| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jerzy Wegiel, Michael Flory, Izabela Kuchna, Krzysztof Nowicki, Jarek Wegiel, Shuang Yong Ma, Nanbert Zhong, Teresa Wierzba Bobrowicz, Mony de Leon, Florence Lai, Wayne P Silverman, Thomas Wisniewsk. Developmental deficits and staging of dynamics of age associated Alzheimer's disease neurodegeneration and neuronal loss in subjects with Down syndrome. Acta neuropathologica communications. vol 10. issue 1. 2022-01-05. PMID:34983655. |
the aims of this study of 14 brain regions including the entorhinal cortex, hippocampus, basal ganglia, and cerebellum in 33 adults with ds 26-72 years of age were to identify the magnitude of brain region-specific developmental neuronal deficits contributing to intellectual deficits, to apply this baseline to identification of the topography and magnitude of neurodegeneration and neuronal and volume losses caused by eoad, and to establish age-based staging of the pattern of genetically driven neuropathology in ds. |
2022-01-05 |
2023-08-13 |
human |
| Yu S Severyukhin, M Lalkovičová, D M Utina, K N Lyakhova, I A Kolesnikova, M E Ermolaeva, A G Molokanov, V N Gaevsky, D A Komarov, E A Krasavi. Comparative Analysis of Behavioral Reactions and Morphological Changes in the Rat Brain After Exposure to Ionizing Radiation with Different Physical Characteristics. Cellular and molecular neurobiology. 2022-01-04. PMID:34982311. |
morphological analysis showed the development of early amyloidosis, autolysis of the ependymal layer, an increase in the number of neurodegenerative changes in various structures of the brain, and the development of neuronal hypertrophy on the 30th day after irradiation in the cerebellum and hippocampal hilus. |
2022-01-04 |
2023-08-13 |
rat |
| Serena Camuso, Piergiorgio La Rosa, Maria Teresa Fiorenza, Sonia Canterin. Pleiotropic effects of BDNF on the cerebellum and hippocampus: Implications for neurodevelopmental disorders. Neurobiology of disease. 2022-01-02. PMID:34974125. |
pleiotropic effects of bdnf on the cerebellum and hippocampus: implications for neurodevelopmental disorders. |
2022-01-02 |
2023-08-13 |
Not clear |
| Serena Camuso, Piergiorgio La Rosa, Maria Teresa Fiorenza, Sonia Canterin. Pleiotropic effects of BDNF on the cerebellum and hippocampus: Implications for neurodevelopmental disorders. Neurobiology of disease. 2022-01-02. PMID:34974125. |
bdnf is present in various brain areas, but highest levels of expression are seen in the cerebellum and hippocampus. |
2022-01-02 |
2023-08-13 |
Not clear |
| Serena Camuso, Piergiorgio La Rosa, Maria Teresa Fiorenza, Sonia Canterin. Pleiotropic effects of BDNF on the cerebellum and hippocampus: Implications for neurodevelopmental disorders. Neurobiology of disease. 2022-01-02. PMID:34974125. |
after birth, bdnf acts in the cerebellum as a mitogenic and chemotactic factor, stimulating the cerebellar granule cell precursors to proliferate, migrate and maturate, while in the hippocampus bdnf plays a fundamental role in synaptic transmission and plasticity, representing a key regulator for the long-term potentiation, learning and memory. |
2022-01-02 |
2023-08-13 |
Not clear |
| Serena Camuso, Piergiorgio La Rosa, Maria Teresa Fiorenza, Sonia Canterin. Pleiotropic effects of BDNF on the cerebellum and hippocampus: Implications for neurodevelopmental disorders. Neurobiology of disease. 2022-01-02. PMID:34974125. |
the purpose of this review is to provide an overview of the current state of knowledge on the bdnf biology and its neurotrophic role in the proper development and functioning of neurons and synapses in two important brain areas of postnatal neurogenesis, the cerebellum and hippocampus. |
2022-01-02 |
2023-08-13 |
Not clear |
| Natalie Grima, Lyndal Henden, Owen Watson, Ian P Blair, Kelly L William. Simultaneous Isolation of High-Quality RNA and DNA From Postmortem Human Central Nervous System Tissues for Omics Studies. Journal of neuropathology and experimental neurology. 2021-12-23. PMID:34939123. |
