| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chayaporn Reakkamnuan, Dania Cheaha, Nifareeda Samerphop, Jakkrit Nukitram, Ekkasit Kumarnsi. Differential local field potential oscillations in the dorsal striatum and locomotor activity induced by morphine and haloperidol in mice. Acta neurobiologiae experimentalis. vol 83. issue 2. 2023-07-26. PMID:37493531. |
dopamine (da) depletion in the dorsal striatum underlies symptoms of basal ganglia pathologies, including parkinson's disease (pd). |
2023-07-26 |
2023-08-14 |
mouse |
| Charles Ducrot, Gregory de Carvalho, Benoit Delignat-Lavaud, Constantin V L Delmas, Priyabrata Halder, Nicolas Giguère, Consiglia Pacelli, Sriparna Mukherjee, Marie-Josée Bourque, Martin Parent, LuLu Y Chen, Louis-Eric Trudea. Conditional deletion of neurexins dysregulates neurotransmission from dopamine neurons. eLife. vol 12. 2023-07-06. PMID:37409563. |
midbrain dopamine (da) neurons are key regulators of basal ganglia functions. |
2023-07-06 |
2023-08-14 |
mouse |
| Ilene Trinh, Angeni Muralidhar, Justin Yang, Nicolás Phielip. Quantified Striatal Dopaminergic Denervation as Predictor for Motor Outcomes in Parkinson's Disease. Movement disorders clinical practice. vol 10. issue 6. 2023-06-19. PMID:37332639. |
a hallmark of parkinson's disease (pd) is progressive loss of dopamine terminals in the basal ganglia, with clinical symptoms including motor and non-motor manifestations such as bradykinesia, rigidity, and cognitive impairment. |
2023-06-19 |
2023-08-14 |
Not clear |
| Cláudia Raquel Marques, Miguel de Almeida Fuzeta, Raquel Medina Dos Santos Cunha, Joana Pereira-Sousa, Deolinda Silva, Jonas Campos, Andreia Teixeira-Castro, Rui Amandi Sousa, Ana Fernandes-Platzgummer, Cláudia L da Silva, António José Salgad. Neurodifferentiation and Neuroprotection Potential of Mesenchymal Stromal Cell-Derived Secretome Produced in Different Dynamic Systems. Biomedicines. vol 11. issue 5. 2023-05-27. PMID:37238911. |
parkinson's disease (pd) is the second most common neurodegenerative disorder and is characterized by the degeneration of the dopamine (da) neurons in the substantia nigra pars compacta, leading to a loss of da in the basal ganglia. |
2023-05-27 |
2023-08-14 |
human |
| M T Herrero, J E Yuste, L Cuenca-Bermejo, P Almela, L Arenas-Betancur, V De Pablos, A Gonzalez-Cuello, E Del Bel, J Navarro-Zaragoza, E Fernández-Villalb. 7-Nitroindazole reduces L-DOPA-induced dyskinesias in non-human Parkinsonian primate. Open biology. vol 13. issue 5. 2023-05-16. PMID:37192671. |
nitric oxide (no) plays a pivotal role in integrating dopamine transmission in the basal ganglia and has been implicated in the pathogenesis of parkinson disease (pd). |
2023-05-16 |
2023-08-14 |
monkey |
| Julia Henkel, Christian Hartmann, Valentina Niccolai, Ruben van de Vijver, Alfons Schnitzler, Katja Biermann-Rube. Reduced syntactic recursion in spontaneous speech of Parkinson's disease patients. Acta psychologica. vol 236. 2023-05-06. PMID:37148642. |
our results suggest a contribution of the basal ganglia to language processing, such as syntactic composition, which, however, does not seem to be dopamine dependent. |
2023-05-06 |
2023-08-14 |
Not clear |
| Andrea Ortone, Alberto Arturo Vergani, Mahboubeh Ahmadipour, Riccardo Mannella, Alberto Mazzon. Dopamine depletion leads to pathological synchronization of distinct basal ganglia loops in the beta band. PLoS computational biology. vol 19. issue 4. 2023-04-27. PMID:37104542. |
dopamine depletion leads to pathological synchronization of distinct basal ganglia loops in the beta band. |
2023-04-27 |
2023-08-14 |
human |
| Andrea Ortone, Alberto Arturo Vergani, Mahboubeh Ahmadipour, Riccardo Mannella, Alberto Mazzon. Dopamine depletion leads to pathological synchronization of distinct basal ganglia loops in the beta band. PLoS computational biology. vol 19. issue 4. 2023-04-27. PMID:37104542. |
motor symptoms of parkinson's disease (pd) are associated with dopamine deficits and pathological oscillation of basal ganglia (bg) neurons in the β range ([12-30] hz). |
2023-04-27 |
2023-08-14 |
human |
| Jian-Ya Peng, Zeng-Xin Qi, Qi Yan, Xiu-Juan Fan, Kang-Li Shen, Hui-Wei Huang, Jian-Hua Lu, Xiao-Qin Wang, Xiao-Xia Fang, Liming Mao, Jianguang Ni, Liang Chen, Qian-Xing Zhuan. Ameliorating parkinsonian motor dysfunction by targeting histamine receptors in entopeduncular nucleus-thalamus circuitry. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 17. 2023-04-17. PMID:37068253. |
in parkinson's disease (pd), reduced dopamine levels in the basal ganglia have been associated with altered neuronal firing and motor dysfunction. |
2023-04-17 |
2023-08-14 |
mouse |
| Bader Alkharisi, Khaled Dostzada, Harleen Kaur, Manoj Kumar, Jeanne Y Wei, Gohar Azha. The Importance of Dopamine Deficiency Evaluation in Non-Alzheimer Disease Dementias. The American journal of case reports. vol 24. 2023-04-05. PMID:37016564. |
