| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gelareh Abulwerdi, Bogdan A Stoica, David J Loane, Alan I Fade. Putative mGluR4 positive allosteric modulators activate G Neurochemistry international. vol 138. 2021-07-30. PMID:32454165. |
a previous study reported that adx88178, a putative metabotropic glutamate receptor 4 (mglur4) positive allosteric modulator (pam), exerts anti-inflammatory effects in microglia by activating mglur4. |
2021-07-30 |
2023-08-13 |
Not clear |
| b' Eduard Parellada, Patricia Gass\\xc3\\xb. Glutamate and microglia activation as a driver of dendritic apoptosis: a core pathophysiological mechanism to understand schizophrenia. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33958577.' |
glutamate and microglia activation as a driver of dendritic apoptosis: a core pathophysiological mechanism to understand schizophrenia. |
2021-06-28 |
2023-08-13 |
Not clear |
| b' Eduard Parellada, Patricia Gass\\xc3\\xb. Glutamate and microglia activation as a driver of dendritic apoptosis: a core pathophysiological mechanism to understand schizophrenia. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33958577.' |
this driving hypothesis has relevant therapeutic implications, including the importance of pharmacological interventions during the prodromal phase or the transition to psychosis, targeting apoptosis, microglia cells or the glutamate storm. |
2021-06-28 |
2023-08-13 |
Not clear |
| Dániel Pukoli, Helga Polyák, Cecilia Rajda, László Vécse. Kynurenines and Neurofilament Light Chain in Multiple Sclerosis. Frontiers in neuroscience. vol 15. 2021-06-12. PMID:34113231. |
this process can initiate a pathogenic cascade, including microglia activation, glutamate excitotoxicity, chronic oxidative stress or accumulated mitochondrial damage in the axons, that finally disrupt the homeostasis of neurons, leads to destabilization of neuronal cell cytoskeleton, contributes to neuro-axonal damage and neurodegeneration. |
2021-06-12 |
2023-08-13 |
Not clear |
| Mohammed E Choudhury, Yuka Kigami, Junya Tanak. Dual Roles of Microglia in the Basal Ganglia in Parkinson's Disease. International journal of molecular sciences. vol 22. issue 8. 2021-05-25. PMID:33918947. |
on the other hand, microglia are also activated in the basal ganglia outputs (the substantia nigra pars reticulata and the globus pallidus) in response to excess glutamate released from hyperactive subthalamic nuclei-derived synapses. |
2021-05-25 |
2023-08-13 |
Not clear |
| Jeniffer Sanguino-Gómez, Jacobus C Buurstede, Oihane Abiega, Carlos P Fitzsimons, Paul J Lucassen, Bart J L Eggen, Sylvie L Lesuis, Onno C Meijer, Harm J Kruger. An emerging role for microglia in stress-effects on memory. The European journal of neuroscience. 2021-05-05. PMID:33724565. |
these microglia have (3) impaired crosstalk with neurons and (4) disrupted glutamate signaling. |
2021-05-05 |
2023-08-13 |
Not clear |
| Renato Socodato, Camila C Portugal, Teresa Canedo, Artur Rodrigues, Tiago O Almeida, Joana F Henriques, Sandra H Vaz, João Magalhães, Cátia M Silva, Filipa I Baptista, Renata L Alves, Vanessa Coelho-Santos, Ana Paula Silva, Roberto Paes-de-Carvalho, Ana Magalhães, Cord Brakebusch, Ana M Sebastião, Teresa Summavielle, António F Ambrósio, João B Relva. Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration. Cell reports. vol 31. issue 12. 2021-04-28. PMID:32579923. |
mechanistically, loss of rhoa in microglia triggers src activation and src-mediated tumor necrosis factor (tnf) production, leading to excitotoxic glutamate secretion. |
2021-04-28 |
2023-08-13 |
mouse |
| Sam Joshva Baskar Jesudasan, Somnath J Gupta, Matthew A Churchward, Kathryn G Todd, Ian R Winshi. Inflammatory Cytokine Profile and Plasticity of Brain and Spinal Microglia in Response to ATP and Glutamate. Frontiers in cellular neuroscience. vol 15. 2021-04-24. PMID:33889075. |
inflammatory cytokine profile and plasticity of brain and spinal microglia in response to atp and glutamate. |
2021-04-24 |
2023-08-13 |
Not clear |
| Sam Joshva Baskar Jesudasan, Somnath J Gupta, Matthew A Churchward, Kathryn G Todd, Ian R Winshi. Inflammatory Cytokine Profile and Plasticity of Brain and Spinal Microglia in Response to ATP and Glutamate. Frontiers in cellular neuroscience. vol 15. 2021-04-24. PMID:33889075. |
the available data indicates that atp and glutamate can induce the release of pro inflammatory factors tnf (tumor necrosis factor), il-1β (interleukin 1 beta), and no (nitric oxide) from microglia. |
2021-04-24 |
2023-08-13 |
Not clear |
| Sam Joshva Baskar Jesudasan, Somnath J Gupta, Matthew A Churchward, Kathryn G Todd, Ian R Winshi. Inflammatory Cytokine Profile and Plasticity of Brain and Spinal Microglia in Response to ATP and Glutamate. Frontiers in cellular neuroscience. vol 15. 2021-04-24. PMID:33889075. |
here, we have compared the response of spinal cord microglia (sm) relative to brain microglia (bm) using physiologically relevant concentrations of glutamate and atp that mimic injured conditions in the central nervous system. |
2021-04-24 |
2023-08-13 |
