelmus, Chris J Mulder, Paul van der Valk, Annemieke J M Rozemuller, Gerd Bouma, Anne-Marie Van Da. Cerebellar presence of immune cells in patients with neuro-coeliac disease. Acta neuropathologica communications. vol 11. issue 1. 2023-03-25. PMID:36966322. |
our aim was to determine if the loss of neurons, especially purkinje cells, coincides with microglia activation and t- and b-cell infiltration in the cerebellum of patients with cd and a concomitant idiopathic neurological disease affecting the cerebellum (neurocd). |
2023-03-25 |
2023-08-14 |
Not clear |
| Yue Zhao, Jiang Yao, Ying Shen, Li-Da S. Sepsis Impairs Purkinje Cell Functions and Motor Behaviors Through Microglia Activation. Cerebellum (London, England). 2023-02-15. PMID:36790600. |
our results show that the sepsis can activate microglia in the cerebellum and promote the secretion of inflammatory factor tnf-α, which increases intrinsic excitability and synaptic transmission of pcs, inhibits the synaptic plasticity of pcs, and impairs motor learning of mice. |
2023-02-15 |
2023-08-14 |
mouse |
| Yukihiro Okada, Nobutake Hosoi, Yasunori Matsuzaki, Yuuki Fukai, Akito Hiraga, Junichi Nakai, Keisuke Nitta, Yoichiro Shinohara, Ayumu Konno, Hirokazu Hira. Development of microglia-targeting adeno-associated viral vectors as tools to study microglial behavior in vivo. Communications biology. vol 5. issue 1. 2022-11-12. PMID:36369525. |
the 1.7-kb genomic sequence upstream of the start codon in exon 1 of the iba1 (aif1) gene, functions as microglia preferential promoter in the striatum and cerebellum. |
2022-11-12 |
2023-08-14 |
mouse |
| Deniz Yilmazer-Hanke, Najwa Ouali Alami, Lubin Fang, Sigried Klotz, Gabor G Kovacs, Helmut Pankratz, Joachim Weis, Istvan Katona, Angelika Scheuerle, Wolfgang J Streit, Kelly Del Tredic. Differential Glial Chitotriosidase 1 (CHIT1) and Chitinase 3-like protein 1 (CHI3L1) Expression in the Human Primary Visual Cortex and Cerebellum after Global Hypoxia-Ischemia. Neuroscience. 2022-11-04. PMID:36332693. |
during the first week post-hibi, a transient reduction of iba1-positive microglia was observed in both regions, and fragmented/clasmatodendritic cerebellar bergmann glia appeared. |
2022-11-04 |
2023-08-14 |
human |
| Alessandro Rava, Piergiorgio La Rosa, Giampiero Palladino, Jessica Dragotto, Antonio Totaro, Jessica Tiberi, Sonia Canterini, Sergio Oddi, Maria Teresa Fiorenz. The appearance of phagocytic microglia in the postnatal brain of Niemann Pick type C mice is developmentally regulated and underscores shortfalls in fine odor discrimination. Journal of cellular physiology. 2022-11-02. PMID:36322609. |
to gain an insight on this issue, we have characterized patterns of microglia activation in the early postnatal cerebellum and young adult olfactory bulb of the hypomorphic npc1 |
2022-11-02 |
2023-08-14 |
mouse |
| Naghmeh Zamani, Laya Takbiri Osgoei, Abbas Aliaghaei, Nasim Zamani, Hossein Hassanian-Moghadda. Chronic exposure to methadone induces activated microglia and astrocyte and cell death in the cerebellum of adult male rats. Metabolic brain disease. 2022-10-26. PMID:36287354. |
chronic exposure to methadone induces activated microglia and astrocyte and cell death in the cerebellum of adult male rats. |
2022-10-26 |
2023-08-14 |
rat |
| Barbara B Shih, Sarah M Brown, Jack Barrington, Lucas Lefevre, Neil A Mabbott, Josef Priller, Gerard Thompson, Alistair B Lawrence, Barry W McCol. Defining the pig microglial transcriptome reveals its core signature, regional heterogeneity, and similarity with human and rodent microglia. Glia. 2022-09-19. PMID:36120803. |
we isolated pig hippocampal tissue and microglia from frontal cortex, hippocampus, and cerebellum, as well as alveolar macrophages from the lungs and conducted rna-sequencing (rnaseq). |
2022-09-19 |
2023-08-14 |
mouse |
| Barbara B Shih, Sarah M Brown, Jack Barrington, Lucas Lefevre, Neil A Mabbott, Josef Priller, Gerard Thompson, Alistair B Lawrence, Barry W McCol. Defining the pig microglial transcriptome reveals its core signature, regional heterogeneity, and similarity with human and rodent microglia. Glia. 2022-09-19. PMID:36120803. |
