| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| August Heidland, Gholamreza Fazeli, André Klassen, Katarina Sebekova, Hans Hennemann, Udo Bahner, Biagio Di Iori. Neuromuscular electrostimulation techniques: historical aspects and current possibilities in treatment of pain and muscle waisting. Clinical nephrology. vol 79 Suppl 1. 2013-02-26. PMID:23249528. |
the pain relieving action of electricity was explained in particular by two main mechanisms: first, segmental inhibition of pain signals to the brain in the dorsal horn of the spinal cord and second, activation of the descending inhibitory pathway with enhanced release of endogenous opioids and other neurochemical compounds (serotonin, noradrenaline, gamma aminobutyric acid (gaba), acetylcholine and adenosine). |
2013-02-26 |
2023-08-12 |
Not clear |
| Florent Viguier, Benoît Michot, Valérie Kayser, Jean-François Bernard, José-Miguel Vela, Michel Hamon, Sylvie Bourgoi. GABA, but not opioids, mediates the anti-hyperalgesic effects of 5-HT7 receptor activation in rats suffering from neuropathic pain. Neuropharmacology. vol 63. issue 6. 2013-01-10. PMID:22820553. |
among receptors mediating serotonin actions in pain control, the 5-ht(7)r is of special interest because it is expressed by primary afferent fibers and intrinsic gabaergic and opioidergic interneurons within the spinal dorsal horn. |
2013-01-10 |
2023-08-12 |
rat |
| Florent Viguier, Benoît Michot, Valérie Kayser, Jean-François Bernard, José-Miguel Vela, Michel Hamon, Sylvie Bourgoi. GABA, but not opioids, mediates the anti-hyperalgesic effects of 5-HT7 receptor activation in rats suffering from neuropathic pain. Neuropharmacology. vol 63. issue 6. 2013-01-10. PMID:22820553. |
further characterization of the anti-hyperalgesic effect of 5-ht(7)r activation by the selective agonist e-55888 showed that it was associated with a decrease in il-1ß mrna overexpression in ipsilateral l4-l6 dorsal root ganglia and lumbar dorsal horn in cci-sn rats. |
2013-01-10 |
2023-08-12 |
rat |
| Florent Viguier, Benoît Michot, Valérie Kayser, Jean-François Bernard, José-Miguel Vela, Michel Hamon, Sylvie Bourgoi. GABA, but not opioids, mediates the anti-hyperalgesic effects of 5-HT7 receptor activation in rats suffering from neuropathic pain. Neuropharmacology. vol 63. issue 6. 2013-01-10. PMID:22820553. |
these data support the idea that 5-ht(7)r-mediated inhibitory control of neuropathic pain is underlain by excitation of gabaergic interneurons within the dorsal horn. |
2013-01-10 |
2023-08-12 |
rat |
| Mark Conno. What would 5-HT do? Regional diversity of 5-HT(1) receptor modulation of primary afferent neurotransmission. British journal of pharmacology. vol 167. issue 2. 2013-01-07. PMID:22462412. |
two recent papers in bjp shed light on this puzzling situation by showing that primary afferent neurotransmission to the superficial layers of the spinal and trigeminal dorsal is inhibited by different subtypes of the 5-ht(1) receptor - 5-ht(1b(and 1d) ) in the trigeminal dorsal horn and 5-ht(1a) in the spinal dorsal horn. |
2013-01-07 |
2023-08-12 |
Not clear |
| I-S Choi, J-H Cho, C-H An, J-K Jung, Y-K Hur, J-K Choi, I-S Jan. 5-HT(1B) receptors inhibit glutamate release from primary afferent terminals in rat medullary dorsal horn neurons. British journal of pharmacology. vol 167. issue 2. 2013-01-07. PMID:22462474. |
5-ht(1b) receptors inhibit glutamate release from primary afferent terminals in rat medullary dorsal horn neurons. |
2013-01-07 |
2023-08-12 |
rat |
| I-S Choi, J-H Cho, C-H An, J-K Jung, Y-K Hur, J-K Choi, I-S Jan. 5-HT(1B) receptors inhibit glutamate release from primary afferent terminals in rat medullary dorsal horn neurons. British journal of pharmacology. vol 167. issue 2. 2013-01-07. PMID:22462474. |
although 5-ht(1b) receptors are expressed in trigeminal sensory neurons, it is still not known whether these receptors can modulate nociceptive transmission from primary afferents onto medullary dorsal horn neurons. |
