| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Temitope Adeoye, Syed I Shah, Ghanim Ulla. Systematic Analysis of Biological Processes Reveals Gene Co-expression Modules Driving Pathway Dysregulation in Alzheimer's Disease. bioRxiv : the preprint server for biology. 2024-04-01. PMID:38559218. |
co-expression networks highlighted the extended involvement of astrocytes and microglia in biological processes beyond neuroinflammation, such as calcium homeostasis, glutamate regulation, lipid metabolism, vesicle-mediated transport, and tor signaling. |
2024-04-01 |
2024-04-04 |
Not clear |
| Meishan Lu, Jiachen Shi, Xue Li, Yanjun Liu, Yuanfa Li. Long-term intake of thermo-induced oxidized oil results in anxiety-like and depression-like behaviors: involvement of microglia and astrocytes. Food & function. 2024-03-27. PMID:38533894. |
tioo primarily induced these two emotional disorders by affecting the differentiation of microglia, the level of inflammatory factors, the activation of astrocytes, and glutamate circulation in brain tissue. |
2024-03-27 |
2024-03-29 |
mouse |
| Yangzhi Xie, Liang Chen, Jiacheng Chen, Yan Luo, Zhe Peng, Hao Zhang, Zhao Pan, Yongjun Che. Metabotropic Glutamate Receptor 8 Suppresses M1 Polarization in Microglia by Alleviating Endoplasmic Reticulum Stress and Mitochondrial Dysfunction. Journal of integrative neuroscience. vol 23. issue 2. 2024-02-29. PMID:38419440. |
metabotropic glutamate receptor 8 suppresses m1 polarization in microglia by alleviating endoplasmic reticulum stress and mitochondrial dysfunction. |
2024-02-29 |
2024-03-02 |
Not clear |
| Priscila G C Almeida, João Victor Nani, Jean Pierre Oses, Elisa Brietzke, Mirian A F Hayash. Neuroinflammation and glial cell activation in mental disorders. Brain, behavior, & immunity - health. vol 2. 2024-02-20. PMID:38377429. |
in this context, microglial dysfunction has recently emerged as a possible pivotal player, as during the neuroinflammatory response, microglia can be over-activated, and excessive production of pro-inflammatory cytokines, which can modify the kynurenine and glutamate signaling, is reported. |
2024-02-20 |
2024-02-23 |
Not clear |
| Jit Chatterjee, Joshua P Koleske, Astoria Chao, Andrew D Sauerbeck, Ji-Kang Chen, Xuanhe Qi, Megan Ouyang, Lucy G Boggs, Rujuta Idate, Lara Isabel Marco Y Marquez, Terrence T Kummer, David H Gutman. Brain injury drives optic glioma formation through neuron-glia signaling. Acta neuropathologica communications. vol 12. issue 1. 2024-02-02. PMID:38308315. |
we further elucidate the underlying molecular and cellular mechanisms, whereby glutamate released from damaged neurons stimulates il-1β release by oligodendrocytes to induce microglia expression of ccl5, a growth factor critical for nf1-opg formation. |
2024-02-02 |
2024-02-05 |
mouse |
| Ze Cao, Xia Min, Xingxing Xie, Maoqing Huang, Yingying Liu, Weimin Sun, Guifang Xu, Miao He, Kaiwen He, Ying Li, Junying Yua. RIPK1 activation in Mecp2-deficient microglia promotes inflammation and glutamate release in RTT. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 6. 2024-01-30. PMID:38289948. |
ripk1 activation in mecp2-deficient microglia promotes inflammation and glutamate release in rtt. |
2024-01-30 |
2024-02-02 |
mouse |
| Ze Cao, Xia Min, Xingxing Xie, Maoqing Huang, Yingying Liu, Weimin Sun, Guifang Xu, Miao He, Kaiwen He, Ying Li, Junying Yua. RIPK1 activation in Mecp2-deficient microglia promotes inflammation and glutamate release in RTT. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 6. 2024-01-30. PMID:38289948. |
