| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrei Turkin, Oksana Tuchina, Friederike Klempi. Microglia Function on Precursor Cells in the Adult Hippocampus and Their Responsiveness to Serotonin Signaling. Frontiers in cell and developmental biology. vol 9. 2021-06-12. PMID:34109176. |
microglia function on precursor cells in the adult hippocampus and their responsiveness to serotonin signaling. |
2021-06-12 |
2023-08-13 |
Not clear |
| Andrei Turkin, Oksana Tuchina, Friederike Klempi. Microglia Function on Precursor Cells in the Adult Hippocampus and Their Responsiveness to Serotonin Signaling. Frontiers in cell and developmental biology. vol 9. 2021-06-12. PMID:34109176. |
in this chapter, we illustrate how microglia contribute to neuroplasticity of the hippocampus and interact with local factors, e.g., bdnf, and external stimuli that promote neurogenesis. |
2021-06-12 |
2023-08-13 |
Not clear |
| Jie Chen, Haochen Wang, Chengliang Luo, Cheng Gao, Yalai Zhang, Guang Chen, Wei Chen, Xiping Chen, Luyang Ta. Chd8 Rescued TBI-Induced Neurological Deficits by Suppressing Apoptosis and Autophagy Via Wnt Signaling Pathway. Cellular and molecular neurobiology. vol 40. issue 7. 2021-06-11. PMID:32034634. |
in vivo, we found that chd8 co-localized in neurons, astrocytes, and microglia, but predominantly presented in neurons in the prefrontal cortex, hippocampus, and cortex. |
2021-06-11 |
2023-08-13 |
Not clear |
| Max Rudolph, Christian W Schmeer, Madlen Günther, Florus Woitke, Carolin Kathner-Schaffert, Lina Karapetow, Julia Lindner, Thomas Lehmann, Gustav Jirikowski, Otto W Witte, Christoph Redecker, Silke Keine. Microglia-mediated phagocytosis of apoptotic nuclei is impaired in the adult murine hippocampus after stroke. Glia. vol 69. issue 8. 2021-06-09. PMID:33942391. |
here, we evaluated the effect of a prefrontal stroke lesion on the phagocytic activity of microglia in the dentate gyrus (dg) of the hippocampus. |
2021-06-09 |
2023-08-13 |
mouse |
| Alok Kumar, J Kalita, Rohit A Sinha, Gajendra Singh, Anjum B, Mukti Shukla, Swasti Tiwari, T N Dhole, U K Misr. Impaired Autophagy Flux is Associated with Proinflammatory Microglia Activation Following Japanese Encephalitis Virus Infection. Neurochemical research. vol 45. issue 9. 2021-06-08. PMID:32613347. |
microglia in cortex were activated and showed higher expression of proinflammatory mrna of il1β, tnf-α, ifnγ and il6, with increased dna damage (h2ax) and neuronal cell death pathways in hippocampus and neurobehavioral dysfunction. |
2021-06-08 |
2023-08-13 |
mouse |
| Yangyang Lin, Jian Jin, Rongke Lv, Yuan Luo, Weiping Dai, Wenchang Li, Yamei Tang, Yuling Wang, Xiaojing Ye, Wei-Jye Li. Repetitive transcranial magnetic stimulation increases the brain's drainage efficiency in a mouse model of Alzheimer's disease. Acta neuropathologica communications. vol 9. issue 1. 2021-06-07. PMID:34078467. |
significant reduction of aβ deposits, suppression of microglia and astrocyte activation, and prevention of decline of neuronal activity as indicated by the elevated c-fos expression, were observed in the prefrontal cortex and hippocampus of the rtms-treated 5xfad mice. |
2021-06-07 |
2023-08-13 |
mouse |
| Zixuan Cai, Ting Ye, Xing Xu, Minhui Gao, Yaru Zhang, Dan Wang, Yiming Gu, Haojie Zhu, Lijuan Tong, Jiashu Lu, Zhuo Chen, Chao Huan. Antidepressive properties of microglial stimulation in a mouse model of depression induced by chronic unpredictable stress. Progress in neuro-psychopharmacology & biological psychiatry. vol 101. 2021-06-04. PMID:32201112. |
the decrease of microglia in the hippocampus is a novel mechanism for depression onset. |
2021-06-04 |
2023-08-13 |
mouse |
