| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luisa Klein, Juliette Van Steenwinckel, Bobbi Fleiss, Till Scheuer, Christoph Bührer, Valerie Faivre, Sophie Lemoine, Corinne Blugeon, Leslie Schwendimann, Zsolt Csaba, Cindy Bokobza, Dulcie A Vousden, Jason P Lerch, Anthony C Vernon, Pierre Gressens, Thomas Schmit. A unique cerebellar pattern of microglia activation in a mouse model of encephalopathy of prematurity. Glia. 2022-05-17. PMID:35579329. |
increased density of iba1+ cerebellar microglia were observed both at p5 and p45, with evidence for increased microglial proliferation at p5 and p10. |
2022-05-17 |
2023-08-13 |
mouse |
| Luisa Klein, Juliette Van Steenwinckel, Bobbi Fleiss, Till Scheuer, Christoph Bührer, Valerie Faivre, Sophie Lemoine, Corinne Blugeon, Leslie Schwendimann, Zsolt Csaba, Cindy Bokobza, Dulcie A Vousden, Jason P Lerch, Anthony C Vernon, Pierre Gressens, Thomas Schmit. A unique cerebellar pattern of microglia activation in a mouse model of encephalopathy of prematurity. Glia. 2022-05-17. PMID:35579329. |
comparison of the transcriptome of microglia isolated from p5 cerebellums and cerebrums revealed significant enrichment of pro-inflammatory markers in microglia from both regions, but cerebellar microglia displayed a unique type i interferon signaling dysregulation. |
2022-05-17 |
2023-08-13 |
mouse |
| Luisa Klein, Juliette Van Steenwinckel, Bobbi Fleiss, Till Scheuer, Christoph Bührer, Valerie Faivre, Sophie Lemoine, Corinne Blugeon, Leslie Schwendimann, Zsolt Csaba, Cindy Bokobza, Dulcie A Vousden, Jason P Lerch, Anthony C Vernon, Pierre Gressens, Thomas Schmit. A unique cerebellar pattern of microglia activation in a mouse model of encephalopathy of prematurity. Glia. 2022-05-17. PMID:35579329. |
further studies are now required to confirm the potential of protective strategies aimed at preventing sustained type i interferon signaling driven by cerebellar microglia as an important therapeutic target. |
2022-05-17 |
2023-08-13 |
mouse |
| William P Marinello, Sagi Enicole A Gillera, Marley J Fanning, Lacey B Malinsky, Cassie L Rhodes, Brian M Horman, Heather B Patisau. Effects of Developmental Exposure to FireMaster® 550 (FM 550) on Microglia Density, Reactivity and Morphology in a Prosocial Animal Model. Neurotoxicology. 2022-05-08. PMID:35526706. |
adult offspring's brains were assessed for number and type (ramified, intermediate, ameboid) of microglia in the medial prefrontal cortex (mpfc), cerebellum (lobules vi-vii) and amygdala. |
2022-05-08 |
2023-08-13 |
mouse |
| Jennifer M Gibson, Tianci Chu, Wenxin Zeng, Ashley C Wethall, Maiying Kong, Nicholas Mellen, Lori A Devlin Phinney, Jun Ca. Perinatal methadone exposure attenuates myelination and induces oligodendrocyte apoptosis in neonatal rat brain. Experimental biology and medicine (Maywood, N.J.). 2022-04-27. PMID:35475383. |
there was no quantitative difference in astrocyte, however, cell density and/or morphologic difference consistent with activation were observed in microglia throughout mtd-exposed cc and cerebellum. |
2022-04-27 |
2023-08-13 |
rat |
| Tuancheng Feng, Lin Luan, Isabel Iscol Katz, Mohammed Ullah, Vivianna M Van Deerlin, John Q Trojanowski, Edward B Lee, Fenghua H. TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss. Acta neuropathologica communications. vol 10. issue 1. 2022-03-15. PMID:35287730. |
