| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Yang, Ying Lai, Xueli Tong, Zipei Li, Yuanyuan Cheng, Li-Wen Tia. Arjunolic acid ameliorates lipopolysaccharide-induced depressive behavior by inhibiting neuroinflammation via microglial SIRT1/AMPK/Notch1 signaling pathway. Journal of ethnopharmacology. 2024-04-26. PMID:38670408. |
neuroinflammation is involved in the pathogenesis of depression disorder by activating microglia cells, increasing proinflammatory cytokines, effecting serotonin synthesis and metabolism, and neuronal apoptosis and neurogenesis. |
2024-04-26 |
2024-04-29 |
Not clear |
| Janna B Hart, Robert K Poon, Robert E Ward, Korry J Hintze, Sara M Freema. Effects of Dietary Fiber on Short Chain Fatty Acid Receptor mRNA in Microglia and Serotonergic Neurons in the Mouse Brain. Neuroscience. 2024-03-02. PMID:38431042. |
thus, our results indicate that the amount and solubility of dietary fiber can change gene expression in the brain's microglia and serotonin neurons, potentially via sensitivity to circulating levels of scfas produced in the gut. |
2024-03-02 |
2024-03-06 |
mouse |
| Yi-Ze Sun, Hai-Bin Zhao, Zhe-Yi Wan. [Mechanism of stress-induced microglial activation in depression and traditional Chinese medicine regulation]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 16. 2023-10-06. PMID:37802855. |
cross-talk between impaired microglia function and neurobiological factors such as inflammatory cytokines, serotonin metabolism, and neuroplasticity may lead to depression. |
2023-10-06 |
2023-10-15 |
Not clear |
| Kai-Chun Yang, Yuan-Hwa Cho. Molecular imaging findings for treatment resistant depression. Progress in brain research. vol 278. 2023-07-06. PMID:37414495. |
there was also limited data to demonstrate the changes in the markers of serotonin, dopamine, amyloid, and microglia over some regions in trd. |
2023-07-06 |
2023-08-14 |
Not clear |
| Giulia Albertini, Ivana D'Andrea, Mélanie Druart, Catherine Béchade, Nayadoleni Nieves-Rivera, Fanny Etienne, Corentin Le Magueresse, Alexandra Rebsam, Nicolas Heck, Luc Maroteaux, Anne Roumie. Serotonin sensing by microglia conditions the proper development of neuronal circuits and of social and adaptive skills. Molecular psychiatry. 2023-05-22. PMID:37217677. |
serotonin sensing by microglia conditions the proper development of neuronal circuits and of social and adaptive skills. |
2023-05-22 |
2023-08-14 |
mouse |
| Giulia Albertini, Ivana D'Andrea, Mélanie Druart, Catherine Béchade, Nayadoleni Nieves-Rivera, Fanny Etienne, Corentin Le Magueresse, Alexandra Rebsam, Nicolas Heck, Luc Maroteaux, Anne Roumie. Serotonin sensing by microglia conditions the proper development of neuronal circuits and of social and adaptive skills. Molecular psychiatry. 2023-05-22. PMID:37217677. |
here, we focused on microglia, which play a role in brain wiring refinement, and we investigated whether the control of these cells by 5-ht is relevant for neurodevelopment and spontaneous behaviors in mice. |
2023-05-22 |
2023-08-14 |
mouse |
| Giulia Albertini, Ivana D'Andrea, Mélanie Druart, Catherine Béchade, Nayadoleni Nieves-Rivera, Fanny Etienne, Corentin Le Magueresse, Alexandra Rebsam, Nicolas Heck, Luc Maroteaux, Anne Roumie. Serotonin sensing by microglia conditions the proper development of neuronal circuits and of social and adaptive skills. Molecular psychiatry. 2023-05-22. PMID:37217677. |
since the main 5-ht sensor in microglia is the 5-ht |
2023-05-22 |
2023-08-14 |
mouse |
| Pei He, Binjun He, Shu Li, Wen Chai, Wei Rao, Yu Zhu, Wenzhi Chen, Ping Zhang, Xiong Zhang, Haili Pan, Renshi X. Distribution Features and Potential Effects of Serotonin in the Cerebrum of SOD1 G93A Transgenic Mice. eNeuro. 2022-10-20. PMID:36265904. |
