| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bálint Botz, Kata Bölcskei, Zsuzsanna Helye. Challenges to develop novel anti-inflammatory and analgesic drugs. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology. vol 9. issue 3. 2017-09-29. PMID:27576790. |
there are in fact some promising novel approaches at different clinical stages of drug development focusing on transient receptor potential vanilloid 1/ankyrin 1 channel antagonism, inhibition of voltage-gated sodium/calcium channels, several enzymes (kinases, semicarbazide-sensitive amine oxidases, and matrix metalloproteinases), cytokines/chemokines, transcription factors, nerve growth factor, and modulation of several g protein-coupled receptors (cannabinoids, purinoceptors, and neuropeptides). |
2017-09-29 |
2023-08-13 |
Not clear |
| Jinghua Shan, Lixia Chen, Keliang L. Protective effects of trans-caryophyllene on maintaining osteoblast function. IUBMB life. vol 69. issue 1. 2017-08-29. PMID:28026135. |
tc has been shown to be an agonist of the cannabinoid type 2 receptor (cb2r), and the effects of tc on osteocalcin secretion and matrix mineralization were abolished in mc3t3e1 cells transfected with cb2r sirna. |
2017-08-29 |
2023-08-13 |
Not clear |
| Angela Gasse, Heidi Pfeiffer, Helga Köhler, Jennifer Schürenkam. Development and validation of a solid-phase extraction method using anion exchange sorbent for the analysis of cannabinoids in plasma and serum by gas chromatography-mass spectrometry. International journal of legal medicine. vol 130. issue 4. 2017-08-01. PMID:27072011. |
the aim of this work was to develop and validate a solid-phase extraction (spe) method for the analysis of cannabinoids with emphasis on a very extensive and effective matrix reduction in order to ensure constant good results in selectivity and sensitivity regardless of the applied measuring technology. |
2017-08-01 |
2023-08-13 |
Not clear |
| Angela Gasse, Heidi Pfeiffer, Helga Köhler, Jennifer Schürenkam. Development and validation of a solid-phase extraction method using anion exchange sorbent for the analysis of cannabinoids in plasma and serum by gas chromatography-mass spectrometry. International journal of legal medicine. vol 130. issue 4. 2017-08-01. PMID:27072011. |
in a first step, the neutral cannabinoids ∆9-tetrahydrocannabinol (thc) and 11-hydroxy-∆9-tetrahydrocannabinol (11-oh-thc) were eluted, leaving 11-nor-9-carboxy-∆9-tetrahydrocannabinol (thc-cooh) and the main interfering matrix components bound to the axs. |
2017-08-01 |
2023-08-13 |
Not clear |
| Florian Franz, Verena Angerer, Simon D Brandt, Gavin McLaughlin, Pierce V Kavanagh, Bjoern Moosmann, Volker Auwärte. In vitro metabolism of the synthetic cannabinoid 3,5-AB-CHMFUPPYCA and its 5,3-regioisomer and investigation of their thermal stability. Drug testing and analysis. vol 9. issue 2. 2017-06-30. PMID:26888282. |
urine is the most common matrix used for abstinence control and the extensive metabolism of synthetic cannabinoids requires implementation of targeted analysis. |
2017-06-30 |
2023-08-13 |
human |
| Claire Tronel, Bérenger Largeau, Maria Joao Santiago Ribeiro, Denis Guilloteau, Anne-Claire Dupont, Nicolas Arlico. Molecular Targets for PET Imaging of Activated Microglia: The Current Situation and Future Expectations. International journal of molecular sciences. vol 18. issue 4. 2017-06-01. PMID:28398245. |
