| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xuyen H Le, Chun-Pong Lee, A Harvey Milla. The mitochondrial pyruvate carrier (MPC) complex mediates one of three pyruvate-supplying pathways that sustain Arabidopsis respiratory metabolism. The Plant cell. vol 33. issue 8. 2021-11-08. PMID:34137858. |
13c-pyruvate feeding of leaves lacking mpc showed metabolic homeostasis was largely maintained except for alanine and glutamate, indicating that transamination contributes to the restoration of the metabolic network to an operating equilibrium by delivering pyruvate independently of mpc into the matrix. |
2021-11-08 |
2023-08-13 |
Not clear |
| Hemen S Ved, Gaurav M Dosh. A Review on Emerging Drug Targets in Treatment of Schizophrenia. Current drug targets. vol 21. issue 15. 2021-10-13. PMID:32538726. |
new therapeutically potential compounds for the treatment of schizophrenia act on metabotropic glutamate receptor, matrix metalloproteinase, endocannabinoid receptor, nicotinic acetylcholine receptor, muscarinic acetylcholine cholinergic receptor and dynorphin /kappa opioid receptor systems. |
2021-10-13 |
2023-08-13 |
Not clear |
| Yunfei Bian, Wei Hou, Xinrou Chen, Jinzhang Fang, Ning Xu, Benfang Helen Rua. Glutamate Dehydrogenase as a Promising Target for Hyperinsulinism Hyperammonemia Syndrome Therapy. Current medicinal chemistry. 2021-09-16. PMID:34525914. |
it has been demonstrated that functional mutations of glutamate dehydrogenase (gdh), an enzyme in the mitochondrial matrix, are responsible for the hhs. |
2021-09-16 |
2023-08-13 |
Not clear |
| Lauri M Louhivuori, Pauli M Turunen, Verna Louhivuori, Ibrahim Al Rayyes, Tommy Nordström, Per Uhlén, Karl E Åkerma. Neurotransmitters and Endothelins Acting on Radial Glial G-Protein-Coupled Receptors Are, Through Proteolytic NRG/ErbB4 Activation, Able to Modify the Migratory Behavior of Neocortical Cells and Mediate Bipolar-to-Multipolar Transition. Stem cells and development. vol 29. issue 17. 2021-09-02. PMID:31941419. |
blocking the radial glial metabotropic glutamate receptor 5 (mglur5), the nonselective cation channel transient receptor potential 3 (trpc3), or matrix metalloproteinases (mmps) results in similar effects as erbb4 blockade. |
2021-09-02 |
2023-08-13 |
Not clear |
| Benjamin Americus, Tamar Lotan, Jerri L Bartholomew, Stephen D Atkinso. A comparison of the structure and function of nematocysts in free-living and parasitic cnidarians (Myxozoa). International journal for parasitology. vol 50. issue 10-11. 2021-08-31. PMID:32707121. |
they are composed of unique nematocyst proteins, nematogalectin and minicollagen, and both likely contain an internal matrix of metal cations covalently bound to the anionic polymer poly-gamma glutamate. |
2021-08-31 |
2023-08-13 |
Not clear |
| Si-Yang Li, Jin Shang, Xiao-Mei Mao, Rui Fan, Hui-Qi Li, Rui-Han Li, Dong-Yan She. Diosgenin exerts anti-tumor effects through inactivation of cAMP/PKA/CREB signaling pathway in colorectal cancer. European journal of pharmacology. vol 908. 2021-08-20. PMID:34324855. |
here, we reported that dsg inhibited proliferation of crc cells in dose- and time-dependent manner, induced apoptosis by modulating p53 and bcl-2 family proteins expression to mediate mitochondrial apoptosis pathway, suppressed migration and invasion by reducing mmp-9 (matrix metalloproteinase) and decreased aerobic glycolysis by mediating glucose transporter (glut) like glut3 and glut4, and pyruvate carboxylase pc downregulation. |
2021-08-20 |
2023-08-13 |
mouse |
| Victor Emmanuel Viana Geddes, Otávio José Bernardes Brustolini, Liliane Tavares de Faria Cavalcante, Filipe Romero Rebello Moreira, Fernando Luz de Castro, Ana Paula de Campos Guimarães, Alexandra Lehmkuhl Gerber, Camila Menezes Figueiredo, Luan Pereira Diniz, Eurico de Arruda Neto, Amilcar Tanuri, Renan Pedra Souza, Iranaia Assunção-Miranda, Soniza Vieira Alves-Leon, Luciana Ferreira Romão, Jorge Paes Barreto Marcondes de Souza, Ana Tereza Ribeiro de Vasconcelos, Renato Santana de Aguia. Common Dysregulation of Innate Immunity Pathways in Human Primary Astrocytes Infected With Chikungunya, Mayaro, Oropouche, and Zika Viruses. Frontiers in cellular and infection microbiology. vol 11. 2021-07-05. PMID:33791243. |