motor cortex, frontal cortex, hippocampus, occipital cortex, anterior cingulate cortex, cerebellum, and spinal cord tissues were obtained from 22 individuals diagnosed with motor neuron disease (mnd) and 13 neurologically normal controls (n = 245 tissues). |
2021-12-23 |
2023-08-13 |
human |
| Glen E Kisby, Peter S Spence. Genotoxic Damage During Brain Development Presages Prototypical Neurodegenerative Disease. Frontiers in neuroscience. vol 15. 2021-12-20. PMID:34924930. |
the principal cycad genotoxin, methylazoxymethanol (mam), forms reactive carbon-centered ions that alkylate nucleic acids in fetal rodent brain and, depending on the timing of systemic administration, induces persistent developmental abnormalities of the cortex, hippocampus, cerebellum, and retina. |
2021-12-20 |
2023-08-13 |
human |
| YouJin Lee, Morgan R Miller, Marty A Fernandez, Elizabeth L Berg, Adriana M Prada, Qing Ouyang, Michael Schmidt, Jill L Silverman, Tracy L Young-Pearse, Eric M Morro. Early lysosome defects precede neurodegeneration with amyloid-β and tau aggregation in NHE6-null rat brain. Brain : a journal of neurology. 2021-12-20. PMID:34928329. |
importantly, we subsequently observe biochemical and in situ evidence of both aβ and tau aggregation in the aged nhe6-null hippocampus and cortex (but not in the cerebellum). |
2021-12-20 |
2023-08-13 |
mouse |
| Xing Zhang, Dongmeng Mei, Yongfang Li, Mingdan You, Da Wang, Dianqi Yao, Yuanyuan Xu, Lingling Zhai, Yi Wan. Arsenic exposure via drinking water during pregnancy and lactation induces autism-like behaviors in male offspring mice. Chemosphere. 2021-12-20. PMID:34929279. |
thus, immunofluorescence staining and western blotting were used to observe the expression of psd-95 and syp, well-known markers for presynaptic and postsynaptic membranes, to assess the synaptic density in offspring cortex, hippocampus and cerebellum. |
2021-12-20 |
2023-08-13 |
mouse |
| Dana C Walters, Regan Lawrence, Trevor Kirby, Jared T Ahrendsen, Matthew P Anderson, Jean-Baptiste Roullet, Eric J Murphy, K Michael Gibso. Postmortem Analyses in a Patient With Succinic Semialdehyde Dehydrogenase Deficiency (SSADHD): II. Histological, Lipid, and Gene Expression Outcomes in Regional Brain Tissue. Journal of child neurology. vol 36. issue 13-14. 2021-12-12. PMID:33557678. |
this study has extended previous metabolic measures in postmortem tissues (frontal and parietal lobes, pons, cerebellum, hippocampus, and cerebral cortex) obtained from a 37-year-old male patient with succinic semialdehyde dehydrogenase deficiency (ssadhd) who expired from sudep (sudden unexplained death in epilepsy). |
2021-12-12 |
2023-08-13 |
Not clear |
| Janace J Gifford, Pooja Deshpande, Priyanka Mehta, George C Wagner, Alexander W Kusneco. The Effect of Valproic Acid Exposure throughout Development on Microglia Number in the Prefrontal Cortex, Hippocampus and Cerebellum. Neuroscience. 2021-12-11. PMID:34780921. |
the effect of valproic acid exposure throughout development on microglia number in the prefrontal cortex, hippocampus and cerebellum. |
2021-12-11 |
2023-08-13 |
Not clear |
| Marianne Khalil, Philippine Hollander, Delphine Raucher-Chéné, Martin Lepage, Katie M Lavign. Structural brain correlates of cognitive function in schizophrenia: A meta-analysis. Neuroscience and biobehavioral reviews. vol 132. 2021-12-11. PMID:34822878. |
brain structure mapped onto the seven yeo functionally defined networks and extraneous structures (amygdala, hippocampus, and cerebellum) typically showed associations with conceptually related cognitive domains, with higher-level domains (e.g., executive function, social cognition) associated with more networks. |
2021-12-11 |
2023-08-13 |
Not clear |
| Patricia Simonetti, Carla Rachel Ono, Camila de Godoi Carneiro, Rafay Ali Khan, Somayeh Shahsavarani, Fatima T Husain, Jeanne Oiticic. Evaluating the efficacy of hearing aids for tinnitus therapy - A Positron emission tomography study. Brain research. vol 1775. 2021-12-10. PMID:34793755. |
