| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrei Turkin, Oksana Tuchina, Friederike Klempi. Microglia Function on Precursor Cells in the Adult Hippocampus and Their Responsiveness to Serotonin Signaling. Frontiers in cell and developmental biology. vol 9. 2021-06-12. PMID:34109176. |
this synopsis sheds light on microglia in healthy brain and pathology that involves serotonin and may be a potential therapeutic model by which microglia play a crucial role in the maintenance of mood. |
2021-06-12 |
2023-08-13 |
Not clear |
| Chen-Meng Qiao, Meng-Fei Sun, Xue-Bing Jia, Yang Li, Bo-Ping Zhang, Li-Ping Zhao, Yun Shi, Zhi-Lan Zhou, Ying-Li Zhu, Chun Cui, Yan-Qin She. Sodium Butyrate Exacerbates Parkinson's Disease by Aggravating Neuroinflammation and Colonic Inflammation in MPTP-Induced Mice Model. Neurochemical research. vol 45. issue 9. 2021-06-08. PMID:32556930. |
interestingly, nab significantly aggravated mptp-induced motor dysfunction (p < 0.01), decreased dopamine (p < 0.05) and 5-ht (p < 0.05) levels, exacerbated declines of dopaminergic neurons (34%, p < 0.05) and downregulated expression of tyrosine hydroxylase (th, 47%, p < 0.05), potentiated glia-mediated neuroinflammation by increasing the number of microglia (17%, p < 0.05) and activating astrocytes (28%, p < 0.01). |
2021-06-08 |
2023-08-13 |
mouse |
| Hang Xu, Xiang Yang Zhang, Wei Wen Wang, Jiesi Wan. Hydroxychloroquine Increased Anxiety-Like Behaviors and Disrupted the Expression of Some Related Genes in the Mouse Brain. Frontiers in pharmacology. vol 12. 2021-05-08. PMID:33953673. |
furthermore, hcq decreased the mrna expression of interleukin-1beta, corticotropin-releasing hormone (crh), a serotonin transporter (slc6a4), and a microglia maker (aif1) in the hippocampus and decreased the mrna expression of brain-derived neurotrophic factor (bdnf) in both the hippocampus and amygdala. |
2021-05-08 |
2023-08-13 |
mouse |
| Xiong Zhang, Lan-Bing Zhu, Jia-Hui He, Hong-Qiu Zhang, Shu-Ya Ji, Chao-Nan Zhang, Na-Na Hou, Chen-Ping Huang, Jian-Hong Zh. Paroxetine suppresses reactive microglia-mediated but not lipopolysaccharide-induced inflammatory responses in primary astrocytes. Journal of neuroinflammation. vol 17. issue 1. 2020-11-23. PMID:32024542. |
we have previously disclosed that paroxetine, a common selective serotonin reuptake inhibitor, ameliorates lps-induced microglia activation. |
2020-11-23 |
2023-08-13 |
Not clear |
| Mouli Tian, Mei Yang, Zhenjie Li, Yiru Wang, Wei Chen, Liye Yang, Yonghua Li, Hongbin Yua. Fluoxetine suppresses inflammatory reaction in microglia under OGD/R challenge via modulation of NF-κB signaling. Bioscience reports. vol 39. issue 4. 2020-04-20. PMID:30944203. |
we aimed to investigate the anti-inflammatory role of fluoxetine, a selective serotonin reuptake inhibitor, in microglia (mg) and the mechanisms under oxygen glucose deprivation/reoxygenation (ogd/r). |
2020-04-20 |
2023-08-13 |
Not clear |
| Wei Wang, Xiongxiong Zhong, Yongyong Li, Ruixian Guo, Sujuan Du, Lili Wen, Yanlu Ying, Tao Yang, Xu-Hong We. Rostral ventromedial medulla-mediated descending facilitation following P2X7 receptor activation is involved in the development of chronic post-operative pain. Journal of neurochemistry. vol 149. issue 6. 2020-03-13. PMID:30570747. |
the 5-ht level increase, 5-ht3 receptor (5-ht3r) up-regulation, and microglia activation were found bilaterally in smir rats with bilateral pain, but only ipsilaterally in smir rats with unilateral pain. |
2020-03-13 |
2023-08-13 |
rat |
| Wei Wang, Xiongxiong Zhong, Yongyong Li, Ruixian Guo, Sujuan Du, Lili Wen, Yanlu Ying, Tao Yang, Xu-Hong We. Rostral ventromedial medulla-mediated descending facilitation following P2X7 receptor activation is involved in the development of chronic post-operative pain. Journal of neurochemistry. vol 149. issue 6. 2020-03-13. PMID:30570747. |
importantly, bbg injected into the rvm also decreased the activation of microglia and the level of 5-ht in the lumbar 3 (l3) spinal cord. |
2020-03-13 |
2023-08-13 |
rat |