increased microglia and astrocyte activation, as well as an accumulation of ubiquitinated proteins, p62 and tdp-43 were also detected in the cerebellum of aged tmem106b deficient mice. |
2022-03-15 |
2023-08-13 |
mouse |
| Julie Bourseguin, Wen Cheng, Emily Talbot, Liana Hardy, Jenny Lai, Ailsa M Jeffries, Michael A Lodato, Eunjung Alice Lee, Svetlana V Khoronenkov. Persistent DNA damage associated with ATM kinase deficiency promotes microglial dysfunction. Nucleic acids research. 2022-02-25. PMID:35212385. |
activation of non-canonical nf-κb signalling is also observed in cerebellar microglia of individuals with ataxia-telangiectasia. |
2022-02-25 |
2023-08-13 |
human |
| Meysam Hassani Moghaddam, Saba Hatari, Amir Mahdi Emam Jome Shahidi, Fatemeh Nikpour, Hossein Salehi Omran, Mobina Fathi, Kimia Vakili, Mohammad Amin Abdollahifar, Mahdi Tizro, Neda Eskandari, Amir Raoofi, Vahid Ebrahimi, Abbas Aliaghae. Human Olfactory Epithelium-Derived Stem Cells Ameliorate Histopathological Deficits and Improve Behavioral Functions in a Rat Model of Cerebellar Ataxia. Journal of chemical neuroanatomy. 2022-01-20. PMID:35051594. |
besides, the implantation of oe-mscs reduced caspase-3 expression and microglia proliferation in the cerebellum upon 3-ap administration. |
2022-01-20 |
2023-08-13 |
human |
| Janace J Gifford, Pooja Deshpande, Priyanka Mehta, George C Wagner, Alexander W Kusneco. The Effect of Valproic Acid Exposure throughout Development on Microglia Number in the Prefrontal Cortex, Hippocampus and Cerebellum. Neuroscience. 2021-12-11. PMID:34780921. |
the effect of valproic acid exposure throughout development on microglia number in the prefrontal cortex, hippocampus and cerebellum. |
2021-12-11 |
2023-08-13 |
Not clear |
| Lu Wang, Zihui Deng, Yan Zhao, Rui Yuan, Mengmeng Yang, Yu Zhang, Yun Li, Yuyan Liu, Feihu Zhou, Hongjun Kan. Mesenchymal stem cells regulate activation of microglia cells to improve hippocampal injury of heat stroke rats. Journal of thermal biology. vol 101. 2021-12-09. PMID:34879909. |
we performed survival analysis, neurological deficit score, histological staining of hippocampus and cerebellum, immunofluorescence staining of microglia, detection of inflammatory and chemokine levels in the hippocampus and cerebellum in each group. |
2021-12-09 |
2023-08-13 |
rat |
| Lu Wang, Zihui Deng, Yan Zhao, Rui Yuan, Mengmeng Yang, Yu Zhang, Yun Li, Yuyan Liu, Feihu Zhou, Hongjun Kan. Mesenchymal stem cells regulate activation of microglia cells to improve hippocampal injury of heat stroke rats. Journal of thermal biology. vol 101. 2021-12-09. PMID:34879909. |
early treatment of mscs can greatly promote the activation of cerebellar microglia in heat stroke rats. |
2021-12-09 |
2023-08-13 |
rat |
| Shoto Sasaki, Takayuki Negishi, Takamasa Tsuzuki, Kazunori Yukaw. Diphenylarsinic acid induced activation of MAP kinases, transcription factors, and oxidative stress-responsive factors and hypersecretion of cytokines in cultured normal human cerebellar astrocytes. Neurotoxicology. 2021-12-09. PMID:34883095. |
these results suggested that aberrantly activated human astrocytes by dpaa exposure might play a pivotal role in the pathogenesis of cerebellar symptoms, affecting adjacent neurons, microglia, brain blood vessels, or astrocyte itself through these brain cytokines in human. |
2021-12-09 |
2023-08-13 |
human |