| Zixuan Cai, Ting Ye, Xing Xu, Minhui Gao, Yaru Zhang, Dan Wang, Yiming Gu, Haojie Zhu, Lijuan Tong, Jiashu Lu, Zhuo Chen, Chao Huan. Antidepressive properties of microglial stimulation in a mouse model of depression induced by chronic unpredictable stress. Progress in neuro-psychopharmacology & biological psychiatry. vol 101. 2021-06-04. PMID:32201112. |
the antidepressant effect of lps appears to be dependent on microglia, as at 5 h after lps administration (100 μg/kg), the cus-induced decrease in microglial numbers and iba-1 mrna levels in the hippocampus was reversed markedly, and inhibition of microglia by minocycline (40 mg/kg) or plx33297 (290 mg/kg) prevented the antidepressant effect of lps in cus mice. |
2021-06-04 |
2023-08-13 |
mouse |
| Zixuan Cai, Ting Ye, Xing Xu, Minhui Gao, Yaru Zhang, Dan Wang, Yiming Gu, Haojie Zhu, Lijuan Tong, Jiashu Lu, Zhuo Chen, Chao Huan. Antidepressive properties of microglial stimulation in a mouse model of depression induced by chronic unpredictable stress. Progress in neuro-psychopharmacology & biological psychiatry. vol 101. 2021-06-04. PMID:32201112. |
these results indicate that a single lps injection displays rapid and sustained antidepressant effects in chronically stressed mice likely through stimulating hippocampal microglia. |
2021-06-04 |
2023-08-13 |
mouse |
| Peili Hu, Dan Wang, Yaru Zhang, Zixuan Cai, Ting Ye, Lijuan Tong, Xing Xu, Jiashu Lu, Fengguo Liu, Xu Lu, Chao Huan. Apoptosis-triggered decline in hippocampal microglia mediates adolescent intermittent alcohol exposure-induced depression-like behaviors in mice. Neuropharmacology. vol 170. 2021-06-03. PMID:32217088. |
apoptosis-triggered decline in hippocampal microglia mediates adolescent intermittent alcohol exposure-induced depression-like behaviors in mice. |
2021-06-03 |
2023-08-13 |
mouse |
| Peili Hu, Dan Wang, Yaru Zhang, Zixuan Cai, Ting Ye, Lijuan Tong, Xing Xu, Jiashu Lu, Fengguo Liu, Xu Lu, Chao Huan. Apoptosis-triggered decline in hippocampal microglia mediates adolescent intermittent alcohol exposure-induced depression-like behaviors in mice. Neuropharmacology. vol 170. 2021-06-03. PMID:32217088. |
since alcohol also activates microglia, we evaluated the dynamic changes in hippocampal microglia in mice receiving adolescent intermittent alcohol exposure (aie). |
2021-06-03 |
2023-08-13 |
mouse |
| Peili Hu, Dan Wang, Yaru Zhang, Zixuan Cai, Ting Ye, Lijuan Tong, Xing Xu, Jiashu Lu, Fengguo Liu, Xu Lu, Chao Huan. Apoptosis-triggered decline in hippocampal microglia mediates adolescent intermittent alcohol exposure-induced depression-like behaviors in mice. Neuropharmacology. vol 170. 2021-06-03. PMID:32217088. |
our results showed that 14 days of aie, followed by 21 days period of no treatment, induced behavioral abnormalities as well as a significant loss and dystrophy of hippocampal microglia in mice. |
2021-06-03 |
2023-08-13 |
mouse |
| Peili Hu, Dan Wang, Yaru Zhang, Zixuan Cai, Ting Ye, Lijuan Tong, Xing Xu, Jiashu Lu, Fengguo Liu, Xu Lu, Chao Huan. Apoptosis-triggered decline in hippocampal microglia mediates adolescent intermittent alcohol exposure-induced depression-like behaviors in mice. Neuropharmacology. vol 170. 2021-06-03. PMID:32217088. |
we found that this aie-induced decline in hippocampal microglia was mediated by both microglial activation and apoptosis, as (i) 1 day of alcohol exposure induced a distinct activation of hippocampal microglia followed by their apoptosis, and (ii) blocking the initial activation of hippocampal microglia by pretreatment with minocycline suppressed the aie-induced apoptosis and loss of hippocampal microglia as well as the aie-induced depression-like symptoms. |