| Wei Wang, Xiongxiong Zhong, Yongyong Li, Ruixian Guo, Sujuan Du, Lili Wen, Yanlu Ying, Tao Yang, Xu-Hong We. Rostral ventromedial medulla-mediated descending facilitation following P2X7 receptor activation is involved in the development of chronic post-operative pain. Journal of neurochemistry. vol 149. issue 6. 2020-03-13. PMID:30570747. |
the microinjection of the p2x7r agonist bzatp, the nadph oxidase activator phorbol-12-myristate-13-acetate, or il-1β into the rvm induced bilateral mechanical allodynia, microglia activation, and 5-ht release in the l3 spinal dorsal horn. |
2020-03-13 |
2023-08-13 |
rat |
| Monika Fleshner, Benjamin N Greenwood, Raz Yirmiy. Neuronal-glial mechanisms of exercise-evoked stress robustness. Current topics in behavioral neurosciences. vol 18. 2019-11-20. PMID:24481547. |
specifically, we propose that sedentary animals respond to an intense acute uncontrollable stressor with excessive serotonin (5-ht) and noradrenergic (ne) activity and/or prolonged down-regulation of the cx3cl1-cx3cr1 axis resulting in activation and proliferation of hippocampal microglia in the absence of pathogenic signals and consequent hippocampal-dependent memory deficits and reduced neurogenesis. |
2019-11-20 |
2023-08-12 |
Not clear |
| Monika Fleshner, Benjamin N Greenwood, Raz Yirmiy. Neuronal-glial mechanisms of exercise-evoked stress robustness. Current topics in behavioral neurosciences. vol 18. 2019-11-20. PMID:24481547. |
in contrast, physically active animals respond to the same stressor with constrained 5-ht and ne activity and rapidly recovering cx3cl1-cx3cr1 axis responses resulting in the quieting of microglia, and protection from negative cognitive and neurobiological effects of stress. |
2019-11-20 |
2023-08-12 |
Not clear |
| Kamaldeep S Dhami, Matthew A Churchward, Glen B Baker, Kathryn G Tod. Fluoxetine and its metabolite norfluoxetine induce microglial apoptosis. Journal of neurochemistry. vol 148. issue 6. 2019-10-28. PMID:30613984. |
we have previously shown that the selective serotonin reuptake inhibitors (ssris) fluoxetine and citalopram promote neuronal survival after oxygen-glucose deprivation, an in vitro model of ischemia, by attenuating the release of glutamate and d-serine from activated microglia. |
2019-10-28 |
2023-08-13 |
Not clear |
| Francisca Taciana Sousa Rodrigues, Marcos Romário Matos de Souza, Camila Nayane de Carvalho Lima, Francisco Eliclécio Rodrigues da Silva, Deiziane Viana da Silva Costa, Cláudio Costa Dos Santos, Fábio Miyajima, Francisca Cléa F de Sousa, Silvânia Maria Mendes Vasconcelos, Tatiana Barichello, João Quevedo, Michael Maes, David F de Lucena, Danielle Maced. Major depression model induced by repeated and intermittent lipopolysaccharide administration: Long-lasting behavioral, neuroimmune and neuroprogressive alterations. Journal of psychiatric research. vol 107. 2019-09-12. PMID:30326340. |
our results show that six weeks post-lps, mice present behavioral despair and anhedonia in association with increased iba1 expression (a microglia activation marker), nf-kb p65 and il-1β levels, indoleamine 2,3-dioxygenase (ido1) mrna expression, kynurenine, quin levels and quin/tryptophan ratio, and lowered tryptophan, 5-ht levels and sat1 mrna expression. |
2019-09-12 |
2023-08-13 |
mouse |
| Jing Ma, Haijing Yan, Ranran Wang, Shuhong Bo, Xiaotong Lu, Jian Zhang, Ajing X. Protective effect of carnosine on white matter damage in corpus striatum induced by chronic cerebral hypoperfusion. Neuroscience letters. vol 683. 2019-03-11. PMID:29928953. |
carnosine (200, 500 mg/kg) significantly recovered the expression of myelin basic protein, suppressed the activation of microglia and reversed the decrease of 5-hydroxytryptamine and dopamine levels in corpus striatum. |
2019-03-11 |
2023-08-13 |
mouse |
| Pan Zhuang, Qiyang Shou, Yanhua Lu, Guangfa Wang, Jieni Qiu, Jun Wang, Lilin He, Jingnan Chen, Jingjing Jiao, Yu Zhan. Arachidonic acid sex-dependently affects obesity through linking gut microbiota-driven inflammation to hypothalamus-adipose-liver axis. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 11. 2018-11-26. PMID:28711599. |
