| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Wang, Xiongxiong Zhong, Yongyong Li, Ruixian Guo, Sujuan Du, Lili Wen, Yanlu Ying, Tao Yang, Xu-Hong We. Rostral ventromedial medulla-mediated descending facilitation following P2X7 receptor activation is involved in the development of chronic post-operative pain. Journal of neurochemistry. vol 149. issue 6. 2020-03-13. PMID:30570747. |
the microinjection of the p2x7r agonist bzatp, the nadph oxidase activator phorbol-12-myristate-13-acetate, or il-1β into the rvm induced bilateral mechanical allodynia, microglia activation, and 5-ht release in the l3 spinal dorsal horn. |
2020-03-13 |
2023-08-13 |
rat |
| Cui, Meyerson, Linderot. Opposite effects of spinal cord stimulation in different phases of carrageenan-induced hyperalgesia. European journal of pain (London, England). vol 3. issue 4. 2019-11-20. PMID:10700364. |
the concomitant increase of the hyperalgesia may reflect an enhanced release of substance p and 5-ht, both peripherally and in the dorsal horn. |
2019-11-20 |
2023-08-12 |
rat |
| H. Bras, E. Jankowska, B. Noga, B. Skoo. Comparison of Effects of Various Types of NA and 5-HT Agonists on Transmission from Group II Muscle Afferents in the Cat. The European journal of neuroscience. vol 2. issue 12. 2019-11-20. PMID:12106064. |
the results suggest that this depression may involve different membrane receptors at different locations, primarily alpha2 adrenoceptors in the intermediate zone/ventral horn and 5-ht1a serotonin receptors in the dorsal horn. |
2019-11-20 |
2023-08-12 |
cat |
| Cristina Alba-Delgado, Sarah Mountadem, Noémie Mermet-Joret, Lénaïc Monconduit, Radhouane Dallel, Alain Artola, Myriam Antr. 5-HT The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 49. 2019-10-10. PMID:30355630. |
5-ht mechanical allodynia, a widespread pain symptom that still lacks effective therapy, is associated with the activation of a dorsally directed polysynaptic circuit within the spinal dorsal horn (sdh) or medullary dorsal horn (mdh), whereby tactile inputs into deep sdh/mdh can gain access to superficial sdh/mdh, eliciting pain. |
2019-10-10 |
2023-08-13 |
Not clear |
| Tyler S Nelso. Dorsal Horn PKCγ Interneurons Mediate Mechanical Allodynia through 5-HT The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 32. 2019-08-26. PMID:31391259. |
dorsal horn pkcγ interneurons mediate mechanical allodynia through 5-ht |
2019-08-26 |
2023-08-13 |
Not clear |
| Irene Sánchez-Brualla, Pascale Boulenguez, Cécile Brocard, Sylvie Liabeuf, Annelise Viallat-Lieutaud, Xavier Navarro, Esther Udina, Frédéric Brocar. Activation of 5-HT Neuroscience. vol 387. 2019-03-14. PMID:28844001. |
activation of 5-ht downregulation of the potassium chloride cotransporter type 2 (kcc2) after a spinal cord injury (sci) disinhibits motoneurons and dorsal horn interneurons causing spasticity and neuropathic pain, respectively. |
2019-03-14 |
2023-08-13 |
Not clear |
| Liam E Potter, Suzanne Doolen, Katherine Mifflin, Gustavo Tenorio, Glen Baker, Bradley K Taylor, Bradley J Ker. Antinociceptive Effects of the Antidepressant Phenelzine are Mediated by Context-Dependent Inhibition of Neuronal Responses in the Dorsal Horn. Neuroscience. vol 383. 2019-03-07. PMID:29752984. |
we also investigated the cellular mechanisms of action of plz in the dorsal horn, and as expected of a monoamine-oxidase inhibitor, plz increased serotonin (5ht) immunoreactivity. |
2019-03-07 |
2023-08-13 |
mouse |