ripk1 inhibition in mecp2-deficient microglia reduced oxidative stress, cytokines production and induction of slc7a11, slc38a1, and gls, which mediate the release of glutamate. |
2024-01-30 |
2024-02-02 |
mouse |
| Ze Cao, Xia Min, Xingxing Xie, Maoqing Huang, Yingying Liu, Weimin Sun, Guifang Xu, Miao He, Kaiwen He, Ying Li, Junying Yua. RIPK1 activation in Mecp2-deficient microglia promotes inflammation and glutamate release in RTT. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 6. 2024-01-30. PMID:38289948. |
mecp2-deficient microglia release high levels of glutamate to impair glutamate-mediated excitatory neurotransmission and promote increased levels of glua1 and glua2/3 proteins in vivo, which was reduced upon ripk1 inhibition. |
2024-01-30 |
2024-02-02 |
mouse |
| Jiang-Ping Wei, Zi-Xuan Zhao, Jing Zeng, Fang-Hong Shang, Lei Hua, Yong Yang, Xiao-Mei Zhan. [Yigong Powder regulates CXCL12/CXCR4 signaling to reduce glutamate release and prevent cognitive decline in mouse model of aging]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 23. 2024-01-11. PMID:38212005. |
furthermore, yigong powder decreased the average fluorescence intensity of cxcl12 and cxcr4, reduced cxcr4-positive astrocytes and microglia, down-regulated the protein levels of p-erk/erk and tnfr1, and lowered the level of glutamate in the brain tissue. |
2024-01-11 |
2024-01-14 |
mouse |
| Mariusz P Gajewski, Steven W Barge. Design, synthesis, and characterization of novel system x Journal of neuroinflammation. vol 20. issue 1. 2023-12-07. PMID:38057869. |
design, synthesis, and characterization of novel system x neuroinflammation appears to involve some degree of excitotoxicity promulgated by microglia, which release glutamate via the system x |
2023-12-07 |
2023-12-10 |
Not clear |
| Dongxia Duan, Lian Wang, Yueyang Feng, Daiyu Hu, Donghong Cu. Picroside Ⅱ attenuates neuropathic pain by regulating inflammation and spinal excitatory synaptic transmission. Canadian journal of physiology and pharmacology. 2023-11-17. PMID:37976472. |
thus, this study suggested that pⅡ attenuated neuropathic pain by inhibiting excitatory glutamate transmission of spinal synapses induced by an inflammatory response on microglia. |
2023-11-17 |
2023-11-20 |
rat |
| Alicja Maciejska, Bartosz Pomierny, Weronika Krzyżanowska, Beata Starek-Świechowicz, Alicja Skórkowska, Bogusława Budziszewsk. Mechanism of microglial cell activation in the benzophenone-3 exposure model. Neuroscience. 2023-10-12. PMID:37827357. |
this compound increases extracellular glutamate concentrations, lipid peroxidation, the number of microglia cells and induces process of apoptosis. |
2023-10-12 |
2023-10-15 |
rat |
| Qihui Zhao, Junli Chen, Mengjun Wu, Xiaoli Yin, Qiaoying Jiang, Hongchang Gao, Hong Zhen. Microbiota from healthy mice alleviates cognitive decline via reshaping the gut-brain metabolic axis in diabetic mice. Chemico-biological interactions. 2023-07-20. PMID:37473910. |
in vitro study, we found that glutamate notably decreased microglia activation and the expression levels of proinflammatory factor. |
2023-07-20 |
2023-08-14 |
mouse |
| Shengwen Wang, Ye Liu, Zekang Wu, Yuwen Jin, Tao Zhang, Zhuo Yang, Chunhua Li. Inhibition of xCT by sulfasalazine alleviates the depression-like behavior of adult male mice subjected to maternal separation stress. Behavioural brain research. 2023-07-01. PMID:37392785. |