also, aa favors pro-inflammatory microbiota and reduces butyrate production and circulating serotonin, which augments global inflammation and triggers hypothalamic leptin resistance via microglia accumulation in male. |
2018-11-26 |
2023-08-13 |
mouse |
| Paula Kopschina Feltes, Janine Doorduin, Hans C Klein, Luis Eduardo Juárez-Orozco, Rudi Ajo Dierckx, Cristina M Moriguchi-Jeckel, Erik Fj de Vrie. Anti-inflammatory treatment for major depressive disorder: implications for patients with an elevated immune profile and non-responders to standard antidepressant therapy. Journal of psychopharmacology (Oxford, England). vol 31. issue 9. 2018-05-17. PMID:28653857. |
stimuli like inflammation and infection can trigger the activation of microglia to release pro-inflammatory cytokines, acting on two main pathways: (1) activation of the hypothalamic-pituitary adrenal axis, generating an imbalance in the serotonergic and noradrenergic circuits; (2) increased activity of the enzyme indoleamine-2,3-dioxygenase, resulting in depletion of serotonin levels and the production of quinolinic acid. |
2018-05-17 |
2023-08-13 |
Not clear |
| P M MacFarlane, C A Mayer, D G Litvi. Microglia modulate brainstem serotonergic expression following neonatal sustained hypoxia exposure: implications for sudden infant death syndrome. The Journal of physiology. vol 594. issue 11. 2017-08-07. PMID:26659585. |
neonatal sustained hypoxia exposure modifies brainstem microglia and serotonin expression. |
2017-08-07 |
2023-08-13 |
Not clear |
| Philippe Leff-Gelman, Ismael Mancilla-Herrera, Mónica Flores-Ramos, Carlos Cruz-Fuentes, Juan Pablo Reyes-Grajeda, María Del Pilar García-Cuétara, Marielle Danitza Bugnot-Pérez, David Ellioth Pulido-Ascenci. The Immune System and the Role of Inflammation in Perinatal Depression. Neuroscience bulletin. vol 32. issue 4. 2017-02-24. PMID:27432060. |
microglia and toll-like receptor 4 play a crucial role in triggering wide and varied stress-induced responses mediated through activation of the inflammasome; this leads to the secretion of inflammatory cytokines, increased serotonin metabolism, and reduction of neurotransmitter availability along with hypothalamic-pituitary-adrenal axis hyperactivity. |
2017-02-24 |
2023-08-13 |
Not clear |
| Hajer El Oussini, Hanna Bayer, Jelena Scekic-Zahirovic, Pauline Vercruysse, Jérôme Sinniger, Sylvie Dirrig-Grosch, Stéphane Dieterlé, Andoni Echaniz-Laguna, Yves Larmet, Kathrin Müller, Jochen H Weishaupt, Dietmar R Thal, Wouter van Rheenen, Kristel van Eijk, Roland Lawson, Laurent Monassier, Luc Maroteaux, Anne Roumier, Philip C Wong, Leonard H van den Berg, Albert C Ludolph, Jan H Veldink, Anke Witting, Luc Dupui. Serotonin 2B receptor slows disease progression and prevents degeneration of spinal cord mononuclear phagocytes in amyotrophic lateral sclerosis. Acta neuropathologica. vol 131. issue 3. 2016-11-08. PMID:26744351. |
here we observed that the serotonin 2b receptor (5-ht2b), a serotonin receptor expressed in microglia, is upregulated in the spinal cord of three different transgenic mouse models of als. |
2016-11-08 |
2023-08-13 |
mouse |
| Marta Kolodziejczak, Catherine Béchade, Nicolas Gervasi, Theano Irinopoulou, Sophie M Banas, Corinne Cordier, Alexandra Rebsam, Anne Roumier, Luc Maroteau. Serotonin Modulates Developmental Microglia via 5-HT2B Receptors: Potential Implication during Synaptic Refinement of Retinogeniculate Projections. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:25857335. |
serotonin modulates developmental microglia via 5-ht2b receptors: potential implication during synaptic refinement of retinogeniculate projections. |
2016-04-19 |
2023-08-13 |
mouse |
| Marta Kolodziejczak, Catherine Béchade, Nicolas Gervasi, Theano Irinopoulou, Sophie M Banas, Corinne Cordier, Alexandra Rebsam, Anne Roumier, Luc Maroteau. Serotonin Modulates Developmental Microglia via 5-HT2B Receptors: Potential Implication during Synaptic Refinement of Retinogeniculate Projections. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:25857335. |
here, we tested the hypothesis of cross-regulation between microglia and serotonin during postnatal brain development in a mouse model of synaptic refinement. |
2016-04-19 |
2023-08-13 |
mouse |