| F Schwaller, A H Kanellopoulos, M Fitzgeral. The developmental emergence of differential brainstem serotonergic control of the sensory spinal cord. Scientific reports. vol 7. issue 1. 2018-12-11. PMID:28533557. |
here we present evidence that descending serotonergic fibres not only inhibit nociceptive activity, but also facilitate non-noxious tactile activity in the healthy adult rat spinal dorsal horn via activation of spinal 5-ht |
2018-12-11 |
2023-08-13 |
rat |
| Danielle Aguiar Diniz, Júlia Alvarenga Petrocchi, Larissa Caldeira Navarro, Tâmara Cristina Souza, Marina Gomes Miranda E Castor, Igor Dimitri Gama Duarte, Thiago Roberto Lima Romer. Serotonin induces peripheral antinociception via the opioidergic system. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 97. 2018-08-07. PMID:29156533. |
studies conducted since 1969 have shown that the release of serotonin (5-ht) in the dorsal horn of the spinal cord contributes to opioid analgesia. |
2018-08-07 |
2023-08-13 |
Not clear |
| Kaicheng Li, Bing Cai, Changlin Li, Xu Zhan. Presynaptic inhibition of nociceptive neurotransmission by somatosensory neuron-secreted suppressors. Science China. Life sciences. vol 60. issue 9. 2018-05-11. PMID:28624955. |
in the dorsal horn of spinal cord, the excitatory afferent synaptic transmission is regulated by the inhibitory neurotransmitter γ-aminobutyric acid and modulators such as opioid peptides released from the spinal interneurons, and by serotonin, norepinepherine and dopamine from the descending inhibitory system. |
2018-05-11 |
2023-08-13 |
Not clear |
| Bin Shu, Fei Yang, Yun Gua. Intra-spinal microstimulation may alleviate chronic pain after spinal cord injury. Medical hypotheses. vol 104. 2018-04-23. PMID:28673596. |
furthermore, isms may directly induce inhibitory postsynaptic potentials in dorsal horn neurons, and trigger the release of endogenous inhibitory neurotransmitters, opioids and serotonin to inhibit postsynaptic neurons and restore the compromised segmental pain inhibition after sci. |
2018-04-23 |
2023-08-13 |
Not clear |
| Yongzhi Xia, Dan Chen, Haijian Xia, Zhengbu Liao, Wenyuan Tang, Yi Ya. Serotonergic projections to lumbar levels and its plasticity following spinal cord injury. Neuroscience letters. vol 649. 2018-03-08. PMID:28396282. |
before birth, we found that 5-hydroxytryptamine (5-ht) fibers invade the lumbar cord as early as e14.5, penetrate into the gray matter from lateral funiculus by e16.5, and then mainly occupied the ventral horn by e18.5 before localizing in the dorsal horn. |
2018-03-08 |
2023-08-13 |
mouse |
| Yongzhi Xia, Dan Chen, Haijian Xia, Zhengbu Liao, Wenyuan Tang, Yi Ya. Serotonergic projections to lumbar levels and its plasticity following spinal cord injury. Neuroscience letters. vol 649. 2018-03-08. PMID:28396282. |
after birth, we found that 5-ht invasion of both dorsal horn and ventral horn were present by the 7th postnatal day (p7). |
2018-03-08 |
2023-08-13 |
mouse |
| Vijay Benade, Ramakrishna Nirogi, Gopinadh Bhyrapuneni, Saivishal Daripelli, Ganesh Ayyanki, Shantaveer Irappanavar, Ranjithkumar Ponnamaneni, Arunkumar Manohara. Mechanistic evaluation of tapentadol in reducing the pain perception using in-vivo brain and spinal cord microdialysis in rats. European journal of pharmacology. vol 809. 2018-02-26. PMID:28412373. |
in the dorsal horn, serotonin, dopamine and norepinephrine levels were significantly increased with mean maximum increases of 220%, 190% and 280%, respectively. |
2018-02-26 |
2023-08-13 |
rat |
