| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marta Kolodziejczak, Catherine Béchade, Nicolas Gervasi, Theano Irinopoulou, Sophie M Banas, Corinne Cordier, Alexandra Rebsam, Anne Roumier, Luc Maroteau. Serotonin Modulates Developmental Microglia via 5-HT2B Receptors: Potential Implication during Synaptic Refinement of Retinogeniculate Projections. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:25857335. |
we found expression of the serotonin 5-ht2b receptor on postnatal microglia, suggesting that serotonin could participate in temporal and spatial synchronization of microglial functions. |
2016-04-19 |
2023-08-13 |
mouse |
| Marta Kolodziejczak, Catherine Béchade, Nicolas Gervasi, Theano Irinopoulou, Sophie M Banas, Corinne Cordier, Alexandra Rebsam, Anne Roumier, Luc Maroteau. Serotonin Modulates Developmental Microglia via 5-HT2B Receptors: Potential Implication during Synaptic Refinement of Retinogeniculate Projections. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:25857335. |
we then investigated whether some developmental steps known to be controlled by serotonin could potentially result from microglia sensitivity to serotonin. |
2016-04-19 |
2023-08-13 |
mouse |
| Konstantin Glebov, Marie Löchner, Ronald Jabs, Thorsten Lau, Olaf Merkel, Patrick Schloss, Christian Steinhäuser, Jochen Walte. Serotonin stimulates secretion of exosomes from microglia cells. Glia. vol 63. issue 4. 2015-10-29. PMID:25451814. |
serotonin stimulates secretion of exosomes from microglia cells. |
2015-10-29 |
2023-08-13 |
Not clear |
| Maria Pannell, Frank Szulzewsky, Vitali Matyash, Susanne A Wolf, Helmut Kettenman. The subpopulation of microglia sensitive to neurotransmitters/neurohormones is modulated by stimulation with LPS, interferon-γ, and IL-4. Glia. vol 62. issue 5. 2014-11-24. PMID:24504982. |
we freshly isolated microglia from healthy adult c57bl/6 mice and found that only a small fraction (1-20%) responded to the application of endothelin, histamine, substance p, serotonin, galanin, somatostatin, angiotensin ii, vasopressin, neurotensin, dopamine, or nicotine. |
2014-11-24 |
2023-08-12 |
mouse |
| Joy Chakraborty, Raghavendra Singh, Debashis Dutta, Amit Naskar, Usha Rajamma, Kochupurackal P Mohanakuma. Quercetin improves behavioral deficiencies, restores astrocytes and microglia, and reduces serotonin metabolism in 3-nitropropionic acid-induced rat model of Huntington's Disease. CNS neuroscience & therapeutics. vol 20. issue 1. 2014-09-29. PMID:24188794. |
quercetin improves behavioral deficiencies, restores astrocytes and microglia, and reduces serotonin metabolism in 3-nitropropionic acid-induced rat model of huntington's disease. |
2014-09-29 |
2023-08-12 |
rat |
| T A Kato, Y Yamauchi, H Horikawa, A Monji, Y Mizoguchi, Y Seki, K Hayakawa, H Utsumi, S Kanb. Neurotransmitters, psychotropic drugs and microglia: clinical implications for psychiatry. Current medicinal chemistry. vol 20. issue 3. 2014-01-17. PMID:23157624. |
therefore, in this review, at first, we summarize recent findings of interaction between microglia and neurotransmitters such as dopamine, serotonin, norepinephrine, acetylcholine and glutamate. |
2014-01-17 |
2023-08-12 |
human |
| Grietje Krabbe, Vitali Matyash, Ulrike Pannasch, Lauren Mamer, Hendrikus W G M Boddeke, Helmut Kettenman. Activation of serotonin receptors promotes microglial injury-induced motility but attenuates phagocytic activity. Brain, behavior, and immunity. vol 26. issue 3. 2012-06-22. PMID:22198120. |