analysis revealed increased glycolytic metabolism in the left orbitofrontal cortex, right temporal lobe and right hippocampus, and reduced glycolytic metabolism in the left cerebellum and inferior parietal lobe within the tinnitus group. |
2021-12-10 |
2023-08-13 |
human |
| Esther García-García, Nerea Chaparro-Cabanillas, Albert Coll-Manzano, Maria Carreras-Caballé, Albert Giralt, Daniel Del Toro, Jordi Alberch, Mercè Masana, Manuel J Rodrígue. Unraveling the Spatiotemporal Distribution of VPS13A in the Mouse Brain. International journal of molecular sciences. vol 22. issue 23. 2021-12-10. PMID:34884823. |
we found a widespread vps13a distribution, with the strongest expression profiles in the pons, hippocampus, and cerebellum. |
2021-12-10 |
2023-08-13 |
mouse |
| Xiyong Dai, Lei Gao, Haibo Zhang, Xinhua Wei, Zaiyi Li. A combination of support vector machine and voxel-based morphometry in adult male alcohol use disorder patients with cognitive deficits. Brain research. vol 1771. 2021-12-09. PMID:34478708. |
the aud patients demonstrated reduced gray matter (gm) volumes that included left amygdala, thalamus, hippocampus, precentral gyrus, cerebellum, calcarine, right supplementary motor area and bilateral superior temporal gyri (voxel-wise p < 0.05, fwe corrected). |
2021-12-09 |
2023-08-13 |
Not clear |
| Lu Wang, Zihui Deng, Yan Zhao, Rui Yuan, Mengmeng Yang, Yu Zhang, Yun Li, Yuyan Liu, Feihu Zhou, Hongjun Kan. Mesenchymal stem cells regulate activation of microglia cells to improve hippocampal injury of heat stroke rats. Journal of thermal biology. vol 101. 2021-12-09. PMID:34879909. |
we performed survival analysis, neurological deficit score, histological staining of hippocampus and cerebellum, immunofluorescence staining of microglia, detection of inflammatory and chemokine levels in the hippocampus and cerebellum in each group. |
2021-12-09 |
2023-08-13 |
rat |
| Lu Wang, Zihui Deng, Yan Zhao, Rui Yuan, Mengmeng Yang, Yu Zhang, Yun Li, Yuyan Liu, Feihu Zhou, Hongjun Kan. Mesenchymal stem cells regulate activation of microglia cells to improve hippocampal injury of heat stroke rats. Journal of thermal biology. vol 101. 2021-12-09. PMID:34879909. |
we found that mscs treatment not only significantly reduced early (day 3) and late (day 28) mortality, but also prominently reduced nerve injury in heat stroke rats, and improved pathology and neuronal cell damage in the hippocampus and cerebellum. |
2021-12-09 |
2023-08-13 |
rat |
| Sameh M Farouk, Ahmed M Abdellatif, Elsayed Metwall. Outer and inner mitochondrial membrane proteins TOMM40 and TIMM50 are intensively concentrated and localized at Purkinje and pyramidal neurons in the New Zealand white rabbit brain. Anatomical record (Hoboken, N.J. : 2007). vol 305. issue 1. 2021-12-08. PMID:34041863. |
in the present study, we quantitatively evaluated the protein expression of the translocase of outer mitochondrial membrane 40 (tomm40) and inner mitochondrial membrane 50 (timm50) complexes, two of the tom/tim complexes, in the cerebral, cerebellar, and hippocampal cortices of the new zealand white rabbit brain, using immunohistochemistry. |
2021-12-08 |
2023-08-13 |
rabbit |
| Sameh M Farouk, Ahmed M Abdellatif, Elsayed Metwall. Outer and inner mitochondrial membrane proteins TOMM40 and TIMM50 are intensively concentrated and localized at Purkinje and pyramidal neurons in the New Zealand white rabbit brain. Anatomical record (Hoboken, N.J. : 2007). vol 305. issue 1. 2021-12-08. PMID:34041863. |
sections from brain specimens were initially stained for cytochrome c oxidase (cox), a well-known mitochondrial marker, which was found to be homogeneously expressed in the cerebrum, but localized to the purkinje and pyramidal neurons of the cerebellum and hippocampus, respectively. |
2021-12-08 |
2023-08-13 |
rabbit |