we overview alternative molecular targets, for which dedicated radiopharmaceuticals have been proposed, including receptors (purinergic receptors p2x7, cannabinoid receptors, α7 and α4β2 nicotinic acetylcholine receptors, adenosine 2a receptor, folate receptor β) and enzymes (cyclooxygenase, nitric oxide synthase, matrix metalloproteinase, β-glucuronidase, and enzymes of the kynurenine pathway), with a particular focus on their respective contribution for the understanding of microglial involvement in neurodegenerative diseases. |
2017-06-01 |
2023-08-13 |
Not clear |
| Carl E Wolf, Justin L Poklis, Alphonse Pokli. Stability of Tetrahydrocannabinol and Cannabidiol in Prepared Quality Control Medible Brownies. Journal of analytical toxicology. vol 41. issue 2. 2017-05-25. PMID:27798074. |
the performance parameters of the assay including possible matrix effects and cannabinoid stability in the brownie qc over time are presented. |
2017-05-25 |
2023-08-13 |
Not clear |
| Karl B Scheidweiler, Maria Andersson, Madeleine J Swortwood, Cristina Sempio, Marilyn A Huesti. Long-term stability of cannabinoids in oral fluid after controlled cannabis administration. Drug testing and analysis. vol 9. issue 1. 2017-05-16. PMID:27539096. |
cannabinoid stability in oral fluid (of) is important for assuring accurate results since of has become a valid alternative matrix of choice for drug testing. |
2017-05-16 |
2023-08-13 |
Not clear |
| Christopher Mwanza, Zheng Chen, Quan Zhang, Shenghuo Chen, Weiwen Wang, Huihua Den. Simultaneous HPLC-APCI-MS/MS quantification of endogenous cannabinoids and glucocorticoids in hair. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 1028. 2017-02-17. PMID:27318292. |
hair matrix could retrospectively record association of endogenous cannabinoids (e.g. |
2017-02-17 |
2023-08-13 |
human |
| Amandine Scocard, Amine Benyamina, Sarah Coscas, Laurent Karil. [Synthetic cannabinoids: A new addiction matrix]. Presse medicale (Paris, France : 1983). vol 46. issue 1. 2017-02-10. PMID:28063756. |
[synthetic cannabinoids: a new addiction matrix]. |
2017-02-10 |
2023-08-13 |
Not clear |
| Marisol S Castaneto, Karl B Scheidweiler, Adarsh Gandhi, Ariane Wohlfarth, Kevin L Klette, Thomas M Martin, Marilyn A Huesti. Quantitative urine confirmatory testing for synthetic cannabinoids in randomly collected urine specimens. Drug testing and analysis. vol 7. issue 6. 2016-03-14. PMID:25231213. |
parent synthetic cannabinoids are rarely detected in urine, the most common matrix employed in workplace drug testing. |
2016-03-14 |
2023-08-13 |
Not clear |
| Yihao Tao, Jun Tang, Qianwei Chen, Jing Guo, Lin Li, Liming Yang, Hua Feng, Gang Zhu, Zhi Che. Cannabinoid CB2 receptor stimulation attenuates brain edema and neurological deficits in a germinal matrix hemorrhage rat model. Brain research. vol 1602. 2015-12-14. PMID:25625355. |
cannabinoid cb2 receptor stimulation attenuates brain edema and neurological deficits in a germinal matrix hemorrhage rat model. |
2015-12-14 |
2023-08-13 |
rat |
| Niels Bjerre Holm, Anders Just Pedersen, Petur Weihe Dalsgaard, Kristian Linne. Metabolites of 5F-AKB-48, a synthetic cannabinoid receptor agonist, identified in human urine and liver microsomal preparations using liquid chromatography high-resolution mass spectrometry. Drug testing and analysis. vol 7. issue 3. 2015-12-01. PMID:24802286. |
synthetic cannabinoids are completely metabolized, and identification of the metabolites is thus crucial when using urine as the sample matrix. |
2015-12-01 |
2023-08-13 |
human |
| Robert Ramer, Burkhard Hin. New insights into antimetastatic and antiangiogenic effects of cannabinoids. International review of cell and molecular biology. vol 314. 2015-09-25. PMID:25619715. |
