| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fan Zhang, Zhi Zhang, Jesse Alt, Siva P Kambhampati, Anjali Sharma, Sarabdeep Singh, Elizabeth Nance, Ajit G Thomas, Camilo Rojas, Rana Rais, Barbara S Slusher, Rangaramanujam M Kannan, Sujatha Kanna. Dendrimer-enabled targeted delivery attenuates glutamate excitotoxicity and improves motor function in a rabbit model of cerebral palsy. Journal of controlled release : official journal of the Controlled Release Society. 2023-04-13. PMID:37054778. |
glutamate carboxypeptidase ii (gcpii), localized on the surface of astrocytes and activated microglia, regulates extracellular glutamate concentration in the central nervous system (cns). |
2023-04-13 |
2023-08-14 |
rabbit |
| Fan Zhang, Zhi Zhang, Jesse Alt, Siva P Kambhampati, Anjali Sharma, Sarabdeep Singh, Elizabeth Nance, Ajit G Thomas, Camilo Rojas, Rana Rais, Barbara S Slusher, Rangaramanujam M Kannan, Sujatha Kanna. Dendrimer-enabled targeted delivery attenuates glutamate excitotoxicity and improves motor function in a rabbit model of cerebral palsy. Journal of controlled release : official journal of the Controlled Release Society. 2023-04-13. PMID:37054778. |
targeted delivery of 2-mppa specifically to activated microglia and astrocytes that over-express gcpii has the potential to mitigate glutamate excitotoxicity and attenuate neuroinflammation. |
2023-04-13 |
2023-08-14 |
rabbit |
| Fan Zhang, Zhi Zhang, Jesse Alt, Siva P Kambhampati, Anjali Sharma, Sarabdeep Singh, Elizabeth Nance, Ajit G Thomas, Camilo Rojas, Rana Rais, Barbara S Slusher, Rangaramanujam M Kannan, Sujatha Kanna. Dendrimer-enabled targeted delivery attenuates glutamate excitotoxicity and improves motor function in a rabbit model of cerebral palsy. Journal of controlled release : official journal of the Controlled Release Society. 2023-04-13. PMID:37054778. |
these results indicate that targeted dendrimer-based delivery specifically to activated microglia and astrocytes can improve the efficacy of 2-mppa by attenuating glutamate excitotoxicity and microglial activation. |
2023-04-13 |
2023-08-14 |
rabbit |
| Matilde Balbi, Giambattista Bonanno, Tiziana Bonifacino, Marco Milanes. The Physio-Pathological Role of Group I Metabotropic Glutamate Receptors Expressed by Microglia in Health and Disease with a Focus on Amyotrophic Lateral Sclerosis. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36982315. |
the physio-pathological role of group i metabotropic glutamate receptors expressed by microglia in health and disease with a focus on amyotrophic lateral sclerosis. |
2023-03-29 |
2023-08-14 |
Not clear |
| Matilde Balbi, Giambattista Bonanno, Tiziana Bonifacino, Marco Milanes. The Physio-Pathological Role of Group I Metabotropic Glutamate Receptors Expressed by Microglia in Health and Disease with a Focus on Amyotrophic Lateral Sclerosis. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36982315. |
in this context, group i metabotropic glutamate receptors (mglurs) are molecular structures that may contribute to the modulation of the reactive phenotype of microglia cells, and this is worthy of exploration. |
2023-03-29 |
2023-08-14 |
Not clear |
| Nirnath Sah, Zhi Zhang, Alicia Chime, Amanda Fowler, Antonio Mendez-Trendler, Anjali Sharma, Kannan Rangaramanujam, Barbara Slusher, Sujatha Kanna. Dendrimer conjugated glutamate carboxypeptidase II inhibitor restores microglial changes in a rabbit model of cerebral palsy. Developmental neuroscience. 2023-03-29. PMID:36990069. |
'activated' microglia overexpress the enzyme glutamate carboxypeptidase ii (gcpii) that hydrolyzes n-acetylaspartylglutamate (naag) to n-acetylaspartate (naa) and glutamate, and we have shown previously that inhibiting microglial gcpii is neuroprotective. |