we found brain regional heterogeneity based on 150 genes showing significant (adjusted p < 0.01) regional variations and that cerebellar microglia were most distinct. |
2022-09-19 |
2023-08-14 |
mouse |
| Sunam Gurung, Darlene Reuter, Abby Norris, Molly Dubois, Marta Maxted, Krista Singleton, Marisol Castillo-Castrejon, James F Papin, Dean A Myer. Early and mid-gestation Zika virus (ZIKV) infection in the olive baboon (Papio anubis) leads to fetal CNS pathology by term gestation. PLoS pathogens. vol 18. issue 8. 2022-08-15. PMID:35969617. |
in the cerebellum, increased microglia were observed in fetuses from both first and second trimester inoculation. |
2022-08-15 |
2023-08-14 |
human |
| Paula Izquierdo-Altarejos, Mar Martínez-García, Vicente Felip. Extracellular Vesicles From Hyperammonemic Rats Induce Neuroinflammation in Cerebellum of Normal Rats: Role of Increased TNFα Content. Frontiers in immunology. vol 13. 2022-08-01. PMID:35911759. |
the aims were: 1) assess if ha-evs induce microglia and astrocytes activation and neuroinflammation in cerebellar slices of normal rats, 2) assess if this is associated with activation of the tnfr1-nf-kb-glutaminase-gat3 pathway, 3) assess if the tnfr1-ccl2-bdnf-trkb pathway is activated by ha-evs and 4) assess if the increased tnfα levels in ha-evs are responsible for the above effects and if they are prevented by blocking the action of tnfα. |
2022-08-01 |
2023-08-14 |
rat |
| Zbigniev Balion, Nataša Svirskienė, Gytis Svirskis, Hermanas Inokaitis, Vytautas Cėpla, Artūras Ulčinas, Tadas Jelinskas, Romuald Eimont, Neringa Paužienė, Ramūnas Valiokas, Aistė Jekabson. Comparison of Microglial Morphology and Function in Primary Cerebellar Cell Cultures on Collagen and Collagen-Mimetic Hydrogels. Biomedicines. vol 10. issue 5. 2022-05-28. PMID:35625762. |
the present study examines microglial cell morphology and function in cerebellar cell organoid cultures on clp-peg hydrogels and compares them to the cultures on crosslinked collagen hydrogels of similar elastomechanical properties. |
2022-05-28 |
2023-08-13 |
Not clear |
| Amira A Sallam, Mohammed A El-Magd, Mona M Ahmed, Heba I Ghamry, Mohammad Y Alshahrani, Rabab A Hegazy, Ahmed Magdy, Magdy F Abou El-Foto. Quercetin alleviated multi-walled carbon nanotubes-induced neurotoxicity in mice through inhibition of oxidation, inflammation, and pyroptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 151. 2022-05-23. PMID:35605300. |
however, treatment with que ameliorated mwcnts-induced neurotoxicity as revealed by 1) elevated acetylcholinesterase (ache) activity, 2) reduced lipid peroxidation biomarker malondialdehyde (mda), 3) improved antioxidant status as indicated by increased levels of reduced glutathione (gsh) and activities of superoxide dismutase (sod), catalase (cat), as well as upregulated expression of nuclear factor erythroid 2-related factor 2 (nrf2) and heme oxygenase-1 (ho-1) genes, 4) decreased levels and expression of inflammatory biomarkers [nitric oxide (no), interleukin 1 beta (il1ß), tumor necrosis factor-alpha (tnfα), and nuclear factor kappa b (nf-κb)], 5) downregulated expression of pyroptosis-related genes [nod-like receptor protein inflammasome 3 (nlrp3) and caspase 1 (casp1)] but with no effect on the apoptotic casp3 gene, 6) minimized axonal degeneration and number of microglia in the cerebral medulla, and 7) diminished the number of degenerated neurons in hippocampus and cerebellum. |
2022-05-23 |
2023-08-13 |
mouse |
| Luisa Klein, Juliette Van Steenwinckel, Bobbi Fleiss, Till Scheuer, Christoph Bührer, Valerie Faivre, Sophie Lemoine, Corinne Blugeon, Leslie Schwendimann, Zsolt Csaba, Cindy Bokobza, Dulcie A Vousden, Jason P Lerch, Anthony C Vernon, Pierre Gressens, Thomas Schmit. A unique cerebellar pattern of microglia activation in a mouse model of encephalopathy of prematurity. Glia. 2022-05-17. PMID:35579329. |
a unique cerebellar pattern of microglia activation in a mouse model of encephalopathy of prematurity. |
2022-05-17 |
2023-08-13 |
mouse |