| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Foley, V Dzelzkalns, S I Beal. delta-Aminolevulinic Acid Synthase of Euglena gracilis: Regulation of Activity. Plant physiology. vol 70. issue 1. 2010-06-29. PMID:16662450. |
delta-aminolevulinic acid (ala), a key precursor of the tetrapyrroles heme and chlorophyll, is capable of being synthesized by two different routes in cells of the unicellular green alga euglena gracilis: from the intact carbon skeleton of glutamate, and via the condensation of glycine and succinyl coa, mediated by the enzyme ala synthase. |
2010-06-29 |
2023-08-12 |
human |
| B A Martin, R W Rinn. A Comparison of Oleic Acid Metabolism in the Soybean (Glycine max [L.] Merr.) Genotypes Williams and A5, a Mutant with Decreased Linoleic Acid in the Seed. Plant physiology. vol 81. issue 1. 2010-06-29. PMID:16664804. |
the metabolism of oleoyl coenzyme a (coa) was examined in developing seed from two soybean (glycine max [l.] merr.) |
2010-06-29 |
2023-08-12 |
Not clear |
| Y Z Cao, K C Oo, A H Huan. Lysophosphatidate Acyltransferase in the Microsomes from Maturing Seeds of Meadowfoam (Limnanthes alba). Plant physiology. vol 94. issue 3. 2010-06-29. PMID:16667817. |
1.51) in the microsomes from the maturing seeds of meadowfoam (limnanthes alba), nasturtium (tropaeolum majus), palm (syagrus cocoides), castor bean (ricinus communis), soybean (glycine max), maize (zea mays), and rapeseed (brassica napus) were tested for their specificities toward 1-oleoyl-lpa or 1-erucoyl-lpa, and oleoyl coenzyme a (coa) or erucoyl coa. |
2010-06-29 |
2023-08-12 |
Not clear |
| Konstantinos A Kouremenos, James Pitt, Philip J Marriot. Metabolic profiling of infant urine using comprehensive two-dimensional gas chromatography: Application to the diagnosis of organic acidurias and biomarker discovery. Journal of chromatography. A. vol 1217. issue 1. 2010-02-23. PMID:19896671. |
a novel urinary metabolite, crotonyl glycine, was also discovered in the mitochondrial 3-hydroxy-3-methylglutaryl coa synthase sample which may be a useful specific diagnostic marker for this disorder. |
2010-02-23 |
2023-08-12 |
Not clear |
| Jeffrey M McCue, William J Driscoll, Gregory P Muelle. In vitro synthesis of arachidonoyl amino acids by cytochrome c. Prostaglandins & other lipid mediators. vol 90. issue 1-2. 2010-01-22. PMID:19683594. |
we have previously observed that the mitochondrial protein, cytochrome c, is capable of catalyzing the formation of the prototypic arachidonoyl amino acid, arachidonoyl glycine, utilizing arachidonoyl coa and glycine as substrates, in the presence of hydrogen peroxide. |
2010-01-22 |
2023-08-12 |
Not clear |
| Thomas Lendrihas, Junshun Zhang, Gregory A Hunter, Gloria C Ferreir. Arg-85 and Thr-430 in murine 5-aminolevulinate synthase coordinate acyl-CoA-binding and contribute to substrate specificity. Protein science : a publication of the Protein Society. vol 18. issue 9. 2009-11-23. PMID:19562746. |
5-aminolevulinate synthase (alas) controls the rate-limiting step of heme biosynthesis in mammals by catalyzing the condensation of succinyl-coenzyme a and glycine to produce 5-aminolevulinate, coenzyme-a (coa), and carbon dioxide. |
2009-11-23 |
2023-08-12 |
Not clear |
| A Bowyer, H Mikolajek, J W Stuart, S P Wood, F Jamil, N Rashid, M Akhtar, J B Coope. Structure and function of the l-threonine dehydrogenase (TkTDH) from the hyperthermophilic archaeon Thermococcus kodakaraensis. Journal of structural biology. vol 168. issue 2. 2009-11-16. PMID:19616102. |
docking studies suggest a mode of interaction of tdh with 2-amino-3-ketobutyrate coa ligase, the subsequent enzyme in the pathway for conversion of threonine to glycine. |
2009-11-16 |
2023-08-12 |
Not clear |