in this context astrocytes play a central role in production of inflammatory cytokines, regulation of extracellular matrix, and control of glutamate driven neurotoxicity in the central nervous system. |
2021-07-05 |
2023-08-13 |
human |
| Victor Emmanuel Viana Geddes, Otávio José Bernardes Brustolini, Liliane Tavares de Faria Cavalcante, Filipe Romero Rebello Moreira, Fernando Luz de Castro, Ana Paula de Campos Guimarães, Alexandra Lehmkuhl Gerber, Camila Menezes Figueiredo, Luan Pereira Diniz, Eurico de Arruda Neto, Amilcar Tanuri, Renan Pedra Souza, Iranaia Assunção-Miranda, Soniza Vieira Alves-Leon, Luciana Ferreira Romão, Jorge Paes Barreto Marcondes de Souza, Ana Tereza Ribeiro de Vasconcelos, Renato Santana de Aguia. Common Dysregulation of Innate Immunity Pathways in Human Primary Astrocytes Infected With Chikungunya, Mayaro, Oropouche, and Zika Viruses. Frontiers in cellular and infection microbiology. vol 11. 2021-07-05. PMID:33791243. |
in contrast, oropouche virus up-regulated cell cycle and dna maintenance and condensation pathways while down-regulated extracellular matrix, collagen metabolism, glutamate and ion transporters pathways. |
2021-07-05 |
2023-08-13 |
human |
| Karina Festerling, Karolina Can, Sebastian Kügler, Michael Mülle. Overshooting Subcellular Redox-Responses in Rett-Mouse Hippocampus during Neurotransmitter Stimulation. Cells. vol 9. issue 12. 2021-06-22. PMID:33255426. |
the rogfp redox sensor was expressed in either the cytosol or the mitochondrial matrix of cultured mouse hippocampal neurons, and the responses to transient stimulation by glutamate, serotonin, dopamine and norepinephrine were characterized. |
2021-06-22 |
2023-08-13 |
mouse |
| Mitchell R McGill, Hartmut Jaeschk. Biomarkers of mitotoxicity after acute liver injury: Further insights into the interpretation of glutamate dehydrogenase. Journal of clinical and translational research. vol 7. issue 1. 2021-06-14. PMID:34027202. |
it was recently proposed that the mitochondrial matrix enzyme glutamate dehydrogenase (gldh) can be measured in circulation as a biomarker of mitochondrial damage. |
2021-06-14 |
2023-08-13 |
mouse |
| Praveen Ballabh, Linda S de Vrie. White matter injury in infants with intraventricular haemorrhage: mechanisms and therapies. Nature reviews. Neurology. vol 17. issue 4. 2021-04-07. PMID:33504979. |
this white matter injury results from a constellation of blood-induced pathological reactions, including oxidative stress, glutamate excitotoxicity, inflammation, perturbed signalling pathways and remodelling of the extracellular matrix. |
2021-04-07 |
2023-08-13 |
Not clear |
| Miriam Marquitan, Melanie D Mark, Andrzej Ernst, Anna Muhs, Stefan Herlitze, Adrian Ruff, Wolfgang Schuhman. Glutamate detection at the cellular level by means of polymer/enzyme multilayer modified carbon nanoelectrodes. Journal of materials chemistry. B. vol 8. issue 16. 2021-04-01. PMID:31942595. |
h2o2 is further reduced to water by means of hrp and electrons are shuttled via the redox polymer matrix that wires the hrp to the electrode surface, hence delivering a current response proportional to the glutamate concentration. |
2021-04-01 |
2023-08-13 |
mouse |
| Deepa Gautam, Arundhati Tiwari, Rameshwar Nath Chaurasia, Debabrata Das. Glutamate induces synthesis of thrombogenic peptides and extracellular vesicle release from human platelets. Scientific reports. vol 9. issue 1. 2020-10-30. PMID:31171802. |
glutamate, too, incited platelet spreading and adhesion on to immobilized matrix under arterial shear, raised mitochondrial transmembrane potential associated with generation of reactive oxygen species and induced activation of amp-activated protein kinase in platelets. |
2020-10-30 |
2023-08-13 |
human |
| Evgeny Sidorov, Dharambir K Sanghera, Jairam K P Vanamal. Biomarker for Ischemic Stroke Using Metabolome: A Clinician Perspective. Journal of stroke. vol 21. issue 1. 2020-09-30. PMID:30732441. |
