| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Guo, G Yin, X H Zi, H X Zhu, Q Pa. Effect of selective serotonin reuptake inhibitors on expression of 5-HT1AR and neurotransmitters in rats with vascular dementia. Genetics and molecular research : GMR. vol 15. issue 4. 2017-03-01. PMID:27966748. |
escitalopram treatments reduced escape latency, elevated platform crossing times, improved ca1 neuronal damage, increased da and 5-ht levels in hippocampal and cortical neurons, as well as elevated expression of 5-ht1ar mrna (p < 0.05). |
2017-03-01 |
2023-08-13 |
rat |
| Giuseppe Musumeci, Paola Castrogiovanni, Sergio Castorina, Rosa Imbesi, Marta Anna Szychlinska, Soraya Scuderi, Carla Loreto, Salvatore Giunt. Changes in serotonin (5-HT) and brain-derived neurotrophic factor (BDFN) expression in frontal cortex and hippocampus of aged rat treated with high tryptophan diet. Brain research bulletin. vol 119. issue Pt A. 2016-08-29. PMID:26444078. |
interestingly, immunohistochemical analyses confirmed that high trp diet significantly elevates the number of 5-ht immunoreactive fibers in both brain areas tested and this correlated with bdnf increase in the fc and hippocampal regions ca1, ca2, ca3 and a strikingly down-regulation of neurotrophin levels in the dentate gyrus (dg) of aged rats. |
2016-08-29 |
2023-08-13 |
rat |
| Claudia Böhm, Maria Pangalos, Dietmar Schmitz, Jochen Wintere. Serotonin Attenuates Feedback Excitation onto O-LM Interneurons. Cerebral cortex (New York, N.Y. : 1991). vol 25. issue 11. 2016-07-18. PMID:26021702. |
here, we focus on the neuromodulatory effects of 5-ht on gabaergic inhibitory oriens lacunosum-moleculare (o-lm) cells in the hippocampal area ca1 of the rat. |
2016-07-18 |
2023-08-13 |
rat |
| Carla Letizia Busceti, Paola Di Pietro, Barbara Riozzi, Anna Traficante, Francesca Biagioni, Robert Nisticò, Francesco Fornai, Giuseppe Battaglia, Ferdinando Nicoletti, Valeria Brun. 5-HT(2C) serotonin receptor blockade prevents tau protein hyperphosphorylation and corrects the defect in hippocampal synaptic plasticity caused by a combination of environmental stressors in mice. Pharmacological research. vol 99. 2016-06-13. PMID:26145279. |
these effects were transient and critically depended on the activation of 5-ht2c serotonin receptors, which are highly expressed in the ca1 region. |
2016-06-13 |
2023-08-13 |
mouse |
| M Kusek, J Sowa, K Tokarski, G Hes. Impaired effect of activation of rat hippocampal 5-HT7 receptors, induced by treatment with the 5-HT7 receptor antagonist SB 269970. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 66. issue 2. 2016-01-12. PMID:25903960. |
in contrast to control preparations, no 5-ht(7) receptor-mediated increase in excitability nor depolarization and an increase in the input resistance of ca1 and ca3 pyramidal neurons were present in slices prepared from rats treated with sb 269970. |
2016-01-12 |
2023-08-13 |
rat |
| M Kusek, J Sowa, K Tokarski, G Hes. Impaired effect of activation of rat hippocampal 5-HT7 receptors, induced by treatment with the 5-HT7 receptor antagonist SB 269970. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 66. issue 2. 2016-01-12. PMID:25903960. |
these data demonstrate that repeated administration of sb 269970 impairs the reactivity of the ca1 hippocampal neuronal network to 5-ht(7) receptor activation. |
2016-01-12 |
2023-08-13 |
rat |
| J Jesús Hernández-Pérez, Blanca E Gutiérrez-Guzmán, Miguel Á López-Vázquez, María E Olvera-Corté. Supramammillary serotonin reduction alters place learning and concomitant hippocampal, septal, and supramammillar theta activity in a Morris water maze. Frontiers in pharmacology. vol 6. 2015-11-20. PMID:26578960. |
in agreement with this hypothesis, serotonin depletion in the sumn/phn results in deficient spatial learning and alterations in ca1 theta activity-related learning in a morris water maze. |
2015-11-20 |
2023-08-13 |
rat |