| Chen-Tao Wang, Cheng-Jie Mao, Xiao-Qi Zhang, Cai-Yi Zhang, Dong-Jun Lv, Ya-Ping Yang, Kai-Lin Xia, Jun-Yi Liu, Fen Wang, Li-Fang Hu, Guang-Yin Xu, Chun-Feng Li. Attenuation of hyperalgesia responses via the modulation of 5-hydroxytryptamine signalings in the rostral ventromedial medulla and spinal cord in a 6-hydroxydopamine-induced rat model of Parkinson's disease. Molecular pain. vol 13. 2017-10-19. PMID:28326933. |
in addition to the degeneration of cell bodies and fibers in the substantia nigra pars compacta, the number of rostral ventromedial medulla 5-hydroxytryptamine neurons and 5-hydroxytryptamine fibers in the spinal dorsal horn was dramatically decreased. |
2017-10-19 |
2023-08-13 |
rat |
| Chen-Tao Wang, Cheng-Jie Mao, Xiao-Qi Zhang, Cai-Yi Zhang, Dong-Jun Lv, Ya-Ping Yang, Kai-Lin Xia, Jun-Yi Liu, Fen Wang, Li-Fang Hu, Guang-Yin Xu, Chun-Feng Li. Attenuation of hyperalgesia responses via the modulation of 5-hydroxytryptamine signalings in the rostral ventromedial medulla and spinal cord in a 6-hydroxydopamine-induced rat model of Parkinson's disease. Molecular pain. vol 13. 2017-10-19. PMID:28326933. |
conclusions these results suggest that the decreased 5-hydroxytryptamine contents in the rostral ventromedial medulla and spinal dorsal horn may be involved in hyperalgesia in the 6-hydroxydopamine-induced rat model of parkinson's disease. |
2017-10-19 |
2023-08-13 |
rat |
| T Akiyama, M Nagamine, A Davoodi, M Ivanov, M Iodi Carstens, E Carsten. Innocuous warming enhances peripheral serotonergic itch signaling and evokes enhanced responses in serotonin-responsive dorsal horn neurons in the mouse. Journal of neurophysiology. vol 117. issue 1. 2017-09-20. PMID:27784810. |
we presently investigated if warming the skin enhances histamine- or serotonin (5-ht)-evoked itch behavior or responses of sensory dorsal root ganglion (drg) cells, and if responses of superficial dorsal horn neurons to innocuous warming are enhanced by these pruritogens. |
2017-09-20 |
2023-08-13 |
mouse |
| T Akiyama, M Nagamine, A Davoodi, M Ivanov, M Iodi Carstens, E Carsten. Innocuous warming enhances peripheral serotonergic itch signaling and evokes enhanced responses in serotonin-responsive dorsal horn neurons in the mouse. Journal of neurophysiology. vol 117. issue 1. 2017-09-20. PMID:27784810. |
single-unit recordings revealed a subpopulation of superficial dorsal horn neurons responsive to intradermal injection of 5-ht. |
2017-09-20 |
2023-08-13 |
mouse |
| Theeradej Thaweerattanasinp, Charles J Heckman, Vicki M Tysselin. Firing characteristics of deep dorsal horn neurons after acute spinal transection during administration of agonists for 5-HT1B/1D and NMDA receptors. Journal of neurophysiology. vol 116. issue 4. 2017-09-05. PMID:27486104. |
spinal cord injury (sci) results in a loss of serotonin (5-ht) to the spinal cord and a loss of inhibition to deep dorsal horn (ddh) neurons, which produces an exaggerated excitatory drive to motoneurons. |
2017-09-05 |
2023-08-13 |
Not clear |
| Anne Gautier, Hanady El Ouaraki, Natacha Bazin, Soha Salam, Guilan Vodjdani, Sylvie Bourgoin, Sophie Pezet, Jean-François Bernard, Michel Hamo. Lentiviral vector-driven inhibition of 5-HT synthesis in B3 bulbo-spinal serotonergic projections - Consequences on nociception, inflammatory and neuropathic pain in rats. Experimental neurology. vol 288. 2017-05-12. PMID:27983993. |
together with the long term disappearance of this enzyme in the whole rostro-caudal extent of b3 group, 5-ht was markedly depleted selectively in the dorsal horn at all levels of the spinal cord. |
2017-05-12 |
2023-08-13 |
rat |