although failed to find specific biomarkers, they discovered several important metabolite-stroke associations which belong to three pathophysiological mechanisms: excitotoxicity with activation of glutamate, resulting in the increase of glutamate derivatives proline and pyroglutamate; oxidative stress with production of free radicals and perturbed concentrations of uric acid, matrix metalloproteinase-9, branch-chained amino acids, sphingolipids, homocysteine, asymmetric dimethylarginine, nitric oxide and folate cycle metabolites; and stroke mediated inflammation, affecting phospholipid metabolism with perturbed levels of lysophosphatidylethanolamine and lysophosphatidylcholine. |
2020-09-30 |
2023-08-13 |
Not clear |
| Ju Gao, Hongwei Yi, Xiaowei Tang, Xiaotang Feng, Miao Yu, Weiwei Sha, Xiang Wang, Xiaobin Zhang, Xiangrong Zhan. DNA Methylation and Gene Expression of Matrix Metalloproteinase 9 Gene in Deficit and Non-deficit Schizophrenia. Frontiers in genetics. vol 9. 2020-09-28. PMID:30619470. |
matrix metalloproteinase 9 (mmp9) might be associated with neural plasticity and glutamate regulation, involved in schizophrenia pathogenesis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Vadim V Tarasov, Andrey A Svistunov, Vladimir N Chubarev, Susanna S Sologova, Polina Mukhortova, Dmitrii Levushkin, Siva G Somasundaram, Cecil E Kirkland, Sergey O Bachurin, Gjumrakch Alie. Alterations of Astrocytes in the Context of Schizophrenic Dementia. Frontiers in pharmacology. vol 10. 2020-09-28. PMID:32116664. |
astrocytes produce the components that altered in schizophrenia extracellular matrix system which are involved in inflammation, functioning of interneurons, glio-, and neurotransmitter system, especially glutamate system. |
2020-09-28 |
2023-08-13 |
Not clear |
| Vito Dozio, Youssef Daali, Jules Desmeules, Jean-Charles Sanche. Deep proteomics and phosphoproteomics reveal novel biological pathways perturbed by morphine, morphine-3-glucuronide and morphine-6-glucuronide in human astrocytes. Journal of neuroscience research. 2020-09-21. PMID:32954564. |
we also find that especially longer exposure to m3g leads to significant dysregulation of biological pathways linked to extracellular matrix organization, antigen presentation, cell adhesion, and glutamate homeostasis, which are crucial for neuron- and leukocyte-astrocyte interactions. |
2020-09-21 |
2023-08-13 |
human |
| Georgi Gegelashvili, Ole Jannik Bjerru. Glutamate transport system as a key constituent of glutamosome: Molecular pathology and pharmacological modulation in chronic pain. Neuropharmacology. vol 161. 2020-07-14. PMID:31047920. |
gluts are physically linked to other glutamate signaling-, transporting- and metabolizing molecules (e.g., glutamine transporters snat3 and asct2, glutamine synthetase, nmda receptor, synaptic vesicles), as well as cellular machineries fueling the transmembrane transport of glutamate (e.g., ion gradient-generating na/k-atpase, glycolytic enzymes, mitochondrial membrane- and matrix proteins, glucose transporters). |
2020-07-14 |
2023-08-13 |
Not clear |
| Abeer A Abo Zeid, Ibrahim Rowida Raafat, Abeer G Ahme. Berberine alleviates monosodium glutamate induced postnatal metabolic disorders associated vascular endothelial dysfunction in newborn rats: possible role of matrix metalloproteinase-1. Archives of physiology and biochemistry. 2020-02-19. PMID:32072839. |
berberine alleviates monosodium glutamate induced postnatal metabolic disorders associated vascular endothelial dysfunction in newborn rats: possible role of matrix metalloproteinase-1. |
2020-02-19 |
2023-08-13 |
rat |
| Ting Xiong, Zihan Li, Xuelong Huang, Kaiqiang Lu, Weiquan Xie, Zhigang Zhou, Jian T. TO901317 inhibits the development of hepatocellular carcinoma by LXRα/Glut1 decreasing glycometabolism. American journal of physiology. Gastrointestinal and liver physiology. vol 316. issue 5. 2020-02-12. PMID:30817182. |
the expressions of liver x receptor (lxr)-α, glucose transporter (glut)-1, proliferating cell nuclear antigen (pcna), and matrix metalloproteinase (mmp)-9 were analyzed from hcc public database (ncbi pubmed database). |
2020-02-12 |
2023-08-13 |
mouse |