| Jian Wang, Peter Alexander, Leeju Wu, Robert Hammer, Ondine Cleaver, Steven L McKnigh. Dependence of mouse embryonic stem cells on threonine catabolism. Science (New York, N.Y.). vol 325. issue 5939. 2009-09-09. PMID:19589965. |
tdh-mediated catabolism of threonine takes place in mitochondria to generate glycine and acetyl-coenzyme a (coa), with glycine facilitating one-carbon metabolism via the glycine cleavage system and acetyl-coa feeding the tricarboxylic acid cycle. |
2009-09-09 |
2023-08-12 |
mouse |
| G A Hunter, G C Ferreir. 5-aminolevulinate synthase: catalysis of the first step of heme biosynthesis. Cellular and molecular biology (Noisy-le-Grand, France). vol 55. issue 1. 2009-06-23. PMID:19268008. |
the reaction cycle involves condensation of glycine with succinyl-coenzyme a to yield 5-aminolevulinate, carbon dioxide, and coa. |
2009-06-23 |
2023-08-12 |
human |
| Kenji Suita, Takaaki Kiryu, Maki Sawada, Maiko Mitsui, Masataka Nakagawa, Kengo Kanamaru, Hiroshi Yamagat. Cyclic GMP acts as a common regulator for the transcriptional activation of the flavonoid biosynthetic pathway in soybean. Planta. vol 229. issue 2. 2009-04-15. PMID:18987879. |
we investigated the cgmp-responsiveness of several genes encoding flavonoid-biosynthetic enzymes in soybean (glycine max l.) involved in legume-specific isoflavone, phytoalexin and anthocyanin biosynthesis, such as phenylalanine ammonia-lyase, cinnamate 4-hydroxylase, 4-coumarate:coa ligase, chalcone synthase, chalcone reductase, chalcone isomerase, 2-hydroxyisoflavanone synthase, 2-hydroxyisoflavanone dehydratase, anthocyanidin synthase, udp-glucose:isoflavone 7-o-glucosyltransferase, and isoflavone reductase, and found that the majority of these genes were induced by cgmp but not by camp. |
2009-04-15 |
2023-08-12 |
Not clear |
| Yan-Guang Cao, Lin Zhang, Chen Ma, Bo-Bo Chang, Yuan-Cheng Chen, Yi-Qun Tang, Xiao-Dong Liu, Xiao-Quan Li. Metabolism of protocatechuic acid influences fatty acid oxidation in rat heart: new anti-angina mechanism implication. Biochemical pharmacology. vol 77. issue 6. 2009-04-01. PMID:19109930. |
in detail, three metabolites, catechol methylated metabolite, acyl-coenzyme (coa) thioester and glycine conjugation, were identified in rat heart. |
2009-04-01 |
2023-08-12 |
rat |
| S Scholl-Bürgi, S H Korman, D A Applegarth, D Karall, Y Lillquist, P Heinz-Erian, A G F Davidson, E Haberlandt, J O Sas. The relation of cerebrospinal fluid and plasma glycine levels in propionic acidaemia, a 'ketotic hyperglycinaemia'. Journal of inherited metabolic disease. vol 31. issue 3. 2008-09-09. PMID:18392751. |
the characteristic elevation of plasma glycine concentrations observed in propionic acidaemia (pa) and other 'ketotic hyperglycinaemias' has been attributed to secondary inhibition of the hepatic glycine cleavage system (gcs) by accumulating coa derivatives of branched-chain amino acid metabolites. |
2008-09-09 |
2023-08-12 |
Not clear |
| Nazneen Naher Islam, Koichi Igarashi, Taro Tachibana, Hiroshi Ooshima, Masayuki Azum. Synthesis and degradation of acyl peptide using enzyme from Pseudomonas aeruginosa. Journal of bioscience and bioengineering. vol 105. issue 3. 2008-08-19. PMID:18397780. |
the detailed properties of the enzyme from pseudomonas aeruginosa, which catalyzes the n-acyl linkage between myristic acid and the n-terminal glycine residue of the octapeptide gnaaaarr-nh(2) (pka) in aqueous solution without atp and coa, were studied. |
2008-08-19 |
2023-08-12 |
Not clear |
| Grant A Mitchell, Nicolas Gauthier, Alain Lesimple, Shu Pei Wang, Orval Mamer, Ijaz Quresh. Hereditary and acquired diseases of acyl-coenzyme A metabolism. Molecular genetics and metabolism. vol 94. issue 1. 2008-07-21. PMID:18337138. |
we review acyl-coa metabolism, including coash synthesis, transesterification of acyl-coas to glycine, glutamate or l-carnitine and hydrolysis of coa esters. |
2008-07-21 |
2023-08-12 |
Not clear |