2023-03-29 |
2023-08-14 |
rabbit |
| Yanying Miao, Guo-Li Zhao, Shuo Cheng, Zhongfeng Wang, Xiong-Li Yan. Activation of retinal glial cells contributes to the degeneration of ganglion cells in experimental glaucoma. Progress in retinal and eye research. vol 93. 2023-02-03. PMID:36736070. |
activated müller cells contribute to rgc degeneration through generating glutamate receptor-mediated excitotoxicity, releasing cytotoxic factors and inducing microglia activation. |
2023-02-03 |
2023-08-14 |
Not clear |
| Mariangela Chisari, Michele Barraco, Claudio Bucolo, Lucia Ciranna, Maria Angela Sortin. Purinergic ionotropic P2X7 and metabotropic glutamate mGlu European journal of pharmacology. 2022-11-26. PMID:36435235. |
purinergic ionotropic p2x7 and metabotropic glutamate mglu microglia represent the resident immune system in the brain. |
2022-11-26 |
2023-08-14 |
Not clear |
| Emily Sun, Aishat Motolani, Leonardo Campos, Tao L. The Pivotal Role of NF-kB in the Pathogenesis and Therapeutics of Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 16. 2022-08-26. PMID:36012242. |
some of these cell types and molecules include reactive microglia and astrocytes, β-secretase, apoe, glutamate, mirna, and tau protein, among others. |
2022-08-26 |
2023-08-14 |
mouse |
| Andrea de Bartolomeis, Annarita Barone, Licia Vellucci, Benedetta Mazza, Mark C Austin, Felice Iasevoli, Mariateresa Ciccarell. Linking Inflammation, Aberrant Glutamate-Dopamine Interaction, and Post-synaptic Changes: Translational Relevance for Schizophrenia and Antipsychotic Treatment: a Systematic Review. Molecular neurobiology. 2022-08-13. PMID:35963926. |
furthermore, the link between inflammation and glutamate is strongly supported by clinical studies aimed at exploring overactive microglia in schizophrenia patients and maternal immune activation models, indicating impaired glutamate regulation and reduced n-methyl-d-aspartate receptor (nmdar) function. |
2022-08-13 |
2023-08-14 |
Not clear |
| Benjamin J Bell, Kristen R Hollinger, Pragney Deme, Shinji Sakamoto, Yuto Hasegawa, David Volsky, Atsushi Kamiya, Norman Haughey, Xiaolei Zhu, Barbara S Slushe. Glutamine antagonist JHU083 improves psychosocial behavior and sleep deficits in EcoHIV-infected mice. Brain, behavior, & immunity - health. vol 23. 2022-06-23. PMID:35734753. |
thus, brain-penetrable gls inhibitors like jhu083 could act as a potential therapeutic modality for both glutamate excitotoxicity and aberrant immune activation in microglia in chronic hiv infection. |
2022-06-23 |
2023-08-14 |
mouse |
| David H Allendorf, Guy C Brow. Neu1 Is Released From Activated Microglia, Stimulating Microglial Phagocytosis and Sensitizing Neurons to Glutamate. Frontiers in cellular neuroscience. vol 16. 2022-06-13. PMID:35693885. |
neu1 is released from activated microglia, stimulating microglial phagocytosis and sensitizing neurons to glutamate. |
2022-06-13 |
2023-08-14 |
Not clear |
| David H Allendorf, Guy C Brow. Neu1 Is Released From Activated Microglia, Stimulating Microglial Phagocytosis and Sensitizing Neurons to Glutamate. Frontiers in cellular neuroscience. vol 16. 2022-06-13. PMID:35693885. |
culture media from activated microglia contained neu1, and when incubated with neurons induced their desialylation, and increased the neuronal death induced by low levels of glutamate. |
2022-06-13 |
2023-08-14 |
Not clear |
| David H Allendorf, Guy C Brow. Neu1 Is Released From Activated Microglia, Stimulating Microglial Phagocytosis and Sensitizing Neurons to Glutamate. Frontiers in cellular neuroscience. vol 16. 2022-06-13. PMID:35693885. |
