| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maeri Yamamoto, Toshiya Inad. Positron emission tomography studies in adult patients with attention-deficit/hyperactivity disorder. Japanese journal of radiology. 2022-12-08. PMID:36480104. |
several previous pet studies on the central dopaminergic transmission-related ligands in patients with adhd have shown altered binding of dopamine markers in the basal ganglia. |
2022-12-08 |
2023-08-14 |
Not clear |
| Jun Lu, Siamak K Sorooshyar. Machine Learning Identifies a Rat Model of Parkinson's Disease via Sleep-Wake Electroencephalogram. Neuroscience. 2022-12-05. PMID:36470477. |
we hypothesize that nigrostriatal dopamine acting at the basal ganglia regulates cortical activity in sleep and wake state, and its depletion systemically alters electroencephalogram (eeg) across frequencies during sleep-wake state. |
2022-12-05 |
2023-08-14 |
rat |
| M Amin, R Wu, T T Postolache, C Gragnol. Linkage and association of novel DRD2 variants to the comorbidity of type 2 diabetes and depression. European review for medical and pharmacological sciences. vol 26. issue 22. 2022-12-02. PMID:36459020. |
the dopamine receptor 2 (drd2) binds dopamine in both central tissues (e.g., basal ganglia, pituitary gland) and peripheral tissues (e.g., adrenal gland, kidneys, intestine) and mediates dopamine actions in cognition, emotional processing, and prolactin-secretion inhibition and stimulation, and in drd2-/- knockout mice insulin secretion is impaired. |
2022-12-02 |
2023-08-14 |
mouse |
| Kazuki Nakahara, Hiroaki Okuda, Ayami Isonishi, Yoshie Kawabe, Tatsuhide Tanaka, Kouko Tatsumi, Akio Wanak. Amino acid transporter Asc-1 (SLC7A10) expression is altered in basal ganglia in experimental Parkinsonism and L-dopa-induced dyskinesia model mice. Journal of chemical neuroanatomy. 2022-11-20. PMID:36403747. |
in parkinson's disease (pd), a decrease in dopamine levels in the striatum causes abnormal circuit activity in the basal ganglia, resulting in increased output via the substantia nigra pars reticulata (snr). |
2022-11-20 |
2023-08-14 |
mouse |
| Kazuki Nakahara, Hiroaki Okuda, Ayami Isonishi, Yoshie Kawabe, Tatsuhide Tanaka, Kouko Tatsumi, Akio Wanak. Amino acid transporter Asc-1 (SLC7A10) expression is altered in basal ganglia in experimental Parkinsonism and L-dopa-induced dyskinesia model mice. Journal of chemical neuroanatomy. 2022-11-20. PMID:36403747. |
a characteristic feature of glutamatergic synaptic transmission in the basal ganglia circuitry under conditions of dopamine depletion is enhanced synaptic activity of nmda receptors. |
2022-11-20 |
2023-08-14 |
mouse |
| Md Mominur Rahman, Md Rezaul Islam, Sadia Afsana Mim, Nasrin Sultana, Dinesh Kumar Chellappan, Kamal Dua, Mohammad Amjad Kamal, Rohit Sharma, Talha Bin Emra. Insights into the Promising Prospect of G Protein and GPCR-Mediated Signaling in Neuropathophysiology and Its Therapeutic Regulation. Oxidative medicine and cellular longevity. vol 2022. 2022-10-03. PMID:36187336. |
gpr6, gpr52, and gpr8 are termed orphan gpcrs because they colocalize with dopamine d1 and d2 receptors in neurons of the basal ganglia, either alone or with both receptors. |
2022-10-03 |
2023-08-14 |
Not clear |
| Alexander N Rodichkin, Melissa K Edler, Jennifer L McGlothan, Tomás R Guilart. Pathophysiological studies of aging Slc39a14 knockout mice to assess the progression of Manganese-Induced Dystonia-Parkinsonism. Neurotoxicology. 2022-09-24. PMID:36152728. |
