| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mark B Stoessel, Ania K Majewsk. Little cells of the little brain: microglia in cerebellar development and function. Trends in neurosciences. vol 44. issue 7. 2021-08-18. PMID:33933255. |
we examine the roles microglia play in cerebellar function, development, and aging. |
2021-08-18 |
2023-08-13 |
Not clear |
| Mark B Stoessel, Ania K Majewsk. Little cells of the little brain: microglia in cerebellar development and function. Trends in neurosciences. vol 44. issue 7. 2021-08-18. PMID:33933255. |
the emerging findings on cerebellar microglia may also provide insights into disease processes involving cerebellar dysfunction. |
2021-08-18 |
2023-08-13 |
Not clear |
| Zachary H Gursky, Julia R Johansson, Anna Y Klintsov. Postnatal alcohol exposure and adolescent exercise have opposite effects on cerebellar microglia in rat. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 80. issue 6. 2021-08-12. PMID:32681672. |
postnatal alcohol exposure and adolescent exercise have opposite effects on cerebellar microglia in rat. |
2021-08-12 |
2023-08-13 |
human |
| Zachary H Gursky, Julia R Johansson, Anna Y Klintsov. Postnatal alcohol exposure and adolescent exercise have opposite effects on cerebellar microglia in rat. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 80. issue 6. 2021-08-12. PMID:32681672. |
given the critical role for the principle neuroimmune cell, microglia, in maintaining synaptic form and function, microglial dysfunction in the cerebellum may be an important mechanism underlying the aberrant cerebellar connectivity observed in rodent models of fetal alcohol spectrum disorders. |
2021-08-12 |
2023-08-13 |
human |
| Zachary H Gursky, Julia R Johansson, Anna Y Klintsov. Postnatal alcohol exposure and adolescent exercise have opposite effects on cerebellar microglia in rat. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 80. issue 6. 2021-08-12. PMID:32681672. |
using an established rodent model of alcohol exposure during human third-trimester fetal development, we examine the cerebellum of male and female long evans rats to determine the impact of early postnatal alcohol exposure on cerebellar microglia, and the potential therapeutic effects of an adolescent intervention consisting of voluntary exercise (running). |
2021-08-12 |
2023-08-13 |
human |
| Zachary H Gursky, Julia R Johansson, Anna Y Klintsov. Postnatal alcohol exposure and adolescent exercise have opposite effects on cerebellar microglia in rat. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 80. issue 6. 2021-08-12. PMID:32681672. |
early postnatal alcohol exposure caused an increase in microglial density throughout cerebellum and a reduction in cerebellar volume, and a reduction in the proportion of fully ramified (often called "resting state") microglia selective to lobules 1-4. |
2021-08-12 |
2023-08-13 |
human |
| Zachary H Gursky, Julia R Johansson, Anna Y Klintsov. Postnatal alcohol exposure and adolescent exercise have opposite effects on cerebellar microglia in rat. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 80. issue 6. 2021-08-12. PMID:32681672. |
in contrast, adolescent exercise decreased microglial density throughout cerebellum and increased cerebellar volume, while activating microglia (as indicated by increases in amoeboid microglia, and reductions in fully and partially ramified microglia) selectively in lobules 1-4. |
2021-08-12 |
2023-08-13 |
human |
| Zachary H Gursky, Julia R Johansson, Anna Y Klintsov. Postnatal alcohol exposure and adolescent exercise have opposite effects on cerebellar microglia in rat. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 80. issue 6. 2021-08-12. PMID:32681672. |
these results suggest that adolescent exercise may be a suitable intervention to ameliorate alcohol-induced neuroimmune dysfunction as it alters microglia density and cerebellar volume in opposite to the effects of developmental alcohol exposure. |