| Chunlian Song, Xin Huang, Yunmei Gao, Xue Zhang, Yulei Wang, Yajing Zhang, Tao Lv, Zhihui Zhang, Yalun Zhang, Qiong Pan, Yue Shu, Xianghua Sh. Histopathology of brain functional areas in pigs infected by porcine pseudorabies virus. Research in veterinary science. vol 141. 2021-12-08. PMID:34763257. |
immunohistochemistry showed that the virus was mainly localized in neurons, microglia, nerve fibers, cerebellar granular layer, and purkinje cell layer. |
2021-12-08 |
2023-08-13 |
Not clear |
| Hadar Levi, Ela Bar, Stav Cohen-Adiv, Suzan Sweitat, Sivan Kanner, Ronit Galron, Yulia Mitiagin, Ari Barzila. Dysfunction of cerebellar microglia in Ataxia-telangiectasia. Glia. 2021-12-02. PMID:34854502. |
dysfunction of cerebellar microglia in ataxia-telangiectasia. |
2021-12-02 |
2023-08-13 |
human |
| Hadar Levi, Ela Bar, Stav Cohen-Adiv, Suzan Sweitat, Sivan Kanner, Ronit Galron, Yulia Mitiagin, Ari Barzila. Dysfunction of cerebellar microglia in Ataxia-telangiectasia. Glia. 2021-12-02. PMID:34854502. |
in our quest to better understand the mechanisms by which atm deficiency causes cerebellar degeneration, we hypothesized that specific vulnerabilities of cerebellar microglia underlie the etiology of a-t. our hypothesis is based on the recent finding that dysfunction of glial cells affect a variety of process leading to impaired neuronal functionality (song et al., 2019). |
2021-12-02 |
2023-08-13 |
human |
| Rianne D Stowell, Ania K Majewsk. Acute ethanol exposure rapidly alters cerebellar and cortical microglial physiology. The European journal of neuroscience. vol 54. issue 5. 2021-09-17. PMID:32064695. |
here, for the first time, we have examined the acute response of microglia to alcohol intoxication in vivo utilizing two-photon microscopy to assess the dynamics of these motile cells in both visual cortex and the cerebellum of mice. |
2021-09-17 |
2023-08-13 |
mouse |
| Hiroshi Mitoma, Mario Manto, Aasef G Shaik. Mechanisms of Ethanol-Induced Cerebellar Ataxia: Underpinnings of Neuronal Death in the Cerebellum. International journal of environmental research and public health. vol 18. issue 16. 2021-09-06. PMID:34444449. |
furthermore, exposure to ethanol during the prenatal period interferes with neurotransmission, neurotrophic factors and retinoic acid-mediated signaling, and reduces the number of microglia, which diminishes expected cerebellar development. |
2021-09-06 |
2023-08-13 |
Not clear |
| Mark B Stoessel, Ania K Majewsk. Little cells of the little brain: microglia in cerebellar development and function. Trends in neurosciences. vol 44. issue 7. 2021-08-18. PMID:33933255. |
little cells of the little brain: microglia in cerebellar development and function. |
2021-08-18 |
2023-08-13 |
Not clear |
| Mark B Stoessel, Ania K Majewsk. Little cells of the little brain: microglia in cerebellar development and function. Trends in neurosciences. vol 44. issue 7. 2021-08-18. PMID:33933255. |
cerebellar microglia represent an example of such specialization, exhibiting a dynamical, transcriptional, and immunological profile that differs from that of other microglial populations. |
2021-08-18 |
2023-08-13 |
Not clear |
| Mark B Stoessel, Ania K Majewsk. Little cells of the little brain: microglia in cerebellar development and function. Trends in neurosciences. vol 44. issue 7. 2021-08-18. PMID:33933255. |
here we review the evidence that cerebellar microglia shape the cerebellar environment and are in turn shaped by it. |
2021-08-18 |
2023-08-13 |
Not clear |