neurochemical, neuropathological, and functional assessment of the dopaminergic system of the basal ganglia revealed absence of neurodegenerative changes of dopamine (da) neurons in the substantia nigra pars compacta (snc), with no changes in da or metabolite concentrations in the striatum of slc39a14-ko mice relative to wildtype (wt). |
2022-09-24 |
2023-08-14 |
mouse |
| Montserrat Padilla-Orozco, Mariana Duhne, Alejandra Fuentes-Serrano, Aidán Ortega, Elvira Galarraga, José Bargas, Esther Lara-Gonzále. Synaptic determinants of cholinergic interneurons hyperactivity during parkinsonism. Frontiers in synaptic neuroscience. vol 14. 2022-09-23. PMID:36147730. |
parkinson's disease is a neurodegenerative ailment generated by the loss of dopamine in the basal ganglia, mainly in the striatum. |
2022-09-23 |
2023-08-14 |
Not clear |
| Jacob D Jones, Holly Timblin, Fawn Baxte. Cumulative Effect of Head Injuries on Nonmotor Outcomes in Parkinson's Disease. The Journal of neuropsychiatry and clinical neurosciences. 2022-09-21. PMID:36128680. |
parkinson's disease (pd) is a neurodegenerative movement disorder that is a result of dopamine depletion in the basal ganglia. |
2022-09-21 |
2023-08-14 |
Not clear |
| Jonah Gordon, Gavin Lockard, Molly Monsour, Adam Alayli, Hassan Choudhary, Cesario V Borlonga. Sequestration of Inflammation in Parkinson's Disease via Stem Cell Therapy. International journal of molecular sciences. vol 23. issue 17. 2022-09-09. PMID:36077534. |
gold standard treatment includes exogenous dopamine therapy in the form of levodopa-carbidopa, or surgical intervention with a deep brain stimulator to the subcortical basal ganglia. |
2022-09-09 |
2023-08-14 |
Not clear |
| Balachandar Vellingiri, Mamatha Chandrasekhar, S Sri Sabari, Abilash Valsala Gopalakrishnan, Arul Narayanasamy, Dhivya Venkatesan, Mahalaxmi Iyer, Kavindra Kesari, Abhijit De. Neurotoxicity of pesticides - A link to neurodegeneration. Ecotoxicology and environmental safety. vol 243. 2022-08-27. PMID:36029574. |
the physiological changes occur due to dopamine depletion in basal ganglia region of the brain. |
2022-08-27 |
2023-08-14 |
Not clear |
| M Grall-Bronnec, C Victorri-Vigneau, T Rouaud, A Verholleman, B Schreck, J Leboucher, E Thiabaud, F Feuillet, M Roy, J B Hardouin, M Guillou-Landreat, P Derkinderen, G Challet-Bouj. Parkinson's disease and iatrogenic impulsive-compulsive behaviors: A case/non-case study to build a complete model of individual vulnerability. Journal of behavioral addictions. 2022-08-12. PMID:35960604. |
first-line medications consist of drugs that act by counteracting dopamine deficiency in the basal ganglia. |
2022-08-12 |
2023-08-14 |
Not clear |
| Florence Véronneau-Veilleux, Philippe Robaey, Mauro Ursino, Fahima Nekk. A mechanistic model of ADHD as resulting from dopamine phasic/tonic imbalance during reinforcement learning. Frontiers in computational neuroscience. vol 16. 2022-08-04. PMID:35923915. |
to this end, we combined a dynamic model of dopamine with a neurocomputational model of the basal ganglia with multiple action channels. |
2022-08-04 |
2023-08-14 |
human |
| Elissavet Akrioti, Timokratis Karamitros, Panagiotis Gkaravelas, Georgia Kouroupi, Rebecca Matsas, Era Taoufi. Early Signs of Molecular Defects in iPSC-Derived Neural Stems Cells from Patients with Familial Parkinson's Disease. Biomolecules. vol 12. issue 7. 2022-07-27. PMID:35883433. |
neurodegeneration of dopamine neurons leads to a prominent dopaminergic deficiency in the basal ganglia, responsible for motor disturbances. |
2022-07-27 |
2023-08-14 |
Not clear |
| Jae Hyun Ryou, Doug Hyun Han, Reeree Lee, Sun Mi Ki. Aripiprazole Improved Post-Streptococcal Dyskinesia by Modulating Dopaminergic Activity: A Case Report. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology. vol 20. issue 3. 2022-07-25. PMID:35879044. |