double immunofluorescence staining showed that tph2, mammalian achaete-scute homolog-1 and 5-ht were mainly expressed in neurons but rarely in microglia or astrocytes in the piriform cortex. |
2022-10-20 |
2023-08-14 |
mouse |
| Rui-Chen Xu, Wen-Teng Miao, Jing-Yi Xu, Wen-Xin Xu, Ming-Ran Liu, Song-Tao Ding, Yu-Xin Jian, Yi-Han Lei, Ning Yan, Han-Deng Li. Neuroprotective Effects of Sodium Butyrate and Monomethyl Fumarate Treatment through GPR109A Modulation and Intestinal Barrier Restoration on PD Mice. Nutrients. vol 14. issue 19. 2022-10-14. PMID:36235813. |
according to our results, mptp-induced defected motor function, decreased dopamine and 5-hydroxytryptamine levels in the striatum, decreased tyrosine hydroxylase-positive neurons and increased activated microglia in the sn, and systemic inflammation were ameliorated by nab or mmf treatment. |
2022-10-14 |
2023-08-14 |
mouse |
| Yuchong Luo, Xiao Chen, Chunren Wei, Hongyang Zhang, Lingyi Zhang, Lu Han, Ke Sun, Boxing Li, Shenglin We. BDNF Alleviates Microglial Inhibition and Stereotypic Behaviors in a Mouse Model of Obsessive-Compulsive Disorder. Frontiers in molecular neuroscience. vol 15. 2022-08-01. PMID:35909449. |
to investigate the role of microglia in this disorder, we established a pharmacological mouse model by using the serotonin (5-ht) 1a/1b receptor agonist ru24969 to mimic monoamine dysregulation in ocd, and we examined the morphological and functional alterations of microglia in this model. |
2022-08-01 |
2023-08-14 |
mouse |
| Kanza M Khan, Gabrielle Bierlein-De La Rosa, Natalie Biggerstaff, Govindhasamy Pushpavathi Selvakumar, Ruixiang Wang, Suzanne Mason, Michael E Dailey, Catherine A Marcinkiewc. Adolescent ethanol drinking promotes hyperalgesia, neuroinflammation and serotonergic deficits in mice that persist into adulthood. Brain, behavior, and immunity. 2022-07-30. PMID:35907582. |
here we report that mice exposed to adolescent intermittent access to ethanol (aie) exhibit increased pain sensitivity and depressive-like behaviors that persist for several weeks after alcohol cessation and are accompanied by elevated cd68 expression in microglia and reduced numbers of serotonin (5-ht)-expressing neurons in the dorsal raphe nucleus (drn). |
2022-07-30 |
2023-08-14 |
mouse |
| Francesca Fagiani, Eva Baronchelli, Anna Pittaluga, Edoardo Pedrini, Chiara Scacchi, Stefano Govoni, Cristina Lann. The Circadian Molecular Machinery in CNS Cells: A Fine Tuner of Neuronal and Glial Activity With Space/Time Resolution. Frontiers in molecular neuroscience. vol 15. 2022-07-18. PMID:35845604. |
not only neurons, but also astrocytes and microglia actively participate in the maintenance of timekeeping within the brain, and the diffusion of circadian information among these cells is fine-tuned by neurotransmitters (e.g., dopamine, serotonin, and γ-aminobutyric acid), thus impacting on the core clock machinery. |
2022-07-18 |
2023-08-14 |
Not clear |
| Gary C Mouradian, Satyan Lakshminrusimha, Girija G Kondur. Perinatal Hypoxemia and Oxygen Sensing. Comprehensive Physiology. vol 11. issue 2. 2021-10-25. PMID:33792908. |
chronic neonatal hypoxia may arise from fetal complications like maternal smoking or from postnatal cardiovascular problems, causing blunting of the hypoxic ventilatory responses throughout at least adolescence due to attenuation of carotid body fibers responses to hypoxia with potential roles of brainstem serotonin, microglia, and inflammation, though these effects depend on the age in which chronic hypoxia initiates. |
2021-10-25 |
2023-08-13 |
Not clear |
| Fenghua Chen, Jibrin Danladi, Maryam Ardalan, Jens R Nyengaard, Connie Sanchez, Gregers Wegene. The rat hippocampal gliovascular system following one week vortioxetine and fluoxetine. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 42. 2021-08-20. PMID:33199100. |