2021-08-12 |
2023-08-13 |
human |
| Wadzanai Manjeese, Nontobeko E Mvubu, Adrie J C Steyn, Thabisile Mpofan. Mycobacterium tuberculosis causes a leaky blood-brain barrier and neuroinflammation in the prefrontal cortex and cerebellum regions of infected mice offspring. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 81. issue 5. 2021-08-05. PMID:33932039. |
neuroinflammation was measured by assessing microglia and astrocyte population in the prefrontal cortex (pfc) and cerebellum (cer) of pups. |
2021-08-05 |
2023-08-13 |
mouse |
| James Morgan, Mariana Alves, Giorgia Conte, Aida Menéndez-Méndez, Laura de Diego-Garcia, Gioacchino de Leo, Edward Beamer, Jonathon Smith, Annette Nicke, Tobias Enge. Characterization of the Expression of the ATP-Gated P2X7 Receptor Following Status Epilepticus and during Epilepsy Using a P2X7-EGFP Reporter Mouse. Neuroscience bulletin. vol 36. issue 11. 2021-07-28. PMID:32895896. |
the results showed increased p2x7-egfp expression after status epilepticus induced by intra-amygdala kainic acid and during epilepsy in different brain regions including the hippocampus, cortex, striatum, thalamus and cerebellum, and this was most evident in microglia and oligodendrocytes. |
2021-07-28 |
2023-08-13 |
mouse |
| Yaiza M Arenas, Andrea Cabrera-Pastor, Nora Juciute, Eloy Mora-Navarro, Vicente Felip. Blocking glycine receptors reduces neuroinflammation and restores neurotransmission in cerebellum through ADAM17-TNFR1-NF-κβ pathway. Journal of neuroinflammation. vol 17. issue 1. 2021-07-21. PMID:32917219. |
the aims were to assess, in cerebellum of hyperammonemic rats, (a) whether blocking glycine receptors with the antagonist strychnine reduces neuroinflammation; (b) the cellular localization of glycine receptor; (c) the effects of blocking glycine receptors on the tnfr1-nf-kb-glutaminase-glutamate-gaba pathway and microglia activation; (d) whether adding extracellular cgmp reproduces the effects of strychnine. |
2021-07-21 |
2023-08-13 |
rat |
| E P G Vazi, F Holanda, N A Santos, C V Cardoso, M F M Martins, E F Bonda. Short-term systemic methotrexate administration in rats induces astrogliosis and microgliosis. Research in veterinary science. vol 138. 2021-07-08. PMID:34091228. |
on the 5th day, brain samples were collected for hematoxylin-eosin and luxol fast blue staining techniques, as well as for immunohistochemical staining for glial fibrillary acidic protein (gfap) expression in astrocytes and iba1 (ionized calcium binding adaptor molecule 1) for microglia in the frontal cortex, hippocampus, hypothalamus and molecular/granular layers of the cerebellum. |
2021-07-08 |
2023-08-13 |
rat |
| Monique Marylin Alves de Almeida, Francesca Pieropan, Larissa de Mattos Oliveira, Manoelito Coelho Dos Santos Junior, Jorge Mauricio David, Juceni Pereira David, Victor Diógenes A da Silva, Cleide Dos Santos Souza, Silvia Lima Costa, Arthur Morgan But. The flavonoid agathisflavone modulates the microglial neuroinflammatory response and enhances remyelination. Pharmacological research. vol 159. 2021-07-06. PMID:32534098. |
here, we examined the effects of the flavonoid agathisflavone on microglia and remyelination in the cerebellar slice model following lysolecithin induced demyelination. |
2021-07-06 |
2023-08-13 |
Not clear |
| Insung Kang, Je Min Yoo, Donghoon Kim, Juhee Kim, Myung Keun Cho, Seung-Eun Lee, Dong Jin Kim, Byung-Chul Lee, Jin Young Lee, Jae-Jun Kim, Nari Shin, Soon Won Choi, Young-Ho Lee, Han Seok Ko, Seokmin Shin, Byung Hee Hong, Kyung-Sun Kan. Graphene Quantum Dots Alleviate Impaired Functions in Niemann-Pick Disease Type C in Vivo. Nano letters. vol 21. issue 5. 2021-06-24. PMID:33472003. |
more importantly, the injection of gqds inhibits the loss of purkinje cells in the cerebellum while also demonstrating reduced activation of microglia. |