this case report aimed to discuss the efficacy of aripiprazole for dyskinesia in patients with functional movement disorder after streptococcal infection, with its biological action of modulating dopamine hyperactivity in the basal ganglia as a dopamine partial agonist. |
2022-07-25 |
2023-08-14 |
Not clear |
| Jae Hyun Ryou, Doug Hyun Han, Reeree Lee, Sun Mi Ki. Aripiprazole Improved Post-Streptococcal Dyskinesia by Modulating Dopaminergic Activity: A Case Report. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology. vol 20. issue 3. 2022-07-25. PMID:35879044. |
this report has shown that the [18f] n -(3-fluoropropyl)-2β-carbon ethoxy-3β-(4-iodophenyl) nortropane positron emission tomography findings of the patient revealed that the dopamine hyperactivity in the basal ganglia at baseline was normalized after aripiprazole treatment due to its balancing effect as a dopamine partial agonist. |
2022-07-25 |
2023-08-14 |
Not clear |
| Kathryn L Todd, Janusz Lipski, Peter S Freeston. The Subthalamic Nucleus Exclusively Evokes Dopamine Release in the Tail of the Striatum. Journal of neurochemistry. 2022-07-23. PMID:35869680. |
our work identifies the stn as an important modulator of dopamine release in a novel dopamine pathway to the tail striatum, largely independent of the classic nigrostriatal pathway, which necessitates a revision of the basal ganglia circuitry with the stn positioned as a central integrator of striatal information. |
2022-07-23 |
2023-08-14 |
rat |
| Rosa Mastrogiacomo, Gabriella Trigilio, Céline Devroye, Daniel Dautan, Valentina Ferretti, Gabriele Losi, Lucia Caffino, Genny Orso, Roberto Marotta, Federica Maltese, Enrica Vitali, Gessica Piras, Alessia Forgiarini, Giada Pacinelli, Annamaria Lia, Debora A Rothmond, John L Waddington, Filippo Drago, Fabio Fumagalli, Maria Antonietta De Luca, Gian Marco Leggio, Giorgio Carmignoto, Cynthia S Weickert, Francesca Managò, Francesco Papale. Dysbindin-1A modulation of astrocytic dopamine and basal ganglia dependent behaviors relevant to schizophrenia. Molecular psychiatry. 2022-07-13. PMID:35821415. |
dysbindin-1a modulation of astrocytic dopamine and basal ganglia dependent behaviors relevant to schizophrenia. |
2022-07-13 |
2023-08-14 |
mouse |
| Rosa Mastrogiacomo, Gabriella Trigilio, Céline Devroye, Daniel Dautan, Valentina Ferretti, Gabriele Losi, Lucia Caffino, Genny Orso, Roberto Marotta, Federica Maltese, Enrica Vitali, Gessica Piras, Alessia Forgiarini, Giada Pacinelli, Annamaria Lia, Debora A Rothmond, John L Waddington, Filippo Drago, Fabio Fumagalli, Maria Antonietta De Luca, Gian Marco Leggio, Giorgio Carmignoto, Cynthia S Weickert, Francesca Managò, Francesco Papale. Dysbindin-1A modulation of astrocytic dopamine and basal ganglia dependent behaviors relevant to schizophrenia. Molecular psychiatry. 2022-07-13. PMID:35821415. |
in agreement, dys1a disruption only in astrocytes resulted in decreased motivation and sensorimotor gating deficits, increased astrocytic dopamine d2 receptors and decreased dopaminergic tone within basal ganglia. |
2022-07-13 |
2023-08-14 |
mouse |
| Arjun Patel, Catherine A Olang, Gregory Lewis, Kesava Mandalaneni, Nikhilesh Anand, Vasavi Rakesh Gorantl. An Overview of Parkinson's Disease: Curcumin as a Possible Alternative Treatment. Cureus. vol 14. issue 5. 2022-06-20. PMID:35719816. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra of the midbrain and basal ganglia, followed by dopamine deficiency in the brain. |
2022-06-20 |
2023-08-14 |
Not clear |