| Jennifer D Cooke, Hannah M Cavender, Hope K Lima, Lawrence M Grove. Antidepressants that inhibit both serotonin and norepinephrine reuptake impair long-term potentiation in hippocampus. Psychopharmacology. vol 231. issue 23. 2015-10-07. PMID:24781518. |
previously, we found that treatment with venlafaxine, a serotonin and norepinephrine reuptake inhibitor (snri), but not citalopram, a selective serotonin reuptake inhibitor (ssri), reduced ltp in hippocampal area ca1 without changing hippocampal bdnf protein expression. |
2015-10-07 |
2023-08-13 |
Not clear |
| Jana D Tchekalarova, Natasha M Ivanova, Daniela M Pechlivanova, Dimitrina Atanasova, Nikolai Lazarov, Lidia Kortenska, Rumiana Mitreva, Valentin Lozanov, Alexander Stoyne. Antiepileptogenic and neuroprotective effects of losartan in kainate model of temporal lobe epilepsy. Pharmacology, biochemistry, and behavior. vol 127. 2015-08-28. PMID:25456349. |
losartan exerted neuroprotection selectively in the ca1 area of the hippocampus in the ka-treated rats and lowered the 5-ht levels both in normal and abnormal conditions. |
2015-08-28 |
2023-08-13 |
rat |
| Miguel Ángel López-Vázquez, Elisa López-Loeza, Naima Lajud Ávila, Blanca Erika Gutiérrez-Guzmán, J Jesús Hernández-Pérez, Yoana Estrada Reyes, María Esther Olvera-Corté. Septal serotonin depletion in rats facilitates working memory in the radial arm maze and increases hippocampal high-frequency theta activity. European journal of pharmacology. vol 734. 2015-01-28. PMID:24742376. |
sprague dawley rats were depleted of 5ht with the infusion of 5,7-dihydroxytriptamine (5,7-dht) in ms/dbb and were subsequently trained in the standard test (win-shift) in the radial arm, while the ca1 eeg activity was simultaneously recorded through telemetry. |
2015-01-28 |
2023-08-13 |
rat |
| Man Tang, Tao He, Xiao Sun, Qing-Yan Meng, Yao Diao, Jie-Yu Lei, Xiao-Jing He, Lei Chen, Xiu-Bo Sang, Shulei Zha. Subregion-specific decreases in hippocampal serotonin transporter protein expression and function associated with endophenotypes of depression. Hippocampus. vol 24. issue 4. 2014-12-03. PMID:24436084. |
the current study sought to determine whether chronic corticosteroid (cort) treatment influences serotonin transporter (5-htt) protein expression and function in the ca1, ca3, and dentate gyrus (dg) subregions of the hippocampus. |
2014-12-03 |
2023-08-12 |
mouse |
| Man Tang, Tao He, Xiao Sun, Qing-Yan Meng, Yao Diao, Jie-Yu Lei, Xiao-Jing He, Lei Chen, Xiu-Bo Sang, Shulei Zha. Subregion-specific decreases in hippocampal serotonin transporter protein expression and function associated with endophenotypes of depression. Hippocampus. vol 24. issue 4. 2014-12-03. PMID:24436084. |
we then determine 5-htt protein expression and synaptosomal 5-ht uptake in the ca1, ca3 and dg subregions. |
2014-12-03 |
2023-08-12 |
mouse |
| Man Tang, Tao He, Xiao Sun, Qing-Yan Meng, Yao Diao, Jie-Yu Lei, Xiao-Jing He, Lei Chen, Xiu-Bo Sang, Shulei Zha. Subregion-specific decreases in hippocampal serotonin transporter protein expression and function associated with endophenotypes of depression. Hippocampus. vol 24. issue 4. 2014-12-03. PMID:24436084. |
cort treatment induced anhedonia and behavioral despair, two core endophenotypes of clinical depression; 5-htt protein expression levels and synaptosomal 5-ht uptake were both decreased in a subregion-specific manner, with the greatest decrease observed in the dg, a moderate decrease in the ca3, and the ca1 showed no apparent change. |
2014-12-03 |
2023-08-12 |
mouse |
| Shimako Yoshitake, Eugenia Kuteeva, Tomas Hökfelt, Françoise Mennicken, Elvar Theodorsson, Masatoshi Yamaguchi, Jan Kehr, Takashi Yoshitak. Correlation between the effects of local and intracerebroventricular infusions of galanin on 5-HT release studied by microdialysis, and distribution of galanin and galanin receptors in prefrontal cortex, ventral hippocampus, amygdala, hypothalamus, and striatum of awake rats. Synapse (New York, N.Y.). vol 68. issue 5. 2014-11-07. PMID:24430888. |