to increase the sensitivity of current dlb guidelines, the dlb consortium published its fourth revised report in 2017 with increased diagnostic weight given to dopamine transporter (dat) uptake in the basal ganglia, demonstrated by single-photon emission computed tomography or positron emission tomography imaging. |
2023-04-05 |
2023-08-14 |
Not clear |
| Nicole E Chambers, Michael Millett, Mark S Moehl. The muscarinic M4 acetylcholine receptor exacerbates symptoms of movement disorders. Biochemical Society transactions. 2023-04-04. PMID:37013974. |
this review reappraises the dopamine-acetylcholine balance hypothesis in light of recent evidence and describes how the gαi/o coupled muscarinic m4 receptor acts in opposition to dopamine signaling in the basal ganglia. |
2023-04-04 |
2023-08-14 |
Not clear |
| Elena Garasto, Alessandro Stefani, Mariangela Pierantozzi, Rocco Cerroni, Matteo Conti, Simone Maranesi, Nicola B Mercuri, Agostino Chiaravalloti, Orazio Schillaci, Andrea Viziano, Arturo Moleti, Renata Sist. Association between hearing sensitivity and dopamine transporter availability in Parkinson's disease. Brain communications. vol 5. issue 2. 2023-04-03. PMID:37006327. |
this study investigates the association between the basal ganglia dopamine transporter availability and the hearing function in parkinson's disease patients, focusing also on the lateralization of both dysfunctions, with respect to that of the motor symptoms, and introducing a further distinction between patients with left-sided and right-sided predominant motor symptoms. |
2023-04-03 |
2023-08-14 |
Not clear |
| Christine J Arasaratnam, Jennifer J Song, Tomoko Yoshida, Maurice A Curtis, Ann M Graybiel, Richard L M Faull, Henry J Waldvoge. DARPP-32 cells and neuropil define striosomal system and isolated matrix cells in human striatum. The Journal of comparative neurology. 2023-04-01. PMID:37002560. |
striatal projection neurons (spns) include relatively intermixed populations expressing d1-type or d2-type dopamine receptors (dspns and ispns) that give rise to the direct (d1) and indirect (d2) output systems of the basal ganglia. |
2023-04-01 |
2023-08-14 |
human |
| Hyeon-Man Bae. Diffusion Measures of Subcortical Structures Using High-Field MRI. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979201. |
the pathology of parkinson's disease (pd) involves the death of dopaminergic neurons in the substantia nigra (sn), which slowly influences downstream basal ganglia pathways as dopamine transport diminishes. |
2023-03-29 |
2023-08-14 |
human |
| Maria Mancini, Silvia Natoli, Fabrizio Gardoni, Monica Di Luca, Antonio Pisan. Dopamine Transmission Imbalance in Neuroinflammation: Perspectives on Long-Term COVID-19. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36982693. |
dopamine (da) is a key neurotransmitter in the basal ganglia, implicated in the control of movement and motivation. |
2023-03-29 |
2023-08-14 |
Not clear |
| Masahiro Naga. [Development of disease-modifying drugs for Parkinson's disease. Is it a tough road?] Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 2023-03-29. PMID:36990797. |
levodopa, a dopamine precursor, is the mainstay of treatment for parkinson's disease to correct the malfunction of basal ganglia circuits caused by dopamine deficiency in the brain. |
2023-03-29 |
2023-08-14 |
Not clear |
| Alana Jaskir, Michael J Fran. On the normative advantages of dopamine and striatal opponency for learning and choice. eLife. vol 12. 2023-03-22. PMID:36946371. |
the basal ganglia (bg) contribute to reinforcement learning (rl) and decision making, but unlike artificial rl agents, it relies on complex circuitry and dynamic dopamine modulaton of opponent striatal pathways to do so. |
2023-03-22 |
2023-08-14 |
Not clear |
| Mojtaba Madadi Asl, Abdol-Hossein Vahabie, Alireza Valizadeh, Peter A Tas. Spike-Timing-Dependent Plasticity Mediated by Dopamine and its Role in Parkinson's Disease Pathophysiology. Frontiers in network physiology. vol 2. 2023-03-17. PMID:36926058. |
motor symptoms of pd are linked to the significant dopamine (da) loss in substantia nigra pars compacta (snc) followed by basal ganglia (bg) circuit dysfunction. |
2023-03-17 |
2023-08-14 |
Not clear |
| Katsunori Kitan. The network configuration in Parkinsonian state compensates network activity change caused by loss of dopamine. Physiological reports. vol 11. issue 4. 2023-02-21. PMID:36802196. |
parkinson's disease is a movement disorder caused by dopamine depletion in the basal ganglia. |
2023-02-21 |
2023-08-14 |
Not clear |
| Finnegan J Calabro, David Montez, Bart Larsen, Charles Laymon, William Foran, Michael Hallquist, Julie Price, Beatriz Lun. Striatal dopamine supports reward expectation and learning: A simultaneous PET/fMRI study. NeuroImage. 2022-12-31. PMID:36586541. |
however, competing evidence supports human dopamine signaling in the basal ganglia as also contributing to the generation of higher order learning heuristics. |
2022-12-31 |
2023-08-14 |
human |