2021-06-03 |
2023-08-13 |
mouse |
| Peili Hu, Dan Wang, Yaru Zhang, Zixuan Cai, Ting Ye, Lijuan Tong, Xing Xu, Jiashu Lu, Fengguo Liu, Xu Lu, Chao Huan. Apoptosis-triggered decline in hippocampal microglia mediates adolescent intermittent alcohol exposure-induced depression-like behaviors in mice. Neuropharmacology. vol 170. 2021-06-03. PMID:32217088. |
lipopolysaccharide (lps), a classical activator of microglia, ameliorated the aie-induced depression-like symptoms by reversing the decline in the hippocampal microglia. |
2021-06-03 |
2023-08-13 |
mouse |
| Charlotte Mezö, Nikolaos Dokalis, Omar Mossad, Ori Staszewski, Jana Neuber, Bahtiyar Yilmaz, Daniel Schnepf, Mercedes Gomez de Agüero, Stephanie C Ganal-Vonarburg, Andrew J Macpherson, Melanie Meyer-Luehmann, Peter Staeheli, Thomas Blank, Marco Prinz, Daniel Ern. Different effects of constitutive and induced microbiota modulation on microglia in a mouse model of Alzheimer's disease. Acta neuropathologica communications. vol 8. issue 1. 2021-05-31. PMID:32727612. |
furthermore, rna-sequencing of hippocampal microglia from spf, gf and abx-treated 5xfad mice revealed distinct microbiota-dependent gene expression profiles associated with phagocytosis and altered microglial activation states. |
2021-05-31 |
2023-08-13 |
mouse |
| J Michael, M S Unger, R Poupardin, P Schernthaner, H Mrowetz, J Attems, L Aigne. Microglia depletion diminishes key elements of the leukotriene pathway in the brain of Alzheimer's Disease mice. Acta neuropathologica communications. vol 8. issue 1. 2021-05-31. PMID:32771067. |
here, we identified the leukotriene (lt) synthesis rate-limiting enzyme 5-lipoxygenase (5-lox) primarily in neurons and to a lesser extent in a subpopulation of microglia in human alzheimer´s disease (ad) hippocampus brain sections and in brains of app swedish ps1 de9 (app-ps1) mice, a transgenic model for alzheimer´s disease (ad) pathology. |
2021-05-31 |
2023-08-13 |
mouse |
| Li Zhou, Xinrong Tao, Gang Pang, Min Mu, Qixian Sun, Fei Liu, Yuting Hu, Huihui Tao, Bing Li, Keyi X. Maternal Nicotine Exposure Alters Hippocampal Microglia Polarization and Promotes Anti-inflammatory Signaling in Juvenile Offspring in Mice. Frontiers in pharmacology. vol 12. 2021-05-30. PMID:34045967. |
maternal nicotine exposure alters hippocampal microglia polarization and promotes anti-inflammatory signaling in juvenile offspring in mice. |
2021-05-30 |
2023-08-13 |
mouse |
| Li Zhou, Xinrong Tao, Gang Pang, Min Mu, Qixian Sun, Fei Liu, Yuting Hu, Huihui Tao, Bing Li, Keyi X. Maternal Nicotine Exposure Alters Hippocampal Microglia Polarization and Promotes Anti-inflammatory Signaling in Juvenile Offspring in Mice. Frontiers in pharmacology. vol 12. 2021-05-30. PMID:34045967. |
in this study, we explored the impact of nicotine on the microglia during the development of hippocampus. |
2021-05-30 |
2023-08-13 |
mouse |
| Tasuku Araki, Yuji Ikegaya, Ryuta Koyam. Microglia attenuate the kainic acid-induced death of hippocampal neurons in slice cultures. Neuropsychopharmacology reports. vol 40. issue 1. 2021-05-28. PMID:31794154. |
microglia attenuate the kainic acid-induced death of hippocampal neurons in slice cultures. |
2021-05-28 |
2023-08-13 |
Not clear |
| Tasuku Araki, Yuji Ikegaya, Ryuta Koyam. Microglia attenuate the kainic acid-induced death of hippocampal neurons in slice cultures. Neuropsychopharmacology reports. vol 40. issue 1. 2021-05-28. PMID:31794154. |
status epilepticus-induced hippocampal neuronal death, astrogliosis, and the activation of microglia are common pathological changes in mesial temporal lobe epilepsy (mtle) with resistance to antiepileptic drugs. |
2021-05-28 |
2023-08-13 |
Not clear |