infusions of galanin on basal extracellular 5-ht levels in medial prefrontal cortex (mpfc), ca1 area of ventral hippocampus (vhpc), central amygdaloid nucleus (cea), ventromedial hypothalamic nucleus ventrolateral part (vmhvl), and ventromedial caudate putamen (cpu). |
2014-11-07 |
2023-08-12 |
rat |
| Zlatina Petkova, Jana Tchekalarova, Daniela Pechlivanova, Slavianka Moyanova, Lidia Kortenska, Rumiana Mitreva, Deyan Popov, Petya Markova, Valentin Lozanov, Dimitrina Atanasova, Nikolai Lazarov, Alexander Stoyne. Treatment with melatonin after status epilepticus attenuates seizure activity and neuronal damage but does not prevent the disturbance in diurnal rhythms and behavioral alterations in spontaneously hypertensive rats in kainate model of temporal lobe epilepsy. Epilepsy & behavior : E&B. vol 31. 2014-09-29. PMID:24440891. |
melatonin reduced neuronal damage specifically in the ca1 area of the hippocampus and piriform cortex and decreased hippocampal serotonin (5-ht) levels both in control and epileptic shrs. |
2014-09-29 |
2023-08-12 |
rat |
| Edaeni Hamid, Emily Church, Christopher A Wells, Zack Zurawski, Heidi E Hamm, Simon Alfor. Modulation of neurotransmission by GPCRs is dependent upon the microarchitecture of the primed vesicle complex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 1. 2014-02-24. PMID:24381287. |
in rat hippocampal ca1 axons, gaba(b) receptors (gaba(b)rs) inhibit presynaptic ca(2+) entry, and we have now demonstrated that 5-ht(1b) receptors (5-ht(1b)rs) liberate gβγ to interact with snare complex c terminals with no effect on ca(2+) entry. |
2014-02-24 |
2023-08-12 |
rat |
| Jana Tchekalarova, Zlatina Petkova, Daniela Pechlivanova, Slavianka Moyanova, Lidia Kortenska, Rumiana Mitreva, Valentin Lozanov, Dimitrina Atanasova, Nikolai Lazarov, Alexander Stoyne. Prophylactic treatment with melatonin after status epilepticus: effects on epileptogenesis, neuronal damage, and behavioral changes in a kainate model of temporal lobe epilepsy. Epilepsy & behavior : E&B. vol 27. issue 1. 2013-09-12. PMID:23435277. |
melatonin reduced the neuronal damage in the ca1 area of the hippocampus and piriform cortex and recovered the decrease of hippocampal serotonin (5-ht) level in rats with epilepsy. |
2013-09-12 |
2023-08-12 |
rat |
| Krzysztof Tokarski, Bartosz Bobula, Małgorzata Grzegorzewska-Hiczwa, Magdalena Kusek, Grzegorz Hes. Stress- and antidepressant treatment-induced modifications of 5-HT₇ receptor functions in the rat brain. Pharmacological reports : PR. vol 64. issue 6. 2013-07-16. PMID:23406741. |
these studies demonstrated that 5-ht(7) receptors play an important role in the modulation of the activity of the hippocampal network by regulating the excitability of pyramidal cells of the ca1 area, as well as via their effect on gaba and glutamatergic transmission. |
2013-07-16 |
2023-08-12 |
rat |
| Harun N Noristani, Alexei Verkhratsky, José J Rodrígue. High tryptophan diet reduces CA1 intraneuronal β-amyloid in the triple transgenic mouse model of Alzheimer's disease. Aging cell. vol 11. issue 5. 2013-04-10. PMID:22702392. |
here, we analysed the effect of chronic (1 month) food diets containing low (ltrp), normal (ntrp) and high tryptophan (htrp), 0.04, 0.20 and 0.40 g/100 g, respectively, on ca1 serotonin transporter (sert) fibre density, intraneuronal aβ deposition and total number of serotonergic (5-ht) neurons in an ad triple transgenic (3xtg-ad) mouse model. |
2013-04-10 |
2023-08-12 |
mouse |
| Harun N Noristani, Alexei Verkhratsky, José J Rodrígue. High tryptophan diet reduces CA1 intraneuronal β-amyloid in the triple transgenic mouse model of Alzheimer's disease. Aging cell. vol 11. issue 5. 2013-04-10. PMID:22702392. |
transgenic animals showed increased sert fibre density in ca1 s.mol compared to diet-matched non-tg irrespective of dietary tryptophan content (104% for ltrp, 74% for ntrp and 35% for htrp); no differences were observed in the total number of 5-ht neurons neither in the dorsal nor in the median raphe nuclei. |
2013-04-10 |
2023-08-12 |
mouse |