2013-01-07 |
2023-08-12 |
rat |
| Zigor Aira, Itsaso Buesa, Mónica Gallego, Gontzal García del Caño, Nahia Mendiable, Janire Mingo, Diego Rada, Juan Bilbao, Manfred Zimmermann, Jon Jatsu Azku. Time-dependent cross talk between spinal serotonin 5-HT2A receptor and mGluR1 subserves spinal hyperexcitability and neuropathic pain after nerve injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 39. 2012-12-10. PMID:23015446. |
upregulation of the serotonin receptor 2a (5-ht(2a)r) in dorsal horn neurons promotes spinal hyperexcitation and impairs spinal μ-opioid mechanisms during neuropathic pain. |
2012-12-10 |
2023-08-12 |
rat |
| Zigor Aira, Itsaso Buesa, Mónica Gallego, Gontzal García del Caño, Nahia Mendiable, Janire Mingo, Diego Rada, Juan Bilbao, Manfred Zimmermann, Jon Jatsu Azku. Time-dependent cross talk between spinal serotonin 5-HT2A receptor and mGluR1 subserves spinal hyperexcitability and neuropathic pain after nerve injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 39. 2012-12-10. PMID:23015446. |
high-affinity 5-ht(2a)r agonist (4-bromo-3,6-dimethoxybenzocyclobuten-1-yl)methylamine hydrobromide (tcb-2) enhanced c-fiber-evoked dorsal horn potentials after snl, which was prevented by mglur1 antagonist aida [(rs)-1-aminoindan-1,5-dicarboxylic acid] but not by group ii mglur antagonist ly 341495 [(2s)-2-amino-2-[(1s,2s)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl)propanoic acid] or nmda antagonist d-ap5 [d-(-)-2-amino-5-phosphonopentanoic acid]. |
2012-12-10 |
2023-08-12 |
rat |
| Zigor Aira, Itsaso Buesa, Mónica Gallego, Gontzal García del Caño, Nahia Mendiable, Janire Mingo, Diego Rada, Juan Bilbao, Manfred Zimmermann, Jon Jatsu Azku. Time-dependent cross talk between spinal serotonin 5-HT2A receptor and mGluR1 subserves spinal hyperexcitability and neuropathic pain after nerve injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 39. 2012-12-10. PMID:23015446. |
5-ht(2a)r and mglur1 were found to be coexpressed in postsynaptic densities in dorsal horn neurons. |
2012-12-10 |
2023-08-12 |
rat |
| F P Zemlan, A Zieleniewski-Murphy, R Maureen Murphy, M M Behbehan. BMY 7378: Partial agonist at spinal cord 5-HT(1A) receptors. Neurochemistry international. vol 16. issue 4. 2012-10-02. PMID:20504590. |
in electrophysiological studies, iontophoretic administration of either the 5-ht(1a) agonist 8-oh-dpat (43.8 +/- 5.4 na) or bmy 7378 (46.3 +/- 5.2 na) significantly inhibited the firing rate of wide-dynamic-range dorsal horn units indicating that bmy 7378 demonstrates significant intrinsic activity at spinal cord 5-ht(1a) receptors. |
2012-10-02 |
2023-08-12 |
rat |
| Kunie Nakajima, Hideaki Obata, Nobuhisa Iriuchijima, Shigeru Sait. An increase in spinal cord noradrenaline is a major contributor to the antihyperalgesic effect of antidepressants after peripheral nerve injury in the rat. Pain. vol 153. issue 5. 2012-08-13. PMID:22424692. |
in microdialysis studies, na and 5-ht concentrations in the spinal dorsal horn were increased after injection of either milnacipran or paroxetine, and only na was increased after maprotiline. |
2012-08-13 |
2023-08-12 |
rat |
| Dongmei Wang, Tingjun Chen, Yun Gao, Rémi Quirion, Yanguo Hon. Inhibition of SNL-induced upregulation of CGRP and NPY in the spinal cord and dorsal root ganglia by the 5-HT(2A) receptor antagonist ketanserin in rats. Pharmacology, biochemistry, and behavior. vol 101. issue 3. 2012-08-02. PMID:22342663. |
the present study demonstrated that: (1) the expression of cgrp was enhanced in the spinal dorsal horn and npy was expressed in the drg containing injured neurons, but not in the adjacent drg containing intact neurons, following l5 snl; (2) the maladaptive changes in cgrp and npy expression in the spinal cord and drg mediated the bioactivity of 5-ht/5-ht(2a) receptors in neuropathic pain and (3) the blockade of 5-ht(2a) receptors by ketanserin reversed the evoked upregulation of both cgrp and npy in the spinal cord and drg contributing to the inhibition of neuropathic pain. |
