| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amy S Kohtz, Joshua Zhao, Gary Aston-Jone. Serotonin signaling in hippocampus during initial cocaine abstinence drives persistent drug seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-03-21. PMID:38514181. |
cocaine-seeking behavior on the first day of the absence of expected drug (extinction day 1, ed1) is reduced by blocking 5-ht signaling in dorsal hippocampus ca1 (ca1) in both male and female rats. |
2024-03-21 |
2024-03-24 |
rat |
| Amy S Kohtz, Joshua Zhao, Gary Aston-Jone. Serotonin signaling in hippocampus during initial cocaine abstinence drives persistent drug seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-03-21. PMID:38514181. |
we hypothesized that the experience of ed1 can substantially influence later relapse behavior, and that dorsal raphe serotonin (dr 5-ht) input to ca1 may be involved. |
2024-03-21 |
2024-03-24 |
rat |
| Amy S Kohtz, Joshua Zhao, Gary Aston-Jone. Serotonin signaling in hippocampus during initial cocaine abstinence drives persistent drug seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-03-21. PMID:38514181. |
inhibition of dr inputs, or 5-ht1a/1b signaling, in ca1 decreased drug-seeking on ed1 and decreased cocaine-seeking 2wk later revealing that 5-ht signaling in ca1 during ed1 contributes to persistent drug-seeking during abstinence. |
2024-03-21 |
2024-03-24 |
rat |
| Amy S Kohtz, Joshua Zhao, Gary Aston-Jone. Serotonin signaling in hippocampus during initial cocaine abstinence drives persistent drug seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-03-21. PMID:38514181. |
thus, treatments that modulate 5-ht dependent memory mechanisms in ca1 during initial abstinence may facilitate later maintenance of abstinence. |
2024-03-21 |
2024-03-24 |
rat |
| Yan Xu, Dong-Guang Liu, Ting-Bo Ning, Jian-Guo Zhu, Ru Yao, Xue Meng, Jing-Chun Yao, Wen-Xue Zha. [Antidepressant mechanism of Shenling Kaixin Granules based on BDNF/TrkB/CREB pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 8. 2023-06-07. PMID:37282906. |
the contents of interleukin 1 beta(il-1β), tumor necrosis factor α(tnf-α), brain-derived neurotrophic factor(bdnf) and 5-hydroxytryptamine(5-ht) in serum were determined by enzyme linked immunosorbent assay(elisa), and the activities of superoxide dismutase(sod) and catalase(cat) in hippocampal ca1 region were also detected. |
2023-06-07 |
2023-08-14 |
rat |
| Yan Xu, Dong-Guang Liu, Ting-Bo Ning, Jian-Guo Zhu, Ru Yao, Xue Meng, Jing-Chun Yao, Wen-Xue Zha. [Antidepressant mechanism of Shenling Kaixin Granules based on BDNF/TrkB/CREB pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 8. 2023-06-07. PMID:37282906. |
additionally, the serum contents of il-1β and tnf-α and the expression of caspase-3 were higher, while the contents of bdnf and 5-ht, the activities of sod and cat in hippocampal ca1 region, the expressions of ngf, bdnf, p-trkb/trkb, p-creb/creb, ho-1 and bcl-2/bax, and the nrf2 nuclear translocation were lower in model group than in control group. |
2023-06-07 |
2023-08-14 |
rat |
| Yan Xu, Dong-Guang Liu, Ting-Bo Ning, Jian-Guo Zhu, Ru Yao, Xue Meng, Jing-Chun Yao, Wen-Xue Zha. [Antidepressant mechanism of Shenling Kaixin Granules based on BDNF/TrkB/CREB pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 8. 2023-06-07. PMID:37282906. |