among the diverse mediators of cannabinoids' antitumorigenic action, the tissue inhibitor of matrix metalloproteinases-1, which is released from cancer cells upon cannabinoid treatment, has been implicated as a pivotal factor conferring both anti-invasive properties of cancer cells as well as antiangiogenic capacities of endothelial cells. |
2015-09-25 |
2023-08-13 |
Not clear |
| Jihyun Kim, Yuran Park, Meejung Park, Eunmi Kim, Wonkyung Yang, Seungkyung Baeck, Sooyeun Lee, Sangbeom Ha. Simultaneous determination of five naphthoylindole-based synthetic cannabinoids and metabolites and their deposition in human and rat hair. Journal of pharmaceutical and biomedical analysis. vol 102. 2015-09-14. PMID:25282599. |
this quantitative lc-ms/ms analytical method for five naphthoylindole-based synthetic cannabinoids and their metabolites was very useful to be applied to authentic hair samples, of which their analytical results suggested the incorporation of synthetic cannabinoids in the hair matrix and provided the information on ingested parent drugs. |
2015-09-14 |
2023-08-13 |
human |
| Matthew N Newmeyer, Nathalie A Desrosiers, Dayong Lee, Damodara R Mendu, Allan J Barnes, David A Gorelick, Marilyn A Huesti. Cannabinoid disposition in oral fluid after controlled cannabis smoking in frequent and occasional smokers. Drug testing and analysis. vol 6. issue 10. 2015-06-19. PMID:24652685. |
oral fluid (of) is an increasingly popular alternative matrix for drug testing, with cannabinoids being the most commonly identified illicit drug. |
2015-06-19 |
2023-08-12 |
Not clear |
| Kenji Kuwayama, Tadashi Yamamuro, Kenji Tsujikawa, Hajime Miyaguchi, Tatsuyuki Kanamori, Yuko T Iwata, Hiroyuki Inou. Utilization of matrix-assisted laser desorption/ionization imaging mass spectrometry to search for cannabis in herb mixtures. Analytical and bioanalytical chemistry. vol 406. issue 19. 2015-05-11. PMID:24838491. |
after a solution containing a matrix reagent was sprayed, the distribution of cannabinoids in the sample was visualized by maldi/ims. |
2015-05-11 |
2023-08-13 |
Not clear |
| Ronald Agius, Bertin Dufaux, Hans-Gerhard Kahl, Thomas Nadulsk. Is urine an alternative to cosmetically treated hair for the detection of drugs and alcohol? Drug testing and analysis. vol 6 Suppl 1. 2015-03-10. PMID:24817057. |
significant difference was found between the positivity rates of cannabinoids in cosmetically treated hair and that in urine indicating urine to be a better alternative to the use of the hair matrix even when cosmetically treated. |
2015-03-10 |
2023-08-13 |
Not clear |
| Mostafa M Ahmed, Kevin C King, Shane M Pearce, Melissa A Ramsey, Gurwattan S Miranpuri, Daniel K Resnic. Novel targets for Spinal Cord Injury related neuropathic pain. Annals of neurosciences. vol 18. issue 4. 2014-12-22. PMID:25205949. |
some of the key mediators in the sustenance of np include the inflammatory processes, cannabinoid receptors, matrix metalloproteases, and their tissue inhibitors. |
2014-12-22 |
2023-08-13 |
Not clear |
| Robert Ramer, Sascha Fischer, Maria Haustein, Katrin Manda, Burkhard Hin. Cannabinoids inhibit angiogenic capacities of endothelial cells via release of tissue inhibitor of matrix metalloproteinases-1 from lung cancer cells. Biochemical pharmacology. vol 91. issue 2. 2014-10-28. PMID:24976505. |
cannabinoids inhibit angiogenic capacities of endothelial cells via release of tissue inhibitor of matrix metalloproteinases-1 from lung cancer cells. |
2014-10-28 |
2023-08-13 |
human |