2021-06-24 |
2023-08-13 |
Not clear |
| Valeria T Barletta, Elena Herranz, Costantina A Treaba, Russell Ouellette, Ambica Mehndiratta, Marco L Loggia, Eric C Klawiter, Carolina Ionete, Sloane A Jacob, Caterina Mainer. Evidence of diffuse cerebellar neuroinflammation in multiple sclerosis by Multiple sclerosis (Houndmills, Basingstoke, England). vol 26. issue 6. 2021-06-07. PMID:30973800. |
evidence of diffuse cerebellar neuroinflammation in multiple sclerosis by activated microglia, which can be detected in vivo by |
2021-06-07 |
2023-08-13 |
Not clear |
| Norhan Elshony, Atef M K Nassar, Yasser S El-Sayed, Dalia Samak, Ahmed Noreldin, Lamiaa Wasef, Hamida Saleh, Yaser H A Elewa, Shereen E Tawfeek, Abdullah A Saati, Gaber El-Saber Batiha, Michał Tomczyk, Masakazu Umezawa, Hazem M Shahee. Ameliorative Role of Cerium Oxide Nanoparticles Against Fipronil Impact on Brain Function, Oxidative Stress, and Apoptotic Cascades in Albino Rats. Frontiers in neuroscience. vol 15. 2021-06-01. PMID:34054412. |
immunohistochemical examination of brain tissues of rats-treated with fip showed abundant ionized calcium-binding adaptor molecule 1 (iba-1) microglia and caspase-3 and apoptotic cells with nearly negative calbindin and synaptophysin reaction, which were countered by fip + cenps treatment that revealed a critical decrease in caspase-3, iba-1 reaction with a strong calbindin positive reaction in most of the purkinje cells and strong synaptophysin reaction in the cerebrum and cerebellum tissues. |
2021-06-01 |
2023-08-13 |
rat |
| Shu-Tao Xie, Ao-Xue Chen, Bo Song, Jia Fan, Wei Li, Zhen Xing, Shi-Yu Peng, Qi-Peng Zhang, Lei Dong, Chao Yan, Xiao-Yang Zhang, Jian-Jun Wang, Jing-Ning Zh. Suppression of microglial activation and monocyte infiltration ameliorates cerebellar hemorrhage induced-brain injury and ataxia. Brain, behavior, and immunity. vol 89. 2021-04-27. PMID:32717406. |
yet the role and mechanism of microglia in cerebellar injury and ataxia after ch are still unknown. |
2021-04-27 |
2023-08-13 |
Not clear |
| Shu-Tao Xie, Ao-Xue Chen, Bo Song, Jia Fan, Wei Li, Zhen Xing, Shi-Yu Peng, Qi-Peng Zhang, Lei Dong, Chao Yan, Xiao-Yang Zhang, Jian-Jun Wang, Jing-Ning Zh. Suppression of microglial activation and monocyte infiltration ameliorates cerebellar hemorrhage induced-brain injury and ataxia. Brain, behavior, and immunity. vol 89. 2021-04-27. PMID:32717406. |
using ki20227, an inhibitor for colony-stimulating factor 1 receptor which mediates the signaling responsible for the survival of microglia, we determined the impact of microglial depletion on cerebellar injury and ataxia in a murine model of ch. |
2021-04-27 |
2023-08-13 |
Not clear |
| Monique Marylin Alves de Almeida, Francesca Pieropan, Tim Footz, Jorge Mauricio David, Juceni Pereira David, Victor Diogenes Amaral da Silva, Cleide Dos Santos Souza, Anastassia Voronova, Arthur Morgan Butt, Silvia Lima Cost. Agathisflavone Modifies Microglial Activation State and Myelination in Organotypic Cerebellar Slices Culture. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2021-04-21. PMID:33881709. |
here, we examined the effects of fab (5-50 μm) on myelination and microglia in organotypic cerebellar slices prepared from p10-p12 sox10-egfp and plp1-dsred transgenic mice. |
2021-04-21 |
2023-08-13 |
mouse |
| Paula Izquierdo-Altarejos, Andrea Cabrera-Pastor, Hernan Gonzalez-King, Carmina Montoliu, Vicente Felip. Extracellular Vesicles from Hyperammonemic Rats Induce Neuroinflammation and Motor Incoordination in Control Rats. Cells. vol 9. issue 3. 2021-03-11. PMID:32121257. |
injection of evs from hyperammonemic, but not from control rats, induces motor incoordination, which is mediated by neuroinflammation, microglia and astrocytes activation and increased il-1b, tnfα, its receptor tnfr1, nf-kb in microglia, glutaminase i, and gat3 in cerebellum. |
2021-03-11 |
2023-08-13 |
rat |