2012-08-02 |
2023-08-12 |
rat |
| Hyo-Jin Jeong, Vanessa A Mitchell, Christopher W Vaugha. Role of 5-HT(1) receptor subtypes in the modulation of pain and synaptic transmission in rat spinal superficial dorsal horn. British journal of pharmacology. vol 165. issue 6. 2012-07-09. PMID:21950560. |
role of 5-ht(1) receptor subtypes in the modulation of pain and synaptic transmission in rat spinal superficial dorsal horn. |
2012-07-09 |
2023-08-12 |
rat |
| Hyo-Jin Jeong, Vanessa A Mitchell, Christopher W Vaugha. Role of 5-HT(1) receptor subtypes in the modulation of pain and synaptic transmission in rat spinal superficial dorsal horn. British journal of pharmacology. vol 165. issue 6. 2012-07-09. PMID:21950560. |
in the present study, we examined the spinal actions of a range of 5-ht(1) agonists, including sumatriptan, on acute pain, plus their effect on afferent-evoked synaptic transmission onto superficial dorsal horn neurons. |
2012-07-09 |
2023-08-12 |
rat |
| Seon Ah Park, Eun Ju Yang, Seong Kyu Han, Soo Joung Par. Age-related changes in the effects of 5-hydroxytryptamine on substantia gelatinosa neurons of the trigeminal subnucleus caudalis. Neuroscience letters. vol 510. issue 2. 2012-06-25. PMID:22260792. |
the descending serotonergic pathway from the brainstem exerts inhibitory or facilitatory effects on nociceptive transmission in the spinal dorsal horn and the vc, and sg neurons of the vc exhibit hyperpolarization, no response or depolarization in response to 5-hydroxytryptamine (5-ht) application. |
2012-06-25 |
2023-08-12 |
mouse |
| Ching-Yi Lin, Yu-Shang Lee, Vernon W Lin, Jerry Silve. Fibronectin inhibits chronic pain development after spinal cord injury. Journal of neurotrauma. vol 29. issue 3. 2012-06-15. PMID:22022865. |
in particular, the reduction of serotonin (5-ht) in the superficial dorsal horn, an important descending brainstem system in the modulation of pain, was blocked with fibronectin treatment. |
2012-06-15 |
2023-08-12 |
Not clear |
| F E Perrin, Y N Gerber, M Teigell, N Lonjon, G Boniface, L Bauchet, J J Rodriguez, J P Hugnot, A M Priva. Anatomical study of serotonergic innervation and 5-HT(1A) receptor in the human spinal cord. Cell death & disease. vol 2. 2012-04-10. PMID:21993394. |
finally, we observed numerous serotonergic profiles in the superficial part (equivalent of rexed lamina ii) of the dorsal horn, which also displayed high levels of 5-ht(1a) receptors. |
2012-04-10 |
2023-08-12 |
human |
| Carla Morgado, Liliana Silva, Patrícia Pereira-Terra, Isaura Tavare. Changes in serotoninergic and noradrenergic descending pain pathways during painful diabetic neuropathy: the preventive action of IGF1. Neurobiology of disease. vol 43. issue 1. 2012-04-09. PMID:21515376. |
based on the facilitatory role of serotoninergic and noradrenergic descending modulation during chronic pain, the increased serotonin and noradrenaline innervation of the dorsal horn in stz-diabetic rats may probably account for enhanced pain during pdn. |
2012-04-09 |
2023-08-12 |
rat |
| Jian Qi, Hua Zhang, Jun Guo, Le Yang, Wen Wang, Tao Chen, Hui Li, Sheng-Xi Wu, Yun-Qing L. Synaptic connections of the neurokinin 1 receptor-like immunoreactive neurons in the rat medullary dorsal horn. PloS one. vol 6. issue 8. 2012-02-15. PMID:21858052. |
the synaptic connections between neurokinin 1 (nk1) receptor-like immunoreactive (li) neurons and γ-aminobutyric acid (gaba)-, glycine (gly)-, serotonin (5-ht)- or dopamine-β-hydroxylase (dbh, a specific marker for norepinephrinergic neuronal structures)-li axon terminals in the rat medullary dorsal horn (mdh) were examined under electron microscope by using a pre-embedding immunohistochemical double-staining technique. |
2012-02-15 |
2023-08-12 |
rat |