Not clear |
| Noémi Lajkó, Diana Kata, Melinda Szabó, Adrienne Mátyás, Karolina Dulka, Imre Földesi, Ferenc Fülöp, Karoly Gulya, László Vécsei, András Mihál. Sensitivity of Rodent Microglia to Kynurenines in Models of Epilepsy and Inflammation In Vivo and In Vitro: Microglia Activation is Inhibited by Kynurenic Acid and the Synthetic Analogue SZR104. International journal of molecular sciences. vol 21. issue 23. 2021-03-02. PMID:33297593. |
since glutamate and microglia are important in the pathogenesis of epilepsy, we investigated the possible action of the synthetic kynurenic acid analogue, szr104, in epileptic mice and the action of kynurenic acid and szr104 on the phagocytotic activity of cultured microglia cells. |
2021-03-02 |
2023-08-13 |
mouse |
| Eunyoung Kim, Undarmaa Otgontenger, Ariunzaya Jamsranjav, Sang Seong Ki. Deleterious Alteration of Glia in the Brain of Alzheimer's Disease. International journal of molecular sciences. vol 21. issue 18. 2021-02-25. PMID:32932623. |
basically, microglia and astrocytes contribute to neuronal sustainability by releasing neuroprotective cytokines, maintaining an adequate amount of glutamate in the synapse, and pruning excessive synaptic terminals. |
2021-02-25 |
2023-08-13 |
Not clear |
| Md Saidur Rahman, Jianbo Yang, Yan Luan, Zhengguo Qiu, Jianshui Zhang, Haixia Lu, Xinlin Chen, Yong Li. Attenuation of Acute Intracerebral Hemorrhage-Induced Microglial Activation and Neuronal Death Mediated by the Blockade of Metabotropic Glutamate Receptor 5 In Vivo. Neurochemical research. vol 45. issue 5. 2021-01-29. PMID:32140955. |
metabotropic glutamate receptor 5 (mglur5) is highly expressed in reactive microglia and is involved in the pathological processes of brain disorders, but its role in intracerebral hemorrhage (ich) remains unknown. |
2021-01-29 |
2023-08-13 |
mouse |
| Huan Liu, Rehana K Leak, Xiaoming H. Neurotransmitter receptors on microglia. Stroke and vascular neurology. vol 1. issue 2. 2021-01-18. PMID:28959464. |
here we review data supporting the importance of neurotransmitter receptors on microglia, with a special emphasis on glutamate, γ-aminobutyric acid (gaba), norepinephrine, cannabinoid and acetylcholine receptors. |
2021-01-18 |
2023-08-13 |
Not clear |
| Chin-Tsang Yang, Shih-Ya Hung, Sheng-Feng Hsu, Iona MacDonald, Jaung-Geng Lin, Sih-Ting Luo, Pei-Lin Lin, Yi-Hung Che. Inhibiting the LPS-induced enhancement of mEPSC frequency in superficial dorsal horn neurons may serve as an electrophysiological model for alleviating pain. Scientific reports. vol 9. issue 1. 2020-10-27. PMID:31690742. |
these results indicate that lps-activated microglia release atp, which stimulates astrocyte p2y1rs to release glutamate, triggering presynaptic mglur5 receptors and increasing presynaptic glutamate release, leading to an increase in mepsc frequency and enhancement of nociceptive transmission in sdh neurons. |
2020-10-27 |
2023-08-13 |
mouse |
| L Iovino, M E Tremblay, L Civier. Glutamate-induced excitotoxicity in Parkinson's disease: The role of glial cells. Journal of pharmacological sciences. vol 144. issue 3. 2020-10-26. PMID:32807662. |
in this review, we discuss the function of astrocytes and microglia in glutamate homeostasis, focusing on how glial dysfunction causes glutamate-induced excitotoxicity leading to neurodegeneration in pd. |
2020-10-26 |
2023-08-13 |
Not clear |
| Yoshinori Kitagawa, Kazuhiro Nakaso, Yosuke Horikoshi, Masaki Morimoto, Takuma Omotani, Akihiro Otsuki, Yoshimi Inagaki, Hideyo Sato, Tatsuya Matsur. System x Scientific reports. vol 9. issue 1. 2020-10-13. PMID:31101857. |
we show that glutamate produced from microglia through the activity of system x |
2020-10-13 |
2023-08-13 |
Not clear |
| Xu-Rui Jin, Xing-Shu Chen, Lan Xia. MeCP2 Deficiency in Neuroglia: New Progress in the Pathogenesis of Rett Syndrome. Frontiers in molecular neuroscience. vol 10. 2020-10-01. PMID:29046627. |
while mecp2-deficient microglia cells fail in response to environmental stimuli, release excessive glutamate, and aggravate impairment of the neuronal circuit. |
2020-10-01 |
2023-08-13 |
mouse |
| Michele Malaguarnera, Marta Llansola, Tiziano Balzano, Belén Gómez-Giménez, Carles Antúnez-Muñoz, Núria Martínez-Alarcón, Rahebeh Mahdinia, Vicente Felip. Bicuculline Reduces Neuroinflammation in Hippocampus and Improves Spatial Learning and Anxiety in Hyperammonemic Rats. Role of Glutamate Receptors. Frontiers in pharmacology. vol 10. 2020-10-01. PMID:30858801. |
the effects of bicuculline on microglia and astrocyte activation, il-1β content, on membrane expression of ampa and nmda glutamate receptors subunits in the hippocampus and on spatial learning and memory as well as anxiety were assessed. |
2020-10-01 |
2023-08-13 |
rat |
| Tanya Miladinovic, Gurmit Sing. Spinal microglia contribute to cancer-induced pain through system x Pain reports. vol 4. issue 3. 2020-10-01. PMID:31583353. |
chronically activated microglia, however, release toxic substances, including excess glutamate, causing cytotoxicity. |
2020-10-01 |
2023-08-13 |
Not clear |