| Richard A Zager, Ali C M Johnson, Masayo Naito, Karol Bomszty. Maleate nephrotoxicity: mechanisms of injury and correlates with ischemic/hypoxic tubular cell death. American journal of physiology. Renal physiology. vol 294. issue 1. 2008-03-04. PMID:17942567. |
maleate toxicity reproduced critical characteristics of the hypoxia/atp depletion-induced injury cascade: 1) glutathione (gsh) conferred protection, but due to its glycine, not cysteine (antioxidant), content; 2) atp reductions reflected decreased production, not na-k-atpase-driven increased consumption; 3) cell death was completely blocked by extracellular acidosis (ph 6.6); 4) intracellular ca(2+) chelation (bapta) mitigated cell death; 5) maleate and hypoxia each caused plasma membrane cholesterol shedding and in both instances, this was completely glycine suppressible; 6) maleate + hypoxia caused neither additive nefa accumulation nor ldh release, implying shared pathogenic pathways; and 7) maleate, like ischemia, induced renal cortical cholesterol loading; increased hmg coa reductase (hmgcr) activity (statin inhibitable), increased hmgcr mrna levels, and increased rna polymerase ii recruitment to the hmgcr locus (chromatin immunoprecipitation, chip, assay) were involved. |
2008-03-04 |
2023-08-12 |
mouse |
| Gregory A Hunter, Junshun Zhang, Gloria C Ferreir. Transient kinetic studies support refinements to the chemical and kinetic mechanisms of aminolevulinate synthase. The Journal of biological chemistry. vol 282. issue 32. 2007-09-19. PMID:17485466. |
5-aminolevulinate synthase catalyzes the pyridoxal 5'-phosphate-dependent condensation of glycine and succinyl-coa to produce carbon dioxide, coa, and 5-aminolevulinate, in a reaction cycle involving the mechanistically unusual successive cleavage of two amino acid substrate alpha-carbon bonds. |
2007-09-19 |
2023-08-12 |
cat |
| Ryuki Hanaoka, Igor B Dawid, Atsuo Kawahar. Cloning and expression of zebrafish genes encoding the heme synthesis enzymes uroporphyrinogen III synthase (UROS) and protoporphyrinogen oxidase (PPO). DNA sequence : the journal of DNA sequencing and mapping. vol 18. issue 1. 2007-05-31. PMID:17364814. |
heme is synthesized from glycine and succinyl coa by eight heme synthesis enzymes. |
2007-05-31 |
2023-08-12 |
human |
| Qamar Bashir, Naeem Rashid, Muhammad Akhta. Mechanism and substrate stereochemistry of 2-amino-3-oxobutyrate CoA ligase: implications for 5-aminolevulinate synthase and related enzymes. Chemical communications (Cambridge, England). issue 48. 2007-02-09. PMID:17146529. |
the condensation process catalysed by 2-amino-3-oxobutyrate coa ligase (kbl; also known as 2-amino-3-ketobutyrate ligase) involves the loss of the pro-r hydrogen atom of glycine and occurs with the inversion of stereochemistry; a similar scenario is envisaged for the condensation step of other alpha-oxoamine synthases. |
2007-02-09 |
2023-08-12 |
Not clear |
| Pornpimon Kiatpapan, Yoshikatsu Murook. Genetic manipulation system in propionibacteria. Journal of bioscience and bioengineering. vol 93. issue 1. 2005-11-03. PMID:16233156. |
ala in propionibacteria could be synthesized via both the c4 pathway (condensation of glycine and succinyl coa) and the c5 pathway (from glutamate). |
2005-11-03 |
2023-08-12 |
Not clear |
| Haydée Fukuda, Adriana Casas, Alcira Batll. Aminolevulinic acid: from its unique biological function to its star role in photodynamic therapy. The international journal of biochemistry & cell biology. vol 37. issue 2. 2005-03-29. PMID:15474973. |
two alternative routes for the formation of ala have been proposed: one involves the condensation of succinyl coa and glycine catalyzed by ala synthetase taking place in the mitochondria, and the second one is the so called 5-carbon route, occurring in the stroma of plastids. |
2005-03-29 |
2023-08-12 |
Not clear |