quantification of phagocytic activity by determining the uptake of microspheres showed that the amoeboid microglia in slices from early postnatal animals or microglia in culture respond to serotonin application with a decreased phagocytic activity whereas we could not detect any significant change in ramified microglia in situ. |
2012-06-22 |
2023-08-12 |
mouse |
| Grietje Krabbe, Vitali Matyash, Ulrike Pannasch, Lauren Mamer, Hendrikus W G M Boddeke, Helmut Kettenman. Activation of serotonin receptors promotes microglial injury-induced motility but attenuates phagocytic activity. Brain, behavior, and immunity. vol 26. issue 3. 2012-06-22. PMID:22198120. |
these data suggest that microglia express functional serotonin receptors linked to distinct microglial properties. |
2012-06-22 |
2023-08-12 |
mouse |
| Grietje Krabbe, Vitali Matyash, Ulrike Pannasch, Lauren Mamer, Hendrikus W G M Boddeke, Helmut Kettenman. Activation of serotonin receptors promotes microglial injury-induced motility but attenuates phagocytic activity. Brain, behavior, and immunity. vol 26. issue 3. 2012-06-22. PMID:22198120. |
the presence of microglial serotonin receptors was confirmed by patch-clamp experiments in culture and amoeboid microglia and by qpcr analysis of rna isolated from primary cultured and acutely isolated adult microglia. |
2012-06-22 |
2023-08-12 |
mouse |
| Grietje Krabbe, Vitali Matyash, Ulrike Pannasch, Lauren Mamer, Hendrikus W G M Boddeke, Helmut Kettenman. Activation of serotonin receptors promotes microglial injury-induced motility but attenuates phagocytic activity. Brain, behavior, and immunity. vol 26. issue 3. 2012-06-22. PMID:22198120. |
similarly, the chemotactic response of cultured microglia to atp was also enhanced by serotonin. |
2012-06-22 |
2023-08-12 |
mouse |
| Gerardo Avila-Martin, Iriana Galan-Arriero, Julio Gómez-Soriano, Julian Taylo. Treatment of rat spinal cord injury with the neurotrophic factor albumin-oleic acid: translational application for paralysis, spasticity and pain. PloS one. vol 6. issue 10. 2012-03-26. PMID:22046257. |
spinal l4-l5 immunohistochemistry demonstrated a unique increase in serotonin fibre innervation up to 4.2 ± 1.1 and 2.3 ± 0.3 fold within the dorsal and ventral horn respectively with alb-oa treatment when compared to uninjured tissue, in addition to a reduction in nr1 nmda receptor phosphorylation and microglia reactivity. |
2012-03-26 |
2023-08-12 |
rat |
| Hideki Horikawa, Takahiro A Kato, Yoshito Mizoguchi, Akira Monji, Yoshihiro Seki, Takatoshi Ohkuri, Leo Gotoh, Megumi Yonaha, Tadashi Ueda, Sadayuki Hashioka, Shigenobu Kanb. Inhibitory effects of SSRIs on IFN-γ induced microglial activation through the regulation of intracellular calcium. Progress in neuro-psychopharmacology & biological psychiatry. vol 34. issue 7. 2010-12-29. PMID:20654672. |
our results showed that the selective serotonin reuptake inhibitors (ssris) paroxetine and sertraline significantly inhibited the generation of no and tumor necrosis factor (tnf)-α from interferon (ifn)-γ-activated 6-3 microglia. |
2010-12-29 |
2023-08-12 |
Not clear |
| Laura Orio, Noemi Llopis, Elisa Torres, Maria Izco, Esther O'Shea, M Isabel Colad. A study on the mechanisms by which minocycline protects against MDMA ('ecstasy')-induced neurotoxicity of 5-HT cortical neurons. Neurotoxicity research. vol 18. issue 2. 2010-09-20. PMID:19777321. |
3,4-methylenedioxymethamphetamine (mdma, 'ecstasy') is a selective 5-ht neurotoxin in rat brain which has been shown to produce acute neuroinflammation characterized by activation of microglia and release of interleukin-1beta (il-1beta). |
2010-09-20 |
2023-08-12 |
rat |
