| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M P Flavin, G Zhao, L T H. Microglial tissue plasminogen activator (tPA) triggers neuronal apoptosis in vitro. Glia. vol 29. issue 4. 2000-04-11. PMID:10652444. |
we previously showed that conditioned medium (cm) harvested from peritoneal macrophages or from activated microglia triggered apoptosis in rat hippocampal neurons in culture. |
2000-04-11 |
2023-08-12 |
human |
| M P Flavin, G Zhao, L T H. Microglial tissue plasminogen activator (tPA) triggers neuronal apoptosis in vitro. Glia. vol 29. issue 4. 2000-04-11. PMID:10652444. |
quiescent microglia produced cm that did not disrupt hippocampal neurons. |
2000-04-11 |
2023-08-12 |
human |
| K Bulloch, M Sadamatsu, A Patel, B S McEwe. Calcitonin gene-related peptide immunoreactivity in the hippocampus and its relationship to cellular changes following exposure to trimethyltin. Journal of neuroscience research. vol 55. issue 4. 2000-03-29. PMID:10723055. |
we have specifically focused on comparing the changes in cgrp-ir with the pattern of apoptosis (via tunel staining), cell-cycle activation (ki67-ir), and in alteration in microglia (ox-42-ir) and astrocyte (ggfap-ir) immunocytochemistry in tmt-treated hippocampus. |
2000-03-29 |
2023-08-12 |
Not clear |
| K Bulloch, M Sadamatsu, A Patel, B S McEwe. Calcitonin gene-related peptide immunoreactivity in the hippocampus and its relationship to cellular changes following exposure to trimethyltin. Journal of neuroscience research. vol 55. issue 4. 2000-03-29. PMID:10723055. |
our results show a marked change in cgrp-ir in regions of the hippocampus that are temporally and anatomically correlated with the induction of apoptosis and activation of microglia, astrocyte, and the cell-cycle marker. |
2000-03-29 |
2023-08-12 |
Not clear |
| A Matsumoto, K Itoh, R Matsumot. A novel carboxypeptidase B that processes native beta-amyloid precursor protein is present in human hippocampus. The European journal of neuroscience. vol 12. issue 1. 2000-03-16. PMID:10651877. |
an immunohistochemical study showed that the protease is expressed in various neuronal perikarya, including those of pyramidal neurons of the hippocampus and ependymal-choroid plexus cells, and in a portion of the microglia of normal brains. |
2000-03-16 |
2023-08-12 |
human |
| S A Kotecha, L C Schlichte. A Kv1.5 to Kv1.3 switch in endogenous hippocampal microglia and a role in proliferation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 24. 2000-01-06. PMID:10594052. |
a kv1.5 to kv1.3 switch in endogenous hippocampal microglia and a role in proliferation. |
2000-01-06 |
2023-08-12 |
rat |
| S A Kotecha, L C Schlichte. A Kv1.5 to Kv1.3 switch in endogenous hippocampal microglia and a role in proliferation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 24. 2000-01-06. PMID:10594052. |
microglia were tissue-printed directly from the hippocampal region using brain slices from 5- to 14-d-old rats. |
2000-01-06 |
2023-08-12 |
rat |
| F Imai, M Sawada, H Suzuki, B V Zlokovic, J Kojima, S Kuno, T Nagatsu, T Nitatori, Y Uchiyama, T Kann. Exogenous microglia enter the brain and migrate into ischaemic hippocampal lesions. Neuroscience letters. vol 272. issue 2. 1999-11-24. PMID:10507558. |
exogenous microglia enter the brain and migrate into ischaemic hippocampal lesions. |
1999-11-24 |
2023-08-12 |
Not clear |
| F Imai, M Sawada, H Suzuki, B V Zlokovic, J Kojima, S Kuno, T Nagatsu, T Nitatori, Y Uchiyama, T Kann. Exogenous microglia enter the brain and migrate into ischaemic hippocampal lesions. Neuroscience letters. vol 272. issue 2. 1999-11-24. PMID:10507558. |
we compared migration of systemically injected microglia into normal brain vs. ischaemic brain using a model of ischaemic hippocampal lesion. |
1999-11-24 |
2023-08-12 |
Not clear |
| F Imai, M Sawada, H Suzuki, B V Zlokovic, J Kojima, S Kuno, T Nagatsu, T Nitatori, Y Uchiyama, T Kann. Exogenous microglia enter the brain and migrate into ischaemic hippocampal lesions. Neuroscience letters. vol 272. issue 2. 1999-11-24. PMID:10507558. |
clusters of dye-tagged cells migrating into the hippocampal ischaemic lesions were confirmed histochemically to be microglia. |
1999-11-24 |
2023-08-12 |
Not clear |
| A V Yermakova, J Rollins, L M Callahan, J Rogers, M K O'Banio. Cyclooxygenase-1 in human Alzheimer and control brain: quantitative analysis of expression by microglia and CA3 hippocampal neurons. Journal of neuropathology and experimental neurology. vol 58. issue 11. 1999-11-17. PMID:10560656. |
cyclooxygenase-1 in human alzheimer and control brain: quantitative analysis of expression by microglia and ca3 hippocampal neurons. |
1999-11-17 |