moreover, the levels of eaat2 and mglur2/3 were ameliorated, the over-activation of the microglia was mitigated, and the levels of glutamate and pro-inflammatory factors were decreased. |
2023-07-01 |
2023-08-14 |
mouse |
| Chenhui Ji, Yalin Tang, Yanyan Zhang, Xiaoyan Huang, Congcong Li, Yuhong Yang, Qihui Wu, Xiaohuan Xia, Qingyuan Cai, Xin-Rui Qi, Jialin C Zhen. Glutaminase 1 deficiency confined in forebrain neurons causes autism spectrum disorder-like behaviors. Cell reports. vol 42. issue 7. 2023-06-29. PMID:37384529. |
mice lacking gls1 in camkiiα-positive neurons display a series of asd-like behaviors, synaptic excitatory and inhibitory (e/i) imbalance, higher spine density, and glutamate receptor expression in the prefrontal cortex, as well as a compromised expression pattern of genes involved in synapse pruning and less engulfed synaptic puncta in microglia. |
2023-06-29 |
2023-08-14 |
mouse |
| Mariusz Gajewski, Steven Barge. Design, synthesis, and characterization of novel Xc- transport inhibitors: Inhibition of microglial glutamate release and neurotoxicity. Research square. 2023-06-09. PMID:37292591. |
neuroinflammation appears to involve some degree of excitotoxicity promulgated by microglia, which release glutamate via the system xc- cystine-glutamate antiporter. |
2023-06-09 |
2023-08-14 |
Not clear |
| Mariusz Gajewski, Steven Barge. Design, synthesis, and characterization of novel Xc- transport inhibitors: Inhibition of microglial glutamate release and neurotoxicity. Research square. 2023-06-09. PMID:37292591. |
these agents were tested for the ability to inhibit release of glutamate from microglia activated with lipopolysaccharide (lps), an activity exhibited by eight of the compounds. |
2023-06-09 |
2023-08-14 |
Not clear |
| Rosanna Tarkany Basting, Marcelo Henrique Napimoga, Carlos Antônio Trindade Silva, Henrique Ballassini Abdalla, Braz Campos Durso, Leopoldo Henrique Barboza Martins, Herbert de Abreu Cavalcanti, Bruce D Hammock, Juliana Trindade Clemente-Napimog. Soluble epoxide hydrolase inhibitor blockage microglial cell activation in subnucleus caudalis in a persistent model of arthritis. International immunopharmacology. vol 120. 2023-05-25. PMID:37230034. |
in tsc, tppu reduces the cytokine storm and attenuates the microglia activated p2x7/cathepsin s/fractalkine pathway and reduces the astrocyte activation and glutamate levels. |
2023-05-25 |
2023-08-14 |
rat |
| b' Marzia Moretti, Riccardo Caraffi, Luca Lorenzini, Ilaria Ottonelli, Michele Sannia, Giuseppe Alastra, Vito Antonio Baldassarro, Alessandro Giuliani, Jason Thomas Duskey, Maura Cescatti, Barbara Ruozi, Luigi Aloe, Maria Angela Vandelli, Luciana Giardino, Giovanni Tosi, Laura Calz\\xc3\\xa. "Combo" Multi-Target Pharmacological Therapy and New Formulations to Reduce Inflammation and Improve Endogenous Remyelination in Traumatic Spinal Cord Injury. Cells. vol 12. issue 9. 2023-05-14. PMID:37174731.' |
a strong anti-inflammatory effect was observed in the short term with a reduction of type m1 microglia and glutamate levels, but with a subsequent increase of trem2. |
2023-05-14 |
2023-08-14 |
mouse |
| Yi-Wen Bai, Qi-Hao Yang, Pei-Jie Chen, Xue-Qiang Wan. Repetitive transcranial magnetic stimulation regulates neuroinflammation in neuropathic pain. Frontiers in immunology. vol 14. 2023-05-14. PMID:37180127. |
in addition, rtms reduces the expression of glutamate receptors (mglur5 and nmdar2b) and microglia and astrocyte markers (iba1 and gfap). |
2023-05-14 |
2023-08-14 |
Not clear |