| Laura Orio, Esther O'Shea, Veronica Sanchez, Jesus M Pradillo, Isabel Escobedo, Jorge Camarero, Maria A Moro, A Richard Green, M Isabel Colad. 3,4-Methylenedioxymethamphetamine increases interleukin-1beta levels and activates microglia in rat brain: studies on the relationship with acute hyperthermia and 5-HT depletion. Journal of neurochemistry. vol 89. issue 6. 2004-07-22. PMID:15189347. |
3,4-methylenedioxymethamphetamine increases interleukin-1beta levels and activates microglia in rat brain: studies on the relationship with acute hyperthermia and 5-ht depletion. |
2004-07-22 |
2023-08-12 |
rat |
| S Y Tsai, T E O'Brien, J A McNult. Microglia play a role in mediating the effects of cytokines on the structure and function of the rat pineal gland. Cell and tissue research. vol 303. issue 3. 2001-09-27. PMID:11320658. |
in contrast, tnf-alpha caused a further decline in 5-ht content even in the absence of microglia in the cultures. |
2001-09-27 |
2023-08-12 |
rat |
| M Revuelta, J L Venero, A Machado, J Can. Serotonin hyperinnervation in the adult rat ventral mesencephalon following unilateral transection of the medial forebrain bundle. Correlation with reactive microglial and astroglial populations. Neuroscience. vol 91. issue 2. 1999-08-02. PMID:10366014. |
we suggest that a pruning effect may underly the axotomy-induced increase in serotonin immunoreactivity in the ventral mesencephalon, and further, that activated astroglia and microglia may play a role in directing serotoninergic axonal regeneration following axotomy. |
1999-08-02 |
2023-08-12 |
rat |
| M Revuelta, J L Venero, A Machado, J Can. Serotonin hyperinnervation in the adult rat ventral mesencephalon following unilateral transection of the medial forebrain bundle. Correlation with reactive microglial and astroglial populations. Neuroscience. vol 91. issue 2. 1999-08-02. PMID:10366014. |
in addition, the distribution pattern of glial fibrillary acidic protein-immunoreactive astrocytes and ox42-immunoreactive microglia correlated highly with the location of increased serotonin fibre density in the ventral mesencephalon, especially in ventral tegmental area and in the most medial part of substantia nigra. |
1999-08-02 |
2023-08-12 |
rat |
| G Huether, I Fettkötter, G Keilhoff, G Wol. Serotonin acts as a radical scavenger and is oxidized to a dimer during the respiratory burst of activated microglia. Journal of neurochemistry. vol 69. issue 5. 1997-11-20. PMID:9349555. |
it is concluded that extracellular 5-ht locally released from platelets and 5-ht nerve endings at sites of brain damage or inflammation, through its suppressant effect on the release of reactive oxygen species during the respiratory burst of activated microglia, may contribute to attenuate secondary tissue damage in the cns. |
1997-11-20 |
2023-08-12 |
rat |
| G Huether, I Fettkötter, G Keilhoff, G Wol. Serotonin acts as a radical scavenger and is oxidized to a dimer during the respiratory burst of activated microglia. Journal of neurochemistry. vol 69. issue 5. 1997-11-20. PMID:9349555. |
serotonin acts as a radical scavenger and is oxidized to a dimer during the respiratory burst of activated microglia. |
1997-11-20 |
2023-08-12 |
rat |
| S Y Tsai, J A McNult. Microglia in the pineal gland of the neonatal rat: characterization and effects on pinealocyte neurite length and serotonin content. Glia. vol 20. issue 3. 1997-09-26. PMID:9215733. |
microglia in the pineal gland of the neonatal rat: characterization and effects on pinealocyte neurite length and serotonin content. |
1997-09-26 |
2023-08-12 |
rat |