compared with the conditions in model group, the sugar preference, the number of entries and time spent in the center of open, total distance of movement, and the number of entries and proportion of time spent in open arm in treatment groups were increased while the number and time of immobility in forced swimming experiment were decreased; the serum contents of il-1β and tnf-α and the expression of caspase-3 were down regulated, while the contents of bdnf and 5-ht, the activities of sod and cat in hippocampal ca1 region, the expressions of ngf, bdnf, p-trkb/trkb, p-creb/creb, ho-1, bcl-2/bax, and nrf2 nuclear translocation were enhanced. |
2023-06-07 |
2023-08-14 |
rat |
| Jing Wang, Yufei Mei, Xiaoqin Zhang, Xiaojie Wei, Yiping Zhang, Dongpi Wang, Jinjin Huang, Keqing Zhu, Guoping Peng, Binggui Su. Aberrant serotonergic signaling contributes to the hyperexcitability of CA1 pyramidal neurons in a mouse model of Alzheimer's disease. Cell reports. vol 42. issue 3. 2023-02-23. PMID:36821438. |
interestingly, chemogenetic activation of serotonin (5-hydroxytryptamine; 5-ht) neurons in the median raphe nucleus (mrn) attenuates the activity of ca1 pns in happ-j20 mice by regulating the intrinsic properties or inhibitory synaptic transmission of ca1 pns through 5-ht3ar and/or 5-ht1ar. |
2023-02-23 |
2023-08-14 |
mouse |
| Nan Nan, Qi Wang, Mei-Jing Li, Yong-Song Xu, Xiao-Meng Guo, Rui Xu, Zhe Ma, Si-Hui Wang, Jing Li, Hui Zhao, Mu-Xin Gon. The Microbiota-Dependent Treatment of Wuzhuyu Decoction for Chronic Migraine Model Rat Associated with Anxiety-Depression Like Behavior. Oxidative medicine and cellular longevity. vol 2023. 2023-01-17. PMID:36647428. |
the cm rats exhibited anxiety- and depression-like behavior with 5-ht and number of neurons decreased in the ca1 and ca2 regions of hippocampal. |
2023-01-17 |
2023-08-14 |
rat |
| Anna Portugalov, Hiba Zaidan, Inna Gaisler-Salomon, Cecilia J Hillard, Irit Akira. FAAH Inhibition Restores Early Life Stress-Induced Alterations in PFC microRNAs Associated with Depressive-Like Behavior in Male and Female Rats. International journal of molecular sciences. vol 23. issue 24. 2022-12-23. PMID:36555739. |
we compared the effects of treatment with the fatty acid amide hydrolase (faah) inhibitor urb597, and the selective serotonin reuptake inhibitor paroxetine, on els-induced depressive-like behavior and the expression of micrornas (mirs) associated with depression in the medial prefrontal cortex (mpfc), hippocampal ca1 area, lateral habenula and dorsal raphe in rats. |
2022-12-23 |
2023-08-14 |
rat |
| Scheila Daiane Schmidt, Carolina Garrido Zinn, Lorena Evelyn Cavalcante, Flávia Fagundes Ferreira, Cristiane Regina Guerino Furini, Ivan Izquierdo, Jociane de Carvalho Myski. Participation of hippocampal 5-HT Neuroscience. 2022-06-19. PMID:35718219. |
focusing on the more recently described 5-ht receptors, we investigated in the ca1 region of the dorsal hippocampus the participation of 5-ht |
2022-06-19 |
2023-08-14 |
Not clear |
| Safa Ghaheri, Ali Niapour, Nona Sakhaie, Farshid Sadegzadeh, Hakimeh Saadat. Postnatal depletion of serotonin affects the morphology of neurons and the function of the hippocampus in male rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2022-02-19. PMID:35181916. |
we found that critical developmental periods of serotonin depletion caused degeneration and swelling of neurons as well as significant neuronal loss in the hippocampal ca1, ca3, and dentate gyrus (dg) areas. |
2022-02-19 |
2023-08-13 |
rat |
| Sepideh Saffarpour, Farinaz Nasirinezha. The CA1 hippocampal serotonin alterations involved in anxiety-like behavior induced by sciatic nerve injury in rats. Scandinavian journal of pain. vol 21. issue 1. 2021-10-28. PMID:32892185. |
the ca1 hippocampal serotonin alterations involved in anxiety-like behavior induced by sciatic nerve injury in rats. |