our findings suggest that astrocytes and microglia may have a role in mediating the pharmacological effects of vortioxetine in rats and that these effects are mediated through mechanisms that go beyond inhibition of the serotonin transporter and may target specific 5-ht receptors. |
2021-08-20 |
2023-08-13 |
rat |
| Catherine Béchade, Ivana D'Andrea, Fanny Etienne, Franck Verdonk, Imane Moutkine, Sophie M Banas, Marta Kolodziejczak, Silvina L Diaz, Christopher N Parkhurst, Wenbiao B Gan, Luc Maroteaux, Anne Roumie. The serotonin 2B receptor is required in neonatal microglia to limit neuroinflammation and sickness behavior in adulthood. Glia. vol 69. issue 3. 2021-08-13. PMID:33095507. |
the serotonin 2b receptor is required in neonatal microglia to limit neuroinflammation and sickness behavior in adulthood. |
2021-08-13 |
2023-08-13 |
Not clear |
| Kinga Sałat, Anna Furgała-Wojas, Robert Sała. The Microglial Activation Inhibitor Minocycline, Used Alone and in Combination with Duloxetine, Attenuates Pain Caused by Oxaliplatin in Mice. Molecules (Basel, Switzerland). vol 26. issue 12. 2021-07-28. PMID:34208184. |
since activated microglia, impaired serotonergic and noradrenergic neurotransmission and overexpressed sodium channels are implicated in oxaliplatin-induced pain, this in vivo study assessed the effect of minocycline, a microglial activation inhibitor used alone or in combination with ambroxol, a sodium channel blocker, or duloxetine, a serotonin and noradrenaline reuptake inhibitor, on oxaliplatin-induced tactile allodynia and cold hyperalgesia. |
2021-07-28 |
2023-08-13 |
mouse |
| Frederick Adams Ekuban, Cai Zong, Madoka Takikawa, Kota Morikawa, Toshihiro Sakurai, Sahoko Ichihara, Ken Itoh, Masayuki Yamamoto, Seiichiroh Ohsako, Gaku Ichihar. Genetic ablation of Nrf2 exacerbates neurotoxic effects of acrylamide in mice. Toxicology. vol 456. 2021-06-22. PMID:33872730. |
the effects of acrylamide were examined by landing foot spread test, immunohistochemistry for noradrenaline (na) and serotonin (5-ht)-containing axons and iba1-positive microglia in the prefrontal cortex as well as quantitative real-time polymerase chain reaction (qrt-pcr) on antioxidant, proinflammatory and anti-inflammatory genes in the prefrontal cortex. |
2021-06-22 |
2023-08-13 |
mouse |
| Andrei Turkin, Oksana Tuchina, Friederike Klempi. Microglia Function on Precursor Cells in the Adult Hippocampus and Their Responsiveness to Serotonin Signaling. Frontiers in cell and developmental biology. vol 9. 2021-06-12. PMID:34109176. |
microglia function on precursor cells in the adult hippocampus and their responsiveness to serotonin signaling. |
2021-06-12 |
2023-08-13 |
Not clear |
| Andrei Turkin, Oksana Tuchina, Friederike Klempi. Microglia Function on Precursor Cells in the Adult Hippocampus and Their Responsiveness to Serotonin Signaling. Frontiers in cell and developmental biology. vol 9. 2021-06-12. PMID:34109176. |
recent evidence shows that microglia interact with serotonin, the neurotransmitter crucially involved in adult neurogenesis, and known for its role in antidepressant action. |
2021-06-12 |
2023-08-13 |
Not clear |
| Andrei Turkin, Oksana Tuchina, Friederike Klempi. Microglia Function on Precursor Cells in the Adult Hippocampus and Their Responsiveness to Serotonin Signaling. Frontiers in cell and developmental biology. vol 9. 2021-06-12. PMID:34109176. |
we summarize the recent findings on the role of various receptors in microglia-mediated neurotransmission and particularly focus on microglia's response to serotonin signaling. |
2021-06-12 |
2023-08-13 |
Not clear |