2023-08-12 |
human |
| K Renkawek, G J Stege, G J Bosma. Dementia, gliosis and expression of the small heat shock proteins hsp27 and alpha B-crystallin in Parkinson's disease. Neuroreport. vol 10. issue 11. 1999-09-30. PMID:10439447. |
we found (1) no detectable expression of hsp in pd without dementia, and low expression in pd with mild dementia; (2) reactive gliosis and increased expression of hsp in the cortex of pdd brains; (3) a strong association between hsp immunoreactivity and the severity of the ad-specific changes, especially with the number of tangles in the hippocampus; (4) a distinct immunoreaction of alpha b-crystallin in microglia in the substantia nigra and in the hippocampus in pdd. |
1999-09-30 |
2023-08-12 |
Not clear |
| M Hartlage-Rübsamen, R Lemke, R Schlieb. Interleukin-1beta, inducible nitric oxide synthase, and nuclear factor-kappaB are induced in morphologically distinct microglia after rat hippocampal lipopolysaccharide/interferon-gamma injection. Journal of neuroscience research. vol 57. issue 3. 1999-09-08. PMID:10412030. |
interleukin-1beta, inducible nitric oxide synthase, and nuclear factor-kappab are induced in morphologically distinct microglia after rat hippocampal lipopolysaccharide/interferon-gamma injection. |
1999-09-08 |
2023-08-12 |
rat |
| M Hartlage-Rübsamen, R Lemke, R Schlieb. Interleukin-1beta, inducible nitric oxide synthase, and nuclear factor-kappaB are induced in morphologically distinct microglia after rat hippocampal lipopolysaccharide/interferon-gamma injection. Journal of neuroscience research. vol 57. issue 3. 1999-09-08. PMID:10412030. |
il-1beta immunoreactivity was detected as early as 3 hr following surgery in ramified microglia in the lesioned hippocampus and in distal cortical layers adjacent to the pia mater. |
1999-09-08 |
2023-08-12 |
rat |
| M Hartlage-Rübsamen, R Lemke, R Schlieb. Interleukin-1beta, inducible nitric oxide synthase, and nuclear factor-kappaB are induced in morphologically distinct microglia after rat hippocampal lipopolysaccharide/interferon-gamma injection. Journal of neuroscience research. vol 57. issue 3. 1999-09-08. PMID:10412030. |
by 12 hr post-injection, il-1beta immunoreactive, ramified microglia with swollen processes were widely distributed throughout hippocampal and neocortical areas, and staining was observed up to 48 hr after treatment. |
1999-09-08 |
2023-08-12 |
rat |
| A G Woods, F R Poulsen, C M Gal. Dexamethasone selectively suppresses microglial trophic responses to hippocampal deafferentation. Neuroscience. vol 91. issue 4. 1999-08-24. PMID:10391435. |
hippocampal deafferentation increases the expression of insulin-like growth factor-1 by microglia, and of ciliary neurotrophic factor and basic fibroblast growth factor by astroglia in fields and periods of reactive axonal growth. |
1999-08-24 |
2023-08-12 |
rat |
| M E Dailey, M Wait. Confocal imaging of microglial cell dynamics in hippocampal slice cultures. Methods (San Diego, Calif.). vol 18. issue 2. 1999-08-03. PMID:10356354. |
confocal imaging of microglial cell dynamics in hippocampal slice cultures. |
1999-08-03 |
2023-08-12 |
rat |
| M Stalder, A Phinney, A Probst, B Sommer, M Staufenbiel, M Jucke. Association of microglia with amyloid plaques in brains of APP23 transgenic mice. The American journal of pathology. vol 154. issue 6. 1999-07-14. PMID:10362792. |
light microscopic analysis revealed that the majority of the amyloid plaques in neocortex and hippocampus of 14- to 18- month-old app23 mice are congophilic and associated with clusters of hypertrophic microglia with intensely stained mac-1- and phosphotyrosine-positive processes. |
1999-07-14 |
2023-08-12 |
mouse |
| P E Lipsk. The clinical potential of cyclooxygenase-2-specific inhibitors. The American journal of medicine. vol 106. issue 5B. 1999-07-08. PMID:10390128. |
further, cox-2 expression may be up-regulated at certain sites: in the kidney during sodium restriction; in the microglia of cognitive centers within the hippocampus and cortex in alzheimer's disease; and in intestinal adenomas and colon tumors. |
1999-07-08 |
2023-08-12 |
human |
| A Vezzani, M Conti, A De Luigi, T Ravizza, D Moneta, F Marchesi, M G De Simon. Interleukin-1beta immunoreactivity and microglia are enhanced in the rat hippocampus by focal kainate application: functional evidence for enhancement of electrographic seizures. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 12. 1999-06-28. PMID:10366638. |
interleukin-1beta immunoreactivity and microglia are enhanced in the rat hippocampus by focal kainate application: functional evidence for enhancement of electrographic seizures. |
1999-06-28 |
2023-08-12 |
human |