2021-10-28 |
2023-08-13 |
rat |
| Sepideh Saffarpour, Farinaz Nasirinezha. The CA1 hippocampal serotonin alterations involved in anxiety-like behavior induced by sciatic nerve injury in rats. Scandinavian journal of pain. vol 21. issue 1. 2021-10-28. PMID:32892185. |
the current study investigated the consequence of pain induced by peripheral neuropathy on the serotonin (5-ht) level of the ca1 region of the hippocampus, which is known as a potential reason, for anxiety associated with neuropathic pain. |
2021-10-28 |
2023-08-13 |
rat |
| Sang Beom Jun, Stephen R Ikeda, Jee Eun Sung, David M Lovinge. Ethanol induces persistent potentiation of 5-HT Neuropharmacology. vol 184. 2021-10-22. PMID:33275959. |
ethanol induces persistent potentiation of 5-ht several studies have shown that ethanol (etoh) can enhance the activity of gabaergic synapses via presynaptic mechanisms, including in hippocampal ca1 neurons. |
2021-10-22 |
2023-08-13 |
Not clear |
| Fenghua Chen, Jibrin Danladi, Maryam Ardalan, Jens R Nyengaard, Connie Sanchez, Gregers Wegene. The rat hippocampal gliovascular system following one week vortioxetine and fluoxetine. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 42. 2021-08-20. PMID:33199100. |
we have previously reported that vortioxetine, unlike the selective serotonin reuptake inhibitor fluoxetine, produces a rapid increase of dendritic spine number and brain derived neurotrophic factor (bdnf)-associated formation of synapses with mitochondrial support in the rat hippocampal ca1 and dentate gyrus. |
2021-08-20 |
2023-08-13 |
rat |
| Zainab Eydipour, Mohammad Nasehi, Salar Vaseghi, Seyed Hamid Jamaldini, Mohammad-Reza Zarrindas. The role of 5-HT4 serotonin receptors in the CA1 hippocampal region on memory acquisition impairment induced by total (TSD) and REM sleep deprivation (RSD). Physiology & behavior. vol 215. 2021-03-04. PMID:31863855. |
the role of 5-ht4 serotonin receptors in the ca1 hippocampal region on memory acquisition impairment induced by total (tsd) and rem sleep deprivation (rsd). |
2021-03-04 |
2023-08-13 |
Not clear |
| Pollyana C Leal, José Marcos M Bispo, Rovena C G J Engelberth, Kayo Diogenes de A Silva, Ywlliane R Meurer, Alessandra M Ribeiro, Regina H Silva, Murilo Marchioro, José R Santo. Serotonergic dysfunction in a model of parkinsonism induced by reserpine. Journal of chemical neuroanatomy. vol 96. 2020-06-15. PMID:30597197. |
after st, 5-ht immunoreactivity decreased in hippocampal subareas (ca1 and ca3) and medial prefrontal cortex (mpfc) compared to vehicle. |
2020-06-15 |
2023-08-13 |
rat |
| Pollyana C Leal, José Marcos M Bispo, Rovena C G J Engelberth, Kayo Diogenes de A Silva, Ywlliane R Meurer, Alessandra M Ribeiro, Regina H Silva, Murilo Marchioro, José R Santo. Serotonergic dysfunction in a model of parkinsonism induced by reserpine. Journal of chemical neuroanatomy. vol 96. 2020-06-15. PMID:30597197. |
furthermore, animals mt-treated also showed progressive decrease of 5-ht immunoreactivity in ca1 and ca3 subareas. |
2020-06-15 |
2023-08-13 |
rat |
| Weiming Li, Baolin Guo, Kai Tao, Fei Li, Zhenru Liu, Han Yao, Dayun Feng, Xufeng Li. Inhibition of SIRT1 in hippocampal CA1 ameliorates PTSD-like behaviors in mice by protections of neuronal plasticity and serotonin homeostasis via NHLH2/MAO-A pathway. Biochemical and biophysical research communications. vol 518. issue 2. 2020-06-15. PMID:31421827. |
inhibition of sirt1 in hippocampal ca1 ameliorates ptsd-like behaviors in mice by protections of neuronal plasticity and serotonin homeostasis via nhlh2/mao-a pathway. |
2020-06-15 |
2023-08-13 |
mouse |