we conclude that activated microglia can release active neu1, possibly by lysosomal exocytosis, and this can both increase microglial phagocytosis and sensitize neurons to glutamate, thus potentiating neuronal death. |
2022-06-13 |
2023-08-14 |
Not clear |
| Ruili Guan, Tao Wang, Xiaoru Dong, Kejun Du, Juan Li, Fang Zhao, Jie Xu, Bin Li, Gang Zheng, Xuefeng Shen, Baohua Cao, Jing Wang, Michael Aschner, Mingchao Liu, Rui Che. Effects of co-exposure to lead and manganese on learning and memory deficits. Journal of environmental sciences (China). vol 121. 2022-06-02. PMID:35654517. |
the reason may involve abnormal activation of microglia leading to excessive regulation of astrocytes, resulting in glutamate reuptake dysfunction in astrocytes and leading to perturbed cognition and synaptic plasticity. |
2022-06-02 |
2023-08-14 |
human |
| Ciro De Luca, Assunta Virtuoso, Michele Papa, Francesco Certo, Giuseppe Maria Vincenzo Barbagallo, Roberto Altier. Regional Development of Glioblastoma: The Anatomical Conundrum of Cancer Biology and Its Surgical Implication. Cells. vol 11. issue 8. 2022-04-23. PMID:35456027. |
in this review, we analyze the anatomical and biological basis of gliomagenesis considering neural stem cells, the spatiotemporal diversity of astrocytes, microglia, neurons and glutamate transporters, extracellular matrix and the peritumoral environment. |
2022-04-23 |
2023-08-13 |
Not clear |
| Angela Maria Casaril, Athanasios Katsalifis, Rolf M Schmidt, Carlos Bas-Ort. Activated glia cells cause bioenergetic impairment of neurons that can be rescued by knock-down of the mitochondrial calcium uniporter. Biochemical and biophysical research communications. vol 608. 2022-04-07. PMID:35390671. |
in neuroinflammation, activated microglia and astrocytes release soluble mediators such as cytokines, glutamate, and reactive oxygen species that negatively affect neuronal function and viability, and thus contribute to neurodegeneration during disease progression. |
2022-04-07 |
2023-08-13 |
rat |
| Yan Zhang, Suliman Khan, Yang Liu, Guofeng Wu, V Wee Yong, Mengzhou Xu. Oxidative Stress Following Intracerebral Hemorrhage: From Molecular Mechanisms to Therapeutic Targets. Frontiers in immunology. vol 13. 2022-03-31. PMID:35355999. |
important sources of reactive oxygen species after hemorrhage are mitochondria dysfunction, degradated products of erythrocytes, excitotoxic glutamate, activated microglia and infiltrated neutrophils. |
2022-03-31 |
2023-08-13 |
Not clear |
| Zhuo Wang, Yunhui Li, Zhikun Zeng, Shuang Guo, Wei Chen, Yi Lu. Leucine-rich repeat containing 8A contributes to the expansion of The potential role of leucine-rich repeat-containing protein 8A in central nervous system: current situation and prospect. Neuroscience. 2022-03-11. PMID:35276302. |
after cerebral ischemia, the swollen astrocytes, neurons and microglia can activate lrrc8a-dependent vracs, which may respectively promote the release of excitatory amino acids (eaa), interaction with ionotropic glutamate receptors, and regulating inflammation, suggesting the pleiotropic roles of lrrc8a in swollen brain cells. |
2022-03-11 |
2023-08-13 |
Not clear |
| Joana Bravo, Inês Ribeiro, Ana Filipa Terceiro, Elva B Andrade, Camila Cabral Portugal, Igor M Lopes, Maria M Azevedo, Mafalda Sousa, Cátia D F Lopes, Andrea C Lobo, Teresa Canedo, João Bettencourt Relvas, Teresa Summaviell. Neuron-Microglia Contact-Dependent Mechanisms Attenuate Methamphetamine-Induced Microglia Reactivity and Enhance Neuronal Plasticity. Cells. vol 11. issue 3. 2022-02-15. PMID:35159165. |
recently, we demonstrated that binge meth administration promotes microgliosis and microglia pro-inflammation via astrocytic glutamate release in a tnf/ip |
2022-02-15 |
2023-08-13 |
Not clear |